44,307 results match your criteria clinical domains


Increased fidelity of protein synthesis extends lifespan.

Cell Metab 2021 Sep 8. Epub 2021 Sep 8.

UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street, London WC1E 6DD, UK; Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, Gower Street, London WC1E 6BT, UK. Electronic address:

Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal aging is poorly understood. Our phylogenetic analysis of RPS23, a key protein in the ribosomal decoding center, uncovered a lysine residue almost universally conserved across all domains of life, which is replaced by an arginine in a small number of hyperthermophilic archaea. Read More

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September 2021

Ethical Considerations in Dementia Diagnosis and Care: AAN Position Statement.

Neurology 2021 Jul;97(2):80-89

From the Department of Neurology (W.C.), University of California San Francisco; Evidence-Based Practice Center (A.Y.T.), ECRI, Plymouth Meeting, PA; Division of Neurology (A.Y.T.), Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia; Department of Neurology (Z.S.), The Pennsylvania State University, Hershey; School of Law (R.J.B.), University of Virginia, Charlottesville; and Department of Neurology (J.A.R.), Lahey Medical Center, Burlington, MA.

Alzheimer disease and other dementias present unique practical challenges for patients, their families, clinicians, and health systems. These challenges reflect not only the growing public health effect of dementia in an aging global population, but also more specific ethical complexities including early loss of patients' capacity to make decisions regarding their own care, the stigma often associated with a dementia diagnosis, the difficulty of balancing concern for patients' welfare with respect for patients' remaining independence, and the effect on the physical, emotional, and financial well-being of family caregivers. Caring for patients with dementia requires respecting patient autonomy while acknowledging progressively diminishing decisional capacity and continuing to provide care in accordance with other core ethical principles (beneficence, justice, and nonmaleficence). Read More

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The use of patient-reported outcomes in routine cancer care: preliminary insights from a multinational scoping survey of oncology practitioners.

Support Care Cancer 2021 Sep 15. Epub 2021 Sep 15.

Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, 5042, Australia.

Background: There exists scant evidence on the optimal approaches to integrating patient-reported outcomes (PROs) in clinical practice. This study gathered oncology practitioners' experiences with implementing PROs in cancer care.

Methods: Between December 2019 and June 2020, we surveyed practitioners who reported spending > 5% of their time providing clinical care to cancer patients. Read More

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September 2021

Liquid-liquid phase separation (LLPS) in cellular physiology and tumor biology.

Am J Cancer Res 2021 15;11(8):3766-3776. Epub 2021 Aug 15.

Cancer Genome Research Center, Chang Gung Memorial Hospital at Linkou Taoyuan 333, Taiwan.

Liquid-liquid phase separation (LLPS) has emerged as a mechanism that has been used to explain the formation of known organelles (e.g. nucleoli, promyelocytic leukemia nuclear bodies (PML NBs), etc) as well as other membraneless condensates (e. Read More

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Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder.

Commun Biol 2021 Sep 14;4(1):1073. Epub 2021 Sep 14.

Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.

Schizophrenia (SZ) and autism spectrum disorder (ASD) share considerable clinical features and intertwined historical roots. It is greatly needed to explore their similarities and differences in pathophysiologic mechanisms. We assembled a large sample size of neuroimaging data (about 600 SZ patients, 1000 ASD patients, and 1700 healthy controls) to study the shared and unique brain abnormality of the two illnesses. Read More

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September 2021

Associations between increased circulating endothelial progenitor cell levels and anxiety/depressive severity, cognitive deficit and function disability among patients with major depressive disorder.

Sci Rep 2021 Sep 14;11(1):18221. Epub 2021 Sep 14.

Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan.

The association of major depressive disorder (MDD) with cardiovascular diseases (CVDs) through endothelial dysfunction is bidirectional. Circulating endothelial progenitor cells (cEPCs), essential for endothelial repair and function, are associated with risks of various CVDs. Here, the relationship of cEPC counts with MDD and the related clinical presentations were investigated in 50 patients with MDD and 46 healthy controls. Read More

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September 2021

Identifying areas of improvement for cultural competence in pharmacy curricula: A multi-school study using the self-assessment of perceived level of cultural competence (SAPLCC) questionnaire.

