1,564 results match your criteria classical brown

The C(P) + O(Σ) → CO ↔ CO(Σ) + O(D)/O(P) reaction: thermal and vibrational relaxation rates from 15 K to 20 000 K.

Phys Chem Chem Phys 2021 May 5. Epub 2021 May 5.

Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland. and Brown University, Providence, RI 02912, USA.

Thermal rates for the C(3P) + O2(3Σg-) ↔ CO(1Σ+)+ O(1D)/O(3P) reaction are investigated over a wide temperature range based on quasi classical trajectory (QCT) simulations on 3-dimensional, reactive potential energy surfaces (PESs) for the 1A', (2)1A', 1A'', 3A' and 3A'' states. These five states are the energetically low-lying states of CO2 and their PESs are computed at the MRCISD+Q/aug-cc-pVTZ level of theory using a state-average CASSCF reference wave function. Analysis of the different electronic states for the CO2 → CO + O dissociation channel rationalizes the topography of this region of the PESs. Read More

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Assessing the Distribution of Exotic Egg Parasitoids of in Europe with a Large-Scale Monitoring Program.

Insects 2021 Apr 1;12(4). Epub 2021 Apr 1.

CREA, Research Centre for Plant Protection and Certification, via di Lanciola 12a, 50125 Firenze, Italy.

The brown marmorated stink bug is an invasive agricultural pest with a worldwide distribution. Classical biological control has been identified as the most promising method to reduce the populations of . Adventive populations of two candidates for releases, and , have recently been detected in Europe. Read More

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Higher circulating intermediate monocytes are associated with cognitive function in women with HIV.

JCI Insight 2021 Apr 29. Epub 2021 Apr 29.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America.

Background: Identifying a quantitative biomarker of neuropsychiatric dysfunction in people with HIV (PWH) remains a significant challenge in the neuroHIV field. The strongest evidence to date implicates the role of monocytes in central nervous system (CNS) dysfunction in HIV, yet no study has examined monocyte subsets in blood as a correlate and/or predictor of neuropsychiatric function in virally suppressed PWH.

Methods: In two independent cohorts of virologically suppressed women with HIV (vsWWH; n=25 and n=18), whole blood samples were obtained either in conjunction with neuropsychiatric assessments (neuropsychological [NP] test battery, self-report depression and stress-related symptom questionnaires) or one year prior to assessments. Read More

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Flipped Quick-Response Code Enables Reliable Blood Grouping.

ACS Nano 2021 04 19;15(4):7649-7658. Epub 2021 Apr 19.

Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing 400044, People's Republic of China.

Accurate and rapid blood typing plays a vital role in a variety of biomedical and forensic scenarios, but recognizing weak agglutination remains challenging. Herein, we demonstrated a flipping identification with a prompt error-discrimination (FLIPPED) platform for automatic blood group readouts. Bromocresol green dye was exploited as a characteristic chromatography indicator for the differentiation of plasma from whole blood by presenting a teal color against a brown color. Read More

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Emerging Forms of Precariousness Related to Autonomy at Work: Toward an Empirical Typology.

Front Sociol 2020 22;5:34. Epub 2020 May 22.

HEC Management School, University of Liège, Liège, Belgium.

Societal, technological, and economical changes in the last decades have led to the development of new work arrangements located in a ≪ gray zone ≫ between standard employment and classical self-employment (Cappelli and Keller, 2013a; ILO, 2016; Katz and Krueger, 2016). Official labor market statistics must be adapted to provide researchers and policymakers with relevant data on this population (Gazier et al., 2016; National Academies of Sciences, Engineering and Medicine, 2017; ILO, 2018). Read More

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Outcome comparison of patients who develop leptomeningeal disease or distant brain recurrence after brain metastases resection cavity radiosurgery.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab036. Epub 2021 Mar 2.

Department of Neurologic Surgery, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Background: To compare the outcomes between patients with leptomeningeal disease (LMD) and distant brain recurrence (DBR) after stereotactic radiosurgery (SRS) brain metastases (BM) resection cavity.

