45,055 results match your criteria clinical picture

Interpretability of time-series deep learning models: a study in cardiovascular patients admitted to Intensive Care Unit.

J Biomed Inform 2021 Jul 26:103876. Epub 2021 Jul 26.

Department of Medical Sciences, Biostatistics Unit, University of Trieste, Trieste, Italy.

Interpretability is fundamental in healthcare problems and the lack of it in deep learning models is currently the major barrier in the usage of such powerful algorithms in the field. The study describes the implementation of an attention layer for Long Short-Term Memory (LSTM) neural network that provides a useful picture on the influence of the several input variables included in the model. A cohort of 10,616 patients with cardiovascular diseases is selected from the MIMIC III dataset, an openly available database of electronic health records (EHRs) including all patients admitted to an ICU at Boston's Medical Centre. Read More

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Intussusception in a child with Acute Lymphoblastic Leukemia: a remarkable presentation with literature review - a case report.

J Egypt Natl Canc Inst 2021 Jul 29;33(1):18. Epub 2021 Jul 29.

Department of Pediatrics, ABVIMS & Dr. RML Hospital, New Delhi, India.

Background: Gastrointestinal complications are not uncommon in patients of Acute Leukemia. Intussusception as a complication in leukemia, although described, is exceedingly rare. Also, it is usually seen after chemotherapy and not as a part of the native disease process. Read More

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[Arousal and regulatory systems in the system of research domain criteria].

Nervenarzt 2021 Jul 29. Epub 2021 Jul 29.

Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Universität Freiburg, Hauptstraße 5, 79104, Freiburg, Deutschland.

Background: The RDoC (research domain criteria) domain arousal and regulatory systems plays an important role for psychiatric disorders.

Objective: What is the association between physiology and function of arousal, sleep and circadian rhythms and psychiatric disorders? What are the therapeutic consequences?

Material And Method: In this narrative review the most important findings related to the topic are presented briefly and concisely. First, the physiology and function of the systems are described. Read More

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Protective effect of Beta vulgaris roots supplementation on anemic phenylhydrazine-intoxicated rats.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.

Anemia is a public health problem that affects many people worldwide. Beetroot (Beta vulgaris) is a plant supposed to have many healthy features. The present study was done to evaluate the anti-anemic effect of beetroot supplement on anemia induced by phenylhydrazine in albino rats. Read More

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Ankle hemophilic arthropathy: literature review.

Am J Blood Res 2021 15;11(3):206-216. Epub 2021 Jun 15.

Department of Ageing, Neurosciences, Head-Neck and Orthopedics Sciences, Orthopedics and Traumatology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS Rome, Italy.

Hemophilia is a bleeding disorder characterized by the deficiency of a coagulation factors. The hemarthrosis is the most common and earliest manifestation. Repeated hemarthrosis over time causes the development of hemophilic arthropathy. Read More

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Pelvic mass, ascites, hydrothorax: a malignant or benign condition? Meigs syndrome with high levels of CA 125.

Prz Menopauzalny 2021 Jun 25;20(2):103-107. Epub 2021 May 25.

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.

Introduction: Abdominal-pelvic mass, ascites and pleural effusion are suggestive of malignant metastatic ovarian cancer. This triad is also present in a rare benign condition called Meigs syndrome. Rarely this condition is associated with an increased CA 125 level. Read More

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Study protocol to develop a core outcome set for thyroid dysfunction to bridge the unmet needs of patient-centred care.

BMJ Open 2021 Jul 28;11(7):e050231. Epub 2021 Jul 28.

Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

Introduction: Thyroid dysfunctions (TD) are common medical conditions affecting all global populations. Improved healthcare leading to increasing survival rates and delayed diagnosis rendered significant burden of the disease in the increasing number of patients with TD with comorbid illnesses. Therefore, reducing the burden of TD and improving the quality of care are crucial. Read More

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Unusual case of malignant pleural mesothelioma.

BMJ Case Rep 2021 Jul 28;14(7). Epub 2021 Jul 28.

Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.

We present the case of a 65-year-old woman who presented with progressive dysphagia and was diagnosed with achalasia. She subsequently developed bilateral chylous pleural effusions, with no cause identified despite extensive investigations (including computed tomography (CT) scans, gastroscopy and medical thoracoscopy (MT)) and review at a dedicated pleural multidisciplinary team meeting.Despite optimal supportive management she deteriorated and was admitted to the intensive care unit, where she passed away due to sepsis and respiratory failure 10 months after initial presentation. Read More

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Coronary Artery Fistula: Association between Pathway Patterns, Clinical Features and Congenital Heart Disease.

