46,063 results match your criteria clinical panel


Does large NGS panel analysed using exome tumour sequencing improve the management of advanced non-small-cell lung cancers?

Lung Cancer 2021 Aug 29;161:98-107. Epub 2021 Aug 29.

Department of Medical Oncology, Georges François Leclerc Cancer Center - UNICANCER, 1 rue du Professeur Marion, Dijon 21000, France; University of Burgundy-Franche Comté, Maison de l'université Esplanade Erasme, 21000 Dijon, France; Platform of Transfert in Biological Oncology, Georges François Leclerc Cancer Center - UNICANCER, 1 rue du Professeur Marion, Dijon 21000, France; Genomic and Immunotherapy Medical Institute, Dijon University Hospital, 14 rue Paul Gaffarel 21000 Dijon, France; UMR INSERM 1231, 7 Boulevard Jeanne d'Arc, 21000 Dijon, France. Electronic address:

Introduction: Non-small-cell lung cancer (NSCLC) is one of the most common and deadly cancers. Several molecular drivers of oncogene addiction are now known to be strong predictive biomarkers for target therapies. Advances in large Next Generation Sequencing (LNGS) have improved the ability to detect potentially targetable mutations. Read More

View Article and Full-Text PDF

[Environmental endocrine disruptors and fertility.]

Gynecol Obstet Fertil Senol 2021 Sep 21. Epub 2021 Sep 21.

Univ Montpellier, INSERM 1203, Développement Embryonnaire Fertilité Environnement, Montpellier, France; CHU Montpellier, Univ Montpellier, Département de Biologie de la Reproduction, Biologie de la Reproduction/DPI et CECOS, Montpellier, France. Electronic address:

Endocrine disruptor chemicals (EDCs) are ubiquitous contaminants in the environment, wildlife, and humans. During the last 20 years, several epidemiological, clinical and experimental studies have demonstrated the role of EDCs on the reduction of male and female fertility. The concept of foetal origins of adult disease is particularly topical in the field of reproduction. Read More

View Article and Full-Text PDF
September 2021

Combined Angio-CT Systems: A Roadmap Tool for Precision Therapy in Interventional Oncology.

Radiol Imaging Cancer 2021 Sep;3(5):e210039

From the Departments of Interventional Radiology (R.T., E.Y.L., Y.M.L., S.Y., R.A., R.A.S., S.G., B.C.O.), Anesthesiology (J.R.R.), and Imaging Physics (A.K.J.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030; Siemens Healthineers, USA (G.C.); and Department of Radiology, Nara Medical University, Nara, Japan (R.T., H.N., T.T., K.K.).

Combined angiography-CT (angio-CT) systems, which combine traditional angiographic imaging with cross-sectional imaging, are a valuable tool for interventional radiology. Although cone-beam CT (CBCT) technology from flat-panel angiography systems has been established as an adjunct cross-sectional imaging tool during interventional procedures, the intrinsic advantages of angio-CT systems concerning superior soft-tissue imaging and contrast resolution, along with operational ease, have sparked renewed interest in their use in interventional oncology procedures. Owing to increases in affordability and usability due to an improved workflow, angio-CT systems have become a viable alternative to stand-alone flat-panel angiographic systems equipped with CBCT. Read More

View Article and Full-Text PDF
September 2021

Promoting and Protecting Mental Health: A Delphi Consensus Study for Actionable Public Mental Health Messages.

Am J Health Promot 2021 Sep 24:890117121998536. Epub 2021 Sep 24.

Mental Health Foundation, London, United Kingdom.

Purpose: Public health campaigns are still relatively rare in mental health. This paper aims to find consensus on the preventive self-management actions (i.e. Read More

View Article and Full-Text PDF
September 2021

Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women: results from a Dutch primary HPV-based screening cohort.

Int J Cancer 2021 Sep 24. Epub 2021 Sep 24.

Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Methylation of host-cell DNA has been proposed as a promising biomarker for triage of high-risk (hr) human papillomavirus (HPV) positive women at screening. This study aims to validate recently identified host-cell DNA methylation markers for triage in an hrHPV-positive cohort derived from primary HPV-based cervical screening in The Netherlands. Methylation markers ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST were evaluated relative to the ACTB reference gene by multiplex quantitative methylation-specific PCR (qMSP) in clinician-collected cervical samples (n=715) from hrHPV-positive women (age 29-60 years), who were enrolled in the Dutch IMPROVE screening trial (NTR5078). Read More

View Article and Full-Text PDF
September 2021

Spotlight influenza: Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, Belgium, 2015 to 2019.