Curr Pharm Teach Learn 2021 Oct 3;13(10):1278-1287. Epub 2021 Aug 3.

Associate Dean, Assessment, Western University of Health Sciences, 309 E. Second St, Pomona, CA 91766, United States. Electronic address:

Introduction: The implementation of culturally competent healthcare services has been considered a key strategy for the provision of patient-centered care; however, a need remains to address the requirements of teaching cultural competence, including identifying gaps, designing and evaluating curricula, and assessing students' progress toward program objectives. The objective of this study was to explore the applicability of the Self-Assessment of Perceived Level of Cultural Competence (SAPLCC) questionnaire in the identification of improvement areas in cultural competence content in pharmacy curricula.

Methods: This study used previously-collected SAPLCC data from student pharmacists at eight United States pharmacy schools. Read More

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October 2021

Alternative model of personality disorders traits predict residential addictions treatment completion.

Drug Alcohol Depend 2021 Sep 1;228:109011. Epub 2021 Sep 1.

Department of Psychology, University of South Florida, Tampa, FL, United States. Electronic address:

Background: Among people receiving residential treatment for a substance use disorder (SUD), premature treatment termination predicts poor post-treatment outcomes. We examined the utility of the alternative model for personality disorders (AMPD) for predicting premature residential SUD treatment termination, including interactions with age and gender.

Methods: Participants (N = 374) were receiving residential treatment for SUD and enrolled in a clinical trial with two conditions: Skills for Improving Distress Intolerance (SIDI) and Supportive Counseling (NCT01741415). Read More

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September 2021

Intervention of 3D printing in health care: Transformation for sustainable development.

Expert Opin Drug Deliv 2021 Sep 14. Epub 2021 Sep 14.

The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Canada.

Introduction: Three-dimensional (3D) technology is the practice of dropping material layer-by-layer in the construction of the desired object. The application of the 3D printing technique has been observed in miscellaneous domains. Personalized medicine becomes the most demanding trend in the healthcare segment. Read More

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September 2021

Factors affecting use of magnesium sulphate for pre-eclampsia or eclampsia: a qualitative evidence synthesis.

BJOG 2021 Sep 14. Epub 2021 Sep 14.

Gender and Women's Health Unit, Centre for Health Equity, School of Population and Global Health, University of Melbourne, 207 Bouverie St, Carlton, VIC, 3053, Australia.

Background: Hypertensive disorders account for 14% of global maternal deaths. Magnesium sulphate (MgSO4) is recommended for prevention and treatment of pre-eclampsia/eclampsia. However, MgSO4 remains underutilized, particularly in low-and-middle-income countries (LMICs). Read More

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September 2021

FIGO good practice recommendations on delayed umbilical cord clamping.

Int J Gynaecol Obstet 2021 Oct;155(1):34-36

Department of Obstetrics and Gynecology, Monash University, Clayton, Australia.

Delayed cord clamping in the first minute in preterm infants born before 34 weeks of gestation improves neonatal hematologic measures and may reduce mortality without increasing any other morbidity. In term-born babies, it also seems to improve both the short- and long-term outcomes and shows favorable scores in fine motor and social domains. However, there is insufficient evidence to show what duration of delay is best. Read More

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October 2021

Can you trust clinical practice guidelines for laparoscopic surgery? A systematic review of clinical practice guidelines for laparoscopic surgery.

Updates Surg 2021 Sep 14. Epub 2021 Sep 14.

Division of Surgery and Interventional Science, Hampstead Campus, University College London, 9th Floor, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.

Background: Clinical practice guidelines aim to support clinicians in providing clinical care and should be supported by evidence. There is currently no information on whether clinical practice guidelines in laparoscopic surgery are supported by evidence.

Methods: We performed a systematic review and identified clinical practice guidelines of laparoscopic surgery published in PubMed and Embase between March 2016 and February 2019. Read More

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September 2021

Adjuvant Priming Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Obsessive-Compulsive Disorder: In Search of a New Paradigm!

J ECT 2021 Sep 13. Epub 2021 Sep 13.

From the Geriatric Mental Health, King George Medical University, Lucknow, Uttar Pradesh Asha Hospital, Banjara Hills, Hyderabad, Telangana Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.

