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The polar flagellar transcriptional regulatory network in deviates from canonical species.

J Bacteriol 2021 Aug 2:JB0027621. Epub 2021 Aug 2.

Department of Biology, Indiana University, Bloomington, IN 47405.

Swimming motility is a critical virulence factor in pathogenesis for numerous species. DS40M4 is a wild isolate that has been recently established as a highly tractable model strain for bacterial genetics studies. We sought to exploit the tractability and relevance of this strain for characterization of flagellar gene regulation in . Read More

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An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB-fused broadening the spectrum of tumor entities in comparison with their soft tissue counterparts.

Brain Pathol 2021 Jul 27:e13010. Epub 2021 Jul 27.

Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.

FET:CREB fusions have been described in a variety of tumors from various phenotypes. Recently, these fusion transcripts were reported in intracranial tumors, variably named intracranial mesenchymal myxoid tumors or angiomatoid fibrous histiocytomas. Controversy remains concerning the terminology for these tumors. Read More

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Comparison of distance of upper central incisor root and incisive canal in different sagittal and vertical skeletal patterns and sex: A retrospective CBCT study.

Int Orthod 2021 Jul 23. Epub 2021 Jul 23.

Department of Oral Radiology, Division of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba Piracicaba, SP, Brazil.

Introduction: To evaluate the influence of sagittal and vertical skeletal patterns (skeletal classes and facial profiles), and sex on the distance between upper central incisors roots and incisive canal.

Material And Methods: Cone-beam computed tomography exams of 172 patients were classified into skeletal classes I, II, and III and according to the facial profile into mesofacial, brachyfacial, and dolichofacial. In sagittal reconstructions, linear measurements were done between central incisors roots and incisive canal at three levels: incisive foramen opening, intermediate region, and the region close to the apex of upper central incisors. Read More

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The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena.

Neurosci Bull 2021 Jul 24. Epub 2021 Jul 24.

Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Ciudad Universitaria, 20131, Aguascalientes, Ags., Mexico.

The periaqueductal gray (PAG) is a complex mesencephalic structure involved in the integration and execution of active and passive self-protective behaviors against imminent threats, such as immobility or flight from a predator. PAG activity is also associated with the integration of responses against physical discomfort (e.g. Read More

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Single worm transcriptomics identifies a developmental core network of oscillating genes with deep conservation across nematodes.

Genome Res 2021 Jul 22. Epub 2021 Jul 22.

Max Planck Institute for Developmental Biology

High-resolution spatial and temporal maps of gene expression have facilitated a comprehensive understanding of animal development and evolution. In nematodes, the small body size represented a major challenge for such studies, but recent advancements have helped overcome this limitation. Here, we have implemented single worm transcriptomics (SWT) in the nematode model organism to provide a high-resolution map of the developmental transcriptome. Read More

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Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis.

Int J Mol Sci 2021 Jul 6;22(14). Epub 2021 Jul 6.

Institute of Clinical Pharmacology, Goethe-University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Interactions of drugs with the classical epigenetic mechanism of DNA methylation or histone modification are increasingly being elucidated mechanistically and used to develop novel classes of epigenetic therapeutics. A data science approach is used to synthesize current knowledge on the pharmacological implications of epigenetic regulation of gene expression. Computer-aided knowledge discovery for epigenetic implications of current approved or investigational drugs was performed by querying information from multiple publicly available gold-standard sources to (i) identify enzymes involved in classical epigenetic processes, (ii) screen original biomedical scientific publications including bibliometric analyses, (iii) identify drugs that interact with epigenetic enzymes, including their additional non-epigenetic targets, and (iv) analyze computational functional genomics of drugs with epigenetic interactions. Read More

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Retention of different temporary cements tested on zirconia crowns and titanium abutments in vitro.

Int J Implant Dent 2021 Jul 20;7(1):62. Epub 2021 Jul 20.

Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, University Charité Berlin, Aßmannshauser Str. 4-6, 14197, Berlin, Germany.

Purpose: The aim of the present study was to examine the retention force of monolithic zirconia copings cemented with various temporary cements on implant abutments in vitro.

Methods: Sixty exercise implants with pre-screwed implant abutments were embedded in resin. Subsequently, 60 CAD/CAM manufactured zirconia copings were divided into three main groups [Harvard Implant Semi-permanent (HAV), implantlink semi Forte (IMP), Temp Bond NE (TBNE)]. Read More

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Anhedonia and Substance Use Disorders by Type, Severity, and With Mental Health Disorders.

