9,140 results match your criteria clinical cytological

Chronic rhinosinusitis with nasal polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG).

Am J Rhinol Allergy 2021 Oct 14:19458924211049867. Epub 2021 Oct 14.

Unit of Clinical Pathology and Center for Molecular Medicine, 507873Department of Medical and Surgical Sciences, 18972University of Foggia, Foggia, Italy.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is typically characterized by Type 2 inflammation. Several biomarkers of eosinophilic inflammation, including Galectin-10, also known as Charcot-Leyden crystal protein (CLCP), have been identified to establish eosinophilic infiltration of polyps, a reliable predictor of recurrence. We aimed to evaluate the Galectin-10 expression in nasal polyps of patients with CRSwNP and to assess the correlation of Charcot-Leyden crystals expression to the severity of CRSwNP according to Clinical-Cytological Grading (CCG). Read More

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October 2021

Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis.

JFMS Open Rep 2021 Jul-Dec;7(2):20551169211050037. Epub 2021 Oct 6.

Linnaeus Veterinary Limited, Solihull, UK.

Case Summary: A 4-year-old female spayed domestic shorthair cat was presented with facial swelling, ocular discharge and intermittent bilateral exophthalmos. Haematology revealed mild eosinophilia. Serum biochemistry showed a markedly elevated creatine kinase activity. Read More

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October 2021

A Spontaneously Regressing Pseudolymphoma in a Dog Resembling Pseudo-Hodgkin's Disease.

Vet Dermatol 1990 Dec;1(4):171-176

Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca New York, U.S.A.

Abstract- A case report of a dog with a lymphohistiocytic proliferative disorder of the skin, third eyelids and lymph nodes is presented. Skin biopsies showed a nodular to diffuse cellular proliferation of lymphohistiocytic cells with many cytological features of malignancy. Numerous Reed-Sternberg cells were present. Read More

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December 1990

Feline acne and results of treatment with mupirocin in an open clinical trial: 25 cases (1994-96).

Vet Dermatol 1997 Sep;8(3):157-164

Department of Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

Clinical and diagnostic parameters, and response to topical mupirocin in 25 cats with feline acne are described. The chin was the most common area affected, but the lower lip, upper lip and the commissure of the lips also frequently had lesions. The most common clinical sign was the presence of crusts, followed by comedones, erythema, alopecia, pruritus and nodules/fistulas. Read More

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September 1997

Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer.

J Hematol Oncol 2021 Oct 12;14(1):164. Epub 2021 Oct 12.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuan nanli 17, Chaoyang District, Beijing, 100021, China.

Peritoneal dissemination (PD) is a major type of gastric cancer (GC) recurrence and leads to rapid death. Current approaches cannot precisely determine which patients are at high risk of PD to provide early intervention. In this study, we developed a technology to detect minimal residual cancer cells in peritoneal lavage fluid (PLF) samples with a personalized assay profiling tumor-specific mutations. Read More

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October 2021

circRNA_0006470 promotes the proliferation and migration of gastric cancer cells by functioning as a sponge of miR-27b-3p.

Neoplasma 2021 Oct 11. Epub 2021 Oct 11.

Department of Clinical Laboratory, SSL Central Hospital of Dongguan City, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.

Cancer pathogenesis is influenced by epigenetic alterations mediated by circular RNAs (circRNAs). In this study, we aimed to investigate the regulatory mechanisms and cytological function of hsa_circ_0006470/miR-27b-3p in gastric cancer (GC). CircRNA and microRNA expression in cancer cells were measured by the qRT-PCR method. Read More

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October 2021

Automated Raman Micro-Spectroscopy of Epithelial Cell Nuclei for High-Throughput Classification.

Cancers (Basel) 2021 Sep 24;13(19). Epub 2021 Sep 24.

Department of Electronic Engineering, Maynooth University, Maynooth, Ireland.

