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A Clinically Applicable Gene Expression based Score predicts Resistance to Induction Treatment in Acute Myeloid Leukemia.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), Germany.

Prediction of resistant disease at initial diagnosis of acute myeloid leukemia (AML) can be achieved with high accuracy by using cytogenetic data and 29 gene expression markers (PS29MRC). Our aim was to establish PS29MRC as a clinically usable assay by using the widely implemented NanoString platform and further validate the classifier in a more recently treated patient cohort. 351 patients with newly diagnosed AML intensively treated within the AMLCG registry were analyzed. Read More

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September 2021

Initial therapy of chronic graft vs. host disease: Analysis of practice variation and failure-free survival.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Fred Hutchinson Cancer Research Center, SEATTLE, Washington, United States.

Prior clinical trials largely considered prednisone 1mg/kg/day with or without calcineurin inhibitor as standard initial therapy for chronic graft vs. host disease (cGVHD) but uncertainty remains regarding the extent of practice variation and whether this affects subsequent outcomes. We assembled a cohort of 745 cGVHD patients treated with initial systemic immune suppressive (IS) therapy from three prior Chronic GVHD Consortium observational studies. Read More

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September 2021

Epidemiology and treatment patterns of idiopathic multicentric Castleman disease in the era of IL-6 directed therapy.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

University of Pennsylvania, Philadelphia, Pennsylvania, United States.

The epidemiology of HHV-8-negative/idiopathic multicentric Castleman disease (iMCD) remains incompletely understood. Prior epidemiologic studies of CD and iMCD have been hampered by difficulties in accurate case ascertainment due to lack of uniform diagnostic criteria and a disease-specific International Classification of Diseases (ICD) code. In this study, we provide reliable estimates of CD and iMCD in the US using a novel claims-based algorithm that includes CD specific ICD-10 diagnosis code (D47. Read More

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September 2021

Pulmonary Open, Robotic and Thoracoscopic Lobectomy (PORTaL) Study: An Analysis of 5,721 Cases.

Ann Surg 2021 Sep 16. Epub 2021 Sep 16.

Division of Thoracic Surgery, and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA Division of Thoracic Surgery, Duke University, Durham, NC Division of Thoracic Surgery, Swedish Cancer Institute, Seattle, WA Division of Thoracic Surgery, Temple University Health System, Philadelphia, PA Division of Thoracic Surgery, NYU Langone, New York, NY General Thoracic Surgery, Baptist Health Medical Group, South Miami, FL Division of Thoracic Surgery, Albany Medical Center, Albany, NY Rod Taylor Thoracic Care Center, Orlando Health UF Health Cancer Center, Orlando FL Division of Thoracic Surgery, Baylor Scott & White The Heart Hospital - Plano, Plano, TX Department of Cardiothoracic Surgery, Northwell Health, New York, NY Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO Division of Thoracic Surgery, NYU Winthrop, Mineola, NY Division of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, MI Division of Thoracic Surgery, Penn State Cancer Institute, Hershey, PA Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Main Line Health Care Thoracic Surgery, Main Line Health, Wynewood, PA Department of Cardiothoracic Surgery, Division of Thoracic Surgery, UPMC, Pittsburgh, PA Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA Division of Thoracic Surgery, Aurora Health Care, Grafton, MI Division of General Thoracic Surgery, Mayo Clinic, Rochester, MN.

Objective: The aim of this study was to analyze outcomes of open lobectomy (OL), video-assisted thoracoscopic lobectomy (VATS) and robotic-assisted lobectomy (RL).

Summary Background Data: Robotic-assisted lobectomy has seen increasing adoption for treatment of early-stage lung cancer. Comparative data regarding these approaches is largely from single-institution case series or administrative datasets. Read More

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September 2021

Can a ToF-PET photon attenuation reconstruction test stopping power estimations in proton therapy? a phantom study.

Phys Med Biol 2021 Sep 17. Epub 2021 Sep 17.

WPE, University Hospital Essen, Essen, GERMANY.

Objective: The aim of the phantom study was to validate and to improve the computed tomography (CT) images used for the dose computation in proton therapy. It was tested, if the joint reconstruction of activity and attenuation images of time-of-flight PET (ToF-PET) scans could improve the estimation of the proton stopping power.

Approach: The attenuation images, i. Read More

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September 2021

Does reduction of the Meyerding grade correlate with outcomes in patients undergoing decompression and fusion for grade I degenerative lumbar spondylolisthesis?

J Neurosurg Spine 2021 Sep 17:1-8. Epub 2021 Sep 17.

1Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.

