13,077 results match your criteria class led

Environmental assessment, mechanical behavior, and chemical properties of self-compacting mortars (SCMs) with harbor dredged sediments to be used in construction.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

University Lille, ULR 4515 - LGCgE, Laboratoire de Génie Civil et géo-Environnement, F-59000, Lille, France.

Environmental and ecological issues have led to the development of new sustainable channels for the recovery of dredged sediments. One of the major difficulties of sediment valorization lies in particular in its very heterogeneous composition. For example, the presences of heavy metals and organic matter have a significant influence on the environmental impact of materials formulated with sediment. Read More

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The MD Anderson Cancer Hospital That R. Lee Clark Built.

Charles M Balch

Ann Surg Oncol 2021 Jun 14. Epub 2021 Jun 14.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The MD Anderson Hospital for Cancer Research (as it was named in 1946) incorporated pioneering changes that set new standards in hospital design, construction, and function. It is remarkable that surgeon R. Lee Clark, the new Director of the MD Anderson Hospital, and with no previous experience in hospital construction, personally led the design and supervision of a world class medical care and research facility. Read More

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Multifunctional ionic porous frameworks for CO conversion and combating microbes.

Chem Sci 2020 Jul 6;11(30):7910-7920. Epub 2020 Jul 6.

Department of Chemistry, Indian Institute of Science Education and Research Bhopal Bhopal Bypass Road, Bhauri Bhopal 462066 Madhya Pradesh India

Porous organic frameworks (POFs) with a heteroatom rich ionic backbone have emerged as advanced materials for catalysis, molecular separation, and antimicrobial applications. The loading of metal ions further enhances Lewis acidity, augmenting the activity associated with such frameworks. Metal-loaded ionic POFs, however, often suffer from physicochemical instability, thereby limiting their scope for diverse applications. Read More

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A retrospective observational study to evaluate the clinical outcomes and routine management of patients with chronic lymphocytic leukaemia treated with idelalisib and rituximab in the UK and Ireland (RETRO-idel).

Br J Haematol 2021 Jun 14. Epub 2021 Jun 14.

Department of Haematology, University Hospital of Wales, Cardiff, UK.

Idelalisib (IDL) is an oral first-in-class phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor approved for chronic lymphocytic leukaemia (CLL) alongside rituximab (R) since 2014. However, little data exist on routine practice. The RETRO-idel was a protocol-led, retrospective study of 110 patients [n = 27 front-line (1L)] who received IDL-R. Read More

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Uncovering potential interspecies signaling factors in plant-derived mixed microbial culture.

Bioorg Med Chem 2021 Jun 4;42:116254. Epub 2021 Jun 4.

Biochemistry Ph.D. Program, The Graduate Center of CUNY, 365 5(th) Ave, New York, NY 10016, USA; Chemistry Ph.D. Program, The Graduate Center of CUNY, 365 5(th) Ave, New York, NY 10016, USA; Department of Chemistry, Hunter College of CUNY, 695 Park Ave, New York, NY 10065, USA.

Microbes use signaling factors for intraspecies and interspecies communications. While many intraspecies signaling factors have been found and characterized, discovery of factors for interspecies communication is lagging behind. To facilitate the discovery of such factors, we explored the potential of a mixed microbial culture (MMC) derived from wheatgrass, in which heterogeneity of this microbial community might elicit signaling factors for interspecies communication. Read More

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Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.

Bioorg Med Chem 2021 Jun 8;42:116251. Epub 2021 Jun 8.

Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address:

Selective inhibition of histone deacetylases (HDACs) is an important strategy in the field of anticancer drug discovery. However, lack of inhibitors that possess high selectivity toward certain HDACs isozymes is associated with adverse side effects that limits their clinical applications. We have initiated a collaborative initiatives between multi-institutions aimed at the discovery of novel and selective HDACs inhibitors. Read More

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Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles.

Front Immunol 2021 25;12:637469. Epub 2021 May 25.

Selecta Biosciences, Watertown, MA, United States.

ImmTOR biodegradable nanoparticles encapsulating rapamycin have been shown to induce a durable tolerogenic immune response to co-administered biologics and gene therapy vectors. Prior mechanism of action studies have demonstrated selective biodistribution of ImmTOR to the spleen and liver following intravenous (IV) administration. In the spleen, ImmTOR has been shown to induce tolerogenic dendritic cells and antigen-specific regulatory T cells and inhibit antigen-specific B cell activation. Read More

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μSPE followed by HPLC-MS/MS for the determination of series D and E resolvins in biological matrices.