Euro Surveill 2021 09;26(38)

National Influenza Centre, Sciensano, Brussels, Belgium.

BackgroundSeasonal influenza-like illness (ILI) affects millions of people yearly. Severe acute respiratory infections (SARI), mainly influenza, are a leading cause of hospitalisation and mortality. Increasing evidence indicates that non-influenza respiratory viruses (NIRV) also contribute to the burden of SARI. Read More

View Article and Full-Text PDF
September 2021

Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic death.

Eur Heart J 2021 Sep 24. Epub 2021 Sep 24.

Division of Cardiology, Toronto General Hospital, The Toronto General Hospital Research Institute, University Health Network, University of Toronto, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.

Aims: Catecholaminergic polymorphic ventricular tachycardia (CPVT) and short QT syndrome (SQTS) are inherited arrhythmogenic disorders that can cause sudden death. Numerous genes have been reported to cause these conditions, but evidence supporting these gene-disease relationships varies considerably. To ensure appropriate utilization of genetic information for CPVT and SQTS patients, we applied an evidence-based reappraisal of previously reported genes. Read More

View Article and Full-Text PDF
September 2021

Urine Drug Screening in the Era of Designer Benzodiazepines: Comparison of Three Immunoassay Platforms, LC-QTOF-MS, and LC-MS/MS.

J Anal Toxicol 2021 Sep 24. Epub 2021 Sep 24.

Department of Pathology, Medical College of Wisconsin, 8701 W Watertown Plank Road, Milwaukee, WI, 53226, USA.

This study investigated the presence of designer benzodiazepines in 35 urine specimens obtained from emergency department patients undergoing urine drug screening. All specimens showed apparent false-positive benzodiazepine screening results (i.e. Read More

View Article and Full-Text PDF
September 2021

Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita.

Front Med (Lausanne) 2021 7;8:713312. Epub 2021 Sep 7.

Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany.

Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies. Mechanistically, inhibition of specific PI3K isoforms, namely PI3Kβ or PI3Kδ, impaired immune complex (IC)-induced neutrophil activation, a key prerequisite for EBA pathogenesis. Data unrelated to EBA showed that neutrophil activation is also modulated by PI3Kα and γ, but their impact on the EBA has, so far, remained elusive. Read More

View Article and Full-Text PDF
September 2021

Genetics Evaluation of Targeted Exome Sequencing in 223 Chinese Probands With Genetic Skeletal Dysplasias.

Front Cell Dev Biol 2021 7;9:715042. Epub 2021 Sep 7.

Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Genetic skeletal dysplasias (GSDs) are a type of disease with complex phenotype and high heterogeneity, characterized by cartilage and bone growth abnormalities. The variable phenotypes of GSD make clinical diagnosis difficult. To explore the clinical utility of targeted exome sequencing (TES) in the diagnosis of GSD, 223 probands with suspected GSD were enrolled for TES with a panel of 322 known disease-causing genes. Read More

View Article and Full-Text PDF
September 2021

A Three-Dimensional Imaging Method for the Quantification and Localization of Dynamic Cell Tracking Posttransplantation.

Front Cell Dev Biol 2021 7;9:698795. Epub 2021 Sep 7.

Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Cell transplantation has been proposed as a promising therapeutic strategy for curing the diseases requiring tissue repairing and functional restoration. A preclinical method to systematically evaluate the fates of donor cells in recipients, spatially and temporally, is demanded for judging therapeutic potentials for the particularly designed cell transplantation. Yet, the dynamic cell tracking methodology for tracing transplanted cells is still at its early phase. Read More

View Article and Full-Text PDF
September 2021

Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants.

J Perinatol 2021 Sep 23. Epub 2021 Sep 23.

Department of Pediatrics and the Tufts Clinical and Translational Science Institute, Tufts University School of Medicine, Boston, MA, USA.

Neonates born to mothers taking opioids during pregnancy are at risk for neonatal opioid withdrawal syndrome (NOWS), for which there is no recognized standard approach to care. Nonpharmacologic treatment is typically used as a first-line approach for management, and pharmacologic treatment is added when clinical signs are not responding to nonpharmacologic measures alone. Although morphine and methadone are the most commonly used pharmacotherapies for NOWS, buprenorphine has emerged as a treatment option based on its pharmacologic profile and results from initial single site clinical trials. Read More

View Article and Full-Text PDF
September 2021

Oncology clinic-based germline genetic testing for exocrine pancreatic cancer enables timely return of results and unveils low uptake of cascade testing.

J Med Genet 2021 Sep 23. Epub 2021 Sep 23.