Methods: Twenty-nine patients having single-fraction SRS after BM resection who developed either LMD ( = 11) or DBR ( = 18) as their initial and only site of intracranial progression were retrospectively reviewed.

Results: Patients developing LMD more commonly had a metachronous presentation (91% vs 50%, = . Read More

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Controlling the breakup of toroidal liquid films on solid surfaces.

Sci Rep 2021 Apr 14;11(1):8120. Epub 2021 Apr 14.

SOFT Group, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK.

The breakup of a slender filament of liquid driven by surface tension is a classical fluid dynamics stability problem that is important in many situations where fine droplets are required. When the filament is resting on a flat solid surface which imposes wetting conditions the subtle interplay with the fluid dynamics makes the instability pathways and mode selection difficult to predict. Here, we show how controlling the static and dynamic wetting of a surface can lead to repeatable switching between a toroidal film of an electrically insulating liquid and patterns of droplets of well-defined dimensions confined to a ring geometry. Read More

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Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results.

Blood 2021 Apr 7. Epub 2021 Apr 7.

City of Hope National Medical Center, Duarte, California, United States.

This phase 1-2 study evaluated brentuximab vedotin (BV) combined with nivolumab (Nivo) as first salvage therapy in patients with relapsed or refractory classical Hodgkin lymphoma. In parts 1 and 2, patients received staggered dosing of BV and Nivo in cycle 1, followed by same-day dosing in cycles 2-4. In part 3, both study drugs were dosed same day for all 4 cycles. Read More

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Survey for Adventive Populations of the Samurai Wasp, (Hymenoptera: Scelionidae) in Pennsylvania at Commercial Fruit Orchards and the Surrounding Forest.

Insects 2021 Mar 19;12(3). Epub 2021 Mar 19.

Fruit Research and Extension Center, Department of Entomology, Pennsylvania State University, Biglerville, PA 17307-0330, USA.

The samurai wasp, (Ashmead) (Hymenoptera: Scelionidae), is an egg parasitoid associated with the brown marmorated stink bug, (Stål) (Hemiptera: Pentatomidae). is a candidate for classical biological control of populations. Since 2014, adventive populations of have been detected in 14 US states, in the Canadian provinces of British Columbia and Ontario, and in two European countries, Switzerland and Italy. Read More

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Isolating Brown Adipocytes from Murine Interscapular Brown Adipose Tissue for Gene and Protein Expression Analysis.

J Vis Exp 2021 03 12(169). Epub 2021 Mar 12.

Masonic Medical Research Institute;

Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis in mammals, and brown adipocytes (BAs) are the functional units of BAT. BAs contain both multilocular lipid droplets and abundant mitochondria, and they express uncoupling protein 1 (UCP1). BAs are categorized into two sub-types based on their origin: embryo derived classical BAs (cBAs) and white adipocytes derived BAs. Read More

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Becoming the temporary surgeon: A grounded theory examination of anaesthetists performing emergency front of neck access in inter-disciplinary simulation-based training.

PLoS One 2021 23;16(3):e0249070. Epub 2021 Mar 23.

Health Research Institute, Faculty of Health & Social Care, Edge Hill University, Ormskirk, United Kingdom.

The time-critical 'can't intubate, can't oxygenate' [CICO] emergency post-induction of anaesthesia is rare, but one which, should it occur, requires Anaesthetists to perform rapid emergency front of neck access [FONA] to the trachea, restoring oxygenation, and preventing death or brain hypoxia. The UK Difficult Airway Society [DAS] has directed all Anaesthetists to be trained with surgical cricothyroidotomy [SCT] as the primary emergency FONA method, sometimes referred to as 'Cric' as a shorthand. We present a longitudinal analysis using a classical approach to Grounded Theory methodology of ten Specialist Trainee Anaesthetists' data during a 6-month training programme delivered jointly by Anaesthetists and Surgeons. Read More

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Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing.

Bull Math Biol 2021 Mar 22;83(5):47. Epub 2021 Mar 22.