Arq Bras Cardiol 2021 Jul;117(1):84-88

Hospital da Criança e Maternidade de São José do Rio Preto, São José do Rio Preto, SP - Brasil.

Background: Coronary artery fistula (CAF) is a direct connection of one or more coronary arteries to cardiac chambers or a large vessel; it may be associated with congenital heart disease.

Objective: To establish CAF pathway patterns from echocardiographic data and to correlate them with clinical aspects and congenital heart disease.

Methods: A total of 7. Read More

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A novel mutation in COL3A1 associates to vascular Ehlers-Danlos syndrome with predominant musculoskeletal involvement.

Mol Genet Genomic Med 2021 Jul 28:e1753. Epub 2021 Jul 28.

DINOGMI Department, University of Genoa, Genoa, Italy.

Background: Vascular Ehlers-Danlos syndrome (vEDS) is a heritable connective tissue disorder caused by defects in the type III collagen protein. It is generally considered the most severe form of Ehlers-Danlos syndrome (EDS) due to an increased risk of spontaneous artery or organ rupture. vEDS has an extremely heterogeneous presentation and muscle rupture is considered a minor diagnostic criterium. Read More

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Spuriously Elevated Cardiac Troponin in the Setting of Atypical Chest Pain Presentation: A Diagnostic Conundrum.

JACC Case Rep 2020 May 20;2(5):790-795. Epub 2020 May 20.

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

A 47-year-old woman presented with atypical chest pain and a troponin level of 30.15 ng/dl. A detailed diagnostic work-up did not detect an acute myocardial infarction but revealed the presence of heterophile antibodies. Read More

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Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease.

Emerg Infect Dis 2021 Jul 27;27(10). Epub 2021 Jul 27.

We report 2 fatal exacerbations of systemic capillary leak syndrome (SCLS), also known as Clarkson disease, associated with coronavirus disease (COVID-19) in the United States. One patient carried an established diagnosis of SCLS and the other sought treatment for new-onset hypotensive shock, hemoconcentration, and anasarca, classic symptoms indicative of an SCLS flare. Both patients had only mild-to-moderate symptoms of COVID-19. Read More

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Registry of Acute Myocardial Infarction. REGION-MI - Russian Registry of Acute Myocardial Infarction.

Kardiologiia 2021 Jul 1;61(6):41-51. Epub 2021 Jul 1.

Yaroslavl Regional Clinical Hospital, Yaroslavl.

Aim      To study features of diagnosis and treatment of acute myocardial infarction (AMI) in Russian hospitals, results of the treatment, and early and late outcomes (6 and 12 months after AMI diagnosis); to evaluate the consistence of the treatment with clinical guidelines; and to evaluate patients' compliance with the treatment.Material and methods  The program was designed for 3 years, including 24 months for recruitment of patients to the study. The study will include 10, 000 patients hospitalized with a confirmed diagnosis (I21 according to ICD-10) of ST segment elevation acute myocardial infarction (MI) (STEMI) or non-ST segment elevation MI (NSTEMI) based on criteria of the European Society of Cardiology Guidelines on Forth Universal Definition of Myocardial Infarction (2018). Read More

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POLR3A variants in hereditary spastic paraparesis and ataxia: clinical, genetic, and neuroradiological findings in a cohort of Italian patients.

Neurol Sci 2021 Jul 23. Epub 2021 Jul 23.

Molecular Medicine and Neurogenetics, IRCCS Fondazione Stella Maris, via dei Giacinti 2, Calambrone, 56128, Pisa, Italy.

Mutations in POLR3A are characterized by high phenotypic heterogeneity, with manifestations ranging from severe childhood-onset hypomyelinating leukodystrophic syndromes to milder and later-onset gait disorders with central hypomyelination, with or without additional non-neurological signs. Recently, a milder phenotype consisting of late-onset spastic ataxia without hypomyelinating leukodystrophy has been suggested to be specific to the intronic c.1909 + 22G > A mutation in POLR3A. Read More

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Coronavirus Disease 2019 as a Possible Cause of Severe Orbital Cellulitis.

J Craniofac Surg 2021 Jul 23. Epub 2021 Jul 23.

Department of Oral Medicine and Pediatric Dentistry, State University of Londrina, Londrina, Brazil.

Abstract: Infection by severe respiratory syndrome coronavirus 2 (coronavirus disease 2019) has been the most important public health event of the last 100 years. The number of cases and deaths caused by this disease, its potential to rapidly spread and the search for a vaccine have been the center of discussion all over the world for over 1 year. In addition to the number of cases and all social, economic, and public health consequences of the pandemic, the variety of symptoms and clinical signs presented by infected patients has been subject of several studies and case reports. Read More

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Upper Gastrointestinal Tract Involvement in Inflammatory Bowel Diseases: Histologic Clues and Pitfalls.

