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Sexual Function and Mood Disorders Among Menopausal Women: A Systematic Scoping Review.

J Sex Med 2022 Jul;19(7):1098-1115

Department of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Kiel, Germany.

Background: Changes in sex hormones during menopause may have detrimental effects on a woman's sexual function and cause mood disorders. The treatment of both conditions is a challenge in gynecology.

Aim: To review the published literature on sexual function and mood disorders among peri- and postmenopausal women. Read More

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Progression-Free Survival at 24 Months as A Landmark After Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B-cell Lymphoma.

Transplant Cell Ther 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) who achieve progression-free survival (PFS) at 24 months (PFS24) following immunochemotherapy (IC) have excellent overall survival (OS) comparable to that of the age- and sex-matched general population. However, a similar landmark has not been established for patients with relapsed or refractory (RR) DLBCL following frontline IC who are subsequently treated with salvage therapy followed by autologous stem cell transplant (ASCT).

Objective: To evaluate the role of PFS24 as a landmark after ASCT in patients with RR DLBCL. Read More

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Dental and maxillofacial manifestations of Steinert's myotonic dystrophy: a retrospective case series and therapeutic investigation.

J Stomatol Oral Maxillofac Surg 2022 Jun 22. Epub 2022 Jun 22.

Department and Maxillo-Facial Surgery, CHU Salengro, Rue Emile Laisne, 59037 Lille, France.

This retrospective study was performed to analyse the facial features and occlusal anomalies in 18 patients with Steinert's myotonic dystrophy (MD1). Medical and surgical management issues noted in this study may contribute to clinical decision-making. This series included 18 patients with MD1 who presented for maxillofacial consultations. Read More

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Clinical impact and prognosis of cryoglobulinemia and cryofibrinogenemia in systemic sclerosis.

Autoimmun Rev 2022 Jun 22:103133. Epub 2022 Jun 22.

Centre Hospitalier Universitaire, Medecine Interne, Toulouse, France; Centre Hospitalier Universitaire, Laboratoire d'Immunologie, Toulouse, France; Clinique Saint-Exupery, Medecine Interne, Toulouse, France; Centre Hospitalier Universitaire, Néphrologie, Toulouse, France; Centre Hospitalier Universitaire, Cardiologie, Toulouse, France; Clinique Ambroise-Paré, Medecine Interne, Toulouse, France; Centre Hospitalier Universitaire, Pneumologie, Toulouse, France; Hopital Joseph Ducuing, Medecine Interne, Toulouse, France; Centre D'investigation Clinique (CIC), 1436 PEPSS Team, Toulouse, France.

Introduction: An association of systemic sclerosis (SSc) with cryoglobulin and/or cryofibrinogenemia has been described. However, clinical, biological, morphological and prognostic implications are unknown. The objective of this study was to describe the phenotype and evaluate the prognosis of cryoglobulinemia and/or cryofibrinogenemia in the progression of SSc. Read More

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Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment.

J Adv Res 2022 Jun 22. Epub 2022 Jun 22.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110031, Taiwan; TMU Research Center of Drug Discovery, Taipei Medical University, Taipei 110031, Taiwan. Electronic address:

Introduction: The tumor microenvironment is mainly flooded with immunosuppressive cells and inhibitory cytokines, resulting in the inability of effective immune cells to infiltrate and recognize tumors and even the loss of anti-cancer ability.

Objectives: We propose a novel HDAC6/HSP90 dual inhibitory strategy as well as a chemoimmunotherapeutic agent that does not only kill tumor cells but also destroys the tumor microenvironment and enhances anti-cancer immunity.

Methods: A hybrid scaffold construction approach was leveraged to furnish a series of rationally designed resorcinol-based hydroxamates as dual selective HDAC6/HSP90 inhibitors. Read More

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Effectiveness of Maintenance and Reliever Therapy using inhaled corticosteroid-formoterol in asthmatics.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.

Background: Real-world evidence on the effectiveness of Maintenance and Reliever Therapy (MART) using inhaled corticosteroids plus long-acting beta 2-agonist (ICS-LABA) is sparse.

Objective: This study aimed to evaluate the clinical effectiveness of MART (ICS-formoterol) by comparing its effectiveness to that of ICS-LABA plus as-needed short-acting beta 2-agonist (SABA) in adult asthmatics.