J Addict Med 2021 Jul 16. Epub 2021 Jul 16.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA (SWS, STL); Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD (SWS, JWB, DHE); The University of Illinois at Chicago, Center for Dissemination and Implementation Science, Chicago, IL (BCB); The Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, University Park, PA (STL).

Objectives: Anhedonia can accompany substance use disorders (SUDs); its severity may vary by substance type, severity of SUD symptoms, or psychiatric comorbidity. The goal of this study was to clarify the contribution of each.

Methods: Data were from participants aged 18 to 65 years in the National Epidemiologic Survey on Alcohol and Related Conditions III (n = 30,999; 51% women), a cross-sectional, nationally representative sample reporting lifetime DSM-5 symptoms and lifetime anhedonia. Read More

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Predictive value of frontal QRS-T angle after cardiac resynchronization therapy.

J Electrocardiol 2021 Jul 3;68:24-29. Epub 2021 Jul 3.

Department of Cardiology, Sancaktepe Sehit Profesor Ilhan Varank Education and Research Hospital, Istanbul, Turkey. Electronic address:

Objective: It is practical and useful to detect patients who benefit from cardiac resynchronization therapy (CRT) by electrocardiographic (ECG) methods. In this study, the predictive role of the frontal QRS-T angle and other ECG parameters was evaluated in CRT responder patients.

Method: Seventy-seven consecutive patients with left ventricular ejection fraction (LVEF) ≤ 35%, New York Heart Association (NYHA) classes II-III, ambulatory class IV and normal sinus rhythm, who had complete left bundle branch block and were treated with CRT were included in this study. Read More

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Low-shot transfer with attention for highly imbalanced cursive character recognition.

Neural Netw 2021 Jul 8;143:489-499. Epub 2021 Jul 8.

School of Electronics and Electrical Engineering, Kyungpook National University, Daegu, 41566, South Korea; Graduate School of Artificial Intelligence, Kyungpook National University, Daegu, 41566, South Korea. Electronic address:

Recognition of ancient Korean-Chinese cursive character (Hanja) is a challenging problem mainly because of large number of classes, damaged cursive characters, various hand-writing styles, and similar confusable characters. They also suffer from lack of training data and class imbalance issues. To address these problems, we propose a unified Regularized Low-shot Attention Transfer with Imbalance τ-Normalizing (RELATIN) framework. Read More

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Association between Maternal Obesity Class, Adherence to Labor Guidelines, and Perinatal Outcomes.

AJP Rep 2021 Apr 15;11(2):e105-e112. Epub 2021 Jul 15.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

 Data are limited concerning rates of perinatal complications in women with a body mass index (BMI) ≥40 kg/m2 compared to women with other BMI classes when guidelines for the safe prevention of the primary cesarean delivery are applied.  The aim of the study is to evaluate labor guideline adherence by BMI class and to compare perinatal outcomes across BMI classes with guideline adherent management.  This retrospective study included low-risk women admitted for delivery between April 2014 and April 2017 after the labor guidelines were implemented. Read More

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Using Zoom and Card Game to Conduct Advance Care Planning Classes: An Innovative Practice.

Omega (Westport) 2021 Jul 18:302228211032735. Epub 2021 Jul 18.

Faculty of Liberal Arts, Prince of Songkla University, Hat Yai, Thailand.

Background: This article demonstrates the innovative practice of using a card game to teach participants about Advance Care Planning (ACP) and palliative care in Thailand via Zoom during the COVID-19 pandemic.

Aims: To assess the feasibility of using online workshops to conduct sensitive topics of palliative care and death and dying.

Methods: The interactive online workshops were conducted after imposition of the COVID-19 restriction and national lockdown in Thailand between March and September 2020. Read More

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Monitoring the dynamics of clinical and laboratory markers of chronic heart failure during 12 months of sacubitril/valsartan treatment.

Vnitr Lek 2021 ;67(4):212-217

Aim: Treatment with sacubitril/valsartan (S/V) significantly improves cardiovascular morbidity, mortality, quality of life and prolongs the survival of chronic heart failure patients with reduced ejection fraction. The aim of the study was to evaluate changes in ejection fraction, NT-proBNP and glomerular filtration after 12 months of sacubitril/valsartan treatment.