Adv Anat Pathol 2021 Jul 26. Epub 2021 Jul 26.

Department of Pathology, Henry Lee Moffitt Cancer Center and Research Institute, Tampa, FL Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ Department of Pathology, University of Szeged and Albert Szent-Györgyi Health Center, Szeged, Hungary.

The upper gastrointestinal (UGI) manifestations of inflammatory bowel diseases (IBDs) are frequently obscured by classic ileal and colonic symptoms and are reported to involve only 0.5% to 4% of adult patients. However, because of the improvement of endoscopic techniques and the growing use of esophagogastroduodenososcopy with biopsy, both asymptomatic and clinically significant esophageal, gastric, and duodenal manifestations are increasingly recognized. Read More

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[Application of picture archiving and communication systems in lateral wedge osteotomy for cubitus varus deformity in teenagers].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):836-840

Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China.

Objective: To investigate effectiveness of picture archiving and communication systems (PACS) in lateral wedge osteotomy for cubitus varus deformity in teenagers.

Methods: A clinical data of 16 teenagers with cubitus varus deformity between July 2014 and July 2016 was retrospectively analyzed. All patients were treated with lateral wedge osteotomy and fixed with plate. Read More

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Oxidative stress in spp. infected donkeys treated with piperazine citrate versus doramectin.

Open Vet J 2021 Apr-Jun;11(2):238-250. Epub 2021 May 6.

Division of Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.

Background: Parasitic infection is one of the main problems in equidae, particularly donkeys.

Aim: This study evaluated the oxidative stress in donkeys infected with spp by determining the correlation between antioxidants levels; malondialdehyde (MDA), total antioxidant capacity (TAC), and the severity of parasitic infection. It also compared the therapeutic efficacy of piperazine citrate as an oral anthelmintic drug and Doramectin as an injectable one. Read More

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Methods for the Development of Healthcare Practice Recommendations Using Systematic Reviews and Meta-Analyses.

Thomas Platz

Front Neurol 2021 8;12:699968. Epub 2021 Jul 8.

BDH-Klinik Greifswald, Institute for Neurorehabilitation and Evidence-Based Practice, "An-Institut," University of Greifswald, Greifswald, Germany.

Quality of healthcare can be improved when the best external evidence available is integrated in clinical decision-making in a systematic explicit manner. With the rapid expansion of clinical evidence, the opportunities for evidence-based high-quality healthcare increase. Paradoxically, the likelihood of any one person to get a complete and balanced picture of the evidence available decreases. Read More

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Untargeted LC/MS-Based Metabolic Phenotyping of Hypopituitarism in Young Males.

Front Pharmacol 2021 8;12:684869. Epub 2021 Jul 8.

Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Hypopituitarism (Hypo-Pit) is partial or complete insufficiency of anterior pituitary hormones. Besides hormone metabolism, the global metabolomics in Hypo-Pit are largely unknown. We aimed to explore potential biomarkers to aid in diagnosis and personalized treatment. Read More

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FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction.

Stroke 2021 Jul 26:STROKEAHA121034191. Epub 2021 Jul 26.

National Reference Center for Hypereosinophilic syndromes (CEREO), France (J.T., M.G., M. Hamidou, G.L., J.-E.K., J.R.).

Background And Purpose: Ischemic stroke has been reported in various conditions associated with eosinophilia. fusion ([Fip1-like 1-platelet-derived growth factor receptor alpha]; ) leads to the proliferation of the eosinophilic lineage and thus to a clonal hypereosinophilic syndrome that is highly responsive to imatinib.

Methods: We previously reported on a nationwide retrospective study of 151 patients with -associated clonal hypereosinophilic syndrome. Read More

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Contributions of diagnostic, cognitive, and somatovisceral information to the prediction of fear ratings in spider phobic and non-spider-fearful individuals.

J Affect Disord 2021 Jul 16;294:296-304. Epub 2021 Jul 16.

Department of Cognition, Emotion, and Methods in Psychology, University of Vienna, Vienna, Austria; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.

Background: Physiological responding is a key characteristic of fear responses. Yet, it is unknown whether the time-consuming measurement of somatovisceral responses ameliorates the prediction of individual fear responses beyond the accuracy reached by the consideration of diagnostic (e.g. Read More

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Correlation Between Pharmacy Students' Implicit Bias Scores, Explicit Bias Scores, and Responses to Clinical Cases.

Am J Pharm Educ 2021 Jul 22:8587. Epub 2021 Jul 22.

University of Missouri - Kansas City, School of Pharmacy, Kansas City, Missouri.