Objectives: Repetitive transcranial magnetic stimulation (rTMS) is used as a therapeutic option for obsessive-compulsive disorder (OCD) in both clinical and research settings. There has been no consensus with regard to target area and other parameters, although 1-Hz rTMS over the supplementary motor area (SMA) is found to be promising. Priming stimulation, which involves high-frequency followed by low-frequency rTMS, has been shown to enhance neural response to low-frequency rTMS. Read More

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September 2021

Electroconvulsive Therapy in Canada During the First Wave of COVID-19: Results of the "What Happened" National Survey.

J ECT 2021 Sep 13. Epub 2021 Sep 13.

From the Interventional Psychiatry Program, Mental Health and Addictions Service, St Michael's Hospital Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health Department of Psychiatry, University of Toronto Institute of Medical Science, University of Toronto Centre for Mental Health, University Health Network Library and Information Services, University Health Network, Toronto, Ontario, Canada Department of Psychiatry, University of California San Diego, San Diego, CA Department of Anesthesia and Pain Management, University Health Network Department of Anesthesiology and Pain Medicine Institute of Health Policy, Management, and Evaluation, University of Toronto Department of Anesthesia Centre for Clinical Ethics, St Michael's Hospital Dalla Lana School of Public Health, University of Toronto Department of Infection Prevention and Control, University Health Network Department of Psychiatry, North York General Hospital, Toronto, Ontario, Canada Department of Psychiatry, University of Michigan, Ann Arbor, MI.

Objectives: The COVID-19 pandemic has disrupted the provision of essential and potentially life-saving procedural treatments such as electroconvulsive therapy (ECT). We surveyed ECT providers across Canada to understand how the first wave of the pandemic affected ECT delivery between mid-March 2020 and mid-May 2020.

Methods: The survey was administered to ECT team members and decision makers at 107 Canadian health care centers with a focus on 5 domains: operations, decision-making, hospital resources, ECT procedure, and patient impact. Read More

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September 2021

Post Intensive Care Syndrome (PICS): an overview of the definition, aetiology, risk factors, and possible counselling and treatment strategies.

Expert Rev Neurother 2021 Sep 14. Epub 2021 Sep 14.

Department of Intensive Care Medicine, Elisabeth-Tweesteden Hospital, Tilburg, the Netherlands.

IntroductionThe post-intensive care syndrome (PICS) has only recently been recognized as a new clinical entity in patients surviving their intensive care unit (ICU) stay due to critical illness. With increasing survival rates of ICU patients worldwide, there is a rising interest regarding post-ICU recovery.Areas coveredFirst, based on current literature a definition is provided of PICS, including the domains of impairments that comprise PICS along with the aetiology and risk factors. Read More

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September 2021

An information-based framework for development national twin registry: Scoping review and focus group discussion.

Int J Health Plann Manage 2021 Sep 29;36(5):1423-1444. Epub 2021 May 29.

Family Health Research Institute, Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Science, Tehran, Iran.

Background: Registries in various clinical domains have been established in the last decades. The specific genetic structure of twins has enabled researchers to find answers to the role of genetics and the environment in medical sciences. Thus, twin registries were developed across the world to support twin studies. Read More

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September 2021

Psychometric validation of the EORTC QLQ-HCC18 in patients with previously treated unresectable hepatocellular carcinoma.

Qual Life Res 2021 Sep 13. Epub 2021 Sep 13.

BeiGene, Ltd, San Mateo, CA, USA.

To demonstrate the measurement properties of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Hepatocellular Carcinoma 18-question module (EORTC QLQ-HCC18) within a previously treated, unresectable hepatocellular carcinoma (HCC) clinical trial population that was distinct from the published QLQ-HCC18 validation population. Analyses were conducted using data from BGB-A317-208, an open label, international, clinical trial assessing efficacy and safety of the monoclonal antibody tislelizumab in adult HCC patients. The EORTC Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and QLQ-HCC18 instruments were assessed at baseline and weeks 3 and 9 follow-up visits. Read More

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September 2021

COVID-19 vaccine hesitancy in patients on dialysis in Italy and France.

Kidney Int Rep 2021 Sep 8. Epub 2021 Sep 8.