Methods: 30 patients (28 men) with chronic heart failure with reduced ejection fraction, functional classes NYHA II-III, EF LK < 40%, NT-proBNP (> 450 ng/l), with glomerular filtration > 0. Read More

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Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes.

Arch Toxicol 2021 Jul 17. Epub 2021 Jul 17.

Unidad de Hepatología Experimental, Health Research Institute La Fe, Valencia, Spain.

Drug-induced liver injury (DILI) is an adverse toxic hepatic clinical reaction associated to the administration of a drug that can occur both at early clinical stages of drug development, as well after normal clinical usage of approved drugs. Because of its unpredictability and clinical relevance, it is of medical concern. Three DILI phenotypes (hepatocellular, cholestatic, and mixed) are currently recognized, based on serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) values. Read More

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Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry: A UK cohort study.

PLoS Med 2021 Jul 16;18(7):e1003704. Epub 2021 Jul 16.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, Bristol, United Kingdom.

Background: One in 10 people in the United Kingdom will need a total knee replacement (TKR) during their lifetime. Access to this life-changing operation has recently been restricted based on body mass index (BMI) due to belief that high BMI may lead to poorer outcomes. We investigated the associations between BMI and revision surgery, mortality, and pain/function using what we believe to be the world's largest joint replacement registry. Read More

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A novel class III endogenous retrovirus with a class I envelope gene in African frogs with an intact genome and developmentally regulated transcripts in Xenopus tropicalis.

Retrovirology 2021 Jul 14;18(1):20. Epub 2021 Jul 14.

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892, USA.

Background: Retroviruses exist as exogenous infectious agents and as endogenous retroviruses (ERVs) integrated into host chromosomes. Such endogenous retroviruses (ERVs) are grouped into three classes roughly corresponding to the seven genera of infectious retroviruses: class I (gamma-, epsilonretroviruses), class II (alpha-, beta-, delta-, lentiretroviruses) and class III (spumaretroviruses). Some ERVs have counterparts among the known infectious retroviruses, while others represent paleovirological relics of extinct or undiscovered retroviruses. Read More

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Evaluation of Nasal Function and Upper Airway Morphology After Bi-Maxillary Surgery Using Rhinomanometry and Computed Tomography.

J Craniofac Surg 2021 Jul 13. Epub 2021 Jul 13.

Department of Oral and Maxillofacial Surgery, Division of Medicine, interdisciplinary Graduate School, University of Yamanashi, Chuoshi, Japan.

Purpose: This study was performed to evaluate changes in nasal airflow, nasal airway resistance, nasal cross-sectional area, pharyngeal horizontal area, nasopharyngeal and oropharyngeal volume following Le Fort I osteotomy (L1) impaction with sagittal split ramus osteotomy (SSRO) in classes II and III.

Materials And Methods: The subjects consisted of 35 patients (6 males and 29 females, 70 sides) 17 of which were diagnosed as class II and 18 as class III who underwent L1 and SSRO. Nasal airflow and resistance were measured using the rhinomanometry system (GM NR-6 EXECUTIVE) before and at 1 and 6 months after surgery. Read More

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Stratification for Identification of Prognostic Categories In the Acute RESpiratory Distress Syndrome (SPIRES) Score.

Crit Care Med 2021 Jul 2. Epub 2021 Jul 2.

1 CIBER de Enfermedades Respiratorias, Instituto Salud Carlos III, Madrid, Spain. 2 Research Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain. 3 Division of Biostatistics, Research Unit, Hospital Universitario Dr. Negrín, Las Palmas, Spain. 4 Intensive Care Unit, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. 5 Intensive Care Unit, Hospital Universitario A Coruña, La Coruña, Spain. 6 Intensive Care Unit, Hospital Universitario Virgen de Arrixaca, Murcia, Spain. 7 Intensive Care Unit, Hospital Universitario Río Hortega, Valladolid, Spain. 8 Intensive Care Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. 9 Intensive Care Unit, Hospital Virgen de la Luz, Cuenca, Spain. 10 Department of Anesthesiology, Hospital Clínico Universitario de Valencia, Valencia, Spain. 11 Intensive Care Unit, Complejo Asistencial Universitario de León, León, Spain. 12 Intensive Care Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. 13 Intensive Care Unit, Hospital Universitario NS de Candelaria, Santa Cruz de Tenerife, Spain. 14 Intensive Care Unit, Fundación Hospital Universitario Jiménez Díaz, Madrid, Spain. 15 Department of Anesthesiology and Critical Care, Hospital Clinic, Institut D'investigació August Pi i Sunyer, Barcelona, Spain. 16 Intensive Care Unit, Hospital Regional Universitario de Málaga Carlos Haya, Málaga, Spain. 17 Intensive Care Unit, Hospital Universitario Mutua Terrassa, Terrassa, Barcelona, Spain. 18 Department of Thoracic Surgery, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain. 19 Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. 20 Department of Public Health, Erasmus MC, Rotterdam, The Netherlands. 21 Department of Respiratory Care, Massachusetts General Hospital, Boston, MA. 22 Department of Anesthesiology, Harvard University, Boston, MA.