Methods: We retrospectively retrieved data from the medical records of the Ajou University Medical Cente r, Korea, to compare clinical outcomes between patients treated with MART (the MART group) and those treated with ICS-LABA plus SABA (the non-MART group). Read More

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SARS-CoV-2 omicron: Light at the end of the long pandemic tunnel or another false dawn for immunodeficient patients?

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Department of Clinical immunology, Auckland Hospital, Park Rd, Grafton 1010, Auckland New Zealand; Department of Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland.

COVID-19 has had a disastrous impact on the world. Apart from at least 6 million deaths, countless COVID-19 survivors are suffering long-term physical and psychiatric morbidity. Hundreds of millions have been plunged into poverty caused by economic misery, particularly in developing nations. Read More

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The Case for Prompt Salvage Infant Peanut Oral Immunotherapy Following Failed Primary Prevention.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

Recent guideline recommendations have shifted from recommending prolonged avoidance of allergenic foods in the first three years of life to a primary prevention approach involving the deliberate early introduction to infants at risk of developing food allergy. Despite this, some infants, especially those with severe eczema who are at highest risk for developing peanut allergy, fail to receive the preventative benefits of early peanut introduction due to hesitancy and other factors. Difficulty adhering to regular ingestion following introduction further reduces the effectiveness of primary prevention. Read More

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Food-dependent Exercise-induced Wheals, Angioedema, and Anaphylaxis: A Systematic Review.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany.

Background: Food-dependent exercise-induced wheals, angioedema, and anaphylaxis remain insufficiently characterized.

Objective: We systematically reviewed the literature on clinical manifestations, laboratory investigations, culprit foods, triggering exercise, comorbidities, and treatment outcomes.

Methods: Using predefined search terms and Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) recommendations, we searched three electronic databases to identify relevant literature published before July 2021. Read More

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Application of Molecular Imaging in Immune Checkpoints Therapy: From Response Assessment to Prognosis Prediction.

Crit Rev Oncol Hematol 2022 Jun 22:103746. Epub 2022 Jun 22.

Department of Breast-Thyroid-Surgery and Cancer Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 East Xiang'an Road, Xiamen, China; Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer (Xiang'an Hospital of Xiamen University), 2000 East Xiang'an Road, Xiamen, China; Xiamen Key Laboratory for Endocrine Related Cancer Precision Medicine, Xiang'an Hospital of Xiamen University, 2000 East Xiang'an Road, Xiamen, China; Xiamen Research Center of Clinical Medicine in Breast & Thyroid Cancers, 2000 East Xiang'an Road, Xiamen, China; Cancer Research Center, School of Medicine, Xiamen University, 4221 South Xiang'an Road, Xiamen, China. Electronic address:

Recently, immune checkpoint therapy (ICT) represented by programmed cell death1 (PD-1) and its major ligands, programmed death ligand 1 (PD-L1), has achieved significant success. Detection of PD-L1 by immunohistochemistry (IHC) is a classic method to guide the treatment of ICT patients. However, PD-L1 expression in the tumor microenvironment is highly complex. Read More

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Amyloidosis Tissue Confirmation for Tafamidis Eligibility Using Transverse Carpal Ligament and Tenosynovium Biopsy.

Can J Cardiol 2022 Jun 22. Epub 2022 Jun 22.

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

In most Canadian provinces, eligibility criteria for public reimbursement coverage for tafamidis for treatment of transthyretin amyloidosis cardiomyopathy (ATTR-CM) include tissue biopsy confirmation of amyloidosis. Carpal tunnel syndrome requiring surgical release is common in ATTR-CM. We report our experience performing simultaneous transverse carpal ligament and tenosynovium biopsy during CTR, with all patients positive for amyloidosis, facilitating initiation of tafamidis. Read More

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Full-endoscopic Lumbar Interbody Fusion Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion with Tubular Retractor System: A Retrospective Controlled Study.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Orthopedic Surgery, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.

Objectives: To compare the safety and clinical efficacy of full-endoscopic lumbar interbody fusion (FE-LIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).

