3,024 results match your criteria cli

Efficacy and one-year outcomes of Luminor® paclitaxel-coated drug-eluting balloon in the treatment of popliteal artery atherosclerosis lesions.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

University of Palermo - Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), Palermo, Italy; Vascular Surgery Unit, AOUP "P. Giaccone", Palermo, Italy.

Purpose: Reporting outcomes with a new generation paclitaxel eluting balloon (Luminor®; iVascular, Vascular, S.L.U. Read More

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"Ranger BTK" a Prospective Single-Centre Cohort Study on a New Drug-Coated Balloon for Below the Knee Lesions in Patients with Critical Limb Ischemia.

Cardiovasc Intervent Radiol 2021 May 4. Epub 2021 May 4.

Université de Paris, INSERM U970, 75015, Paris, France.

Purpose: Restenosis remains a limitation of endovascular angioplasty with a patency of 30% in BTK at 12 months. Several studies on drug-coated balloons have not demonstrated any improvements in terms of patency and target lesions revascularization in BTK lesions. This prospective single-centre cohort study evaluates the safety and efficacy of a new generation low-dose drug-coated balloon (DCB) with a reduced crystalline structure to treat below the knee (BTK) lesions in patients with critical limb ischemia (CLI). Read More

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A Comparison of Prognostic Scores (Mayo, UK-PBC, and GLOBE) in Primary Biliary Cholangitis.

Am J Gastroenterol 2021 May 4. Epub 2021 May 4.

Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; Department of Internal Medicine IV, Jena University Hospital, Friedrich Schiller University, Jena, Germany; Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany; Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa, Greece; Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium; Arizona State University, Phoenix, Arizona, USA; Liver Unit, Hospital Cli[Combining Acute Accent]nic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain; Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy; Department of Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Introduction: Comparative data on scores that predict outcome in primary biliary cholangitis (PBC) are scarce. We aimed to assess and compare the prognostic value of the Mayo Risk Score (MRS, 1989 and 1994), UK-PBC score, and GLOBE score in a large international cohort of patients with PBC.

Methods: Ursodeoxycholic acid-treated patients from 7 centers participating in the GLOBAL PBC Study Group were included. Read More

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Cerenkov Luminescence Imaging in prostate cancer: not the only light that shines.

J Nucl Med 2021 Apr 30. Epub 2021 Apr 30.

Netherlands Cancer Institute - Antoni van Leeuwenhoek, Netherlands.

Introduction: Cerenkov luminescence imaging (CLI) is a novel imaging technology that might have the ability to assess surgical margins intra-operatively during prostatectomy using Gallium-68 prostate-specific membrane antigen ([Ga]Ga-PSMA-11). This study evaluates the accuracy of CLI compared to histopathology and as exploratory objective investigates the characteristics of the identified chemiluminescence signal. After intravenous injection of a mean Ga-PSMA-11 activity of 69MBq intraoperatively, all excised specimens were imaged with CLI. Read More

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Intraperitoneal Glucose Transport to Micrometastasis: A Multimodal In Vivo Imaging Investigation in a Mouse Lymphoma Model.

Int J Mol Sci 2021 Apr 23;22(9). Epub 2021 Apr 23.

Department of Medical Imaging, University of Pécs Medical School, 7624 Pécs, Hungary.

Bc-DLFL.1 is a novel spontaneous, high-grade transplantable mouse B-cell lymphoma model for selective serosal propagation. These cells attach to the omentum and mesentery and show dissemination in mesenteric lymph nodes. Read More

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Anxiety and COVID-19: A study of online content readability.

J Prev Interv Community 2021 Apr 19:1-9. Epub 2021 Apr 19.

Department of Public Health, William Paterson University, Wayne, New Jersey, USA.

The uncertain and unprecedented nature of the COVID-19 pandemic is anxiety-provoking and some people are seeking information about this anxiety online. The purpose of this study was to assess the readability levels of online articles related to anxiety and COVID-19. The first 50 English language URLs to appear in a Google search in July 2020 were assessed for readability using Readable. Read More

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Trends and causes of readmission following peripheral vascular intervention in patients with peripheral vascular disease.

