93,700 results match your criteria classification prognosis

Effects of different molecular subtypes and tumor biology on the prognosis of medulloblastoma.

Childs Nerv Syst 2021 Sep 22. Epub 2021 Sep 22.

Istanbul Faculty of Medicine, Neurosurgery Department, Istanbul University, Istanbul, Turkey.

Purpose: Medulloblastoma is one of the most common malignant brain tumors in the pediatric population. Recent studies identified four distinct medulloblastoma subgroups with different molecular alterations and pathways, and natural courses and outcomes. To evaluate the results of surgical and medical treatments of patients with medulloblastoma and compare them among the medulloblastoma subgroups. Read More

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September 2021

Differences in clinical phenotypes of primary Sjögren's syndrome depending on early or late onset.

Adv Clin Exp Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Rheumatology and Internal Medicine, Wroclaw University Clinical Hospital, Poland.

Background: Previous research suggests that systemic involvement in primary Sjögren's syndrome (pSS) is a marker of disease prognosis.

Objectives: To evaluate pSS disease activity and the clinical phenotype of pSS patients depending on the age at diagnosis with long-term follow-up.

Material And Methods: The study group consisted of patients diagnosed with pSS based on the 2016 pSS classification criteria. Read More

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September 2021

Avascular necrosis after femoral neck fracture in children and adolescents: poor prognosis and risk factors.

Int Orthop 2021 Sep 21. Epub 2021 Sep 21.

Department of Joint Diseases, Traumatology & Orthopedics Institute of Guangzhou University of Chinese Medicine, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510000, Guangdong, China.

Introduction: Avascular necrosis (AVN) after femoral neck fracture (FNF) is a rare and severe paediatric condition, but only few studies described its prognosis and risk factors. The present study aimed to evaluate the outcomes and independent factors for poor prognosis of AVN after FNF in children and adolescents.

Method: This retrospective study included children and adolescents with AVN after FNF who received conservative treatment (CT group) or non-vascularized bone grafting (NVBG group) between 2000 and 2018. Read More

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September 2021

Gallbladder perforation: a single-center experience in north India and a step-up approach for management.

Hepatobiliary Pancreat Dis Int 2021 Sep 8. Epub 2021 Sep 8.

Department of Surgical Gastroenterology, King George's Medical University, Lucknow, Uttar Pradesh 226003, India.

Background: Spontaneous gallbladder perforation (GBP) is an uncommon diagnosis. This study presented the experience of managing spontaneous GBP over nine years at a large, tertiary care university hospital in north India and investigated the outcomes and treatment strategies.

Methods: A retrospective review of prospectively maintained digital database of consecutive patients was performed. Read More

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September 2021

WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists.

Eur J Radiol 2021 Aug 28;143:109937. Epub 2021 Aug 28.

Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India.

The WHO classification of soft tissue tumours categorizes the lesions based on histological differentiation. In the recent fifth edition (2020), many new entities have been introduced, based on their distinct biological behaviour, genetics and morphology. With the recent advances and better understanding of molecular genetics, several novel recurrent genetic alterations have been incorporated in this edition. Read More

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Self-Internal-Reference Probe System for Control-Free Quantification of Mutation Abundance.

Anal Chem 2021 Sep 21. Epub 2021 Sep 21.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China.

Gene mutations are important biomarkers for the diagnosis, classification, monitoring, and prognosis evaluation of cancers and genetic diseases. Both personalized cancer treatment and noninvasive prenatal testing require methods to accurately determine the abundance of mutation. At present, the widely adopted and convenient methods for measuring mutation abundance are mainly based on relative quantification, which requires negative samples and strict control of the analyte amounts. Read More

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September 2021

Mutational landscape of TRPC6, WT1, LMX1B, APOL1, PTPRO, PMM2, LAMB2 and WT1 genes associated with Steroid resistant nephrotic syndrome.

Mol Biol Rep 2021 Sep 21. Epub 2021 Sep 21.

Department of Animal Biotechnology, College of Veterinary Sciences and Animal Husbandry, Anand Agricultural University, Anand, 388110, Gujarat, India.

Background: Nephrotic syndrome appears as a group of symptoms like proteinuria, edema and hyperlipidemia. Identification of monogenic forms revealed the physiology and pathogenesis of the SRNS.