Department of Surgery, McGill University, Montreal, Québec, Canada

Background: Traditional medical genetics models are unable to meet the growing demand for germline genetic testing (GT) in patients with exocrine pancreatic cancer (PC). This study investigates the impact of an ambulatory oncology clinic-based GT model.

Methods: From 2012 to 2021, patients with PC were prospectively enrolled and considered for GT. Read More

View Article and Full-Text PDF
September 2021

Characteristics of patients with chronic hypoparathyroidism not adequately controlled with conventional treatment and management patterns in Spain.

Endocrinol Diabetes Nutr (Engl Ed) 2021 May 6;68(5):304-311. Epub 2021 Sep 6.

Shire Pharmaceuticals Ibérica SL, miembro del grupo empresarial Takeda, Madrid, Spain. Electronic address:

Background And Objective: The current guidelines on hypoparathyroidism offer a model for treating patients but do not cover real-world situations or patient diversity. Given the lack of data regarding hypoparathyroidism, a Delphi panel was convened in Spain to establish consensus in defining the characteristics of patients with chronic hypoparathyroidism not adequately controlled with conventional treatment, as well as to investigate patterns of management.

Material And Methods: A presentation matrix provided a framework for characterizing inadequately controlled chronic hypoparathyroidism, based on four predefined patient groups: group 1 (normal biochemical levels and the patient feeling well); group 2 (abnormal biochemical levels and the patient feeling well); group 3 (normal biochemical levels and the patient feeling unwell); and group 4 (abnormal biochemical levels and the patient feeling unwell). Read More

View Article and Full-Text PDF

Whole genome sequencing in the diagnosis of primary ciliary dyskinesia.

BMC Med Genomics 2021 Sep 23;14(1):234. Epub 2021 Sep 23.

School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Background: It is estimated that 1-13% of cases of bronchiectasis in adults globally are attributable to primary ciliary dyskinesia (PCD) but many adult patients with bronchiectasis have not been investigated for PCD. PCD is a disorder caused by mutations in genes required for motile cilium structure or function, resulting in impaired mucociliary clearance. Symptoms appear in infancy but diagnosis is often late or missed, often due to the lack of a "gold standard" diagnostic tool and non-specific symptoms. Read More

View Article and Full-Text PDF
September 2021

Exploring core competencies of clinical nurse preceptors: A nominal group technique study.

Nurse Educ Pract 2021 Sep 11;56:103200. Epub 2021 Sep 11.

School of Nursing & Nursing Department, Chang Gung University of Science and Technology & Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan. Electronic address:

Aim: The aim of this study was to explore core competencies of nurse preceptors based on the perspectives of postgraduate-year nurses, nurse preceptors and head nurses.

Background: Perspectives of core competencies of nurse preceptors are varied among postgraduate-year nurses, nurse preceptors and head nurses, which makes it difficult to establish preceptor training programs and develop evaluation instruments.

Design: A nominal group technique study. Read More

View Article and Full-Text PDF
September 2021

BSHI/BTS guidance on crossmatching before deceased donor kidney transplantation.

Int J Immunogenet 2021 Sep 23. Epub 2021 Sep 23.

Transplantation Laboratory, Manchester Royal Infirmary, Manchester, UK.

All UK H&I laboratories and transplant units operate under a single national kidney offering policy, but there have been variations in approach regarding when to undertake the pre-transplant crossmatch test. In order to minimize cold ischaemia times for deceased donor kidney transplantation we sought to find ways to be able to report a crossmatch result as early as possible in the donation process. A panel of experts in transplant surgery, nephrology, specialist nursing in organ donation and H&I (all relevant UK laboratories represented) assessed evidence and opinion concerning five factors that relate to the effectiveness of the crossmatch process, as follows: when the result should be ready for reporting; what level of donor HLA typing is needed; crossmatch sample type and availability; fairness and equity; risks and patient safety. Read More

View Article and Full-Text PDF
September 2021

Verification of analytical bacterial spectrum of QIAstat-Dx® GI V2 and Novodiag® Bacterial GE+ V2-0 diagnostic panels.

J Antimicrob Chemother 2021 Sep;76(Supplement_3):iii50-iii57

Department of Clinical Microbiology, Zealand University Hospital, Koege, Ingemannsvej 46, DK-4200 Slagelse, Denmark.

Background: Implementing multiplex PCR or syndromic panel-based testing platforms to detect microbial species that cause acute diarrhoea may guide patient management more effectively and efficiently.

Objectives: To assess and compare the performance of two syndromic panel-based testing systems, QIAstat-Dx® Gastrointestinal Panel V2 (QGI) and the Novodiag® Bacterial GE+ V2-0 (NGE).

