198,710 results match your criteria clinical influence

May the Cleaning of Prescriptive Documents Using Best Evidence Reduce the Cost of Prescribed Healthcare?

Value Health Reg Issues 2021 Apr 16;25:108-111. Epub 2021 Apr 16.

National Research University Higher School of Economics, Moscow. Electronic address:

Objectives: Clinical practice is developing under influence of the evidence-based clinical practice guidelines (EBCPG). In Russia development of the documents prescribing the content of care is connected with the idea that they may be used as well for estimation of the cost of care. The outcome is the national healthcare legislation of 2011. Read More

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Inter-session repeatability of markerless motion capture gait kinematics.

J Biomech 2021 Apr 8;121:110422. Epub 2021 Apr 8.

Mechanical and Materials Engineering, Queen's University, Canada.

The clinical uptake and influence of gait analysis has been hindered by inherent limitations of marker-based motion capture systems, which have long been the standard method for the collection of gait data including kinematics. Markerless motion capture offers an alternative method for the collection of gait kinematics that presents several practical benefits over marker-based systems. This work aimed to determine the reliability of lower limb gait kinematics from video based markerless motion capture using an established experimental protocol for testing reliability. Read More

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External rotation of the tibial component should be avoided in lateral unicompartmental knee arthroplasty.

Knee 2021 Apr 16;30:70-77. Epub 2021 Apr 16.

Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

Background: Lateral unicompartmental knee arthroplasty (UKA) leads to good clinical outcomes for isolated lateral osteoarthritis. However, the impact of the tibial component position on postoperative outcomes in lateral UKA is yet to be determined.

Purpose: This study investigated the influence of tibial component malposition on clinical outcomes in lateral UKA. Read More

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Analysis of factors that could affect symptomatic outcome in patients having laparoscopic excision of deep rectovaginal endometriosis in BSGE endometriosis centres.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 16;261:17-24. Epub 2021 Apr 16.

Birmingham Women's and Children's Hospital, Edgbaston, Birmingham, B15 2TG, United Kingdom. Electronic address:

Objective: Investigate factors that influence quality of life after laparoscopic excision of deep rectovaginal endometriosis.

Study Design: A multicentre prospective cohort study involving 63 hospitals accredited as British Society for Gynaecological Endoscopy specialist endometriosis centres was conducted. The study population comprised of 8368 women who had undergone laparoscopic surgical excision of deep rectovaginal endometriosis requiring dissection of the pararectal space. Read More

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Prevalence and influence of LPA gene variants and isoform size on the Lp(a)-lowering effect of pelacarsen.

Atherosclerosis 2021 Mar 30;324:102-108. Epub 2021 Mar 30.

Ionis Pharmaceuticals, Carlsbad, CA, USA; Division of Cardiovascular Sciences, University of California San Diego, La Jolla, CA, USA. Electronic address:

Background And Aims: Antisense oligonucleotides (ASOs) targeting LPA to lower lipoprotein(a) [Lp(a]] are in clinical trials. Patients have been recruited according to various Lp(a) thresholds, but the prevalence of LPA genetic variants and their effect on efficacy of these ASOs are not well described.

Methods: We analyzed data from 4 clinical trials of the ASO pelacarsen targeting apolipoprotein(a) that included 455 patients. Read More

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Investigating DWI changes in white matter of meningioma patients treated with proton therapy.

Phys Med 2021 Apr 16;84:72-79. Epub 2021 Apr 16.

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy. Electronic address:

Purpose: To evaluate changes in diffusion and perfusion-related properties of white matter (WM) induced by proton therapy, which is capable of a greater dose sparing to organs at risk with respect to conventional X-ray radiotherapy, and to eventually expose early manifestations of delayed neuro-toxicities.