Methods And Results: We performed Illumina panel sequencing of seven genes in 90 Indian patients to determine the role of these genetic mutations in nephrotic syndrome prognosis. Read More

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September 2021

Mitochondria-related changes and metabolic dysfunction in low prognosis patients under the POSEIDON classification.

Hum Reprod 2021 Sep 21. Epub 2021 Sep 21.

Reproductive Medical Center, Peking University People's Hospital, Peking University, Beijing, China.

Study Question: What is the relationship between mitochondria of granulosa cells (GCs) and age and ovarian function in the patients under the POSEIDON classification?

Summary Answer: Our results revealed obvious abnormal mitochondrial-related changes in low prognosis IVF population, where age and the function of ovarian reserve exerted a divergent effect on mitochondrial content and function.

What Is Known Already: Mitochondria have an important role in the cross-talk between GCs and oocytes. However, factors affecting mitochondria of GCs and related mechanisms are still poorly understood. Read More

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September 2021

A novel immune subtype classification of ER-positive, PR-negative and HER2-negative breast cancer based on the genomic and transcriptomic landscape.

J Transl Med 2021 Sep 20;19(1):398. Epub 2021 Sep 20.

Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, 710061, Xi'an, People's Republic of China.

Background: The diversity and plasticity behind ER+/PR-/HER2- breast cancer have not been widely explored. It is essential to identify heterogeneous microenvironment phenotypes and investigate specific genomic events driving the formation of these phenotypes.

Methods: Based on the immune-related gene expression profiles of 411 ER+/PR-/HER2- breast cancers in the METABRIC cohort, we used consensus clustering to identify heterogeneous immune subtypes and assessed their reproducibility in an independent meta-cohort including 135 patients collected from GEO database. Read More

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September 2021

The value of arterial spin labeling imaging in the classification and prognostic evaluation of neonatal hypoxic-ischemic encephalopathy.

Curr Neurovasc Res 2021 Sep 19. Epub 2021 Sep 19.

Department of Radiology, The Second Hospita of Hebei Medical University, Shijiazhuang 050005. China.

Objective: This study aims to investigate the correlation between cerebral blood flow (CBF) values and neonatal behavioral neurological assessment (NBNA) in hypoxic-ischemic encephalopathy (HIE), the relationship between early CBF value changes and the prognosis of neonatal HIE, and the consistency between the clinical grading and magnetic resonance (MR) grading of HIE.

Methods: Forty neonates with HIE were scanned using the three-dimensional arterial spin labeling (ASL) sequencing of the cranial magnetic resonance imaging (MRI). These newborns were classified as having mild, moderate and severe HIE, according to the clinical grading, and as being normal or having mild, moderate, or severe HIE, according to the MRI grading. Read More

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September 2021

Comparison of Molecular Markers and Classical Histopathological Diagnostic Methods in Grade II and III Glial Tumors and Their Prognostic Outcomes.

Turk Neurosurg 2020 Jul 16. Epub 2020 Jul 16.

Akdeniz University, School of Medicine, Department of Neurosurgery, Antalya, Turkey.

Aim: demonstrate the changes in Grade II and III glial tumors after a new classification.

Material And Methods: The previous diagnoses and postoperative treatment of the 83 patients were recorded. We used real-time PCR (mutation assay) for the analysis of IDH1 and IDH2, while we used FISH test to determine 1p/19q codeletion. Read More

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Reliability, validity, and minimal clinically important differences of the Japanese version of the early clinical assessment of balance in children with cerebral palsy.

Disabil Rehabil 2021 Sep 19:1-7. Epub 2021 Sep 19.

Department of Public Health, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Purpose: We aimed to translate the Early Clinical Assessment of Balance (ECAB) from English to Japanese and examine the content validity, inter-rater reliability, intra-rater reliability, construct validity, and minimal clinically important difference (MCID) for children with cerebral palsy (CP).

Methods: The ECAB was translated into Japanese per international standards. The study included 106 children with CP and, aged 1. Read More

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September 2021

Platelet Endothelial Aggregation Receptor 1 Polymorphism Is Associated With Functional Outcome in Small-Artery Occlusion Stroke Patients Treated With Aspirin.