Raman micro-spectroscopy is a powerful technique for the identification and classification of cancer cells and tissues. In recent years, the application of Raman spectroscopy to detect bladder, cervical, and oral cytological samples has been reported to have an accuracy greater than that of standard pathology. However, despite being entirely non-invasive and relatively inexpensive, the slow recording time, and lack of reproducibility have prevented the clinical adoption of the technology. Read More

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September 2021

The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.

Blood Adv 2021 Oct 12. Epub 2021 Oct 12.

Belgian Cancer Registry, Brussels, Belgium.

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem-cell disorders characterized by ineffective hematopoiesis leading to peripheral cytopenias and in a substantial proportion of cases to acute myeloid leukemia. The deletion of the long arm of chromosome 11, del(11q), is a rare but recurrent clonal event in MDS. Here, we detail the largest series of 113 cases of MDS and myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) harboring a del(11q) analyzed at clinical, cytological, cytogenetic and molecular levels. Read More

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October 2021

Thyroid nodules with indeterminate cytopathology: a constant challenge in everyday practice. The effectiveness of clinical decisions using diagnostic tools available in Poland.

Pol Arch Intern Med 2021 Oct 11. Epub 2021 Oct 11.

Introduction: A crucial issue in the management of thyroid nodules is to estimate, as accurately as possible, the malignancy risk in thyroid lesions. The key tool for risk stratification is fine needle aspiration biopsy. Unfortunately, approximately 20 % of biopsy results are indeterminate. Read More

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October 2021

Diagnostic imaging features, cytological examination, and treatment of lymphocytic tenosynovitis of the common digital extensor tendon sheath in an eventing horse.

Vet Anim Sci 2021 Dec 26;14:100209. Epub 2021 Sep 26.

Orthopedic Surgery and Rehabilitation Center, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, Bang Khen Campus, Bangkok, Thailand.

In horses, the structures at the dorsal aspect of the carpus, including the digital extensor tendons, their related tendon sheaths, and bones, are vulnerable to injury because of their superficial location. Injuries to these structures may result in lameness of the affected limb(s) and reduce a horse's athletic performance. A 13-year-old eventing horse that routinely underwent regular exercise exhibited dorsolateral distension of the right carpus. Read More

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December 2021

[The effect of Hashimoto's thyroiditis on the diagnostic efficacy of ultrasound-guided fine needle aspiration cytology for thyroid nodules ≥ 1 cm].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Sep;35(9):807-812

Department of Ultrasound,the First Affiliated Hospital of Chongqing Medical University,Chongqing,400012,China.

To explore the diagnostic efficacy of ultrasound-guided fine needle aspiration cytology(US-FNAC) for thyroid nodules ≥1 cm, and the effect of Hashimoto's thyroiditis(HT) on it. The clinical data of 1027 cases of thyroid nodules ≥ 1 cm were retrospectively analyzed. Two-dimensional ultrasound, US-FNAC and BRAFV600E gene testing were performed. Read More

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September 2021

A novel technique of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration in the diagnosis of submucosal recurrence of nasopharyngeal carcinoma after chemoradiotherapy.

Radiother Oncol 2021 Oct 7. Epub 2021 Oct 7.

Department of Endoscopy Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China. Electronic address:

Background: Recurrence of nasopharyngeal carcinoma (NPC) after chemoradiotherapy is common, but submucosal recurrence of NPC is rare. The final pathological results determine the optimal therapeutic schedule for treatment of NPC recurrence, but tissue retrieval from submucosal lesions is usually difficult. The present study aimed to assess the safety and efficacy of a novel approach of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration (ENUS-TNNA) for submucosal neoplasms in patients with suspected NPC recurrence. Read More

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October 2021

Classification of cytological samples from oral potentially malignant lesions through Raman spectroscopy: A pilot study.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 27;266:120437. Epub 2021 Sep 27.

Centre for Radiation and Environmental Science, FOCAS Research Institute, Technological University Dublin, City Campus, Dublin, Ireland; School of Physics & Clinical & Optometric Sciences, Technological University Dublin, City Campus, Dublin, Ireland.