Department of Mathematics, North Carolina State University, Box 8205, Raleigh, NC, 27695-8205, USA.

During the hemostatic phase of wound healing, vascular injury leads to endothelial cell damage, initiation of a coagulation cascade involving platelets, and formation of a fibrin-rich clot. As this cascade culminates, activation of the protease thrombin occurs and soluble fibrinogen is converted into an insoluble polymerized fibrin network. Fibrin polymerization is critical for bleeding cessation and subsequent stages of wound healing. Read More

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Leptomeningeal disease and neurologic death after surgical resection and radiosurgery for brain metastases: A multi-institutional analysis.

Adv Radiat Oncol 2021 Mar-Apr;6(2):100644. Epub 2021 Jan 8.

Department of Radiation Oncology, Stanford University, Stanford, California.

Purpose: Postoperative stereotactic radiosurgery (SRS) is associated with up to 30% risk of subsequent leptomeningeal disease (LMD). Radiographic patterns of LMD (classical sugarcoating [cLMD] vs. nodular [nLMD]) in this setting has been shown to be prognostic. Read More

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January 2021

Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis.

Elife 2021 03 15;10. Epub 2021 Mar 15.

Department of Medicine, Leon H. Charney Division of Cardiology, Cardiovascular Research Program, New York University Grossman School of Medicine, New York, United States.

Atherosclerosis is a disease of chronic inflammation. We investigated the roles of the cytokines IL-4 and IL-13, the classical activators of STAT6, in the resolution of atherosclerosis inflammation. Using mice, resolution was impaired, and in control mice, in both progressing and resolving plaques, levels of IL-4 were stably low and IL-13 was undetectable. Read More

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Comparative Analysis of Phenology Algorithms of the Spring Barley Model in APSIM 7.9 and APSIM Next Generation: A Case Study for High Latitudes.

Plants (Basel) 2021 Feb 26;10(3). Epub 2021 Feb 26.

Department of Agricultural Research for Northern Sweden, Swedish University of Agricultural Science, 90183 Umeå, Sweden.

Phenology algorithms in crop growth models have inevitable systematic errors and uncertainties. In this study, the phenology simulation algorithms in APSIM classical (APSIM 7.9) and APSIM next generation (APSIM-NG) were compared for spring barley models at high latitudes. Read More

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February 2021

Monocyte phenotype as a predictive marker for wound healing in diabetes-related foot ulcers.

J Diabetes Complications 2021 May 16;35(5):107889. Epub 2021 Feb 16.

Diabetes Centre, Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia; Greg Brown Diabetes and Endocrinology Research Laboratory, Sydney Medical School (Central), Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; NSW Health Pathology, Sydney, NSW, Australia.

Aims: Delayed healing of diabetes-related foot ulcers (DRFUs) is associated with increased macrophage and matrix metalloproteinases (MMPs) at the wound site. Whether circulating monocyte phenotype and/or MMPs are altered in association with wound healing outcome is unknown, and was investigated in this study.

Methods: Blood was obtained from 21 participants with DRFU, at initial visit (V1), week-4 (V2), and week-8 (V3) for measurement of monocyte number (CD14), phenotype (CD16, CD163) and chemokine receptors (CCRs) by flow cytometry, and circulating MMPs and TIMP-1 by ELISA. Read More

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Complex plasmon-exciton dynamics revealed through quantum dot light emission in a nanocavity.

Nat Commun 2021 Feb 26;12(1):1310. Epub 2021 Feb 26.

Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel.

Plasmonic cavities can confine electromagnetic radiation to deep sub-wavelength regimes. This facilitates strong coupling phenomena to be observed at the limit of individual quantum emitters. Here, we report an extensive set of measurements of plasmonic cavities hosting one to a few semiconductor quantum dots. Read More

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February 2021

Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction, and estimating benefits from novel interventions.

Eur J Prev Cardiol 2020 Oct 7. Epub 2020 Oct 7.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK.

