149,823 results match your criteria clinical metabolic

Network pharmacology-based exploration of therapeutic mechanism of Liu-Yu-Tang in atypical antipsychotic drug-induced metabolic syndrome.

Comput Biol Med 2021 Apr 30;134:104452. Epub 2021 Apr 30.

Shanghai Clinical Research Center for Mental Health, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, PR China. Electronic address:

Background: Metabolic syndrome (MetS) is prevalent in patients receiving atypical antipsychotic drugs (AADs), but there are few effective interventions. The Traditional Chinese herbal decoction Liu-Yu-Tang (LYT) has achieved clinical improvement for AAD-induced MetS, but its pharmacological mechanism remains unclear.

Method: A network pharmacology-based method was utilized in this study. Read More

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Antineoplastic dosing in overweight and obese cancer patients: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)/Società Italiana Endocrinologia (SIE)/Società Italiana Farmacologia (SIF) multidisciplinary consensus position paper.

ESMO Open 2021 May 10;6(3):100153. Epub 2021 May 10.

Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy.

Most anticancer molecules are administered in body-size-based dosing schedules, bringing up unsolved issues regarding pharmacokinetic data in heavy patients. The worldwide spread of obesity has not been matched by improved methods and strategies for tailored drug dosage in this population. The weight or body surface area (BSA)-based approaches may fail to fully reflect the complexity of the anthropometric features besides obesity in cancer patients suffering from sarcopenia. Read More

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Burosumab treatment for fibrous dysplasia.

Bone 2021 May 10:116004. Epub 2021 May 10.

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare mosaic disorder of Gα activation. Fibroblast Growth Factor 23 (FGF23)-mediated hypophosphatemia is a feature of FD/MAS that has been associated with poor skeletal outcomes. Standard therapy includes oral phosphorus and vitamin D analogs; however, treatment is limited by potential adverse renal and gastrointestinal effects. Read More

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The protective effect of zinc on morphine-induced testicular toxicity via p53 and Akt pathways: An in vitro and in vivo approach.

J Trace Elem Med Biol 2021 May 8;67:126776. Epub 2021 May 8.

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

Background: Chronic use of morphine is associated with reproductive complications, such as hypogonadism and infertility. While the side effects of morphine have been extensively studied in the testis, much less is known regarding the effects of morphine on Sertoli cells and the effects of zinc on morphine-induced testicular injury as well as their underlying mechanisms. Therefore, the purpose of this study was to investigate the effect of morphine (alone and co-administered with zinc) on cell viability and apoptosis of the testicular (Sertoli) cells as well as the tumor suppressor p53 and phosphorylated-protein kinase B (p-Akt) protein levels in both in vitro and in vivo models. Read More

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Does vitamin C supplementation exert profitable effects on serum lipid profile in patients with type 2 diabetes? A systematic review and dose-response meta-analysis.

Pharmacol Res 2021 May 10:105665. Epub 2021 May 10.

Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address:

Previous studies have reported that vitamin C supplementation may decrease lipid profile in patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the influence of vitamin C supplementation on lipid profile in patients with T2DM. Studies examining the effects of vitamin C supplementation on lipid profile in patients with T2DM, published up to November 2020, were identified through PubMed, SCOPUS, and Embase databases. Read More

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Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.

Life Sci 2021 May 10:119592. Epub 2021 May 10.

Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is one of the common malignancies worldwide. Slit-Robo GTPase-activating proteins (SRGAPs) have been shown to regulate the occurrence and development of various tumors. However, their specific roles in HCC remain elusive. Read More

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Anesthetic Management of a Child With Propionic Acidemia Complicated by Bacteremia and Severe Acute Respiratory Syndrome Coronavirus 2.

J Med Cases 2021 Apr 8;12(4):152-156. Epub 2021 Feb 8.

Department of Anesthesiology and Critical Care, Saint Louis University Hospital, 1201 S. Grand Boulevard, St. Louis, MO 63104, USA.

Propionic acidemia (PA) is a rare, multi-systemic inborn error of metabolism. PA results from an impaired activity of the mitochondrial enzyme, propionyl-CoA carboxylase (PCC). PCC holds an essential role in the catabolic pathways for odd-chain fatty acids, cholesterol side-chains and branched-chain amino acids. Read More

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Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program.

PLoS One 2021 13;16(5):e0251651. Epub 2021 May 13.

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America.

Background: The risk factors associated with the stages of Coronavirus Disease-2019 (COVID-19) disease progression are not well known. We aim to identify risk factors specific to each state of COVID-19 progression from SARS-CoV-2 infection through death.

Methods And Results: We included 648,202 participants from the Veteran Affairs Million Veteran Program (2011-). Read More

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From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure With Preserved Ejection Fraction Paradigm Revisited.