Néphrologie et Dialyse, Centre Hospitalier Le Mans, 194 Avenue Rubillard, 72037, Le Mans, France.

Introduction: Patients on dialysis (HDP) are a category at high risk from COVID-19 and thus a high-priority group for vaccination. COVID-19 vaccine hesitancy has been a concern since the availability of the first vaccine. The objective of this study was to determine hesitancy rates and factors associated with hesitancy towards COVID-19 vaccination in HDP. Read More

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September 2021

Characteristics and Quality of National Cardiac Registries: A Systematic Review.

Circ Cardiovasc Qual Outcomes 2021 Sep 14:CIRCOUTCOMES121007963. Epub 2021 Sep 14.

Department of Cardiology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia (L.P.D., J.L., L.B., D.E.).

Background: National cardiac registries are increasingly used for informing health policy, improving the quality and cost-effectiveness of patient care, clinical research, and monitoring the safety of novel treatments. However, the quality of registries is variable. We aimed to assess the characteristics and quality of national cardiac registries across all subspecialties of cardiac care. Read More

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September 2021

Space-velocity thermostatted kinetic theory model of tumor growth.

Math Biosci Eng 2021 Jun;18(5):5525-5551

Laboratoire de Physique Théorique de la Matière Condensée, Sorbonne Université, CNRS, 4 place Jussieu, case courrier 121, 75252 Paris Cedex 05, France.

The competition between cancer cells and immune system cells in inhomogeneous conditions is described at cell scale within the framework of the thermostatted kinetic theory. Cell learning is reproduced by increased cell activity during favorable interactions. The cell activity fluctuations are controlled by a thermostat. Read More

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A Multivariable Analysis to Evaluate the Presence or Absence of Gender Differences in Baseline ImPACT Composite Scores and Symptom Severity Ratings in Student-Athletes Ages 12-18 Years.

Pediatr Exerc Sci 2021 Sep 11:1-8. Epub 2021 Sep 11.

Icahn School of Medicine at Mount Sinai.

Introduction: Gender differences in neurocognitive function have been reported over the past few decades. However, multiple studies that report gender differences in Immediate Post-Concussion Assessment and Cognitive Tests composite scores ignore potential confounders which may lead to inaccurate results.

Methods: A total of 4829 male and 2477 female baseline Immediate Post-Concussion Assessment and Cognitive Tests from 2009 to 2019 of subjects ages 12-18 years were used to evaluate gender differences in baseline neurocognitive scores and symptom severity ratings. Read More

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September 2021

Development of a Standardized Program for the Collaboration of Adult and Children's Surgeons.

J Surg Res 2021 Sep 10;269:36-43. Epub 2021 Sep 10.

Department of Surgery, The Pennsylvania State University, College of Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania. Electronic address:

Background: Children's hospitals within larger hospitals (CH/LH) have the specific clinical advantage of easily facilitated collaboration between adult and children's surgeons. These collaborations, which we have termed hybrid surgical offerings (HSOs) are often required for disease processes requiring interventions that fall outside the customary practice of children's surgeons. Formal models to describe or evaluate these practices are lacking. Read More

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September 2021

Sensitivity of diffusion-weighted magnetic resonance imaging in transient global amnesia as a function of time from symptom onset.

Acad Emerg Med 2021 Sep 13. Epub 2021 Sep 13.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: To systematically evaluate the sensitivity of diffusion-weighted magnetic resonance imaging (DW-MRI) for transient global amnesia (TGA) across various time frames compared to the reference-standard clinical criteria.

Methods: All indexed publications related to TGA and MRI through June 2020 were retrieved by a medical librarian. Two independent reviewers identified original research studies of adults with a clinical diagnosis of TGA using Caplan, Hodges, and Warlow criteria (reference standard) who were evaluated with DW-MRI. Read More

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September 2021

Knowledge attitude and practice of dental students and practitioners during the early days of Covid 19 pandemic in India: a cross sectional study.

Int J Clin Pract 2021 Sep 13:e14858. Epub 2021 Sep 13.

Popular educational Association, 11-4-356; Baliga House, Bhavanthi Street, Mangalore, Dakshina Kannada, Karnataka, India, 575001.