Objective: Reduction of Meyerding grade is often performed during fusion for spondylolisthesis. Although radiographic appearance may improve, correlation with patient-reported outcomes (PROs) is rarely reported. In this study, the authors' aim was to assess the impact of spondylolisthesis reduction on 24-month PRO measures after decompression and fusion surgery for Meyerding grade I degenerative lumbar spondylolisthesis. Read More

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September 2021

Surgical outcomes with anatomic reduction of high-grade spondylolisthesis revisited: an analysis of 101 patients.

J Neurosurg Spine 2021 Sep 17:1-11. Epub 2021 Sep 17.

4Spine Center, Werner-Wicker-Clinic, Bad Wildungen, Germany.

Objective: The ideal strategy for high-grade L5-S1 isthmic spondylolisthesis (HGS) remains controversial. Critical questions include the impact of reduction on clinical outcomes, rate of pseudarthrosis, and postoperative foot drop. The scope of this study was to delineate predictors of radiographic and clinical outcome factors after surgery for HGS and to identify risk factors of foot drop. Read More

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September 2021

Cognitive and gait outcomes after primary endoscopic third ventriculostomy in adults with chronic obstructive hydrocephalus.

J Neurosurg 2021 Sep 17:1-8. Epub 2021 Sep 17.

12Department of Clinical Neurosciences, Division of Neurosurgery, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.

Objective: The object of this study was to determine the short- and long-term efficacy of primary endoscopic third ventriculostomy (ETV) on cognition and gait in adults with chronic obstructive hydrocephalus.

Methods: Patients were prospectively accrued through the Adult Hydrocephalus Clinical Research Network patient registry. Patients with previously untreated congenital or acquired obstructive hydrocephalus were included in this study. Read More

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September 2021

Assessing the impact of dual-task reactive step practice in people with Parkinson's disease: A feasibility study.

Hum Mov Sci 2021 Sep 14;80:102876. Epub 2021 Sep 14.

College of Health Solutions, Arizona State University, Phoenix, AZ, USA; Phoenix VA Health Care Center, Phoenix, AZ, USA. Electronic address:

Reactive stepping is impaired in people with Parkinson's Disease (PD) but can be improved with training. However, it is unclear if reactive steps can be improved when performing a concurrent cognitive task, a common and fall-relevant circumstance. We assessed the feasibility and preliminary effectiveness of dual-task reactive step training. Read More

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September 2021

A multicenter study to evaluate the pharmacokinetics and safety of liposomal bupivacaine for postsurgical analgesia in pediatric patients aged 6 to less than 17 years (PLAY).

J Clin Anesth 2021 Sep 14;75:110503. Epub 2021 Sep 14.

Cleveland Clinic, Cleveland, OH, United States of America.

Study Objective: To evaluate the pharmacokinetics and safety of liposomal bupivacaine in pediatric patients undergoing spine or cardiac surgery.

Design: Multicenter, open-label, phase 3, randomized trial (PLAY; NCT03682302).

Setting: Operating room. Read More

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September 2021

Drugs for patients with epilepsy and excessive daytime sleepiness.

Epilepsy Behav 2021 Sep 14;124:108311. Epub 2021 Sep 14.

Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.

Excessive daytime sleepiness (EDS) and attentional deficits are often observed in people with epilepsy. They may be the consequence of seizures and subclinical discharges as well as of comorbid conditions as obstructive sleep apnea/hypopnea syndrome (OSAS), attention deficit hyperactivity disorder (ADHD), or other less frequent disorders. Excessive daytime sleepiness may also be caused or worsened by antiseizure medications (ASMs). Read More

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September 2021

Targeting HER2 heterogeneity in breast cancer.

Cancer Treat Rev 2021 Sep 2;100:102286. Epub 2021 Sep 2.

Genomic and Molecular Pathology Services, Pathgroup, Nashville, TN, United States.

The identification of Human epidermal growth factor receptor 2 (HER2) as a target in breast cancer and the subsequent development of HER2-targeted therapies has revolutionized the treatment of patients with HER2-positive breast cancer. However, there is an increasing awareness of how frequently tumors have low or heterogeneous expression of HER2. It is now recognized that this impacts the degree of benefit from HER2-targeted therapies. Read More

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September 2021

Single-level subject-specific finite element model can predict fracture outcomes in three-level spine segments under different loading rates.

Comput Biol Med 2021 Sep 9;137:104833. Epub 2021 Sep 9.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Osteoporosis-related vertebral compression fracture can occur under normal physiological activities. Bone metastasis is another source of vertebral fracture. Different loading rates, either high-energy traumas such as falls or low-energy traumas under normal physiological activities, can result in different fracture outcomes. Read More

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September 2021

Role of SIX1, EYA2, and E-cadherin in ovarian carcinoma. Evidence on epithelial-mesenchymal transition from an immunohistochemical study.

