221,291 results match your criteria clinical course


Depression subtypes and their response to cognitive behavioral therapy: A latent transition analysis.

Depress Anxiety 2021 May 7. Epub 2021 May 7.

Clinical and Applied Psychology Unit, Department of Psychology, University of Sheffield, Sheffield, UK.

Background: Depression is a heterogeneous condition, with multiple possible symptom-profiles leading to the same diagnosis. Descriptive depression subtypes based on observation and theory have so far proven to have limited clinical utility.

Aim: To identify depression subtypes and to examine their time-course and prognosis using data-driven methods. Read More

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Diverse changes in microglia morphology and axonal pathology during the course of 1 year after mild traumatic brain injury in pigs.

Brain Pathol 2021 May 7:e12953. Epub 2021 May 7.

Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.

Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long-term neurological dysfunction. The mechanical forces that are caused by TBI propagate through the brain to produce diffuse axonal injury (DAI) and trigger secondary neuroinflammatory cascades. Read More

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Treatment patterns and disease course of previously untreated Primary Central Nervous System Lymphoma - feasibility of MTX-based regimens in clinical routine.

Eur J Haematol 2021 May 7. Epub 2021 May 7.

Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), University of Cologne, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany.

Background: Primary Central Nervous System Lymphoma (PCNSL) is a rare type of aggressive lymphoma of the central nervous system. Treatment strategies improved significantly over the past decades, differ regionally but mainly consist of rituximab and high-dosed methotrexate (MTX)-based therapies.

Methods: We assessed clinical outcomes of 100 patients with newly diagnosed PCNSL between 2010-2020 at the University Hospital of Cologne, Germany. Read More

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Therapy outcomes for neurodiverse couples: Exploring a solution-focused approach.

J Marital Fam Ther 2021 May 7. Epub 2021 May 7.

Florida State University, Tallahassee, FL, USA.

The need for clinical approaches that address romantic relationship concerns of adults with Aautism spectrum disorder (ASD) has been essentially overlooked. There are a growing number of recommendations in the available literature to increase the availability and evaluation of treatment approaches that are appropriate for couples that include an adult with ASD. The aim of the present study was to explore clinical outcomes of a neurodiverse couple who participated in twelve sessions of solution-focused brief therapy. Read More

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Clinical spectrum and long-term course of sustained ventricular tachycardia in pediatric patients: 10 years of experience.

Anatol J Cardiol 2021 May;25(5):313-322

Department of Pediatric Cardiology, University of Health Sciences, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey.

Objective: Pediatric ventricular tachycardias (VTs) have heterogeneous etiology and different clinical features. This study aimed to evaluate the clinical spectrum and long-term course of pediatric sustained VTs.

Methods: Patients diagnosed as having sustained VT between 2010 and 2020 were evaluated retrospectively. Read More

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[Modern ideas about bulbourethral glands].

Urologiia 2021 May(2):128-134

V.I. Vernadsky Crimean Federal University, Simferopol, Republic of Crimea, Russia.

Bulbourethral glands are the accessory glands of the male reproductive system, the leading function of which is associated with ejaculation and includes both the neutralization of the acidic urine residues and environment of the female vagina, and friction reduction during the sexual intercourse. These glands play the role of immune barrier for urogenital infections, and also synthesize important autocrine and paracrine factors for the male urogenital system development. Glands pathologies usually have a subclinical course, however they can also lead to the functional disorders of the human urogenital system. Read More

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[The cell technologies in modification of mesh materials used in urology].

Urologiia 2021 May(2):94-99

Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia.

Based on the literary analysis, the influence of cellular technologies on the results of implantation of mesh materials was studied. The scientific literature of recent years contains a large amount of data devoted to the study of mesh structures and the possibilities of their modification using multipotent stromal cells (MSC) for implantation into patients for correcting tissue defects and pelvic organ prolapse. However, the ideal implant has not yet been created. Read More

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The Bern Early Recognition and Intervention Centre for mental crisis (FETZ Bern)-An 8-year evaluation.

Early Interv Psychiatry 2021 May 6. Epub 2021 May 6.