Catheter Cardiovasc Interv 2021 Apr 16. Epub 2021 Apr 16.

Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.

Objectives: To study the risk factors associated with 30-readmission postperipheral vascular intervention (PVI) in peripheral artery disease (PAD).

Background: There has been a paucity of data regarding the trend and predictors of PVI readmission.

Methods: We performed an observational cohort study of patients admitted with peripheral vascular disease for PVI using the NRD for the years 2010-2014. Read More

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Vaccination with cathepsin L mimotopes of Fasciola hepatica in goats reduces worm burden, morphometric measurements, and reproductive structures.

Microb Pathog 2021 Apr 9;155:104859. Epub 2021 Apr 9.

Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, Tecamachalco, Puebla, Mexico.

Fasciolosis is a worldwide emergent zoonotic disease that significantly constrains the productivity of livestock. We conducted an experimental trial with four groups of five goats each, vaccinated with 1 × 10 phage particles of cathepsin L1 (CLI: DPWWLKQ), CL1 (SGTFLFS), and CL2 (PPIRNGK) mimotopes combined with Quil A adjuvant. Animals received a booster four weeks later. Read More

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Pollen PCP-B peptides unlock a stigma peptide-receptor kinase gating mechanism for pollination.

Science 2021 04;372(6538):171-175

School of Life Sciences, East China Normal University, Shanghai, China.

Sexual reproduction in angiosperms relies on precise communications between the pollen and pistil. The molecular mechanisms underlying these communications remain elusive. We established that in , a stigmatic gatekeeper, the ANJEA-FERONIA (ANJ-FER) receptor kinase complex, perceives the RAPID ALKALINIZATION FACTOR peptides RALF23 and RALF33 to induce reactive oxygen species (ROS) production in the stigma papillae, whereas pollination reduces stigmatic ROS, allowing pollen hydration. Read More

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Clinical practice patterns and ascertainment bias for cardiovascular events in a randomized trial: A survey of investigators in the BEST-CLI trial.

Vasc Med 2021 Apr;26(2):180-186

Division of Cardiology and Section of Vascular Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Ascertainment bias is a well-recognized source of bias in research, but few studies have systematically analyzed sources of ascertainment bias in randomized trials in which blinding is not possible and endpoint assessment is not protocolized. In the current study, we sought to evaluate differences in the clinical practice patterns of trial investigators with respect to bias in the ascertainment of pre-revascularization patient risk and the incidence of secondary endpoints post-revascularization. We conducted a cross-sectional survey of active investigators ( = 936) from the Best Endovascular Versus Best Surgical Therapy for Patients with Critical Limb Ischemia (BEST-CLI) trial. Read More

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Intensifying our focus on critical limb ischemia.

Vasc Med 2021 Apr;26(2):121-122

Division of Cardiology, Rocky Mountain Regional VA Medical Center, University of Colorado, Denver, CO, USA.

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End-stage renal disease patients undergoing angioplasty and bypass for critical limb ischemia have worse outcomes compared to non-ESRD patients: Systematic review and meta-analysis.

Catheter Cardiovasc Interv 2021 Apr 6. Epub 2021 Apr 6.

Department of Medicine and Center of Excellence for Cardiovascular Diseases & Sciences, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.

Background: End-stage renal disease (ESRD) is associated with increased morbidity and mortality following lower extremity amputation for critical limb ischemia (CLI). Angioplasty and bypass are used in ESRD patients with CLI; however, the treatment of choice remains controversial. We compared the long-term outcomes in patients with CLI undergoing angioplasty or bypass to evaluate the differences between patients with ESRD and those without ESRD. Read More

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Risk of peripheral artery disease according to race and sex: The Atherosclerosis Risk in Communities (ARIC) study.