Methods: The QGI and NGE panels include 16 and 14 bacterial gastrointestinal pathogens, respectively. Read More

View Article and Full-Text PDF
September 2021

Nutritional management of type 2 diabetes in subjects with obesity: an international guideline for clinical practice.

Crit Rev Food Sci Nutr 2021 Sep 23:1-13. Epub 2021 Sep 23.

Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Naples, Italy.

Type 2 diabetes mellitus (T2DM) and obesity represent a global public health problem. Current nutritional recommendations focused on weight loss and overall dietary quality. However, there is no consensus on the optimal macronutrient composition of the diet, particularly for the long-term management of T2DM in subjects with obesity. Read More

View Article and Full-Text PDF
September 2021

Multi-incident analysis of reviews of serious adverse clinical events in children with serious bacterial infection and/or sepsis in Queensland, Australia between 2012 and 2017.

J Paediatr Child Health 2021 Sep 23. Epub 2021 Sep 23.

Queensland Paediatric Quality Council, Queensland Health, Brisbane, Queensland, Australia.

Aim: To report on findings from a multi-incident analysis of reviews of serious paediatric adverse clinical events related to serious bacterial infection and/or sepsis (hereafter referred to as sepsis for brevity) in Queensland, Australia, between 2012 and 2017.

Methods: The Queensland Paediatric Quality Council reviewed documentation from reviews of serious adverse events occurring in children (<18 years) with a diagnosis of sepsis at Queensland public hospitals between 2012 and 2017, including clinical details, coronial reports, autopsy reports and root cause analysis documents. A multi-incident tool was designed and used by an expert panel to identify patient and facility demographics, contributing factors, and human and system factors associated with paediatric serious adverse events. Read More

View Article and Full-Text PDF
September 2021

Molecular typing of clinical and environmental Aspergillus fumigatus isolates from Iran using microsatellites.

Curr Med Mycol 2021 Mar;7(1):25-30

Department of Medical Laboratory Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.

Background And Purpose: Because of the growing incidence of infection, typing methods of species are increasingly being used. Accordingly, studying the spread and population dynamics of strains isolating from clinical and environment, from a single host to large-scale ecosystems is definitely needed. In the current study, we carried out a genetic analysis of nine microsatellite loci in isolates from different regions of Iran to compare and explore the genetic diversity between environmental and clinical strains. Read More

View Article and Full-Text PDF

Vitamins as primary or adjunctive treatment in infertile men with varicocele: A systematic review.

Arab J Urol 2021 29;19(3):264-273. Epub 2021 May 29.

U-merge Ltd. (Urology for Emerging Countries), London, UK.

Objective: To investigate the usage and the efficacy of vitamins as primary or adjuvant treatment in infertile men with varicocele.

Methods: A systematic search in PubMed, the Medical Literature Analysis and Retrieval System Online (MEDLINE) and Cochrane Library with the terms (varicocele) AND (vitamins) was performed. We searched for studies: a) reporting the administration of vitamins (individually or as part of a complex) in men with varicocele and infertility, b) primarily or adjuvant to invasive treatment, and c) reporting the impact on semen parameters and/or pregnancy rates. Read More

View Article and Full-Text PDF

Coexistence of Two Rare Genetic Variants in Canonical and Non-canonical Exons of : A Potential Source of Misinterpretation.

Front Genet 2021 6;12:722291. Epub 2021 Sep 6.

Russian National Research Center of Surgery Named After B.V. Petrovsky, Moscow, Russia.

Primary cardiac channelopathies are a group of diseases wherein the role of DNA testing in aiding diagnosis and treatment-based decision-making is gaining increasing attention. However, in some cases, evaluating the pathogenicity of new variants is still challenging. We report an accurate multistage assessment of a rare genetic variant in the gene using next-generation sequencing (NGS) techniques and Sanger sequencing. Read More

View Article and Full-Text PDF
September 2021

A web-based fuzzy risk predictive-decision model of de novo stress urinary incontinence in women undergoing pelvic organ prolapse surgery.

Curr Urol 2021 Sep 9;15(3):131-136. Epub 2021 Aug 9.

Research Center for Evidence-Based Medicine, A Joanna Briggs Institute Affiliated Group, Urology Department, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Pelvic organ prolapse (POP) and stress urinary incontinence (SUI) are common conditions affecting women's health and quality of life. In 50% of cases, SUI occurs after POP surgery, which is called de novo SUI. Predicting the risk of de novo SUI is a complex multi-attribute decision-making process. Read More

View Article and Full-Text PDF
September 2021

Monitoring circulating tumor-DNA during surgical treatment in patients with gastrointestinal stromal tumors.