Methods: A total of 70 patients with single-level lumbar degenerative diseases underwent FE-LIF or MIS-TLIF with a tubular retractor system from August 2018 to August 2020. Postoperatively, the efficacy and safety were compared using several clinical and radiological indices. Read More

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Feasibility and clinical utility of a workflow interfacing radiation oncology lung stereotactic body radiotherapy treatment planning and diagnostic radiology.

Pract Radiat Oncol 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah. Electronic address:

Stereotactic body radiotherapy (SBRT) is commonly used to treat early stage non-small cell lung cancer (NSCLC). SBRT beam arrangements include multiple entry/exit pathways resulting in irregular low dose distributions within normal lung parenchyma. An improved understanding of post-treatment radiographic changes may improve the ability to predict clinical complications including radiation pneumonitis as well as assist in early detection of local failures. Read More

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Comparison of two non-union models with damaged periosteum in mice: Segmental defect and pin-clip fixation versus transverse fracture and K-wire stabilization.

Bone 2022 Jun 22:116475. Epub 2022 Jun 22.

Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany.

Despite growing knowledge about the mechanisms of fracture healing, non-union formation still represents a major complication in trauma and orthopedic surgery. Non-union models in mice gain increasing interest, because they allow investigating the molecular and cellular mechanisms of failed fracture healing. These models often use segmental defects to achieve non-union formation. Read More

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Impact of operability and total metastatic ablation on outcomes after stereotactic ablative radiotherapy (SABR) for oligometastases.

Int J Radiat Oncol Biol Phys 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, Australia.

Purpose: Medical operability is prognostic for survival after SABR in primary malignancies. This study investigates the prognostic significance of medical operability and total versus subtotal ablation of all oligometastatic disease sites.

Material/methods: Consecutive patients with 1-5 sites of active extracranial oligometastases had medical operability status and presence of subtotal versus total metastatic ablation recorded prospectively on an institutional database. Read More

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Frequency of unscheduled visits to the Obstetrical Triage Assessment unit by pregnant adolescents in an urban Canadian Center compared to a matched cohort of pregnant women.

J Obstet Gynaecol Can 2022 Jun 22. Epub 2022 Jun 22.

Division of Pediatric and Adolescent Gynecology, Department of Surgery, Children's Hospital of Eastern Ontario; University of Ottawa, Department of Obstetrics and Gynecology, Ottawa, Canada; Clinical Research Unit, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Canada.

Objectives: People from marginalized and vulnerable populations present more frequently for unscheduled, emergency obstetrical services at labour and delivery triage units. Based on our clinical experience, pregnant adolescents visit the obstetrical triage assessment units (OTAU) more often than adults do. This study was designed to assess this phenomenon by quantifying and describing the frequency of unscheduled visits to the OTAU by pregnant adolescents (age <20 y) compared with a matched cohort of adult pregnant patients (age ≥20 y). Read More

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Conflicts of Interest among Patients: Do They Exist and Can They Bias Patient-Reported Outcome Measures? A Survey of Shoulder and Elbow Patients.

J Shoulder Elbow Surg 2022 Jun 22. Epub 2022 Jun 22.

Hannover Medical School Trauma Department Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Background: Potential conflicts of interest (COI) are common among physicians and may bias physician-reported outcome assessment in orthopedic research. It is unclear whether patients have COI and if this COI could affect patient-reported outcome measures (PROMs). The purposes of this study were to investigate (1) existence of COIs among patients and (2) their potential to bias PROMs with a pseudonymized survey among consecutive shoulder and elbow patients. Read More

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Primary Contributors to Dietary Acid Load in Patients with Urolithiasis.

J Ren Nutr 2022 Jun 22. Epub 2022 Jun 22.

Senior Scientist, University of Wisconsin School of Medicine and Public Health, Department of Urology; and Clinical Nutritionist, UW Health University Hospital and Clinics, 1685 Highland Avenue, 3258 MFCB, Madison, WI 53705-2281.

Objective: In susceptible individuals, high dietary acid load may contribute to the formation of certain types of kidney stones via lowering urine pH and citrate excretion. The objective of this study was to determine the contribution of dietary acid from food groups in people with urolithiasis.