Atherosclerosis 2021 May 29;324:52-57. Epub 2021 Mar 29.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background And Aims: Previous community-based studies have demonstrated sex and race-based disparities in the risk of cardiovascular disease. We sought to examine the association of sex and race with incident peripheral artery disease (PAD-) and critical limb ischemia (CLI-) related hospitalizations.

Methods: In 13,451 Black and White ARIC participants without prevalent PAD at baseline (1987-89), we estimated the cumulative incidence of PAD- and CLI-related hospitalization over a median follow-up of 26 years. Read More

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Validation of ERICVA Risk Score as a Predictor of One Year Amputation-Free Survival of Patients with Critical Limb Ischemia.

Ann Vasc Surg 2021 Apr 2. Epub 2021 Apr 2.

Department of Vascular Surgery, Galway University Hospital, Galway, Ireland; Department of Vascular Surgery, National University of Ireland Galway, Ireland.

Background: The ERICVA score was derived to predict amputation-free survival in patients with critical limb ischemia (CLI). It may be a useful tool to stratify patients in trials of novel interventions to treat CLI but, as yet, it has not been externally validated.

Methods: A prospective database of CLI patients was developed during prescreening of patients for a phase 1 stem cell therapy clinical trial. Read More

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PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties.

Int J Mol Sci 2021 Mar 8;22(5). Epub 2021 Mar 8.

National Centre for Nuclear Research, Radioisotope Centre POLATOM, 05-400 Otwock, Poland.

A new PSMA ligand (PSMA-D4) containing the Glu-CO-Lys pharmacophore connected with a new linker system (L-Trp-4-Amc) and chelator DOTA was developed for radiolabeling with therapeutic radionuclides. Herein we describe the synthesis, radiolabeling, and preliminary biological evaluation of the novel PSMA-D4 ligand. Synthesized PSMA-D4 was characterized using TOF-ESI-MS, NMR, and HPLC methods. Read More

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Estrogen-related receptor α is involved in angiogenesis and skeletal muscle revascularization in hindlimb ischemia.

FASEB J 2021 May;35(5):e21480

Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, TX, USA.

Skeletal muscle ischemia is a major consequence of peripheral arterial disease (PAD) or critical limb ischemia (CLI). Although therapeutic options for resolving muscle ischemia in PAD/CLI are limited, the issue is compounded by poor understanding of the mechanisms driving muscle vascularization. We found that nuclear receptor estrogen-related receptor alpha (ERRα) expression is induced in murine skeletal muscle by hindlimb ischemia (HLI), and in cultured myotubes by hypoxia, suggesting a potential role for ERRα in ischemic response. Read More

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[Systematic review and Meta-analysis of clinical efficacy and safety of Ginkgo Leaf Tablets in treatment of acute cerebral infarction].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1537-1546

Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700,China Institute for Brain Disorders,Beijing University of Chinese Medicine Beijing 100700,China.

To systematically evaluate the clinical efficacy and safety of Ginkgo Leaf Tablets(GLT) in the treatment of acute cerebral infarction(ACI). Seven databases both at home and abroad were systematically retrieved from their establishment to March 2020. The data of the included studies were extracted after review and screening. Read More

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Main Factors Predicting Nonresponders to Autologous Cell Therapy for Critical Limb Ischemia in Patients With Diabetic Foot.

Angiology 2021 Mar 30:33197211005614. Epub 2021 Mar 30.

Diabetes Centre, Tameside Hospital NHS Foundation Trust and University of Manchester, Lancashire, United Kingdom.

Autologous cell therapy (ACT) is a new treatment for patients with no-option critical limb ischemia (NO-CLI). We evaluated the factors involved in the nonresponse to ACT in patients with CLI and diabetic foot. Diabetic patients (n = 72) with NO-CLI treated using ACT in our foot clinic over a period of 8 years were divided into responders (n = 57) and nonresponders (n = 15). Read More

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The Real-World CONSEQUENT ALL COMERS Study: Predictors for Target Lesion Revascularization and Mortality in an Unselected Patient Population.

Angiology 2021 Mar 29:3319721997314. Epub 2021 Mar 29.

GRN Academic Teaching Hospital Weinheim, Germany.

