8,929 results match your criteria classify obese

The 5-Factor Modified Frailty Index as a Predictor of 30-day Complications in Pressure Ulcer Repair.

J Surg Res 2021 Apr 16;265:21-26. Epub 2021 Apr 16.

Division of Plastic Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah. Electronic address:

Background: The 5-item modified frailty index (mFI-5) is a validated tool to assess postoperative risks in older surgical candidates. We sought to compare the predictive ability of mFI-5 to its individual components and other established risk factors for complications in flap reconstruction of late-stage pressure ulcer repair.

Methods: The 2012 to 2018 American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) database was queried for pressure ulcer diagnosis and reconstructive flap repair procedures. Read More

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Probiotics for preventing gestational diabetes.

Cochrane Database Syst Rev 2021 Apr 19;4:CD009951. Epub 2021 Apr 19.

School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia.

Background: Gestational diabetes mellitus (GDM) is associated with a range of adverse pregnancy outcomes for mother and infant. The prevention of GDM using lifestyle interventions has proven difficult. The gut microbiome (the composite of bacteria present in the intestines) influences host inflammatory pathways, glucose and lipid metabolism and, in other settings, alteration of the gut microbiome has been shown to impact on these host responses. Read More

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Food/Non-Food Classification of Real-Life Egocentric Images in Low- and Middle-Income Countries Based on Image Tagging Features.

Front Artif Intell 2021 1;4:644712. Epub 2021 Apr 1.

Department of Electrical and Computer Engineering, University of Pittsburgh, PA, United States.

Malnutrition, including both undernutrition and obesity, is a significant problem in low- and middle-income countries (LMICs). In order to study malnutrition and develop effective intervention strategies, it is crucial to evaluate nutritional status in LMICs at the individual, household, and community levels. In a multinational research project supported by the Bill & Melinda Gates Foundation, we have been using a wearable technology to conduct objective dietary assessment in sub-Saharan Africa. Read More

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Factors associated with prognosis after small-vessel occlusion among young and middle-aged patients: a hospital-based follow-up study.

Postgrad Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China.

Objective: Small-vessel occlusions are the most common causes of mild strokes and, in China, account for approximately 27.3% of ischemic stroke cases. However, the factors associated with short- and long-term outcomes appear contradictory. Read More

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Human white adipose tissue displays selective insulin resistance in the obese state.

Diabetes 2021 Apr 16. Epub 2021 Apr 16.

Department of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, 141 86, Stockholm, Sweden

Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. Whether similar mechanisms operate in white adipose tissue (WAT) of obese subjects and to what extent these are normalized by weight loss is unknown. We determined insulin sensitivity by hyperinsulinemic euglycemic clamp and the insulin response in subcutaneous WAT by RNA-sequencing in 23 women with obesity before and two years after bariatric surgery. Read More

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Understanding factors associated with sarcopenic obesity in older African women from a low-income setting: a cross-sectional analysis.

BMC Geriatr 2021 Apr 14;21(1):247. Epub 2021 Apr 14.

Health Sciences and Sport, University of Stirling, Stirling, Scotland.

Background: High rates of food insecurity, obesity and obesity-related comorbidities in ageing South African (SA) women may amplify the risk of developing sarcopenic obesity. This study aimed to investigate the prevalence and correlates of sarcopenic obesity and its diagnostic components [grip strength, appendicular skeletal muscle mass (ASM) and body mass index (BMI)] in older SA women from a low-income setting.

Methods: This cross-sectional study recruited black SA women between the ages of 60-85 years (n = 122) from a low-income community. Read More

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Stratification of Surgical Risk in DIEP Breast Reconstruction Based on Classification of Obesity.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Background:  From both a medical and surgical perspective, obese breast cancer patients are considered to possess higher risk when undergoing autologous breast reconstruction relative to nonobese patients. However, few studies have evaluated the continuum of risk across the full range of obesity. This study sought to compare surgical risk between the three World Health Organization (WHO) classes of obesity in patients undergoing deep inferior epigastric perforator (DIEP) flap breast reconstruction. Read More

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Peroral endoscopic myotomy is equally safe and highly effective treatment option in achalasia patients with both lower and higher ASA classification status.

Esophagus 2021 Apr 13. Epub 2021 Apr 13.

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Introduction: The American Society of Anesthesiologists (ASA) physical status classification system was developed as a simple categorization of patients' physiological status that predicts the operative risk. Peroral endoscopic myotomy (POEM) is a less invasive alternative to surgical myotomy in achalasia. As such, POEM seems to be an appealing option for high-risk patients with achalasia. Read More

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Are overweight and obesity risk factors for invasive mechanical ventilation in severe coronavirus disease 2019 pneumonia?