J Pharm Biomed Anal 2021 May 29;203:114181. Epub 2021 May 29.

University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment, 64100, TE, Italy.

The critical role of acute inflammatory processes is recognized in many chronic diseases; a key point in molecular mechanisms of acute inflammation resolution is represented by a new group of pro-resolving lipid mediators that include distinct families of molecules: lipoxins, resolvins, protectins and maresins, collectively termed "specialized pro-resolving mediators" (SPMs). In particular, resolvins are active in the picogram to nanogram dose range, whereby they can directly modulate a plethora of anti-inflammatory responses. The presented method proposes an analytical protocol able to extract and to quantify 6 different resolvins from 3 different matrices (plasma, cells and exudates). Read More

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Structural development of salicylanilide-based SPAK inhibitors as candidate antihypertensive agents.

ChemMedChem 2021 Jun 9. Epub 2021 Jun 9.


Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Read More

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Low-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets for cancer immunotherapy.

Oncoimmunology 2021 May 24;10(1):1916243. Epub 2021 May 24.

Molecular Pharmacology Program, Sloan Kettering Institute, New York, USA.

Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by changes in human leukocyte antigen (HLA) ligands. We investigated the effects of CDK4/6i, abemaciclib and palbociclib, on the immunopeptidome at nontoxic levels in breast cancer cell lines by biochemical identification of HLA ligands followed by network analyses. This treatment led to upregulation of HLA and revealed hundreds of induced HLA ligands in breast cancer cell lines. Read More

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The role of tazemetostat in relapsed/refractory follicular lymphoma.

Ther Adv Hematol 2021 27;12:20406207211015882. Epub 2021 May 27.

Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Large strides have been made in the treatment of follicular lymphoma (FL) over the last few years. Although the majority of patients respond to upfront therapy, many experience disease progression with a progressive shortening of subsequent treatment free intervals. New treatment options are therefore crucial for such patients. Read More

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Class IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice.

J Inflamm Res 2021 31;14:2301-2315. Epub 2021 May 31.

Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China.

Objective: Perioperative neurocognitive disorders (PND) are a common complication in the elderly. Histone deacetylases (HDACs) are a class of enzymes that control the acetylation status of intracellular proteins. Thus, we explored whether HDACs trigger the release of high mobility group box 1 (HMGB1) through altering the acetylation status in the hippocampi of aged mice. Read More

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Design, Synthesis, and Structure-Activity Relationship Studies of the Anaephene Antibiotics.

Chem Biol Drug Des 2021 Jun 8. Epub 2021 Jun 8.

Department of Chemistry, Illinois State University, Campus Box 4160, Normal, Illinois, 61790-4160, United States.

The natural products, anaephenes A (1) and B (2), were found to have antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA). In this report, we expanded on our previous synthetic efforts by preparing a library of eighteen analogues in order to understand the structure-activity relationships (SAR) of this interesting class of natural products. These analogues were selected to explore the biological impact of structural variations in the alkyl chain and on the phenol moiety. Read More

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[Spontaneous intracranial hypotension: A rare cause of headache in systemic lupus erythematosus].

Rev Med Interne 2021 Jun 4. Epub 2021 Jun 4.

Service de médecine Interne, CHU de Caen Normandie, 14000 Caen, France.

Introduction: Spontaneous intracranial hypotension (SIH), a rare cause of headache, may be idiopathic or secondary, in particular to Systemic Lupus Erythematosus (SLE) where it remains exceptionally evoked or documented.

Case Report: A 36-year-old woman presented with postural headache, recurrent nausea and vomiting. The discovery of a nephrotic syndrome led to the diagnosis of SLE with lupus nephropathy (class IV-G-(A)). Read More

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A CNN-based unified framework utilizing projection loss in unison with label noise handling for multiple Myeloma cancer diagnosis.

Med Image Anal 2021 May 13;72:102099. Epub 2021 May 13.