The potential of Raman microspectroscopy of exfoliated cells has been demonstrated for oral cancer diagnosis. In this study, brush biopsies were collected from the buccal mucosa/tongue of healthy donors (n = 31) and from oral mucosal dysplastic lesions (n = 31 patients). Raman spectra were acquired and subjected to partial least squares-discriminant analysis (PLS-DA). Read More

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September 2021

Clinical evaluation of a real-time optoelectronic device in cervical cancer screening.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 28. Epub 2021 Sep 28.

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: Early screening and intervention are crucial for the prevention and treatment of cervical cancer. TruScreen is a real-time, intelligent, pathological diagnostic technology designed for cervical cancer screening. The aim of this study was to evaluate the clinical value of TruScreen in screening for cervical lesions. Read More

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September 2021

Risk of malignancy associated with diagnostic categories of the proposed World Health Organization International System for Reporting Pancreaticobiliary Cytopathology.

Cancer Cytopathol 2021 Oct 8. Epub 2021 Oct 8.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

Background: The World Health Organization (WHO) has proposed an updated international classification system for reporting pancreaticobiliary cytology. Substantial changes to the prior Papanicolaou Society of Cytopathology (PSC) system have been recommended. Chiefly, the "neoplastic: benign" and "neoplastic: other" categories have been replaced by 2 new categories-"pancreatic neoplasia-low-grade" (PaN-Low) and "pancreatic neoplasia-high-grade" (PaN-High)-stratifying neoplastic mucinous cysts by cytological atypia. Read More

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October 2021

Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study.

PLoS One 2021 7;16(10):e0257915. Epub 2021 Oct 7.

CHU de Martinique, Pôle de Biologie - Pathologie, Laboratoire de Virologie, Martinique, France.

The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. Read More

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October 2021

Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer.

Cancer Med 2021 Oct 7. Epub 2021 Oct 7.

Division of Pulmonary Medicine, Department of Internal Medicine, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan.

Background: Bronchoscopy is a minimally invasive procedure for establishing the diagnosis of lung cancer. It sometimes fails to obtain tissue samples but readily collects cytological samples.

Methods: We developed PNA-LNA dual-PCR (PLDP), which amplified mutant sequences by a high-fidelity DNA polymerase in the presence of a peptide nucleic acid (PNA) oligomer having a wild-type sequence. Read More

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October 2021

Tolerability and outcome of palliative treatment for metastatic pulmonary carcinoma in cats.

J Small Anim Pract 2021 Oct 4. Epub 2021 Oct 4.

Oncology Service, Queen Mother Hospital for Animals, Royal Veterinary College, Hatfield, AL9 7TA, Hertfordshire, UK.

Objectives: Pulmonary carcinoma is uncommon in cats and reporting of outcomes following medical treatment is limited, especially in presence of metastases. The aim of this study was to describe the outcome of cats affected by metastatic primary pulmonary carcinoma and to evaluate the tolerability of palliative treatment in this patient population.

Materials And Methods: Medical records were searched for cats with a cytological or histopathological diagnosis of primary pulmonary carcinoma and evidence of metastatic disease. Read More

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October 2021

Treatment of acute erythroleukaemia with high-dose cytarabine in a cat with feline leukaemia virus infection.

Vet Med Sci 2021 Oct 2. Epub 2021 Oct 2.

College of Veterinary Medicine, Seoul National University, Seoul, Korea.

Erythroleukaemia is a malignant neoplasm of the erythroid lineage that rarely occurs in cats. It is associated with the feline leukaemia virus (FeLV), and owing to the poor prognosis, treatment is rarely reported. A 4-year-old female Korean domestic shorthair cat was presented with hyporexia, fever, lethargy, severe anaemia and rubricytosis. Read More

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October 2021

Accuracy and other quality indicators of solid pancreatic mass endoscopic ultrasound-guided fine needle aspiration and biopsy in two academic endoscopy centers.