Arch Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Research Unit in Endocrine Diseases, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,

Objective: Describe the demographic, clinical, and biochemical characteristics of overweight or obese people with severe COVID-19 pneumonia and evaluate its association with mechanical ventilation requirements in a Mexican cohort.

Methods: Data were obtained from medical electronic records. Patients were divided in three groups according to the World Health Organization (WHO) classification of body mass index (BMI): lean, overweight and obese. Read More

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Commercial foods for infants under the age of 36 months: an assessment of the availability and nutrient profile of ultra-processed foods.

Public Health Nutr 2021 Apr 12:1-20. Epub 2021 Apr 12.

Programa de Pós-Graduação em Nutrição, Universidade Federal do Rio Grande do Norte, Av. Senador Salgado Filho, 3000, cep 59.078-900 Natal, RN - Brazil.

Objective: Considering the negative impact of the consumption of ultra-processed foods on health, this study assessed the availability and nutritional profile of commercial ultra-processed foods for infants in Natal, Brazil.

Design: A cross-sectional exploratory study.

Setting: Foods targeted at children under the age of 36 months sold in retail establishments located in high and low-income areas of the one capital city of Brazil. Read More

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Time-dependence and comparison of regional and overall anthropometric features between Asian and Caucasian populations with obstructive sleep apnea: a cumulative meta-analysis.

J Thorac Dis 2021 Mar;13(3):1746-1759

Interdisciplinary Center of Sleep Medicine, Charité University Hospital, Berlin, Germany.

Background: Anthropometric measurements are simple and reachable tools for self-evaluating and screening patients with a high risk of obstructive sleep apnea (OSA). However, the accumulated relationship of obesity on the anthropometric characteristics of OSA is not well understood. The aim of the study was to show the time-dependent trend of OSA patients and compare overall and regional anthropometric between two ethnicities. Read More

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The role of body mass index on quality indicators following minimally-invasive radical prostatectomy.

Investig Clin Urol 2021 Mar 31. Epub 2021 Mar 31.

Department of Urology, Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA.

Purpose: We sought to determine the role of body mass index (BMI) on quality indicators, such as length of stay and readmission. The National Surgical Quality Improvement Program (NSQIP) database was queried to examine the effect of obesity, defined as BMI >30, on outcomes after Minimally Invasive Radical Retropubic Prostatectomy (MI-RRP).

Materials And Methods: Utilizing the NSQIP database, patient records were identified using the Current Procedural Terminology (CPT) code 55866 (laparoscopy, surgical prostatectomy, radical retropubic) during a 10-year period (2007-2017). Read More

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Factors and Economic Outcomes Associated with Documented Difficult Intubation in the United States.

Clinicoecon Outcomes Res 2021 1;13:227-239. Epub 2021 Apr 1.

Healthcare Economics Outcomes Research, Medtronic, Mansfield, MA, USA.

Purpose: Establishing good mechanical ventilation is a critical component and prerequisite to a wide range of surgical and medical interventions. Yet difficulties in intubating patients, and a variety of associated complications, are well documented. The economic burden resulting from difficult intubation (DI), however, is not well understood. Read More

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Prepregnancy body mass index and gestational weight gain affect the offspring neurobehavioral development at one year of age.

J Matern Fetal Neonatal Med 2021 Apr 8:1-10. Epub 2021 Apr 8.

Department of Neonatology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Objective: Recent data show that maternal prepregnancy body mass index (BMI) and gestational weight gain (GWG) are associated with offspring neurobehavior in childhood. However, little is known about the effect on infants that less than 20 months of age, and whether this association has sex differences.

Methods: In this birth cohort study, a total of 661 mother-infant pairs were enrolled in Shanghai, China, between February 2017 and April 2019. Read More

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Premature Ejaculation and Endocrine Disorders: A Literature Review.

World J Mens Health 2021 Mar 22. Epub 2021 Mar 22.

Department of Urology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey.

Premature ejaculation (PE) is the most common male sexual dysfunction, with 30% of men experiencing PE worldwide. According to the generally accepted classification, there are two types of PE: lifetime PE and acquired PE. Various biological and psychological causes are known to be involved in the etiology of PE. Read More

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International evidence for the effectiveness of the front-of-package nutrition label called Nutri-Score.

Cent Eur J Public Health 2021 Mar;29(1):76-79

Nutritional Epidemiology Research Group, Sorbonne Paris Nord University, Bobigny, France.