Aims : To investigate the population attributable fraction due to elevated lipoprotein (a) (Lp(a)) and the utility of measuring Lp(a) in cardiovascular disease (CVD) risk prediction.

Methods And Results : In 413 734 participants from UK Biobank, associations of serum Lp(a) with composite fatal/non-fatal CVD (n = 10 066 events), fatal CVD (n = 3247), coronary heart disease (CHD; n = 18 292), peripheral vascular disease (PVD; n = 2716), and aortic stenosis (n = 901) were compared using Cox models. Median Lp(a) was 19. Read More

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October 2020

Integration of LC/MS-based molecular networking and classical phytochemical approach allows in-depth annotation of the metabolome of non-model organisms - The case study of the brown seaweed Taonia atomaria.

Talanta 2021 Apr 4;225:121925. Epub 2020 Dec 4.

Université de Toulon, MAPIEM, Toulon, EA 4323, France. Electronic address:

Untargeted LC-MS based metabolomics is a useful approach in many research areas such as medicine, systems biology, environmental sciences or even ecology. In such an approach, annotation of metabolomes of non-model organisms remains a significant challenge. In this study, an analytical workflow combining a classical phytochemical approach, using the isolation and the full characterization of the chemical structure of natural products, together with the use of MS/MS-based molecular networking with various levels of restrictiveness was developed. Read More

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[Neurological symptoms in spinal syndromes].

Stefanie Behnke

Radiologe 2021 Mar 15;61(3):242-250. Epub 2021 Feb 15.

Klinik für Neurologie, Knappschaftskliniken Saar, Standort Sulzbach, An der Klinik 10, 66280, Sulzbach, Deutschland.

Background: Spinal cord injuries are frequently associated with severe clinical-neurological deficits. These are evident with specific symptoms and syndromes. Hereby, a thorough knowledge of spinal neuroanatomy is essential. Read More

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Epidermodysplasia Verruciformis After Hematopoietic Stem Cell Transplantation in a Patient With Severe Combined Immunodeficiency Syndrome.

Am J Dermatopathol 2021 May;43(5):e65-e67

Pathology, Hacettepe University, School of Medicine, Ankara, Turkey.

Abstract: Epidermodysplasia verruciformis (EV) is a rare dermatologic disorder that is characterized by skin-colored-to-light brown flat, discrete or confluent papules resembling verruca plana. EV is divided into 2 forms: a classical genetic form and an acquired form. Classical genetic EV is caused by mutations in EVER1 and EVER2 genes. Read More

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TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.

Mol Metab 2021 May 29;47:101173. Epub 2021 Jan 29.

Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: Brown adipose tissue (BAT) thermogenesis offers the potential to improve metabolic health in mice and humans. However, humans predominantly live under thermoneutral conditions, leading to BAT whitening, a reduction in BAT mitochondrial content and metabolic activity. Recent studies have established mitophagy as a major driver of mitochondrial degradation in the whitening of thermogenic brite/beige adipocytes, yet the pathways mediating mitochondrial breakdown in whitening of classical BAT remain largely elusive. Read More

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Dog domestication and the dual dispersal of people and dogs into the Americas.

Proc Natl Acad Sci U S A 2021 Feb;118(6)

Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912;

Advances in the isolation and sequencing of ancient DNA have begun to reveal the population histories of both people and dogs. Over the last 10,000 y, the genetic signatures of ancient dog remains have been linked with known human dispersals in regions such as the Arctic and the remote Pacific. It is suspected, however, that this relationship has a much deeper antiquity, and that the tandem movement of people and dogs may have begun soon after the domestication of the dog from a gray wolf ancestor in the late Pleistocene. Read More

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February 2021

Multiple Brown tumors in a Case of Primary Hyperparathyroidism with Pathological Fracture in Femur.

J Orthop Case Rep 2020 Sep;10(6):49-53

Department of Orthopedics, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.