University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

Aim: Early detection of, and intervention for, psychosis during its prodromal phase has the potential to alter the course of the disease and has therefore become a major objective of modern clinical psychiatry. An increasing number of early detection and intervention services have been established in Europe and worldwide. This study aims to describe and evaluate an early detection and intervention service for children, adolescents and adults (FETZ Bern) aged from eight to 40 years with a population catchment area of 1. Read More

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Genotype-phenotype studies in a large cohort of Brazilian patients with Hunter syndrome.

Am J Med Genet C Semin Med Genet 2021 May 7. Epub 2021 May 7.

Medical Genetics Service, HCPA, Porto Alegre, Rio Grande do Sul, Brazil.

Mucopolysaccharidosis type II (MPS II) is an X-linked inherited disease caused by pathogenic variants in the IDS gene, leading to deficiency of the lysosomal enzyme iduronate-2-sulfatase and consequent widespread storage of glycosaminoglycans, leading to several clinical consequences, with progressive manifestations which most times includes cognitive decline. MPS II has wide allelic and clinical heterogeneity and a complex genotype-phenotype correlation. We evaluated data from 501 Brazilian patients diagnosed with MPS II from 1982 to 2020. Read More

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Triangular extension of hinge flaps: A novel technique to resolve stomal stenosis and prevent restenosis in staged buccal mucosal urethroplasty.

Int J Urol 2021 May 6. Epub 2021 May 6.

Departments of, Department of, Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.

Objectives: To verify the utility of triangular extension of a hinge flap in buccal mucosal staged urethroplasty to resolve stomal stenosis after the first stage and ultimately prevent restenosis.

Methods: A total of 23 patients (triangular extension group) were studied in 2013-2019. In the first stage, buccal mucosa was transplanted, and an extended triangle portion of the mucosa was placed beside the proximal and/or distal stoma that was created when the stricture segment of the urethra was resected. Read More

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Intrinsic radiomic expression patterns after 20 Gy demonstrate early metabolic response of oropharyngeal cancers.

Med Phys 2021 May 6. Epub 2021 May 6.

Department of Radiation Oncology, Duke University.

Purpose: This study investigated the prognostic potential of intra-treatment PET radiomics data in patients undergoing definitive (chemo)radiation therapy for oropharyngeal cancer (OPC) on a prospective clinical trial. We hypothesized that the radiomic expression of OPC tumors after 20 Gy is associated with recurrence free survival (RFS).

Materials And Methods: Sixty-four patients undergoing definitive (chemo)radiation for OPC were prospectively enrolled on an IRB-approved study. Read More

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Childhood arterial ischemic stroke due to mineralizing angiopathy: an 18-year single-center experience.

Dev Med Child Neurol 2021 May 6. Epub 2021 May 6.

Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.

Mineralizing angiopathy is a unique, age-specific stroke syndrome characterized by basal ganglia infarction and lenticulostriate calcification after minor head injury in early childhood. There is limited understanding of the pathophysiology, course, and clinical outcome of this syndrome. We describe the clinical and radiographical phenotype of a single-center, consecutively enrolled cohort of children with mineralizing angiopathy from January 2002 to January 2020 and provide a comparative analysis to previously published literature. Read More

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Urinary Markers of Podocyte Dysfunction in Chronic Glomerulonephritis.

Adv Exp Med Biol 2021 ;1306:81-99

Tareev Clinic, Department of Nephrology, Sechenov First Moscow State Medical University, Moscow, Russia.

Chronic glomerulonephritis (CGN) is a disease with a steady progressive course that involves the development of nephrosclerosis, which is especially evident in clinical courses with incidences of high proteinuria (PU). Currently, proteinuria is considered the main laboratory feature (sign) of CGN activity and progression because proteinuria is closely related to the process of tubulointerstitial fibrosis, which is correlated with the grade of renal insufficiency. The injury to podocytes, which are key components of the filtration barrier, plays a central role in proteinuria development. Read More

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January 2021

One-Year Adherence to Continuous Positive Airway Pressure With Telemonitoring in Sleep Apnea Hypopnea Syndrome: A Randomized Controlled Trial.

Front Med (Lausanne) 2021 20;8:626361. Epub 2021 Apr 20.

Service de Pneumologie, Département des Spécialités de Médecine, Hôpitaux Universitaires Genevois (HUG), Geneva, Switzerland.