Acta Gastroenterol Belg 2021 Jul-Sep;84(3):451-455

Department of Gastroenterology, Hepatopancreatology and Digestive oncology, Erasme Hospital, Université Libre de Bruxelles, Belgium.

Background And Aims: Endoscopic ultrasound fine-needle aspiration/biopsy (EUS-FNA/FNB) is highly accurate, but discrepancies between cytological and surgical diagnoses are still observed. We aimed to determine its accuracy and monitor quality indicators in our facilities.

Patients And Methods: We performed a retrospective review of all cases of pancreatic solid lesions evaluated by EUS-FNA/FNB, between July 2015 and June 2018, in two centers. Read More

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October 2021

Systemic cytology. A novel diagnostic approach for assessment of early systemic disease.

Med Hypotheses 2021 Nov 20;156:110682. Epub 2021 Sep 20.

School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Rama VI Rd, Bangkok 10400, Thailand; Thailand Center of Excellence in Physics, Ministry of Higher Education, Science, Research and Innovation, 328 Si Ayutthaya Road, Bangkok 10400, Thailand; Department of Physics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Recognition of low grade or asymptomatic systemic diseases suggests prevention of the worst, yet has been proven challenging ever since. Biomarker-based liquid biopsy has emerged in recent years as a practical platform for the assessment of systemic diseases yet, technical realizations were mainly focused on cancer, faced challenges in accuracy at early stage and are lacking provision of sufficient evidence of disease. In particular in cell-based cancer liquid biopsy, obstacles are rarity and heterogeneity of circulating tumor and tumor-associated rare cells. Read More

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November 2021

Applying criteria for hepatocellular neoplasm of uncertain malignant potential reclassifies more than half of hepatocellular adenomas.

Ann Diagn Pathol 2021 Sep 25;55:151833. Epub 2021 Sep 25.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States of America. Electronic address:

Objectives: Hepatocellular adenoma (HCA) is a benign well-differentiated hepatocellular neoplasm that can be difficult to distinguish from well-differentiated hepatocellular carcinoma (HCC). The term "well-differentiated hepatocellular neoplasm of uncertain malignant potential" (HUMP) has been proposed for neoplasms resembling HCAs, but arising in atypical clinical situations (in females over 50 years old or under 15, in males, with anabolic steroid use, or in some congenital conditions), and/or with atypical pathological features (focal cytological/architectural atypia, β-catenin activation, or focal reticulin loss) insufficient for an unequivocal diagnosis of HCC.

Methods: This study evaluated HUMP criteria on 42 previously diagnosed HCAs from 33 patients. Read More

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September 2021

Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests?

Arch Endocrinol Metab 2021 Sep 29. Epub 2021 Sep 29.

Programa de Pós-Graduação em Ciências Aplicadas à Cirurgia e à Oftalmologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Objective: To analyze the association of clinical, anatomical, and ultrasound (US) characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules.

Methods: The association between malignancies and the following variables were analyzed: III-B or IV-B, age < 55 years and ≥ 55 years, sex, family history of thyroid cancer, history of irradiation, nodule size, and ACR TI-RADS classification in 62 participants who underwent thyroidectomy.

Results: Of the 62 participants, 87. Read More

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September 2021

Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan.

Sci Rep 2021 Sep 28;11(1):19257. Epub 2021 Sep 28.

AIDS Clinical Center, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 192-8655, Japan.

Anal high-risk human papillomavirus (hr-HPV) infection is widely considered a cause of anal cancer. However, epidemiological data are quite limited in Japan. This study investigated anal HPV infections and cytological abnormalities among MSM with or without HIV infection. Read More

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September 2021

Upper urothelial tract High Grade Carcinoma: Comparison of Urine Cytology and DNA Methylation Analysis in Urinary Samples.

Hum Pathol 2021 Sep 25. Epub 2021 Sep 25.

Department of Urology, Università Cattolica Del S. Cuore; Fondazione Policlinico "A. Gemelli", 00138, Rome, Italy.