Circ Res 2021 May 13;128(10):1451-1467. Epub 2021 May 13.

RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston (M.R.Z.).

In accordance with the comorbidity-inflammation paradigm, comorbidities and especially metabolic comorbidities are presumed to drive development and severity of heart failure with preserved ejection fraction through a cascade of events ranging from systemic inflammation to myocardial fibrosis. Recently, novel experimental and clinical evidence emerged, which strengthens the validity of the inflammatory/profibrotic paradigm. This evidence consists among others of (1) myocardial infiltration by immunocompetent cells not only because of an obesity-induced metabolic load but also because of an arterial hypertension-induced hemodynamic load. Read More

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Mass Spectrometry Imaging Identifies Metabolic Patterns Associated with Malignant Potential in Pheochromocytoma and Paraganglioma.

Eur J Endocrinol 2021 May 1. Epub 2021 May 1.

F Beuschlein, Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, UniversitatsSpital Zurich, Zurich, 8091, Switzerland.

Objective: Within the past decade, important genetic drivers of pheochromocytoma and paraganglioma (PPGLs) development have been identified. The pathophysiological mechanism that translate these alterations into functional autonomy and potentially malignant behavior have not been elucidated in detail. Here we used MALDI-mass spectrometry imaging (MALDI-MSI) of formalin-fixed paraffin-embedded tissue specimens to comprehensively characterize the metabolic profiles of PPGLs. Read More

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Relevance of Anthropometric Measurements in a Multiethnic Obesity Cohort: Observational Study.

Interact J Med Res 2021 May 13;10(2):e27784. Epub 2021 May 13.

Mohammad Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Background: The prevalence of obesity is increasing worldwide, and the Middle East is not an exception to this increasing trend. Obesity increases the risk of multiple metabolic complications, such as diabetes mellitus. Measurement of obesity has primarily relied on the BMI to identify risk; however, both bedside and office-based anthropometric measures of obesity can provide more detailed information on risk. Read More

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Impact of Donor and Recipient Clinical Characteristics and Hepatic Histology on Steatosis/Fibrosis Following Liver Transplantation.

Transplantation 2021 Feb 8. Epub 2021 Feb 8.

1Department of Surgery, University of California San Francisco, San Francisco, CA, USA 2Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA 3Division of Hepatology and Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL, USA 4Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA 5Department of Surgery, University of Michigan, Ann Arbor, MI, USA 6Department of Surgery, University of Washington, Seattle, WA, USA 7Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA 8Division of Gastroenterology and Hepatology, University of Colorado Denver, Aurora, CO, USA 9Immune Tolerance Network, San Francisco, CA, USA 10Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA.

Background: Deceased donor and recipient predictors of post transplant steatosis/steatohepatitis and fibrosis are not well known.

Aim: Evaluate the prevalence and assess donor and recipient predictors of steatosis, steatohepatitis, and fibrosis in LT recipients.

Methods: Using the ITN A-WISH multicenter study (NCT00135694), donor and recipient demographic and clinical features were collected. Read More

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February 2021

IL-34 reprograms glycolytic and osteoclastic RA macrophages via Syndecan-1 and M-CSFR.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Jesse Brown VA Medical Center, Chicago, IL, 60612, USA.

Objective: In RA, IL-34 serum levels are linked with increased disease severity. IL-34 binds to two receptors, M-CSFR and Syndecan-1 (SDC-1), which are co-expressed in RA macrophages (MФs). Expression of both IL-34 and SDC-1 is strikingly elevated in the RA synovium, yet their mechanism of action remains undefined. Read More

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Assessing the Causal Relationships between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Clinical Epidemiology Program, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital Boston MA, USA.

Objective: Hyperuricemia is closely associated with insulin resistance syndrome (and its many cardiometabolic sequalae); however, whether they are causally related has long been debated. We used bidirectional Mendelian randomization (MR) to investigate the potential causal nature and direction between insulin resistance and hyperuricemia, along with gout.

Methods: We used genome-wide association data (N=288,649 for SU, N=763,813 for gout, N=153,525 for fasting insulin) to select genetic instruments for two-sample MR analyses, using multiple MR methods to address potential pleiotropic associations. Read More

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Association between cardiac high-energy phosphate metabolism and whole body metabolism in healthy female adults.

Physiol Res 2021 May 12. Epub 2021 May 12.

Cardiovascular Research, Clinical and Translational and Biosciences Research Institutes, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

Decline in cardiac high-energy phosphate metabolism [phosphocreatine-to-ATP (PCr/ATP) ratio] and whole body metabolism increase the risk of heart failure and metabolic diseases. The aim of the present study was to assess the relationship between PCr/ATP ratio and measures of body metabolic function. A total of 35 healthy women (56 +/- 14. Read More

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[Metabolic mechanism of Prunella vulgaris in treatment of ethanol-induced oxidative stress in rats based on metabonomics].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1813-1821

Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine Changsha 410208, China.