Telemedicine (TM) for continuous positive airway pressure (CPAP) treated patients may save health-care resources without compromising treatment effectiveness. We assessed the effect of TM (AirView Online System, ResMed) during the CPAP habituation phase on 3-month and 1-year treatment adherence and efficacy in patients with moderate-to-severe obstructive sleep apnea (OSA). At CPAP initiation, 120 patients diagnosed with OSA were randomized to either usual care (UC) or TM during the habituation phase (clinical registration: ISRCTN12865936). Read More

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Factors Predicting the Outcome of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 5-Year Retrospective Study.

Indian Dermatol Online J 2021 Mar-Apr;12(2):258-265. Epub 2021 Mar 2.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Clinicodemographic and laboratory parameters predicting the outcome of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) may vary among populations owing to genotypic and environmental variations. There is a scarcity of studies evaluating these parameters in Indian population.

Aims: To analyze clinicodemographic and laboratory parameters predicting disease outcome in patients of SJS/TEN. Read More

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Sinonasal Renal Cell-Like Adenocarcinoma.

Cureus 2021 Apr 4;13(4):e14285. Epub 2021 Apr 4.

Otolaryngology - Head and Neck Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.

Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a newly defined, rare malignant tumor of the nasal cavity. The clinical course and response to treatment remain uncertain. The purpose of this study is to report a new case of SNRCLA and review the literature to determine clinical characteristics, treatment options, and outcomes. Read More

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Autologous adipose-derived stem cells therapy in COPD treatment: a case report.

Respirol Case Rep 2021 May 28;9(5):e00748. Epub 2021 Apr 28.

Hanoi Medical University Hanoi Vietnam.

Here, we describe the clinical course of a patient with chronic obstructive pulmonary disease treated with autologous adipose-derived stem cell therapy. In September 2019, our patient was admitted to Bach Mai Hospital. His post-bronchodilator forced expiratory volume in 1 sec (FEV) was 21% and FEV/forced vital capacity (FVC) was 40%. Read More

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Infantile giant cell hepatitis with autoimmune hemolytic anemia.

World J Hepatol 2021 Apr;13(4):411-420

Department of Pediatrics, National Research Center for Maternal and Child Health, Nur-Sultan 010000, Kazakhstan.

Giant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. Read More

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Trisomy 21 as a Risk Factor for Severe Illness in COVID-19: Report of two Cases.

Tanaffos 2020 Dec;19(4):413-417

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

COVID-19 leads to mild symptoms within the majority of infected patients, but can cause severe multiple organ failure and death. There is only limited information regarding the consequences of this new emerging infection with congenital disorders. According to the previous studies, many people with Down syndrome are considered high risk for complications related to respiratory diseases. Read More

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December 2020

Efficacy and Safety of Tripterygium Glycoside in the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis Based on the Duration of Medication.

Front Endocrinol (Lausanne) 2021 20;12:656621. Epub 2021 Apr 20.

School of Life and Science, Beijing University of Chinese Medicine, Beijing, China.

Aim: The aim of this study was to assess the clinical efficacy and safety of Tripterygium-derived glycosides (TG) after 3-month and 6-month of treatments of diabetic nephropathy (DN) and to resolve the conflict between medicine guidance and clinical practice for TG application.

Methods: We conducted a systematic review and meta-analysis of randomized controlled trials involving TG application in treating DN. We extensively searched PubMed, Cochrane Library, CNKI, VIP, Wan-Fang, CBM, Chinese Clinical Trial Registry, and WHO International Clinical Trial Registration Platform till November 2020, along with grey literature for diabetes and all other relevant publications to gather eligible studies. Read More

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Intentional Discontinuation of Psychostimulants Used to Treat ADHD in Youth: A Review and Analysis.

Front Psychiatry 2021 20;12:642798. Epub 2021 Apr 20.

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States.

This paper reviews the literature on intentional discontinuation of psychostimulants in ADHD to summarize what is known about clinical course of controlled discontinuation and guide practitioners who are considering stopping these medications for youth with ADHD. A systematic search was executed in Cochrane CENTRAL, EMBASE, Psychinfo, and MEDLINE databases to identify all articles that addressed the topic of deprescribing of psychotropic medications in children and adolescents. Keywords and search strings were developed using "PICO" framework, involving Population of interest (<18 y. Read More

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Supplemental Learning in Respiratory Physiology for Healthcare Professionals Towards Successful Treatment of COVID-19.

Front Physiol 2021 20;12:624528. Epub 2021 Apr 20.