Methods: Apparent diffusion coefficient (ADC) and IVIM parameters (D, D* and f) were estimated from diffusion-weighted MRI (DWI) in 46 patients affected by meningioma and treated with proton therapy. The impact on changes in diffusion and perfusion-related WM properties of dose and time, as well as the influence of demographic and pre-treatment clinical information, were investigated through linear mixed-effects models. Read More

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Volumetric parcellation of the cardiac right ventricle for regional geometric and functional assessment.

Med Image Anal 2021 Apr 6;71:102044. Epub 2021 Apr 6.

ICREA, Barcelona, Spain; IDIBAPS, Barcelona, Spain; KULeuven, Leuven, Belgium.

3D echocardiography is an increasingly popular tool for assessing cardiac remodelling in the right ventricle (RV). It allows quantification of the cardiac chambers without any geometric assumptions, which is the main weakness of 2D echocardiography. However, regional quantification of geometry and function is limited by the lower spatial and temporal resolution and the scarcity of identifiable anatomical landmarks, especially within the ventricular cavity. Read More

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Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartoma: Electroclinical patterns and the relationship with surgical prognosis.

Epilepsy Behav 2021 Apr 16;118:107957. Epub 2021 Apr 16.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Stereotactic and Functional Neurosurgery, Beijing Neurosurgical Institute, Beijing, China. Electronic address:

Background: Radiofrequency thermocoagulation (RFTC) guided by stereo-electroencephalography (SEEG) has been proved to be a safe method to reduce seizure frequency in patients with drug-resistant epilepsy. However, there are few reports addressing the value and safety of this procedure in hypothalamic hamartoma (HH).

Objective: To present the results of our experience using SEEG-guided RFTC in HH patients with drug-resistant epilepsy, and identify outcome predictors. Read More

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Genotyping atypical porcine pestivirus using NS5a.

Infect Genet Evol 2021 Apr 16:104866. Epub 2021 Apr 16.

Veterinary Diagnostic Laboratory and Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA. Electronic address:

Atypical porcine pestivirus (APPV) is an emerging virus discovered in 2014 and it can cause congenital tremors in pigs. Molecular epidemiology serves as an essential tool in monitoring and controlling the disease. Virus epidemiology mainly relies on genome sequencing and phylogenetic characterization. Read More

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Toxicol Lett 2021 Apr 16. Epub 2021 Apr 16.

Medical Sciences Graduate Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Acute kidney injury (AKI) is a frequent and potentially fatal complication of snakebites. In the setting of snakebites, endothelial biomarkers may be used to predict disease severity and can play a major role in AKI pathophysiology. The aim of this study was to investigate the potential role of endothelial biomarkers in predicting AKI in Bothrops envenoming. Read More

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A Hazard Evaluation of the Reproductive/Developmental Toxicity of Cobalt in Medical Devices.

Regul Toxicol Pharmacol 2021 Apr 16:104932. Epub 2021 Apr 16.

Cardno ChemRisk, 20 Stanwix Street, Suite 505, Pittsburgh, PA 15222.

Cobalt (Co) is an essential element with human exposure occurring from the diet, supplement ingestion, occupational sources, and medical devices. The European Chemical Agency (ECHA) recently voted to classify Co metal as a Reproductive Hazard Category 1B; presumed human reproductive toxicant due to adverse testicular effects in male rodents. A weight of evidence evaluation of the preclinical reproductive and developmental toxicity studies and available clinical data was performed to critically evaluate the relevance of this proposed classification for Co in medical devices. Read More

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Extracellular vesicles for tissue repair and regeneration: evidence, challenges and opportunities.

Adv Drug Deliv Rev 2021 Apr 16. Epub 2021 Apr 16.

Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden; Department of Materials, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK; Institute of Biomedical Engineering, Imperial College London, London, UK. Electronic address:

Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. Read More

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Burden of Kidney Disease, Health-Related Quality of Life, and Employment Among Patients Receiving Peritoneal Dialysis and In-Center Hemodialysis: Findings From the DOPPS Program.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. Electronic address:

Rationale & Objective: Individuals faced with decisions regarding kidney replacement therapy options need information on how dialysis treatments might affect daily activities and quality of life, and what factors might influence the evolution over time of the impact of dialysis on daily activities and quality of life.