Ann Diagn Pathol 2021 Sep 8;55:151815. Epub 2021 Sep 8.

Department of Pathology, Faculty of Medicine, Menoufia University, Egypt.

This study aims to investigate the expression of SIX1, EYA2, and E-cadherin in ovarian cancer (OC). It was conducted on 97 cases of surface epithelial tumors (SEOTs). Immunohistochemistry (IHC) staining for the three markers was applied to archival paraffin-embedded sections. Read More

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September 2021

Use of non-contrast MR in diagnosing secondary lymphedema of the upper extremities.

Clin Imaging 2021 Sep 10;80:400-405. Epub 2021 Sep 10.

Beth Israel Deaconess Medical Center, Department of Radiology, 330 Brookline Ave., Boston, MA 02215, United States of America. Electronic address:

Purpose: The purpose of the study is to determine if a combination of dermal thickening and subcutaneous fluid honeycombing on non-contrast MRI, termed the dermal rim sign (DRS), can be diagnostically analogous to dermal backflow seen on lymphoscintigraphy in patients with secondary upper extremity lymphedema.

Materials And Methods: Upper extremity MRI and lymphoscintigraphy were performed on patients referred to a multidisciplinary lymphedema clinic for suspicion of secondary lymphedema. Sensitivity, specificity, and positive and negative predictive values of DRS on MRI in detecting dermal backflow on lymphoscintigraphy and the correlation between DRS, Indocyanine Green (ICG) lymphography, bioimpedence L-Dex® ratio and MRI Lymphedema Staging were calculated. Read More

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September 2021

An unexpected cause of cervical radiculopathy: A broken knife blade in the neck for 28 years.

Joint Bone Spine 2021 Sep 14:105268. Epub 2021 Sep 14.

Consultant, Rheumatology clinic, 21000 Skikda, Algeria. Electronic address:

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September 2021

Efficacy of photodynamic therapy in women with HSIL and LSIL and early stage of squamous cervical cancer: a systematic review and meta-analysis.

Photodiagnosis Photodyn Ther 2021 Sep 14:102530. Epub 2021 Sep 14.

V.F. Snegirev Clinic of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University, 119991, Moscow, Russian Federation, Yelanskogo St. 2/1; I.M. Sechenov First Moscow State Medical University (Sechenov University). Electronic address:

Background: We sought to conduct a systematic review and meta-analysis of randomized and non-randomized clinical trials to assess the efficacy of photodynamic therapy (PDT) in cervical epithelial neoplasia (CIN) and early-stage cervical cancer. Additionally, according to the results, we tried to consider which stage of CIN is more sensitive/susceptible to PDT.

Methods: A systematic search was conducted using electronic databases including PubMed, ClinicalTrials. Read More

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September 2021

Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog.

Theriogenology 2021 Aug 15;175:100-110. Epub 2021 Aug 15.

Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, Hungary; ATRC Aurigon Ltd., Dunakeszi, Hungary.

The role of anti-Müllerian hormone (AMH) and insulin-like peptide 3 (INSL3) in male infertility is not fully understood. We used the downregulated testis as a model of gonadotropin-dependent infertility. Serum testosterone and AMH concentrations were studied in five adult male Beagles implanted (day 0) with 4. Read More

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Reaction dynamics and residue identification of haemoglobin modification by acrolein, a lipid-peroxidation by-product.

Biochim Biophys Acta Gen Subj 2021 Sep 14:130013. Epub 2021 Sep 14.

Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand; Biol21 Molecular Science and Biotechnology Institute, Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

Background: Lipid hydroperoxides decompose to reactive aldehydes, such as acrolein. Measurement of oxidative stress markers in the clinic could improve risk stratification for patients.

Methods: To aid the development of diagnostic oxidative stress markers, we defined the acrolein modifications of haemoglobin using mass spectrometry. Read More

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September 2021

Association of chemokines IP-10/CXCL10 and I-TAC/CXCL11 with insulin resistance and enhance leukocyte endothelial arrest in obesity.

Microvasc Res 2021 Sep 14:104254. Epub 2021 Sep 14.

INCLIVA Biomedical Research Institute, Valencia, Spain; Endocrinology and Nutrition Service, University Clinic Hospital of Valencia, Valencia, Spain; CIBERDEM: Diabetes and Associated Metabolic Diseases Networking Biomedical Research- ISCIII, Madrid, Spain; Department of Medicine, Faculty of Medicine, University of Valencia, Spain. Electronic address:

Background And Aims: Obesity is a key contributing factor to incidental type 2 diabetes and cardiovascular disease. CXCR3 receptor and its ligands CXCL 10 and 11 are associated with atherosclerosis and cardiovascular disease. The aim of our study was to analyse the role of the CXCR3 ligands on insulin resistance (IR) and endothelial dysfunction in human obesity. Read More

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September 2021

Tetraspanin CD82 regulates S1PR-mediated hematopoietic stem and progenitor cell mobilization.

