Curr Opin Neurol 2021 Aug 2. Epub 2021 Aug 2.
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK Department of Genetics Center for Genomics and Personalized Medicine, Stanford University School of Medicine, Stanford, California, USA Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
Purpose Of Review: Amyotrophic lateral sclerosis (ALS) is an archetypal complex disease wherein disease risk and severity are, for the majority of patients, the product of interaction between multiple genetic and environmental factors. We are in a period of unprecedented discovery with new large-scale genome-wide association study (GWAS) and accelerating discovery of risk genes. However, much of the observed heritability of ALS is undiscovered and we are not yet approaching elucidation of the total genetic architecture, which will be necessary for comprehensive disease subclassification. Read More