Prunella vulgaris(PV) is an edible and traditional medicinal herb which has a wide range application in fighting inflammation and oxidative stress, and protecting liver. Now it has been used to treat various types of liver diseases and has significant clinical efficacy. This study aims to investigate the effects of PV on ethanol-induced oxidative stress injury in rats and its metabolic mechanism. Read More

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[Effect of Dendrobii officinalis superfine powder on overeating greasy-induced metabolic hypertension in rats].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1658-1666

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobii officinalis, with a definite effect of nourishing Yin and clearing heat, has been a folk habit for drinking after being mixed with water. Because its superfine powder has the advantages of high dissolution and convenient drinking, we observed the effect of D. officinalis superfine powder on metabolic hypertension model rats and its possible mechanism in this experiment, which can be used as a reference for its clinical application for hypertension. Read More

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TFB2M activates aerobic glycolysis in hepatocellular carcinoma cells through the NAD /SIRT3/HIF-1α signaling.

J Gastroenterol Hepatol 2021 May 12. Epub 2021 May 12.

Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background: Increased aerobic glycolysis has been well-known as a hallmark of cancer, which is closely related to mitochondrial dysfunction. TFB2M (mitochondrial transcription factor B2) is a core mitochondrial transcription factor, which has been shown by us to play an oncogenic role in hepatocellular carcinoma (HCC). However, whether TFB2M contributes to the aerobic glycolysis in HCC cells remains unexplored. Read More

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Gut microbiota and its diet-related activity in children with intestinal failure on long-term parenteral nutrition.

JPEN J Parenter Enteral Nutr 2021 May 13. Epub 2021 May 13.

Department of Pediatric Gastroenterology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

Background: This study characterized the gut microbiota and its diet-related metabolic activity in children with intestinal failure (IF) on parenteral nutrition (PN) compared with healthy controls and in relation to disease characteristics.

Methods: Serial fecal samples were collected from 15 IF patients (n = 68) and from 25 healthy children (n = 25). The fecal microbiota, and short chain fatty acids (SCFA) were measured. Read More

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SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System.

Stem Cell Rev Rep 2021 May 12. Epub 2021 May 12.

Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, 3000, Belgium.

Astrocytes, the main supportive cell type of the brain, show functional impairments upon ageing and in a broad spectrum of neurological disorders. Limited access to human astroglia for pre-clinical studies has been a major bottleneck delaying our understanding of their role in brain health and disease. We demonstrate here that functionally mature human astrocytes can be generated by SOX9 overexpression for 6 days in pluripotent stem cell (PSC)-derived neural progenitor cells. Read More

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Utility of measuring serum creatinine to detect renal compromise in ED patients receiving IV contrast-enhanced CT scan.

Emerg Radiol 2021 May 12. Epub 2021 May 12.

Department of Emergency Medicine, Mount Sinai Medical Center, New York, NY, USA.

Objective: The objectives of this study are to determine the efficacy of a roster of clinical factors in identifying risk for renal insufficiency in emergency department (ED) patients requiring intravenous contrast-enhanced CT scan (IVCE-CT) and to help mitigate potential for developing contrast-induced nephropathy (CIN).

Methods: A review was conducted of consecutive ED patients who received IVCE-CT during a 4-month period in our urban ED. The values of ED serum creatinine (SCr) performed were tabulated. Read More

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Combined Oral Contraceptive Pill-Induced Hypertension and Hypertensive Disorders of Pregnancy: Shared Mechanisms and Clinical Similarities.

Curr Hypertens Rep 2021 May 13;23(5):29. Epub 2021 May 13.

Division of Nephrology and Hypertension, Department of Internal Medicine, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street, SW, Rochester, MN, USA.

Purpose Of Review: Oral contraceptive pill-induced hypertension (OCPIH) and hypertensive disorders in pregnancy (HDP) share common risk factors and pathophysiological mechanisms, yet the bidirectional relationship between these two conditions is not well-established. We review and describe OCPIH and HDP to better understand how hormonal and metabolic imbalances affect hypertension.

Recent Findings: Oral contraceptive pills continue to be a popular method of contraception, with an incidence of OCPIH ranging from 1-8. Read More

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Safety and tolerability of chronic intranasal oxytocin in older men: results from a randomized controlled trial.

Psychopharmacology (Berl) 2021 May 12. Epub 2021 May 12.

Department of Psychology, University of Florida, P.O. Box 112250, Gainesville, FL, 32611, USA.