Objectives: Front-of-package nutrition labels are intended to easily convey to consumers comprehensible information about the nutritional composition of pre-packaged food and are thus a tool in the combat against the growing prevalence of nutrition-related disorders, such as obesity, type 2 diabetes, cardiovascular disease, and some types of cancer. The objective of the present narrative review was first to describe Nutri-Score and then to synthesize some of the international scientific evidence for its effectiveness. Guided by scientific data and collective expertise, France formally adopted labelling of pre-packaged food with the 5-colour Nutri-Score label in October 2017 and that move was later followed by Belgium, Spain, Germany, Switzerland, the Netherlands, and Luxembourg. Read More

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Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.

PLoS One 2021 8;16(4):e0249773. Epub 2021 Apr 8.

Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, México.

There has been limited study of Native American whole genome diversity to date, which impairs effective implementation of personalized medicine and a detailed description of its demographic history. Here we report high coverage whole genome sequencing of 76 unrelated individuals, from 27 indigenous groups across Mexico, with more than 97% average Native American ancestry. On average, each individual has 3. Read More

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Predictive scoring system for advanced liver fibrosis in Japanese patients with severe obesity.

Surg Today 2021 Apr 7. Epub 2021 Apr 7.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba, 028-3695, Japan.

Purpose: The aim of this study was to examine the predictive scoring system of advanced liver fibrosis in severely obese Japanese patients.

Methods: Seventy-two patients underwent laparoscopic sleeve gastrectomy and intraoperative liver biopsies. We classified these patients into two groups: Brunt stage ≥ 2 (advanced fibrosis) and 0/1 (none/mild fibrosis). Read More

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Body mass index is not associated with embryo ploidy in patients undergoing in vitro fertilization with preimplantation genetic testing.

Fertil Steril 2021 Apr 4. Epub 2021 Apr 4.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center, New York, New York.

Objective: To assess the association between body mass index (BMI) and embryo aneuploidy and mosaicism in a cohort of patients undergoing in vitro fertilization (IVF) with trophectoderm biopsy for preimplantation genetic testing for aneuploidy (PGT-A) using next-generation sequencing technology.

Design: Retrospective cohort study.

Setting: Academic center. Read More

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Prevalence of overweight and obesity, and associations with socio-demographic factors in Kuwait.

BMC Public Health 2021 Apr 7;21(1):667. Epub 2021 Apr 7.

Australian Geospatial Health Laboratory, Health Research Institute, University of Canberra, Canberra, Australia.

Background: Kuwait is amongst countries in the Gulf region with high income economy. According to the World Health Organisation (WHO), one in five adults in the Gulf region is obese. This study sought to evaluate the prevalence and magnitude of association between overweight, obesity, central obesity, and socio-demographic factors in Kuwait. Read More

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Identifying and measuring the behavioural, dietary, and physical activity components of weight management consultations delivered by general practice nurses in routine care.

BMC Fam Pract 2021 Apr 7;22(1):65. Epub 2021 Apr 7.

Nuffield Department of Primary Care Health Sciences, University, of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.

Background: Many people with obesity receive weight loss consultations by general practice nurses (GPNs) in routine primary care. This exploratory study aimed to characterise the components of these consultations, including behaviour change techniques (BCTs), and dietary and physical activity recommendations.

Methods: We analysed audio recordings of weight management consultations conducted by 8 GPNs as part of the 'usual care' group in a randomised controlled trial (ISRCTN75092026). Read More

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Blood Pressure in Childhood and Adolescence.

Am J Hypertens 2021 Apr;34(3):242-249

The Heart Institute, Cincinnati Children's Hospital, and the University of Cincinnati, Cincinnati, Ohio, USA.

Elevated blood pressure (BP) and hypertension commonly occur in children and adolescents and increase the risk of cardiovascular disease in adulthood. The purpose of this review is to summarize recent research in pediatric hypertension including changes in defining hypertension, BP measurement techniques, hypertension epidemiology, risk factors, treatment, and BP-related target organ damage. Defining pediatric hypertension using the 2017 American Academy of Pediatrics' updated Clinical Practice Guideline resulted in a larger proportion of children being classified as having elevated BP or hypertension compared with prior guidelines. Read More

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A Comparative Analysis of Antibiotic Usage in Diabetic Foot Infections Against Healing Time.

J Foot Ankle Surg 2021 Mar 13. Epub 2021 Mar 13.

Department of Clinical Nursing, Medical University of Warsaw, Warsaw, Poland.