Front Cardiovasc Med 2021 1;8:664012. Epub 2021 Sep 1.

Department of Neurology, Yangpu Hospital Tongji University School of Medicine, Shanghai, China.

The role of genetic polymorphisms is important in defining the patient's prognosis and outcomes in coronary artery disease. The present study aimed to explore the association between platelet endothelial aggregation receptor 1 (PEAR1) rs12041331 polymorphism and the outcomes in patients with acute ischemic stroke treated with aspirin or dual antiplatelet therapy (DAPT) with clopidogrel. A total of 868 ischemic stroke patients admitted to our hospital from January 1, 2016 to December 30, 2018 were retrospectively studied. Read More

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September 2021

Development and Validation of a Novel Model for Predicting Prognosis of Non-PCR Patients After Neoadjuvant Therapy for Breast Cancer.

Front Oncol 2021 1;11:675533. Epub 2021 Sep 1.

Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Purpose: Pathologic complete response (pCR) after neoadjuvant therapy is an important indicator of long-term prognosis and the primary endpoint of many neoadjuvant studies. For breast cancer patients who do not achieve pCR, prognostic indicators related to prognosis are particularly important. This study is constructing a prediction model with more accurate and reliable prediction results by combining multiple clinicopathological factors, so as to provide a more accurate decision-making basis for subsequent clinical treatment. Read More

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September 2021

Adjuvant Treatment Recommendations in Early-Stage Endometrial Cancer: What Changes With the Introduction of The Integrated Molecular-Based Risk Assessment.

Front Oncol 2021 1;11:612450. Epub 2021 Sep 1.

Direzione Scientifica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Adjuvant therapy recommendations for endometrial cancer were historically based on the individual patient's risk of disease recurrence using clinicopathologic factors such as age, stage, histologic subtype, tumor grade, and lymphovascular space invasion. Despite the excellent prognosis for early stages, considerable under- and overtreatment remains. Integrated genomic characterization by the Cancer Genome Atlas (TCGA) in 2013 defined four distinct endometrial cancer subgroups (POLE mutated, microsatellite instability, low copy number, and high copy number) with possible prognostic value. Read More

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September 2021

What Effect Does Epstein-Barr Virus Have on Extranodal Natural Killer/T-Cell Lymphoma Prognosis? A Review of 153 Reported Cases.

Cureus 2021 Sep 15;13(9):e17987. Epub 2021 Sep 15.

Department of Dermatology, University of Florida, Gainesville, USA.

The primary aim of this review is to identify the relationship between Epstein-Barr virus (EBV) and prognosis in extranodal natural killer/T-cell lymphoma (ENKTL). Additionally, a literature review of ENKTL was carried out. The investigators designed and implemented a 21-year literature review using the online databases PubMed and Google Scholar. Read More

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September 2021

Machine Learning-Derived Echocardiographic Phenotypes Predict Heart Failure Incidence in Asymptomatic Individuals.

JACC Cardiovasc Imaging 2021 Sep 8. Epub 2021 Sep 8.

Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, Institut national de la santé et de la recherche médicale 1116, Centre Hospitalier Universitaire Régional de Nancy, France; French Clinical Research Infrastructure Network "Investigation" Network Initiative - Cardiovascular and Renal Clinical Trialists" Cardiovascular and Renal Clinical Trialists Network, France. Electronic address:

Objectives: This study sought to identify homogenous echocardiographic phenotypes in community-based cohorts and assess their association with outcomes.

Background: Asymptomatic cardiac dysfunction leads to a high risk of long-term cardiovascular morbidity and mortality; however, better echocardiographic classification of asymptomatic individuals remains a challenge.

Methods: Echocardiographic phenotypes were identified using K-means clustering in the first generation of the STANISLAS (Yearly non-invasive follow-up of Health status of Lorraine insured inhabitants) cohort (N = 827; mean age: 60 ± 5 years; men: 48%), and their associations with vascular function and circulating biomarkers were also assessed. Read More

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September 2021

ACTION-1: study protocol for a randomised controlled trial on ACT-guided heparinization during open abdominal aortic aneurysm repair.

Trials 2021 Sep 19;22(1):639. Epub 2021 Sep 19.