The purpose of this study is to identify the extent of implicit and explicit bias in a sample of pharmacy students and to determine if there is an association between implicit bias, explicit bias, and responses to clinical cases. Investigators sent links to two online surveys to students. In the first survey, students responded to two clinical cases. Read More

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Giant pes anserinus bursitis: A rare soft tissue mass of the medial knee.

Reumatol Clin (Engl Ed) 2021 Aug-Sep;17(7):420-421

Servei de Traumatologia, Hospital Moisès Broggi,Sant Joan Despí, Barcelona, Spain.

Bursae are small, jelly-like sacs that are located throughout the body, mainly around the shoulder, elbow, hip, knee, and heel in a number over 150. They contain a small amount of fluid, and are positioned between bones and soft tissues, acting as cushions to help reduce friction. Pes anserinus bursae, despite being clinically frequent, are not visible either by ultrasound (US) or magnetic resonance image (MRI). Read More

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Personalized Metabolic Profile by Synergic Use of NMR and HRMS.

Molecules 2021 Jul 8;26(14). Epub 2021 Jul 8.

Department of Chemical Science and Technology, University of Rome "Tor Vergata", 00133 Rome, Italy.

A new strategy that takes advantage of the synergism between NMR and UHPLC-HRMS yields accurate concentrations of a high number of compounds in biofluids to delineate a personalized metabolic profile (SYNHMET). Metabolite identification and quantification by this method result in a higher accuracy compared to the use of the two techniques separately, even in urine, one of the most challenging biofluids to characterize due to its complexity and variability. We quantified a total of 165 metabolites in the urine of healthy subjects, patients with chronic cystitis, and patients with bladder cancer, with a minimum number of missing values. Read More

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[Clinical Findings in Two patients with DSD 46XY caused by new variant of the Gene and review of the literature of the role of DHH signaling pathway in sex development].

Probl Endokrinol (Mosk) 2021 Jun 7;67(3):73-77. Epub 2021 Jun 7.

Endocrinology Research Center; Research Center for Medical Genetics; Republican children's clinical hospital.

Mutations in the gene DHH are an extremely rare cause of disorders of sex development 46,XY (DSD,46XY). The article describes the clinical cases of two unrelated patients with gonadal dysgenesis 46,XY with female phenotype. By using a next generation sequencing method, in both cases the same biallelic variant substitution c. Read More

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A presumed extragonadal germ cell tumor that turned out to be a gastric cancer-a case report.

Transl Androl Urol 2021 Jun;10(6):2528-2533

Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.

A solely retroperitoneal mass in males in combination with elevated serum Alpha-Fetoprotein (AFP) and beta-human choriogonadotropin (β-HCG) levels is highly indicative of a metastatic testicular cancer. Although testicular cancers are rare, they represent the most common diagnosed cancer in males between 14 and 40 years. However, in cases without evidence of a primary testicular tumor, the rare diagnosis of a retroperitoneal extragonadal germ cell tumor (EGCT) must be assumed. Read More

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An unusual presentation of Huntington's disease.

Clin Case Rep 2021 Jul 16;9(7):e04547. Epub 2021 Jul 16.

Department of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.

We describe the case of a 59-year-old woman who exhibited psychotic symptoms, cognitive dysfunction, and restlessness. While the clinical picture and 18F-FDG PET/CT suggested the presence of a tauopathy, especially frontotemporal dementia or progressive supranuclear palsy, genetic testing eventually revealed Huntington's disease. Read More

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Transcranial Doppler Based Cerebrovascular Reactivity Indices in Adult Traumatic Brain Injury: A Scoping Review of Associations With Patient Oriented Outcomes.

Front Pharmacol 2021 6;12:690921. Epub 2021 Jul 6.

Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Disruption in cerebrovascular reactivity following traumatic brain injury (TBI) is a known phenomenon that may hold prognostic value and clinical relevance. Ultimately, improved knowledge of this process and more robust means of continuous assessment may lead to advances in precision medicine following TBI. One such method is transcranial Doppler (TCD), which has been employed to evaluate cerebrovascular reactivity following injury utilizing a continuous time-series approach. Read More

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Pain modulation by your partner: An experimental investigation from a social-affective perspective.

PLoS One 2021 22;16(7):e0254069. Epub 2021 Jul 22.

Department of Clinical Psychology, Justus-Liebig-University Giessen, Giessen, Germany.

Background: Social context such as the relationship between a person experiencing pain and a caregiver has been shown to affect the experience of pain, yet, results are not consistent. Possibly, differential effects of interpersonal relationships are modulated by affective states expressed by social partners. Viewing partner pictures in experimental designs is not only associated with lowered perceived pain intensity, but also affects neural responses. Read More

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