The study aimed to analyze bacterial flora in diabetic foot infection, empiric and targeted antibiotic therapy, and factors influencing wound healing duration. The study we undertook a review analysis of data in 118 cases of diabetic foot among 98 patients who reported to the Wound Care Clinic in Warsaw, Poland between 01/2014 and 12/2018. Collected data included sociodemographic data, wounds information, used treatment, results of the microbiological examination, and empiric and targeted antibiotic therapy. Read More

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Pre-pregnancy maternal BMI classification is associated with preschool childhood diet quality and childhood obesity in the Avon Longitudinal Study of Parents and Children.

Public Health Nutr 2021 Apr 6:1-19. Epub 2021 Apr 6.

Centre for Academic Child Health, Bristol Medical School, University of Bristol, Bristol, UK.

Objective: To explore the effect of maternal BMI class pre-pregnancy (overweight/obese versus healthy weight/underweight) on childhood diet quality and on childhood overweight/obesity risk.

Design: Dietary data were collected using 3-day parental-completed food records for their children at ages 18 and 43 months. An index of diet quality was derived by classification of food items into core and non-core foods. Read More

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BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes.

Gastroenterology 2021 Apr 2. Epub 2021 Apr 2.

Comprehensive Cancer Center Munich at the Klinikum rechts der Isar (CCCM(TUM)), Technische Universität München, 81675 Munich, Germany. Electronic address:

Backgroung & Aims: The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized therapy. The contribution of mechanisms regulating the cancer stem cell (CSC) population in different subtypes remains unknown.

Methods: Using RNA-seq, we identified B-cell CLL/lymphoma 3 (BCL3), an atypical NF-κB signaling member, as differing in pancreatic CSCs. Read More

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Dyslipidemia and Its Components Across Body Mass Index Levels Among Type II Diabetic Patients in the West of Iran.

Int J Prev Med 2020 11;11:188. Epub 2020 Dec 11.

Department of Epidemiology, Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The combination of dyslipidemia, obesity, and hyperglycemia can accelerate the progression to cardiovascular disease. Therefore, this study aimed to investigate dyslipidemia and its components across body mass index (BMI) levels among type II diabetic patients.

Methods: The data for this cross-sectional study were extracted from the records of diabetic patients during 2014 to 2015. Read More

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December 2020

Sitosterolemia: Twenty Years of Discovery of the Function of .

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

Sitosterolemia is a lipid disorder characterized by the accumulation of dietary xenosterols in plasma and tissues caused by mutations in either or . encodes a pair of ABC half transporters that form a heterodimer (G5G8), which then traffics to the surface of hepatocytes and enterocytes and promotes the secretion of cholesterol and xenosterols into the bile and the intestinal lumen. We review the literature from the initial description of the disease, the discovery of its genetic basis, current therapy, and what has been learned from animal, cellular, and molecular investigations of the transporter in the twenty years since its discovery. Read More

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The Effects of Time-Restricted Eating versus Standard Dietary Advice on Weight, Metabolic Health and the Consumption of Processed Food: A Pragmatic Randomised Controlled Trial in Community-Based Adults.

Nutrients 2021 Mar 23;13(3). Epub 2021 Mar 23.

Service of Endocrinology, Diabetes, Nutrition and Therapeutic Education, Department of Medicine, Geneva University Hospitals (HUG), 1211 Geneva, Switzerland.

Weight loss is key to controlling the increasing prevalence of metabolic syndrome (MS) and its components, i.e., central obesity, hypertension, prediabetes and dyslipidaemia. Read More

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New Insights into Endometrial Cancer.

Cancers (Basel) 2021 Mar 24;13(7). Epub 2021 Mar 24.

Department of Experimental Medicine and Centre of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, Italy.

EC is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors, such as aging and obesity, tends to become a public health issue. Although EC is a hormone-dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. Furthermore, its immune environment has been slightly characterized, but recent evidences point out how EC microenvironment may increase self-tolerance by reducing the recruitment of cytotoxic immune cells to the tumor site and/or modifying their phenotype, making these cells no longer able to suppress tumor growth. Read More

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Discordance between Body-Mass Index and Body Adiposity Index in the Classification of Weight Status of Elderly Patients with Stable Coronary Artery Disease.

J Clin Med 2021 Mar 1;10(5). Epub 2021 Mar 1.

Department of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences, Medical University of Silesia, 41-900 Bytom, Poland.

Background And Aims: Body-mass index (BMI) is a popular method implemented to define weight status. However, describing obesity by BMI may result in inaccurate assessment of adiposity. The Body Adiposity Index (BAI) is intended to be a directly validated method of estimating body fat percentage. Read More

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