Mol Cancer Ther 2021 Sep 22. Epub 2021 Sep 22.

Sahlgrenska Center for Cancer Research, Depart. of Laboratory Medicine, Institute of Biomedicine/Wallenberg Centre for Molecular and Translational Medicine/Depart. of Clinical Genetics and Genomics, Sahlgrenska Academy at University of Gothenburg/Region Västra Götaland, Sahlgrenska University Hospital

The majority of patients diagnosed with advanced gastrointestinal stromal tumor (GIST) are successfully treated with a combination of surgery and tyrosine kinase inhibitors (TKIs). However, it remains challenging to monitor treatment efficacy and identify relapse early. Here, we utilized a sequencing strategy based on molecular barcodes and developed a GIST-specific panel to monitor tumor-specific and TKI resistance mutations in cell-free DNA and applied the approach to patients undergoing surgical treatment. Read More

View Article and Full-Text PDF
September 2021

Antitumor activity of the novel BTK inhibitor TG-1701 is associated with disruption of Ikaros signaling in patients with B-cell non-Hodgkin lymphoma.

Clin Cancer Res 2021 Sep 22. Epub 2021 Sep 22.

Lymphoma Translational group, Josep Carreras Leukaemia Research Institute

Purpose: Despite the remarkable activity of BTK inhibitors (BTKi) in relapsed B-cell non-Hodgkin lymphoma (B-NHL), no clinically-relevant biomarker has been associated to these agents so far. The relevance of phosphoproteomic profiling for the early identification of BTKi responders remains underexplored.

Experimental Design: A set of six clinical samples from an ongoing phase 1 trial dosing chronic lymphocytic leukemia (CLL) patients with TG-1701, a novel irreversible and highly specific BTKi, were characterized by phosphoproteomic and RNA-seq analysis. Read More

View Article and Full-Text PDF
September 2021

Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.

Int Psychogeriatr 2021 Sep 23:1-5. Epub 2021 Sep 23.

Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.

Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer's disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these etiologies. MCI patients (n = 92) and healthy comparators (n = 31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Read More

View Article and Full-Text PDF
September 2021

Changes in serum biomarkers of inflammation in bovine besnoitiosis.

Parasit Vectors 2021 Sep 22;14(1):488. Epub 2021 Sep 22.

Animal Health Department, Faculty of Veterinary Sciences, SALUVET, Complutense University of Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain.

Background: Acute and chronic besnoitiosis in extensive natural-service herds can have relevant effects in the health of bulls and negative consequences in their productive performance. Recent progress has been made in order to elucidate the pathogenesis of this disease. In this context, the study of biomarkers of inflammation in serum would contribute to gaining knowledge about the physiopathology of bovine besnoitiosis. Read More

View Article and Full-Text PDF
September 2021

Adult Acute Myeloid Leukemia with the KMT2A-Mixed Lineage Leukemia T10 Fusion: An Analysis of 10 Cases Showed Common Features and Frequent Mutations in the RAS Signaling Pathway.

Acta Haematol 2021 Sep 22:1-7. Epub 2021 Sep 22.

Department of Hematology, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital, Changzhou, China.

Mixed lineage leukemia (MLL) T10 is a relatively rare partner for the KMT2A lysine (K)-specific methyltransferase 2A gene. The common features and coexisting mutations of acute myeloid leukemia (AML) patients with KMT2A-MLLT10 remain unknown. In this study, 10 adult AML patients with KMT2A-MLLT10 fusions were picked up from 496 AML patients by using RT-polymerase chain reaction (PCR) and/or fluorescence in situ hybridization, and then screened for mutations in the 49 genes panel with next-generation sequencing and PCR, followed by direct Sanger sequencing. Read More

View Article and Full-Text PDF
September 2021

Acute Lymphoblastic Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2021 09 20;19(9):1079-1109. Epub 2021 Sep 20.

National Comprehensive Cancer Network.

The NCCN Guidelines for Acute Lymphoblastic Leukemia (ALL) focus on the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk assessment and stratification for risk-adapted therapy; treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL for both adolescent and young adult and adult patients; and supportive care considerations. Given the complexity of ALL treatment regimens and the required supportive care measures, the NCCN ALL Panel recommends that patients be treated at a specialized cancer center with expertise in the management of ALL This portion of the Guidelines focuses on the management of Ph-positive and Ph-negative ALL in adolescents and young adults, and management in relapsed settings. Read More

View Article and Full-Text PDF
September 2021