Department of Vascular Surgery, Dijklander ziekenhuis, Maelsonstraat 3, 1624, NP, Hoorn, The Netherlands.

Background: Heparin is used worldwide for 70 years during all non-cardiac arterial procedures (NCAP) to reduce thrombo-embolic complications (TEC). But heparin also increases blood loss causing possible harm for the patient. Heparin has an unpredictable effect in the individual patient. Read More

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September 2021

Role of P16 Expression in the Prognosis of Patients With Laryngeal Cancer: A Single Retrospective Analysis.

Cancer Control 2021 Jan-Dec;28:10732748211033544

Department G.F. Ingrassia, Section of Anatomic Pathology, 60279University of Catania, Catania, Italy.

Background: A possible oncogenic role of human papillomavirus (HPV) in head and neck cancers (mainly oropharynx tumors) has been suggested. This significant association has been considered true for oropharynx tumors; however, the association between HPV infection and laryngeal carcinomas is yet to be established. The aim of this study was to evaluate the relationship between p16 expression and long-term overall, disease-free, and disease-specific survival (OS, DF, and DSS, respectively) in patients surgically treated for laryngeal carcinoma. Read More

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September 2021

Prospective selected biomarkers in COVID-19 diagnosis and treatment.

Biomark Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Genetic Engineering & Biotechnology, School of Life Sciences, Shahjalal University of Science & Technology, Sylhet, Bangladesh.

COVID-19 has become a global health concern, due to the high transmissible nature of its causal agent and lack of proper treatment. Early diagnosis and nonspecific medical supports of the patients appeared to be effective strategy so far to combat the pandemic caused by COVID-19 outbreak. Biomarkers can play pivotal roles in timely and proper diagnosis of COVID-19 patients, as well as for distinguishing them from other pulmonary infections. Read More

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September 2021

Quantitative Lesion Water Uptake as Stroke Imaging Biomarker: A Tool for Treatment Selection in the Extended Time Window?

Stroke 2021 Sep 20:STROKEAHA120033025. Epub 2021 Sep 20.

Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany. (G.B., S.T., R.M., L.M., T.D.F., H.K., M.T.N., S.E., N.v.H., J.F., U.H.).

Background And Purpose: Patients presenting in the extended time window may benefit from mechanical thrombectomy. However, selection for mechanical thrombectomy in this patient group has only been performed using specialized image processing platforms, which are not widely available. We hypothesized that quantitative lesion water uptake calculated in acute stroke computed tomography (CT) may serve as imaging biomarker to estimate ischemic lesion progression and predict clinical outcome in patients undergoing mechanical thrombectomy in the extended time window. Read More

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September 2021

Ultrasound- Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis.

Circ Cardiovasc Interv 2021 Sep 20:CIRCINTERVENTIONS121010742. Epub 2021 Sep 20.

Oxford Heart Centre, Oxford University Hospitals, NHS Trust, United Kingdom (R.A.K., J.J.H.B., S.R., R.S., F.M., D.T.-P., R.K., A.P.B.).

Background: Access site vascular and bleeding complications remain problematic for patients undergoing transcatheter aortic valve replacement (TAVR). Ultrasound-guided transfemoral access approach has been suggested as a technique to reduce access site complications, but there is wide variation in adoption in TAVR. We performed a systematic review and meta-analysis to compare access site vascular and bleeding complications according to the Valve Academic Research Consortium-2 classification following the use of either ultrasound- or conventional fluoroscopy-guided transfemoral TAVR access. Read More

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September 2021


Wiad Lek 2021 ;74(8):1900-1904


Objective: The aim: Develop a classification of post-traumatic soft tissue defects of the hand to standardize the care of this group of patients. And in order to simplify the choice of plastic technic for post-traumatic soft tissue defects of the hand by surgeons and traumatologists.

Patients And Methods: Materials and methods: We analyzed the treatment of 54 patients with hand injury and PTSTD. Read More

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September 2021

The impact of intravertebral cleft on cement leakage in percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a case-control study.

BMC Musculoskelet Disord 2021 Sep 18;22(1):805. Epub 2021 Sep 18.

Department of Spinal Surgery, Beijing Luhe Hospital, Capital Medical University, No.82, Xinhua South Road, Touzhou District, Beijing, 101149, China.