Stem Cell Reports 2021 Sep 8. Epub 2021 Sep 8.

Department of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA. Electronic address:

Hematopoietic stem and progenitor cell (HSPC) mobilization into the blood occurs under normal physiological conditions and is stimulated in the clinic to enable the isolation of HSPCs for transplantation therapies. In the present study, we identify the tetraspanin CD82 as a novel regulator of HSPC mobilization. Using a global CD82 knockout (CD82KO) mouse, we measure enhanced HSPC mobilization after granulocyte-colony stimulating factor (G-CSF) or AMD3100 treatment, which we find is promoted by increased surface expression of the sphingosine 1-phosphate receptor 1 (S1PR) on CD82KO HSPCs. Read More

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September 2021

The circle method for preoperative TAVI sizing in a Sievers type 0 stenotic bicuspid aortic valve.

Multimed Man Cardiothorac Surg 2021 Sep 10;2021. Epub 2021 Sep 10.

Department of Anaesthesiology, German Heart Center Berlin, Germany.

The most common congenital cardiac anomaly, affecting an estimated 0.4-2.25% of the general population, is the bicuspid aortic valve. Read More

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September 2021

Protracted respiratory findings in children post-SARS-CoV-2 infection.

Pediatr Pulmonol 2021 Sep 17. Epub 2021 Sep 17.

Division of Pulmonary Medicine, The Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Introduction: Although prolonged respiratory symptoms following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been described in adults, data are emerging that children also experience long-term sequelae of coronavirus disease 2019 (COVID-19). The respiratory sequelae of COVID-19 in children remain poorly characterized. In this study we describe health data and respiratory findings in pediatric patients presenting with persistent respiratory symptoms following COVID-19. Read More

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September 2021

An interactive eye-tracking system for measuring radiologists' visual fixations in volumetric CT images: Implementation and initial eye-tracking accuracy validation.

Med Phys 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology.

Purpose: Eye tracking approaches have been used to understand the visual search process in radiology. However, previous eye tracking work in computer tomography (CT) has been limited largely to single cross-sectional images or video playback of the reconstructed volume, which do not accurately reflect radiologists' visual search activities and their interactivity with 3-dimensional image data at a computer workstation (e.g. Read More

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September 2021

Do the telomere ends justify the physical means?

J Am Geriatr Soc 2021 Sep 17. Epub 2021 Sep 17.

Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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September 2021

Accelerated aging in older cancer survivors.

J Am Geriatr Soc 2021 Sep 17. Epub 2021 Sep 17.

University of Connecticut, Farmington, Connecticut, USA.

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September 2021

Antibody maintenance 3 months after complete mRNA COVID-19 vaccination in hemodialysis.

Nephrol Dial Transplant 2021 Sep 17. Epub 2021 Sep 17.

Department of Nephrology and Renal Transplantation, Hospital Clínic of Barcelona, Barcelona, Spain.

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September 2021

Metabolomic Identification of Alpha-Ketoglutaric Acid Elevation in Pediatric Chronic Graft-versus-Host Disease.

Blood 2021 Sep 17. Epub 2021 Sep 17.

BC Children's Hospital, Vancouver, BC, Canada.

Chronic graft versus host disease (cGvHD) is the most common cause for non-relapse mortality post allogenic hematopoietic stem cell transplant (HSCT). However, there are no well-defined biomarkers for cGvHD or late acute GvHD (aGvHD). This study is a longitudinal evaluation of metabolomic patterns of cGvHD and late aGvHD in pediatric HSCT recipients. Read More

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September 2021

Application of artificial intelligence to the electrocardiogram.

Eur Heart J 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Artificial intelligence (AI) has given the electrocardiogram (ECG) and clinicians reading them super-human diagnostic abilities. Trained without hard-coded rules by finding often subclinical patterns in huge datasets, AI transforms the ECG, a ubiquitous, non-invasive cardiac test that is integrated into practice workflows, into a screening tool and predictor of cardiac and non-cardiac diseases, often in asymptomatic individuals. This review describes the mathematical background behind supervised AI algorithms, and discusses selected AI ECG cardiac screening algorithms including those for the detection of left ventricular dysfunction, episodic atrial fibrillation from a tracing recorded during normal sinus rhythm, and other structural and valvular diseases. Read More

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September 2021