Study Design: Observational cohort study.

Setting & Participants: 7,771 HD and PD participants from 6 countries participating in the Peritoneal and Dialysis Outcomes and Practice Patterns Studies (PDOPPS/DOPPS). Read More

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Comparison of four PCR and two point of care assays used in the laboratory detection of SARS-CoV-2.

J Virol Methods 2021 Apr 16:114165. Epub 2021 Apr 16.

Military Medical Centre of the Hungarian Defence Forces, H-1134, Budapest, Róbert Károly krt. 44, Hungary; Semmelweis University - Faculty of Medicine, H-1085, Budapest, Üllői út 26., Hungary. Electronic address:

Seeing the global emergence and the lack of a definitive cure for COVID-19, it is essential to find the most sensitive and specific detection method to identify infected patients in a timely manner. Our paper aims to compare the clinical sensitivity of different commercial RT-qPCR (Genesig, 1copy, DNA-Techonolgy and Charité primer-probe sets), isothermal PCR (Ustar Isothermal Amplification-Real Time Fluorescent Assay) and immunochromatographic antigen detection (BOCREDIT COVID-19 Ag) assays developed to use in laboratory diagnosis of COVID-19. A total of 119 nasopharyngeal swab specimens were collected from symptomatic patients. Read More

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Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,000,000 person-years of follow-up (ACS - Air Pollution Study).

Environ Res 2021 Apr 16:111154. Epub 2021 Apr 16.

Department of Invasive Cardiology, Medical University of Bialystok, 24A M. Skłodowskiej-Curie St., 15-276 Białystok; Tel.: +48857468496; Fax: +48857468828.

Background: There is a lack of studies directly comparing the effect of air pollution on acute coronary syndrome (ACS) occurrence in industrial and non-industrial areas.

Objectives: A comparison of association of air pollution exposure with ACS in two cohorts of industrially different areas.

Materials And Methods: The study covered 6,000,000 person-years of follow-up and five pollutants between 2008 and 2017. Read More

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Does the perceived neighborhood environment promote mental health during pregnancy? Confirmation of a pathway through social cohesion in two Spanish samples.

Environ Res 2021 Apr 16:111192. Epub 2021 Apr 16.

Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Paseo Doctor Begiristain S/n, 20014, Donostia-San Sebastián, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5, Madrid, 28029, Spain; Health Department of the Basque Government, Sub-directorate of Public Health of Gipuzkoa, 20013, San Sebastian, Spain; Faculty of Psychology, University of the Basque Country UPV/EHU, San Sebastian, Spain. Electronic address:

Physical neighborhood attributes such as greenness, walkability and environmental pollution may have an influence on people's behavior and health. It has been claimed that part of such effects may come from the promotion of physical activity and the strengthening of social cohesion. In this study, we recruited samples of pregnant women in two Spanish cities (Donostia-San Sebastián, 440 participants and Barcelona, 360 participants) who filled in a questionnaire and wore an accelerometer for 1 week during the first trimester of pregnancy. Read More

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Radiolabeling Optimization and Preclinical Evaluation of the New PSMA Imaging Agent [F]AlF-P16-093.

Bioconjug Chem 2021 Apr 19. Epub 2021 Apr 19.

Five Eleven Pharma Inc., Philadelphia, Pennsylvania 19104, United States.

Prostate-specific membrane antigen (PSMA)-targeted radioligands have played an increasing role in the diagnosis of prostate cancer. [Ga]Ga-P16-093 is a PSMA-targeting agent for positron emission tomography imaging, currently under a Phase 2 clinical trial. In the present study, P16-093 was labeled with F via [F]AlF complex formation, and the biological properties of [F]AlF-P16-093 were evaluated. Read More

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A Clinical and Budgetary Impact Analysis of Introducing Sugammadex for Routine Reversal of Neuromuscular Blockade in a Hypothetical Cohort in the US.