Objectives: To develop a scoring model for stratifying patients with acute respiratory distress syndrome into risk categories (Stratification for identification of Prognostic categories In the acute RESpiratory distress syndrome score) for early prediction of death in the ICU, independent of the underlying disease and cause of death.

Design: A development and validation study using clinical data from four prospective, multicenter, observational cohorts.

Setting: A network of multidisciplinary ICUs. Read More

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Association of HLA-B Gene Polymorphisms with Type 2 Diabetes in Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan.

J Diabetes Res 2021 16;2021:6669731. Epub 2021 Jun 16.

Department of Pharmacy, University of Peshawar, Pakistan.

Human leukocyte antigen (HLA) system is the most polymorphic and gene dense region of human DNA that has shown many disease associations. It has been further divided into HLA classes I, II, and III. Polymorphism in HLA class II genes has been reported to play an important role in the pathogenesis of type 1 diabetes (T1D). Read More

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Imaging-guided cardiac resynchronization therapy: A meta-analysis of randomized controlled trials.

Pacing Clin Electrophysiol 2021 Jul 13. Epub 2021 Jul 13.

Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.

Background: Among patients with heart failure and left ventricular (LV) dysfunction despite guideline directed medical therapy, cardiac resynchronization (CRT) is an effective technology to reverse LV remodeling. Given that a large portion of patients are non-responders, alternatives to traditional LV-lead placement have been explored. A promising alternative is image targeted placement of an LV-lead to latest mechanically activated segment without scar. Read More

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Distribution of comorbidities as primary diagnoses by obesity class among patients in a large US paediatric healthcare system.

Clin Obes 2021 Jul 12:e12478. Epub 2021 Jul 12.

University of Texas Health Science Center at Houston, School of Public Health, Houston, Texas, USA.

There is little documentation of the distribution of specific health conditions across obesity classes (I, II, III), especially for paediatric populations who are seen for routine care in large United States US healthcare systems. The aim of this study was to assess the odds of presenting ≥2 obesity-related comorbidities as well as assess the overall distribution of these co-morbidities in children by class I/II/III obesity status controlling for key sociodemographic characteristics. This retrospective (2015-2019) electronic health record review analysed 49 276 patients from the Children's Health System of Texas diagnosed with obesity-related health conditions by obesity status (no obesity, class I, II, III). Read More

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Total Laparoscopic Hysterectomy: Making It Safe and Successful for Obese Patients.

JSLS 2021 Apr-Jun;25(2)

Laparoscopic Institute for Gynecology and Oncology; 4370 Alpine Rd, Ste 104, Portola Valley, CA 94028-7927.

Objective: To investigate outcomes and ascertain the safety and efficacy on patients having total laparoscopic hysterectomy (TLH), stratified by body mass index (BMI), focusing on high-BMI patients.

Methods: This was a retrospective cohort study that reviewed 2,266 patients with benign gynecologic diagnoses, early cervical, endometrial, and ovarian carcinoma from September 1996 to October 2017. BMI was from 14. Read More

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Efficacy and safety of fremanezumab in patients with episodic and chronic migraine with documented inadequate response to 2 to 4 classes of migraine preventive medications over 6 months of treatment in the phase 3b FOCUS study.

J Headache Pain 2021 Jul 10;22(1):68. Epub 2021 Jul 10.

Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty of the University Duisburg-Essen, Essen, Germany.