Design: & Methods: Patients with calcium urolithiasis (n=83) who completed food records were used for this retrospective analysis. Read More

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Symptom control and survival for people severely ill with COVID: a multicentre cohort study (CovPall-Symptom).

J Pain Symptom Manage 2022 Jun 22. Epub 2022 Jun 22.

International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, UK.

Context: Evidence of symptom control outcomes in severe COVID is scant.

Objective: To determine changes in symptoms among people severely ill or dying with COVID supported by palliative care, and associations with treatments and survival.

Methods: Multicentre cohort study of people with COVID across England and Wales supported by palliative care services, during the pandemic in 2020 and 2021. Read More

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Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges.

Semin Cancer Biol 2022 Jun 22. Epub 2022 Jun 22.

University of Perugia, Department of Surgery and Medicine, Unit of Medical Oncology, Perugia, Italy. Electronic address:

Immune checkpoint inhibitors (ICIs) have demonstrated impressive antitumor activity in patients with advanced and early stage melanoma, thus improving long-term survival outcomes. However, most patients derive limited benefit from immunotherapy, due to the development of primary, adaptive, or acquired resistance mechanisms. Immunotherapy resistance is a complex phenomenon that depends on genetic and epigenetic mechanisms which, in turn, drive the interplay between cancer cells and the tumor microenvironment (TME). Read More

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MicroRNA-29c-3p in dual-labeled exosome is a potential diagnostic marker of subjective cognitive decline.

Neurobiol Dis 2022 Jun 22:105800. Epub 2022 Jun 22.

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China. Electronic address:

Objective: The present study aimed to determine whether peripheral blood neural cell adhesion molecule (NCAM)/amphiphysin 1 dual-labeled exosomal proteins and microRNAs (miRs) might serve as a marker for the early diagnosis of Alzheimer's disease (AD).

Methods: This observational, retrospective, multicenter study used a two-stage design conducted in Beijing and Shanghai, China. The subjects included 76 patients with subjective cognitive decline (SCD), 80 with amnestic mild cognitive impairment (aMCI), 76 with dementia of Alzheimer's type (AD), 40 with vascular dementia (VaD), and 40 controls in the discovery stage. Read More

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Development of an osmoprotective microemulsion as a therapeutic platform for ocular surface protection.

Int J Pharm 2022 Jun 22:121948. Epub 2022 Jun 22.

Ophthalmology Innovation, Therapy and Pharmaceutical Development (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy (UCM), Plaza Ramón y Cajal s/n, Madrid 28040, Spain; National Ocular Pathology Network (OFTARED), Carlos III Health Institute, San Carlos Clinical Hospital Health Research Institute (IdISSC), Madrid 28040, Spain. Electronic address:

Self-emulsified osmoprotective ophthalmic microemulsions (O/A) were prepared by combining betaine/leucine, clusterin/oleanolic acid, and hyaluronic acid or Dextran. The microemulsions contained an internal oily phase (1.2%), an external aqueous phase (96. Read More

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High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis.

Microb Pathog 2022 Jun 22:105644. Epub 2022 Jun 22.

Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Affiliated to Istituto Pasteur Italia, 00185, Rome, Italy. Electronic address:

Merkel cell polyomavirus (MCPyV) has been detected in respiratory specimens including those from Cystic Fibrosis (CF) patients, raising questions about its immunological and clinical relevance in the respiratory tract. MCPyV might promote an inappropriate antiviral response contributing to a chronic inflammatory response and resulting in detrimental effects in CF. Respiratory samples (n = 1138) were randomly collected from respiratory tract of CF patients (n = 539) during July 2018-October 2019. Read More

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Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.

Eur J Pharm Sci 2022 Jun 22:106246. Epub 2022 Jun 22.

Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, 00014, Helsinki, Finland. Electronic address:

Organic Anion Transporting Polypeptide 1B1 is important to the hepatic elimination and distribution of many drugs. If OATP1B1 function is decreased, it can increase plasma exposure of e.g. Read More

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Efficacy of teicoplanin in bloodstream infections caused by Enterococcus faecium: post-hoc analysis of a nationwide surveillance.

Int J Infect Dis 2022 Jun 22. Epub 2022 Jun 22.