Adv Ther 2021 Apr 19. Epub 2021 Apr 19.

Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.

Introduction: Sugammadex rapidly reverses the effects of rocuronium- and vecuronium-induced neuromuscular blockade (NMB), offering a more complete and predictable NMB recovery than cholinesterase inhibitors. Despite clinical benefits, cost pressures on hospital budgets influence the choice of the NMB reversal method. This study evaluated clinical and healthcare system payer's budget impacts associated with sugammadex in the US for routine reversal of moderate or deep rocuronium- or vecuronium-induced NMB in adults undergoing surgery. Read More

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Differentiation of clinical patterns and survival outcomes of hepatocellular carcinoma on hepatitis B and nonalcoholic fatty liver disease.

J Chin Med Assoc 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan, ROC Department of Pathology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan, ROC Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan, ROC University of Taipei, Taipei, Taiwan, ROC.

Background: The main etiologies of hepatocellular carcinoma (HCC) were often hepatitis B virus (HBV) or C and alcohol, rarely autoimmune and biliary diseases. Nonalcoholic fatty liver disease (NAFLD) has been an emerging role that could lead to chronic liver disease, nonalcoholic steatohepatitis, cirrhosis, and eventually HCC in recent years. The aim of our study is to investigate and compare the clinical features of HCC in NAFLD and HBV patients, including age, gender, cirrhosis, liver function tests, largest tumor size and cancer stage at the time of diagnosis. Read More

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[Google Reviews: a descriptive study of 700 orthodontic practices].

Orthod Fr 2021 Mar;92(1):167-176

Département d'orthodontie, Faculté d'Odontologie, rue Guillaume Paradin, 69372 Lyon cedex 08, France, Unité Fonctionnelle d'Orthopédie Dento-Faciale, Centre de Traitements Dentaires, Hospices Civils de Lyon, 6-8 place Depéret, 69365 Lyon cedex 03, France.

As it is the case in the medical sector, Google reviews of orthodontic practices are on the rise. The main objective of the study was to describe the internet ratings and opinions on orthodontic practices in France. The second objective was to test the factors that influence the number of reviews and the overall rating. Read More

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[Stripping: contribution to the control of iatrogenic periodontal effects].

Orthod Fr 2021 Mar;92(1):141-157

CHU de Rennes, Pôle d'Odontologie et de Chirurgie Buccale, 2 place Pasteur, 35000 Rennes, France.

The gum and the gingival festoon in particular are essential elements of the good periodontal health and the harmony of the smile. How does this engage orthodontics? Orthodontists are directly concerned by the vertical position of the collars which they must consider. More indirectly, they can have an influence on the gum festoon and in particular on the papillae. Read More

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Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics.

Elife 2021 Apr 19;10. Epub 2021 Apr 19.

Infectious Diseases and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, United States.

In this era of rising antibiotic resistance, in contrast to our increasing understanding of mechanisms that cause resistance, our understanding of mechanisms that influence the propensity to evolve resistance remains limited. Here, we identified genetic factors that facilitate the evolution of resistance to carbapenems, the antibiotic of 'last resort,' in , the major carbapenem resistant species. In clinical isolates, we found that high-level transposon insertional mutagenesis plays an important role in contributing to high-level resistance frequencies in several major and emerging carbapenem-resistant lineages. Read More

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Comparison of early and delayed lumbar disc herniation surgery and the treatment outcome.

Med Glas (Zenica) 2021 Aug 1;18(2). Epub 2021 Aug 1.

Department of Neurosurgery, University Clinical Hospital, Mostar, Bosnia and Herzegovina.