Laboratory Oncology Unit, Dr. B.R.A.IRCH, AIIMS, New Delhi 110029, India. Electronic address:

Multiple Myeloma (MM) is a malignancy of plasma cells. Similar to other forms of cancer, it demands prompt diagnosis for reducing the risk of mortality. The conventional diagnostic tools are resource-intense and hence, these solutions are not easily scalable for extending their reach to the masses. Read More

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Predicting changes in substance use following psychedelic experiences: natural language processing of psychedelic session narratives.

Am J Drug Alcohol Abuse 2021 Jun 5:1-11. Epub 2021 Jun 5.

Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

: Experiences with psychedelic drugs, such as psilocybin or lysergic acid diethylamide (LSD), are sometimes followed by changes in patterns of tobacco, opioid, and alcohol consumption. But, the specific characteristics of psychedelic experiences that lead to changes in drug consumption are unknown.: Determine whether quantitative descriptions of psychedelic experiences derived using Natural Language Processing (NLP) would allow us to predict who would quit or reduce using drugs following a psychedelic experience. Read More

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Memory Seeds Enable High Structural Phase Purity in 2D Perovskite Films for High-Efficiency Devices.

Adv Mater 2021 Jun 6:e2007176. Epub 2021 Jun 6.

Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, 77005, USA.

2D perovskites are a class of halide perovskites offering a pathway for realizing efficient and durable optoelectronic devices. However, the broad chemical phase space and lack of understanding of film formation have led to quasi-2D perovskite films with polydispersity in perovskite layer thicknesses, which have hindered device performance and stability. Here, a simple and scalable approach is reported, termed as the "phase-selective method", to fabricate 2D perovskite thin films with homogenous layer thickness (phase purity). Read More

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Uncovering biosynthetic relationships between antifungal nonadrides and octadrides.

Chem Sci 2020 Oct 7;11(42):11570-11578. Epub 2020 Oct 7.

School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK

Maleidrides are a class of bioactive secondary metabolites unique to filamentous fungi, which contain one or more maleic anhydrides fused to a 7-, 8- or 9- membered carbocycle (named heptadrides, octadrides and nonadrides respectively). Herein structural and biosynthetic studies on the antifungal octadride, zopfiellin, and nonadrides scytalidin, deoxyscytalidin and castaneiolide are described. A combination of genome sequencing, bioinformatic analyses, gene disruptions, biotransformations, isotopic feeding studies, NMR and X-ray crystallography revealed that they share a common biosynthetic pathway, diverging only after the nonadride deoxyscytalidin. Read More

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October 2020

A class of analytic solutions for verification and convergence analysis of linear and nonlinear fluid-structure interaction algorithms.

Comput Methods Appl Mech Eng 2020 Apr 15;362. Epub 2020 Apr 15.

Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, NCRC B20, 2800 Plymouth Rd, Ann Arbor, 48109, United States of America.

Fluid-structure interaction (FSI) problems are pervasive in the computational engineering community. The need to address challenging FSI problems has led to the development of a broad range of numerical methods addressing a variety of applicationspecific demands. While a range of numerical and experimental benchmarks are present in the literature, few solutions are available that enable both verification and spatiotemporal convergence analysis. Read More

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Comparison of the materno-fetal transfer of fifteen structurally related bisphenol analogues using an ex vivo human placental perfusion model.

Chemosphere 2021 Aug 15;276:130213. Epub 2021 Mar 15.

ToxAlim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France. Electronic address:

Regulatory measures and public concerns regarding bisphenol A (BPA) have led to its replacement by a variety of alternatives in consumer products. Due to their structural similarity to BPA, these alternatives are under surveillance, however, for potential endocrine disruption. Understanding the materno-fetal transfer of these BPA-related alternatives across the placenta is therefore crucial to assess prenatal exposure risks. Read More

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Biomarker Jeopardy.

J Adv Pract Oncol 2021 Apr 1;12(3):285-288. Epub 2021 Apr 1.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

The popular Biomarker Jeopardy session returned this year at JADPRO Live 2020. Sandra E. Kurtin, PhD, ANP-C, AOCN®, led the session, and was joined by Alyssa Henglefelt, PharmD, BCOP, and Allyson Price, PA-C. Read More

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A high-density narrow-field inhibitory retinal interneuron with direct coupling to Müller glia.

J Neurosci 2021 Jun 1. Epub 2021 Jun 1.

Department of Physiology and Biophysics, University of Washington, Seattle, WA.