We evaluated the safety and efficacy of a resveratrol-paclitaxel-coated peripheral balloon catheter in an all-comer patient cohort undergoing endovascular treatment of above-the-knee and below-the-knee peripheral artery disease. CONSEQUENT ALL COMERS (Clinical Post-Market Clinical Follow-up [PMCF] on Peripheral Arteries treated with SeQuent Please OTW [Over-the Wire]) is a prospective, single-arm, multicenter observational study (ClinicalTrials Identifier: NCT02460042). The primary end point was the 12-month target lesion revascularization (TLR) rate. Read More

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A polymeric micellar drug delivery system developed through a design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel.

Int J Pharm 2021 Mar 26;601:120523. Epub 2021 Mar 26.

Cancer Systems Imaging, The University of Texas M.D Anderson Cancer Center, Houston, TX 77054, USA. Electronic address:

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Inhibition of TLR4/MAPKs Pathway Contributes to the Protection of Salvianolic Acid A Against Lipotoxicity-Induced Myocardial Damage in Cardiomyocytes and Obese Mice.

Front Pharmacol 2021 8;12:627123. Epub 2021 Mar 8.

College of Life Science, Zhejiang Chinese Medical University, Hangzhou, China.

The occurrence of lipotoxicity during obesity-associated cardiomyopathy is detrimental to health. Salvianolic acid A (SAA), a natural polyphenol extract of (Danshen in China), is known to be cardioprotective. However, its clinical benefits against obesity-associated cardiomyocyte injuries are unclear. Read More

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Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Qingdu Decoction against Chronic Liver Injury.

Evid Based Complement Alternat Med 2021 3;2021:6661667. Epub 2021 Mar 3.

School of Traditional Chinese Medicine, Capital Medical University, Beijing 10069, China.

Background: Qingdu Decoction (QDD) is a traditional Chinese medicine formula for treating chronic liver injury (CLI). . A network pharmacology combining experimental validation was used to investigate potential mechanisms of QDD against CLI. Read More

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Resveratrol Confers Vascular Protection by Suppressing TLR4/Syk/NLRP3 Signaling in Oxidized Low-Density Lipoprotein-Activated Platelets.

Oxid Med Cell Longev 2021 25;2021:8819231. Epub 2021 Feb 25.

MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China.

This study investigated the effect of resveratrol on Toll-like receptor 4- (TLR4-) mediated matrix metalloproteinase 3 (MMP3) and MMP9 expression in oxidized low-density lipoprotein- (ox-LDL-) activated platelets and the potential molecule mechanism. Human platelets were used in the present study. The results showed that resveratrol suppressed TLR4, MMP3, and MMP9 expression in ox-LDL-activated platelets. Read More

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February 2021

Analyses of the pericyte transcriptome in ischemic skeletal muscles.

Stem Cell Res Ther 2021 Mar 16;12(1):183. Epub 2021 Mar 16.

Department of Biophysics, Escola Paulista de Medicina, Federal University of São Paulo, Rua Mirassol 207, São Paulo, SP, 04044-010, Brazil.

Background: Peripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the most advanced stage of PAD, can cause nonhealing ulcers and strong chronic pain, and it shortens the patients' life expectancy. Cell-based angiogenic therapies are becoming a real therapeutic approach to treat CLI. Read More

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pUDK-HGF Gene Therapy to Relieve CLI Rest Pain and Ulcer: A Phase II, Double-Blind, Randomized Placebo-Controlled Trial.

Hum Gene Ther 2021 Mar 17. Epub 2021 Mar 17.

Beijing Institute of Radiation Medicine, 96702, Beijing, Beijing, China;

This phase II clinical trial investigated the efficacy and safety of intramuscular injection of plasmid pUDK-HGF which encodes the human hepatocyte growth factor gene in patients with critical limb ischemia (CLI). Resting pain patients (n=119) and patients with leg ulcers (n=121) were enrolled as two cohorts and randomized to receive pUDK-HGF treatment on days 0, 14, and 28. In the resting pain cohort, the proportion of patients with complete pain relief on day 180 after receiving pUDK-HGF injection, as the primary outcome, was significantly higher than that of the placebo group on the same day (p = 0. Read More

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Online educational materials for appendectomy patients have good quality but poor readability.