School of Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

The immunological and pathophysiological response to COVID-19 can cause severe respiratory impairment affecting gas exchange and lung mechanics. Such was the scale of the respiratory support needed during the first wave of the pandemic, that recruitment of non-respiratory clinical staff was essential to help deal with the growing number of cases. It quickly became apparent that it was vital to rapidly equip these healthcare professionals with appropriate physiological knowledge and practical skills if therapies were to be applied effectively. Read More

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Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson's Disease.

Front Neurosci 2021 20;15:633022. Epub 2021 Apr 20.

Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To explore the association between lipoprotein-related phospholipase A2 (Lp-PLA2) and the risk of Parkinson's disease (PD).

Methods: A case-control study involving 58 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected. Read More

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Population Pharmacokinetics of CC-122.

Clin Pharmacol 2021 28;13:61-71. Epub 2021 Apr 28.

Clinical Pharmacology & Pharmacometrics, Bristol Myers Squibb, Summit, NJ, USA.

Background: CC-122 is a cereblon-modulating agent that exerts direct cell-autonomous activity against malignant B cells and immunomodulatory effects. Herein, a population pharmacokinetic (popPK) model of CC-122 was developed and the influence of demographic and disease-related covariates on population pharmacokinetic parameters was assessed based on data from three clinical studies of CC-122 (dose range, 0.5-15 mg) in healthy subjects and cancer patients. Read More

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Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome.

World J Gastroenterol 2021 Apr;27(15):1643-1654

Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: In the early stage of acute pancreatitis (AP), a large number of cytokines induced by local pancreatic inflammation seriously damage the intestinal barrier function, and intestinal bacteria and endotoxins enter the blood, causing inflammatory storm, resulting in multiple organ failure, infectious complications, and other disorders, eventually leading to death. Intestinal failure occurs early in the course of AP, accelerating its development. As an alternative method to detect small intestinal bacterial overgrowth, the hydrogen breath test is safe, noninvasive, and convenient, reflecting the number of intestinal bacteria in AP indirectly. Read More

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Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.

Nat Genet 2021 May 6. Epub 2021 May 6.

Translational Genomics Core of Partners HealthCare Personalized Medicine, Cambridge, MA, USA.

A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the course that the disease takes over time (progression and prognosis). To assess how genetic variation influences the progression of PD over time to dementia, a major determinant for quality of life, we performed a longitudinal genome-wide survival study of 11.2 million variants in 3,821 patients with PD over 31,053 visits. Read More

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A putative "chemokine switch" that regulates systemic acute inflammation in humans.

Sci Rep 2021 May 6;11(1):9703. Epub 2021 May 6.

Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St, Pittsburgh, PA, 15213, USA.

Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients. Using dynamic network analyses, we inferred a novel control architecture for systemic inflammation: a three-way switch comprising the chemokines MCP-1/CCL2, MIG/CXCL9, and IP-10/CXCL10. Read More

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Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress.

Sci Rep 2021 May 6;11(1):9658. Epub 2021 May 6.

Laboratório de Virologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, CCS, Bloco A, Sala 121 Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.

ACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case-control study was conducted with 213 SARS-CoV-2 positive individuals where cases were defined as COVID-19 patients with respiratory distress requiring oxygen support (N = 38) and controls were those with mild to moderate symptoms of the disease who did not need oxygen therapy along the entire clinical course (N = 175). Read More

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Learning-by-Teaching and Service Learning to Promote Bleeding Control Education: An Academic-Community Partnership.

Nurse Educ 2021 May 4. Epub 2021 May 4.

Author Affiliations: Assistant Professor (Dr Courville), Clinical Instructor (Ms Lowe), Undergraduate Nursing Student (Ms Dannelley), Graduate Nurse Class of Spring 2020 (Mr Sellers), and Associate Professor (Dr Deal), The University of Texas at Tyler, Longview.

Background: Stop the Bleed is a free 1-hour class that teaches laypersons to identify and treat life-threatening bleeding. The training requires a 1:10 instructor-to-participant ratio, which creates a resource drain on volunteer instructors. Nursing students are eligible to assist instructors. Read More

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Bridging the feedback gap: a sociotechnical approach to informing clinicians of patients' subsequent clinical course and outcomes.

BMJ Qual Saf 2021 May 6. Epub 2021 May 6.

Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA.

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