Asia-Pacific Foundation for Infectious Diseases, Suite 1712, Rosedale Officetel 280, Gwangpyeong-ro, Gangnam-gu, Seoul 06367, Republic of Korea.

Objectives: Vancomycin and teicoplanin are glycopeptides with activity against Enterococcus faecium. However, studies on the clinical efficacy of teicoplanin are limited. The present study was aimed to compare the therapeutic efficacy of teicoplanin and vancomycin in E. Read More

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The development and application of a chairside oral health risk and need stratification tool in general dental services.

J Dent 2022 Jun 22:104206. Epub 2022 Jun 22.

Dental Public Health, Cardiff University School of Dentistry. Electronic address:

Objective: To describe the development and application of the Assessment of Clinical Oral Risks and Needs (ACORN) stratification tool based on a traffic light system in National Health Service (NHS) general dental services (GDS) Wales, UK.

Materials And Methods: This was a secondary analysis of routinely-collected dental care data. All courses of treatment provided in dental practices participating in NHS GDS Reform Programme between July 2018 - September 2019, in which an ACORN assessment and age were recorded were included in the analysis. Read More

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The Gut-lung Axis in Severe Acute Panceatitis-associated Lung Injury: the Protection by the Gut Microbiota through Short-chain Fatty Acids.

Pharmacol Res 2022 Jun 22:106321. Epub 2022 Jun 22.

Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116000, P.R. China; Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116000, P.R. China. Electronic address:

The role of gut microbiota in regulating the intestinal homeostasis, as well as the pathogenesis of severe acute pancreatitis-associated lung injury (PALI) is widely recognized. The bioactive functions of metabolites with small molecule weight and the detail molecular mechanisms of PALI mediated by "gut-lung axis" have gradually raised the attentions of researchers. Several studies have proved that short-chain fatty acids (SCFAs) produced by gut microbiome play crucial roles and varied activities in the process of PALI. Read More

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Association of Lymph Node Sampling and Clinical Volume in Lobectomy for Non-Small Cell Lung Cancer.

Ann Thorac Surg 2022 Jun 22. Epub 2022 Jun 22.

Division of Thoracic Surgery, Massachusetts General Hospital, Boston MA.

Background: Sampling ≥10 lymph nodes during lobectomy for non-small cell lung cancer (NSCLC) is a current surveillance metric and potential quality metric of American College of Surgeons Commission on Cancer. We sought to determine guideline adherence and its relationship to hospital lobectomy volume within the Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD).

Methods: Participant-centers providing elective lobectomy for NSCLC within the STS-GTSD (2012-2019) were divided into tertiles according to annual volume. Read More

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Role of olmesartan in ameliorating diabetic nephropathy in rats by targeting the AGE/PKC, TLR4/P38-MAPK and SIRT-1 autophagic signaling pathways.

Eur J Pharmacol 2022 Jun 22:175117. Epub 2022 Jun 22.

Department of Biochemistry, German University in Cairo, Cairo, Egypt.

Diabetic nephropathy (DN) is one of the most serious consequences of diabetes and the most common reason for end-stage renal disease. The current study was set out to investigate the ability of olmesartan medoxomil (OM) to treat DN by evaluating the reno-protective effects of this drug on fat/fructose/streptozotocin (F/Fr/STZ)-induced diabetic rat model. This model was induced by feeding rats high F/Fr diet for 7 weeks followed by injection of a single sub-diabetogenic dose of STZ (35mg/kg; i. Read More

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Effect of macular pigment carotenoids on cognitive functions: A systematic review.

Physiol Behav 2022 Jun 22:113891. Epub 2022 Jun 22.

Vision Science Research Group (CIVIUS), Department of Physics of Condensed Matter - Optics Area, Av. de la Reina Mercedes, S/N, 41012 Sevilla, University of Seville, Spain; Faculty of Optics and Optometry, Campus Universitario de Espinardo, Edificio 35, 30100 Espinardo, Murcia, University of Murcia, Spain. Electronic address:

Lutein and zeaxanthin-xanthophyll carotenoids with antioxidant and anti-inflammatory characteristics-are present in the retina and the brain. High concentrations of these carotenoids have been positively related to cognitive performance. Therefore, this systematic review analyses the relationship between macular pigment density and cognitive functions. Read More

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