Numerous studies showed that bladder urothelial carcinoma and upper urothelial tract carcinoma (UTUC) display clinical and genomic similarities. In order to analyze that the same panel of biomarkers used in the diagnosis of bladder urothelial carcinoma could be suitable for early detection of UTUC, we performed a retrospective study in which we analyzed Bladder EpiCheck scores in the urinary samples obtained by selective ureteral catheterization in a high grade UTUC cohort, correlating the results with urinary cytology and diagnostic uretheral biopsies. The present study represents a retrospective analysis of 82 patients with clinically localized high grade UTUC (60 renal pelvis UTUC, 22 ureter UTUC) who had undergone a radical nephroureterectomy (RNU) at our Urology department from June 2018 to November 2020. Read More

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September 2021

Validation of On-Farm Bacteriological Systems for Endometritis Diagnosis in Postpartum Dairy Cows.

Animals (Basel) 2021 Sep 15;11(9). Epub 2021 Sep 15.

Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.

The objective of this study was to validate the accuracy of the results of on-farm bacteriological culture media (Tri-plate and Petrifilm) from endometrial samples compared with the ones from the diagnostic laboratory. A cross-sectional observational study was set up within two dairy herd clients of the Université de Montréal. A total of 189 cows in the postpartum period were systematically enrolled to collect two uterine samples from cytobrushes during the same examination. Read More

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September 2021

Flavors of Non-Random Meiotic Segregation of Autosomes and Sex Chromosomes.

Genes (Basel) 2021 Aug 28;12(9). Epub 2021 Aug 28.

School of Biological Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.

Segregation of chromosomes is a multistep process occurring both at mitosis and meiosis to ensure that daughter cells receive a complete set of genetic information. Critical components in the chromosome segregation include centromeres, kinetochores, components of sister chromatid and homologous chromosomes cohesion, microtubule organizing centres, and spindles. Based on the cytological work in the grasshopper , it has been accepted for decades that segregation of homologs at meiosis is fundamentally random. Read More

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A Diagnostic Dilemma of White Matter Lesions and Cerebral Oedema without Identifiable Cause-A Neurological Conundrum.

Brain Sci 2021 Sep 18;11(9). Epub 2021 Sep 18.

Neurology Department, Liverpool Hospital, Liverpool, NSW 2170, Australia.

Introduction: This paper describes a case of bi-frontal vasogenic oedema associated with bilateral frontal lobe and left parietal lobe white matter lesions where extensive investigations, including brain biopsy, failed to establish a diagnosis.

Case Report: A 67-year-old female presented with three weeks' history of memory loss, fatigue, insomnia, nausea, and occasional dysphasia. Physical examination was unremarkable, yet cerebral CT and MRI showed bilateral frontal lobe vasogenic oedema. Read More

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September 2021

Periosteal Myxoid Leiomyosarcoma Histologically Mimicking Extraskeletal Myxoid Chondrosarcoma: Report of a Case with Histopathological and Cytopathological Comparison with Extraskeletal Myxoid Chondrosarcoma.

Acta Cytol 2021 Sep 20:1-8. Epub 2021 Sep 20.

Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

Myxoid leiomyosarcoma (MLS) is a rare variant of leiomyosarcoma, with most cases occurring in the uterus. A case of MLS arising in the periosteal region of the tibia, mimicking extraskeletal myxoid chondrosarcoma (EMC), is described. The evaluation included histological and cytological comparison with EMC. Read More

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September 2021

Eosinophil-mediated lung inflammation associated with elevated natural killer T cell response in COVID-19 patients.

Korean J Intern Med 2021 Sep 27. Epub 2021 Sep 27.

Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea.

Background/aims: Coronavirus disease 2019 (COVID-19) is associated with acute respiratory syndrome. The mechanisms underlying the different degrees of pneumonia severity in patients with COVID-19 remain elusive. This study provides evidence that COVID-19 is associated with eosinophil-mediated inflammation. Read More

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September 2021