Am J Surg 2021 Mar 3. Epub 2021 Mar 3.

Department of Surgery, University of British Columbia & Paul's Hospital, C303 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada. Electronic address:

Background: Guidelines recommend patient health-related information be written at or below the sixth-grade level. This study evaluates the readability level and quality of online appendectomy patient education materials.

Methods: Webpages were evaluated using seven readability formulae: Flesh-Kincaid Grade Level (FKGL), Gunning Fog Index (GFI), Coleman-Liau Index (CLI), Automated Readability Index (ARI), Simple Measure of Gobbledygook (SMOG), Flesch Reading Ease (FRE), and New Dale-Chall (NDC). Read More

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Low admission blood pressure as a marker of poor 1-year survival in patients with revascularized critical limb ischemia.

J Hypertens 2021 Mar 11. Epub 2021 Mar 11.

ESH Excellence Center, Vascular Medicine Department Medical Information Department Clinical Research Center ESH Excellence Center, Internal Medicine Department, Groupe Hospitalier Paris St Joseph Inserm UMR 1153-CRESS, Paris, France.

Objective: To contrast the association between blood pressure (BP) level and antihypertensive medications at hospital admission with 1-year mortality in patients undergoing revascularization for critical limb ischemia (CLI).

Methods: From November 2013 to May 2019, 315 consecutive patients were retrospectively included. A median of seven (IQR 3-13) separate readings were recorded for each patient before revascularization procedure and the average represented patient's mean BP. Read More

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sepal: Identifying Transcript Profiles with Spatial Patterns by Diffusion-based Modeling.

Bioinformatics 2021 Mar 11. Epub 2021 Mar 11.

1Science for Life Laboratory, KTH Royal Institute of Technology, Dept. of Gene Technology.

Motivation: Collection of spatial signals in large numbers has become a routine task in multiple omicsfields, but parsing of these rich data sets still pose certain challenges. In whole or near-full transcriptome spatial techniques, spurious expression profiles are intermixed with those exhibiting an organized structure. To distinguish profiles with spatial patterns from the background noise, a metric that enables quantification of spatial structure is desirable. Read More

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Spinal cord stimulation in the treatment of peripheral vascular disease: a systematic review - revival of a promising therapeutic option?

Br J Neurosurg 2021 Mar 11:1-9. Epub 2021 Mar 11.

Department of Stereotactic and Functional Neurosurgery, University Cologne Hospital, Cologne, Germany.

Introduction: Peripheral vascular disease (PVD) is caused by a blood circulation disorder of the arteries and Critical Limb Ischemia (CLI) is the advanced state of PVD. For patients with surgically non-reconstructable CLI, Spinal Cord Stimulation (SCS) appears to be an alternative therapeutic option.

Objective: The aim of our study was to investigate the efficacy of SCS in non-reconstructable CLI compared with the conservative treatment and re-appraise the existing literature in light of the recent advances in neuromodulation. Read More

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Rationale and Design of Therapeutic Angiogenesis by Cell Transplantation Using Adipose-Derived Regenerative Cells in Patients With Critical Limb Ischemia - TACT-ADRC Multicenter Trial.

Circ Rep 2020 Aug 8;2(9):531-535. Epub 2020 Aug 8.

Department of Cardiology, Nagoya University Graduate School of Medicine Nagoya Japan.

Despite the growing knowledge regarding optimal treatments for critical limb ischemia (CLI), there are still a considerable number of patients who have to undergo major limb amputation. Intramuscular injection of autologous adipose-derived regenerative cells (ADRCs) in these patients has shown therapeutic potential in improving tissue ischemia, in both preclinical and initial pilot studies. Here, we present a clinical protocol for ADRCs use in a multicenter trial. Read More

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