Background: The impact of intravertebral cleft (IVC) on cement leakage in percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs) has been discussed. However, the results were conflicting, as the study population and cement leakage classification were heterogeneous. The aim of the study was to evaluate the impact of IVC on the incidence of leakage through vein, leakage through cortex as well as general leakage in PVP for OVCFs. Read More

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September 2021

Prognostic value of the TCGA molecular classification in uterine carcinosarcoma.

Int J Gynaecol Obstet 2021 Sep 18. Epub 2021 Sep 18.

Gynecopathology and Breast Pathology Unit, Department of Woman's Health Science, Agostino Gemelli University Polyclinic, Rome, Italy.

Background: The TCGA molecular groups of endometrial carcinoma are "POLE-mutated" (POLEmut), "microsatellite-instable/mismatch repair-deficient" (MSI/MMRd), "TP53-mutated/p53-abnormal" (TP53mut/p53abn) and "no specific molecular profile" (NSMP).

Objective: Prognostic assessment of the TCGA groups in uterine carcinosarcoma (UCS).

Search Strategy: Systematic review from January 2000 to January 2021. Read More

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September 2021

Validating a nodal regression system for gastric cancer: An ancillary cohort study of the GASTRODOC trial.

Int J Surg 2021 Sep 15;94:106112. Epub 2021 Sep 15.

General and Oncologic Surgery, Department of Surgery, Morgagni-Pierantoni Hospital, Forlì, Italy.

Background: To validate a nodal regression system for gastric cancer and to verify its impact on prognosis.

Methods: This is an ancillary study which included 47 patients of the GASTRODOC trial. The dedicated pathologists of each Institute were invited to revise all the lymph nodes included in the surgical specimens in order to classify the regression according to the grading system proposed by Tsekrekos et al. Read More

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September 2021

Eye-preserving therapies for advanced retinoblastoma: a multicenter cohort of 1678 patients in China.

Ophthalmology 2021 Sep 15. Epub 2021 Sep 15.

Department of Ophthalmology, Hainan Eye Hospital and Key laboratory of ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University.

Purpose: Multiple eye-preserving treatments have been widely used in China for the last 15 years, however, controversy remains on using eye-preserving therapies for advanced retinoblastoma (The International Intraocular Retinoblastoma Classification: groups D and E). This study attempts to estimate the impact of eye-preserving therapies for the long-term prognosis of advanced retinoblastoma with regard to overall survival and ocular salvage.

Design: A retrospective cohort study covering all 31 provinces (38 retinoblastoma treating centers) of Chinese mainland. Read More

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September 2021

Artificial intelligence in cancer research, diagnosis and therapy.

Nat Rev Cancer 2021 Sep 17. Epub 2021 Sep 17.

National Center for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, USA.

Standfirst: Artificial intelligence and machine learning techniques are breaking into biomedical research and health care, which importantly includes cancer research and oncology, where the potential applications are vast. These include detection and diagnosis of cancer, subtype classification, optimization of cancer treatment and identification of new therapeutic targets in drug discovery. While big data used to train machine learning models may already exist, leveraging this opportunity to realize the full promise of artificial intelligence in both the cancer research space and the clinical space will first require significant obstacles to be surmounted. Read More

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September 2021

SMASH-U aetiological classification: a predictor of long-term functional outcome after intracerebral haemorrhage.

Eur J Neurol 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: SMASH-U is a systematic aetiological classification system for intracerebral haemorrhage (ICH) proven to be a predictor of post-ICH haematoma expansion and mortality. However, its role in predicting functional outcome remains elusive. Therefore, we aimed to investigate whether SMASH-U is associated with long-term functional outcome after ICH and improves the accuracy of prediction when added to max-ICH score. Read More

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September 2021

Cortactin and HER2 as potential markers for dural-targeted therapy in advanced gastric cancer.

Clin Exp Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Oncological Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, 233000, China.

To study the role of HER2/cortactin co-overexpression in advanced gastric cancer (GC). This study retrospectively enrolled 246 patients with stage III GC from January 2015 to December 2016 at our hospital. We explored, using immunostaining techniques, the role of the expression of cortactin and HER2 in the progression of advanced GC. Read More

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September 2021