Background: Fremanezumab, a fully humanized monoclonal antibody (IgG2Δa) selectively targets the calcitonin gene-related peptide and has proven efficacy for the preventive treatment of migraine. In this study, we evaluated the long-term efficacy, safety, and tolerability of monthly and quarterly fremanezumab.

Methods: Episodic migraine and chronic migraine patients completing the 12-week double-blind period of the FOCUS trial entered the 12-week open-label extension and received 3 monthly doses of fremanezumab (225 mg). Read More

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Perceived facilitating and hindering factors to exclusive breastfeeding among Latin American immigrant women living in Colmenar Viejo (Community of Madrid, Spain).

Health Soc Care Community 2021 Jul 10. Epub 2021 Jul 10.

Nursing Department, Universidad Autónoma de Madrid, Madrid, Spain.

The way in which an infant is breastfed by a migrant woman reflects her bio-psycho-social circumstances and her process of cultural transformation and adaptation to the host country. Exploring facilitating and hindering factors to exclusive breastfeeding (EBF) of immigrant mothers in Spain is essential for the development of guidelines that protect EBF. The aim of this qualitative study is to explore the factors perceived as facilitating or hindering EBF during the first six months of the baby's life by Latin American women living in Colmenar Viejo, a city in the Community of Madrid (Spain). Read More

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An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus.

Paediatr Drugs 2021 Jul 10;23(4):331-347. Epub 2021 Jul 10.

Children and Adolescent Institute, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.

Childhood-onset systemic lupus erythematosus (cSLE) is a prototype of a multisystemic, inflammatory, heterogeneous autoimmune condition. This disease is characterized by simultaneous or sequential organ and system involvement, with unpredictable flare and high levels of morbidity and mortality. Racial/ethnic background, socioeconomic status, cost of medications, difficulty accessing health care, and poor adherence seem to impact lupus outcomes and treatment response. Read More

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Impact of rescanning and repositioning on radiomic features employing a multi-object phantom in magnetic resonance imaging.

Sci Rep 2021 Jul 9;11(1):14248. Epub 2021 Jul 9.

Department of Diagnostic and Interventional Radiology, Institute for Diagnostic and Interventional Radiology, University Hospital Frankfurt, Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Our purpose was to analyze the robustness and reproducibility of magnetic resonance imaging (MRI) radiomic features. We constructed a multi-object fruit phantom to perform MRI acquisition as scan-rescan using a 3 Tesla MRI scanner. We applied T2-weighted (T2w) half-Fourier acquisition single-shot turbo spin-echo (HASTE), T2w turbo spin-echo (TSE), T2w fluid-attenuated inversion recovery (FLAIR), T2 map and T1-weighted (T1w) TSE. Read More

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Operative treatment of fragility fractures of the pelvis is connected with lower mortality. A single institution experience.

PLoS One 2021 9;16(7):e0253408. Epub 2021 Jul 9.

Department of Orthopaedics and Traumatology, University Medical Center, Mainz, Germany.

Background: Fragility fractures of the pelvis (FFP) represent an increasing clinical entity. Until today, there are no guidelines for treatment of FFP. In our center, recommendation for operative treatment was given to all patients, who suffered an FFP type III and IV and to patients with an FFP type IIwith unsuccessful non-operative treatment. Read More

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The Airway Volume Related to the Maxillo-Mandibular Position Using 3D Analysis.

Biomed Res Int 2021 21;2021:6670191. Epub 2021 Jun 21.

Centre of Excellence in Morphological and Surgical Studies, University of La Frontera, Chile.

Objective: The aim of this research was to compare three cephalometric analyses and their correlation with the airway volume in subjects with different skeletal classes using 2D and 3D images. . Cross-sectional descriptive study. Read More

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Latest Advances for the Treatment of Chronic Plaque Psoriasis with Biologics and Oral Small Molecules.

Biologics 2021 29;15:247-253. Epub 2021 Jun 29.

Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.

Psoriasis is a common immune-mediated chronic skin disease. Disease severity is influenced by several factors including the extent and localization of skin lesions, severity of pruritus and comorbidities, such as psoriatic arthritis. Moderate to severe psoriasis is defined when cutaneous involvement is diffuse, covering more than 10% of the body surface areas and/or involving the sensitive areas such as face, genitalia, folds or nails or has high impact on patients' quality of life, and it occurs in approximately 15% of cases. Read More

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