Aim: The novel coronavirus disease-2019 (COVID-19) is a major health problem and has affected people innumerable number of people around the world. The current online based study was conducted to assess the knowledge, attitude and practice (KAP) of dental students and professionals from during the early days of lockdown in India from April 2 to May 1 2020.

Methodology: An online cross sectional study was undertaken through WhatsApp Messenger and through email groups among the dental students and professionals. Read More

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September 2021

A Mixed-Methods Evaluation of Patient Education Materials for Colorectal Cancer.

Dis Colon Rectum 2021 Oct;64(10):1249-1258

Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Patient education materials are created by professional organizations to inform patients about their disease and its treatment. However, it remains unclear if these materials are appropriate for patients.

Objective: This study aims to broadly evaluate the education materials for patients with colorectal cancer. Read More

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October 2021

Structural validity of a computerized neurocognitive battery for youth affected by human immunodeficiency virus in Botswana.

Psychol Assess 2021 Sep 13. Epub 2021 Sep 13.

Department of Psychiatry.

Children born to mothers infected with the human immunodeficiency virus (HIV) during pregnancy experience increased risk of neurocognitive impairment. In Botswana, HIV infection is common among youth, but standardized cognitive screening is limited. The Penn Computerized Neurocognitive Battery (PennCNB), a tool that streamlines evaluation of neurocognitive functioning, was culturally adapted for use among youth in this high-burden, low-resource setting. Read More

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September 2021

Self-reported cognitive impairment in cervical cancer survivors: A cross-sectional study.

Psychooncology 2021 Sep 13. Epub 2021 Sep 13.

Department of Gynecological Oncology, Oslo University Hospital, Oslo, Norway.

Objective: Cancer-related cognitive impairment (CRCI) is a major obstacle for cervical cancer survivors, preventing the return to their social life. This study assessed the prevalence of CRCI in cervical cancer survivors and studied the association of self-reported cognitive impairment with treatment regimen and the quality of life (QoL) domains depression, anxiety, and fatigue.

Methods: Six hundred twenty one cervical cancer survivors, treated with combined chemo-radiotherapy (CCRT) (n = 458) or surgery only (n = 163) were invited in this cross-sectional study. Read More

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September 2021

Patient-Reported Outcomes with Selpercatinib Treatment Among Patients with RET-Mutant Medullary Thyroid Cancer in the Phase 1/2 LIBRETTO-001Trial.

Oncologist 2021 Sep 13. Epub 2021 Sep 13.

The University of Texas MD,Anderson Cancer Center.

Background: Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease-related diarrhea, primarily due to non-RET kinase inhibition. We report diarrhea and other patient reported-outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET-mutant MTC in the ongoing, phase 1/2 LIBRETTO-001 trial.

Materials And Methods: Instrument completion timepoints were baseline (Cycle 1, Day 1) and approximately every other 28-day cycle until Cycle 13 (every 12 weeks thereafter) for EORTC QLQ-C30, and baseline, weekly during Cycle 1, and Day 1 of every cycle for mSTIDAT. Read More

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September 2021

Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.

Cochrane Database Syst Rev 2021 Sep 13;9:CD012814. Epub 2021 Sep 13.

Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

Background: Cholangiocarcinoma (cancer in the bile duct) is an aggressive tumour for which surgical resection is a mainstay of treatment. Despite complete resection, recurrences of the cancer are common and lead to poor prognosis in patients. Postoperative adjuvant chemotherapy given after surgical resection may reduce the risk of cancer recurrence by eradicating residual cancer and micrometastatic lesions. Read More

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September 2021

A prospective cohort study of the association between the Apgar score and developmental status at 3 years of age: the Japan Environment and Children's Study (JECS).

Eur J Pediatr 2021 Sep 13. Epub 2021 Sep 13.

Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

Apgar score (AS) is a well-established tool for assessing viability of newborns, and its association with subsequent child development has been suggested. We aimed to assess whether Apgar scores (ASs) ≥ 7 (generally considered normal) are associated with the developmental status at 3 years of age while adjusting for perinatal and socioeconomic confounders. We extracted the data of ASs at 1 and 5 min among participants of the Japan Environment and Children's Study datasets, which were used in this nationwide cohort study. Read More

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September 2021