Aim To evaluate the influence of preoperative symptoms duration on surgical outcome of one-level lumbar disc herniation surgery. Methods In a prospective randomized study, 67 adult patients with one-level lumbar disc herniation were analysed. The patients whose duration of symptoms was <6 months were included in the case group, while those with the duration of symptoms ˃6 months formed the control group. Read More

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Correlation between Sleep Characteristics and Cognitive Decline in the Elderly: A Cross-Sectional Study in China.

Int J Clin Pract 2021 Apr 19:e14225. Epub 2021 Apr 19.

Department of Psychiatry, Shanghai Pudong New Area Mental Heath Center, Tongji University School of Medicine, 165 Sanlin Road, 200124, Shanghai, China.

Study Objectives: In this study, we conducted a cross-sectional analysis of the sleep characteristics in the elderly Chinese people to comprehensively investigate the association between sleep and cognitive function in the elderly. We aimed to evaluate the most important demographic factors, conventional physiological indices, and living habits that may influence sleep.

Methods: We surveyed 2901 elderly people (age ≥ 60 years old) face-to-face from July 1 , to December 31 , 2017, who were recruited from 17 communities of the Pudong New Area (Shanghai, China) by probability proportional to size. Read More

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Digital interventions for the management of chronic obstructive pulmonary disease.

Cochrane Database Syst Rev 2021 Apr 19;4:CD013246. Epub 2021 Apr 19.

Department of Rural Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.

Background: Chronic obstructive pulmonary disease (COPD) is associated with dyspnoea, cough or sputum production (or both) and affects quality of life and functional status. More efficient approaches to alternative management that may include patients themselves managing their condition need further exploration in order to reduce the impact on both patients and healthcare services. Digital interventions may potentially impact on health behaviours and encourage patient engagement. Read More

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New taxonomy for prolonged disorders of consciousness may help with decisions on withdrawal of clinically assisted nutrition and hydration: A proposed decision-making pathway.

J Rehabil Med 2021 Apr 19. Epub 2021 Apr 19.

Center for Innovative Care and Health Technology (ciTechcare), Polytechnic of Leiria, Leiria, Portugal. E-mil:

The number of patients surviving severe brain injury is increasing; however, many are left in a prolonged disorder of consciousness. With appropriate treatment, patients with prolonged disorders of consciousness can survive for years. Unless an advance directive exists, the treating clinicians can authorize withdrawal of clinically assisted nutrition and hydration for these patients, based on best interests. Read More

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Relationship between Functional Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics Analyses.

Endocr Res 2021 Apr 17:1-11. Epub 2021 Apr 17.

Diabetes Center, Ali Asghar Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran.

To investigate the link between two variants (rs4705342 and rs4705343) in the promoter of the cluster with Type 2 diabetes mellitus (T2DM) risk. A total of 1200 subjects were genotyped using the ARMS-PCR method. The rs4705342 variant enhanced the risk of T2DM under codominant CC (OR = 3. Read More

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Recruiting Persons with Dementia and Caregivers in a Clinical Trial: Dyads Perceptions.

West J Nurs Res 2021 Apr 17:1939459211008563. Epub 2021 Apr 17.

College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA.

Recruitment for dementia research is challenging and costly. Using Ajzen's Theory of Planned Behavior we explored attitudes, perceived norms, and perceived behavioral control of persons living with dementia (PLWD) and their caregivers who participated in one clinical trial to better understand factors that influence dyads' decisions to enroll. We conducted semi-structured telephone interviews with 12 PLWD and 9 caregivers and utilized directed content analysis. Read More

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Concurrent Diagnosis of Anxiety Increases Postoperative Length of Stay Among Patients Receiving Esophagectomy for Esophageal Cancer.

Psychooncology 2021 Apr 18. Epub 2021 Apr 18.

Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Objective: Psychiatric comorbidities disproportionately affect patients with cancer. While identified risk factors for prolonged length of stay (LOS) after esophagectomy are primarily medical comorbidities, the impact of psychiatric comorbidities on perioperative outcomes is unclear. We hypothesized that psychiatric comorbidities would prolong LOS in patients with esophageal cancer. Read More

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