Rationale: Most studies evaluating the safety and tolerability of intranasal oxytocin (OT) have not reported consistent adverse events (AEs), but they have largely focused on young men and single-dose administration. Thus, it is unclear whether these findings translate to older individuals and with longer administration periods.

Objective: Extending previous work, this study investigated the safety and tolerability of chronic intranasal OT in generally healthy older men. Read More

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Clinical and genetic analysis of KATP variants with heart failure risk in patients with decreased serum ApoA-I levels.

J Clin Endocrinol Metab 2021 May 13. Epub 2021 May 13.

Department of Cardiology, Guangzhou First People's Hospital, South China University of Technology, Guangzhou 510180, China.

Context: Lower serum concentration of apolipoprotein A-I (ApoA-I) is causally associated with heart failure (HF) risk. ATP-sensitive potassium channels (KATP), as a gating channel coupling vascular reactivity and metabolism with ischemic protection, become a new potential target of management for HF. The KATP gene sequence is highly polymorphic and high degree of genetic heterogeneity. Read More

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Association of admitting physician specialty and care quality and outcomes in non-ST-segment elevation myocardial infarction (NSTEMI): insights from a national registry.

Eur Heart J Qual Care Clin Outcomes 2021 May 12. Epub 2021 May 12.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, United Kingdom (UK).

Background: Little is known about the association between admitting physician specialty and care quality and outcomes for non-ST-segment elevation myocardial infarction (NSTEMI).

Methods & Results: We identified 288,420 patients hospitalised with NSTEMI between 2010-2017 in the United Kingdom (UK) Myocardial Infarction National Audit Project (MINAP) database. The cohort was dichotomised according to care under a non-cardiologist (n = 146,722) and care under a cardiologist (n = 141,698) within the first 24 hours of admission to hospital. Read More

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Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance).

JNCI Cancer Spectr 2021 Jun 12;5(3):pkab025. Epub 2021 Apr 12.

Department of Medical Oncology, Dana-Farber/Harvard Cancer Center, Boston, MA, USA.

Background: Obesity and inactivity are associated with increased risk of cancer-related and overall mortality in breast cancer, but there are few data in metastatic disease.

Methods: Cancer and Leukemia Group B 40502 was a randomized trial of first-line taxane-based chemotherapy for patients with metastatic breast cancer. Height and weight were collected at enrollment. Read More

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Idiopathic pulmonary fibrosis cluster analysis highlights diagnostic delay and cardiovascular comorbidity association with outcome.

ERJ Open Res 2021 Apr 10;7(2). Epub 2021 May 10.

Interstitial Lung Disease Unit, Respiratory Dept, Bellvitge University Hospital, IDIBELL, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain.

Introduction: Idiopathic pulmonary fibrosis (IPF) prognosis is heterogeneous despite antifibrotic treatment. Cluster analysis has proven to be a useful tool in identifying interstitial lung disease phenotypes, which has yet to be performed in IPF. The aim of this study is to identify phenotypes of IPF with different prognoses and requirements. Read More

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Host-bacteria metabolic crosstalk drives biofilm.

Microb Cell 2021 Apr 19;8(5):106-107. Epub 2021 Apr 19.

Department of Pediatrics, Columbia University, New York, NY 10032, USA.

is a prominent pathogen that can cause intractable lung infections in humans. persists in the airway despite inflammation and immune cell recruitment by adapting to host-derived antimicrobial factors. A key component of the immune response to infection are host metabolites that regulate inflammation and bacterial survival. Read More

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The Protective Effect of 1,25(OH)D on Myocardial Function is Mediated Sirtuin 3-Regulated Fatty Acid Metabolism.

Front Cell Dev Biol 2021 26;9:627135. Epub 2021 Apr 26.

Department of Clinical Nutrition, Shengjing Hospital of China Medical University, Shenyang, China.

Energy substrate imbalance is a major cause of cardiac dysfunction. Vitamin D/vitamin D receptor (VD/VDR) deficiency is involved in the pathogenesis of various cardiac diseases; however, the exact underlying mechanism remains unclear. The aim of this study was to investigate whether vitamin D modulates mitochondrial fatty acid oxidase sirtuin 3 signaling to protect the myocardium. Read More

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Stress Hyperglycemia in Children and Adolescents as a Prognostic Indicator for the Development of Type 1 Diabetes Mellitus.

Front Pediatr 2021 26;9:670976. Epub 2021 Apr 26.

Second Department of Internal Medicine and Research Institute, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Hyperglycemia is a common manifestation in the course of severe disease and is the result of acute metabolic and hormonal changes associated with various factors such as trauma, stress, surgery, or infection. Numerous studies demonstrate the association of adverse clinical events with stress hyperglycemia. This article briefly describes the pathophysiological mechanisms which lead to hyperglycemia under stressful circumstances particularly in the pediatric and adolescent population. Read More

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