Introduction: Pathological fractures in long bones are commonly caused by simple bone cyst or Osteogenesis imperfecta in children and by metastatic tumors from primary carcinoma, multiple myeloma, osteoporosis, and bone tumors in adults. Hyperparathyroidism causing pathological fractures, though a well-known entity, is seen infrequently in clinical practice. The fractures occur in the expansile fibro-cystic bone lesions called as "Brown tumor. Read More

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September 2020

Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice.

Int J Mol Sci 2021 Jan 18;22(2). Epub 2021 Jan 18.

Institute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan.

Adult humans and mice possess significant classical brown adipose tissues (BAT) and, upon cold-induction, acquire brown-like adipocytes in certain depots of white adipose tissues (WAT), known as beige adipose tissues or WAT browning/beiging. Activating thermogenic classical BAT or WAT beiging to generate heat limits diet-induced obesity or type-2 diabetes in mice. Adiponectin is a beneficial adipokine resisting diabetes, and causing "healthy obese" by increasing WAT expansion to limit lipotoxicity in other metabolic tissues during high-fat feeding. Read More

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January 2021

Survey of spiking in the mouse visual system reveals functional hierarchy.

Nature 2021 04 20;592(7852):86-92. Epub 2021 Jan 20.

Allen Institute for Brain Science, Seattle, WA, USA.

The anatomy of the mammalian visual system, from the retina to the neocortex, is organized hierarchically. However, direct observation of cellular-level functional interactions across this hierarchy is lacking due to the challenge of simultaneously recording activity across numerous regions. Here we describe a large, open dataset-part of the Allen Brain Observatory-that surveys spiking from tens of thousands of units in six cortical and two thalamic regions in the brains of mice responding to a battery of visual stimuli. Read More

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Residents' Perceptions of Effective Features of Educational Podcasts.

West J Emerg Med 2020 Dec 10;22(1):26-32. Epub 2020 Dec 10.

University of Washington, Department of Emergency Medicine, Seattle, Washington.

Introduction: Educational podcasts are used by emergency medicine (EM) trainees to supplement clinical learning and to foster a sense of connection to broader physician communities. Yet residents report difficulties remembering what they learned from listening, and the features of podcasts that residents find most effective for learning remain poorly understood. Therefore, we sought to explore residents' perceptions of the design features of educational podcasts that they felt most effectively promoted learning. Read More

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December 2020

How to assess the recovery of muscular function following nerve injury: A view from surgeons and patients.

J Plast Reconstr Aesthet Surg 2020 Dec 11. Epub 2020 Dec 11.

Peripheral Nerve Injury Research Unit, Royal National Orthopaedic Hospital, Stanmore, United Kingdom; UCL Centre for Nerve Engineering, University College London, London, United Kingdom. Electronic address:

Patient experience of motor recovery from denervation paralysis is complex and textured. The Medical Research Council (MRC) system of grading muscle peak volitional force is widely used as a single measure of assessment. However, it is becoming clear that current motor function assessments are not reflecting the patient lived experience of muscle reinnervation. Read More

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December 2020

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus.

Adipocyte 2021 12;10(1):48-65

Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine , Beijing China.

Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a thermogenic tissue that acts a pivotal part in maintaining the core body temperature. White adipocytes display high plasticity and can transdifferentiate into beige adipocytes which have many similar morphological and functional properties with brown adipocytes under the stimulations of exercise, cold exposure and other factors. Read More

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December 2021

Insight into the kinetically and thermodynamically controlled biosynthesis of silver nanoparticles.

IET Nanobiotechnol 2020 Dec;14(9):864-869

Department of Bioengineering, BIT, Mesra, Ranchi, Jharkhand 835215, India.

The mechanism of nanoparticles (NPs) synthesis is a crucial prerequisite for the engineering of desirable material properties and is elusive due to the difficulty of studying the synthesis path and also due to lack of published work. The present study moves beyond the current conventional study of characterisation of NPs synthesis. It focuses on study of classical kinetics of metal NP using silver as a model metal to perform the required experiments, it aimed at understanding the crystallisation process which is the major root for the synthesis of metal NP. Read More

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December 2020