Amacrine cells are interneurons composing the most diverse cell class in the mammalian retina. They help encode visual features such as edges or directed motion by mediating excitatory and inhibitory interactions between input (i.e. Read More

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Study protocol: a mixed methods study to assess the psychological impact of the COVID-19 pandemic among Portuguese and Swiss higher education students.

JMIR Res Protoc 2021 May 26. Epub 2021 May 26.

School of Health Sciences, Polytechnic of Leiria, Campus 2 - Morro do Lena - Alto do Vieiro; Apartado 4137, Leiria, PT.

Background: Higher education students are particularly vulnerable to both everyday stressors and mental health problems. Public health emergencies may generate a range of unforeseen potential stressors for vulnerable individuals and communities. The current pandemic has apparently led to an increase in psychiatric symptoms among these students. Read More

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CircHECTD1 Regulates Cell Proliferation and Migration by the miR-320-5p/SLC2A1 Axis in Glioblastoma Multiform.

Front Oncol 2021 17;11:666391. Epub 2021 May 17.

Department of Anatomy and Neurobiology, Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, China.

Glioblastoma multiform (GBM) is the most common and malignant primary brain cancer in adults, and thus, novel potential therapeutic targets for diagnosis and treatment are urgently needed. Circular RNAs (circRNAs) are a class of widespread and diverse endogenous RNAs that have been suggested as potential critical mediators during progression of various tumors. In this study, we investigated the involvement of circHECTD1 in GBM progression. Read More

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Rapid high-intensity light-curing of bulk-fill composites: A quantitative analysis of marginal integrity.

J Dent 2021 May 30;111:103708. Epub 2021 May 30.

Department of Conservative and Preventive Dentistry, Center for Dental Medicine, University of Zurich, Plattenstrasse 11, Zurich, Switzerland. Electronic address:

Objectives: To investigate the effect of rapid high-intensity light-curing on the marginal integrity of four bulk-fill composites, including two materials specifically designed for high-intensity curing.

Methods: Class V cavities were prepared on buccal surfaces of intact human molars with simulated pulpal pressure, filled in a single increment and light-cured using a conventional (10 s @ 1,340 mW/cm) or high-intensity (3 s @ 3,440 mW/cm) protocol. The restorations were subjected to thermo-mechanical loading (TML) comprising 1,200,000 mechanical loading cycles and 3,000 thermocycles. Read More

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Mutations as Actionable Targets: A Paradigm Shift in the Management of Colorectal Cancer and Novel Avenues.

JCO Oncol Pract 2021 Jun 2:OP2100160. Epub 2021 Jun 2.

MD Anderson Cancer Center, Houston, TX.

mutations in colorectal cancer have been studied over the past several decades. V600E mutation, a class I mutation, is the most common oncogenic alteration in colorectal cancer. Until recently, the V600E mutation was not among actionable genes for colorectal cancer. Read More

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Incorporating a Civility Program Into a Healthcare System: Journey or Expedition?

Clin Nurse Spec 2021 Jul-Aug 01;35(4):171-179

Author Affiliations: Clinical Nurse Specialist (Drs Garcia and Tidwell, Mss Allen and Watt) and Nurse Scientist (Dr Griffis), Children's Health, Children's Medical Center Dallas, Texas.

Purpose/objectives: Incivility contributes to employee dissatisfaction, turnover, patient errors, and a disrespectful culture. Turnover rates and employee exit interviews alerted hospital leaders to uncivil behaviors exhibited by staff. A clinical nurse specialist (CNS) team captured this as an opportunity to create a civility program to develop team cohesiveness and improve patient safety. Read More

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Factors influencing the involvement of doctor of pharmacy students in research and scholarship projects.

Curr Pharm Teach Learn 2021 Jul 5;13(7):796-803. Epub 2021 Apr 5.

College of Pharmacy, Ferris State University, 25 Michigan NE, Suite 7000, Grand Rapids, MI 49503, United States. Electronic address:

Introduction: The study objective was to determine factors that stimulate or hinder student pharmacist participation in research and scholarship, to determine factors faculty believe are motivators or barriers for student pharmacist participation, and to compare student and faculty responses.

Methods: An electronic questionnaire was developed and emailed to all students enrolled in the doctor of pharmacy program and to all program faculty. To increase response rate, students were provided class time to complete the survey. Read More

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Statistical Methods for Degradation Estimation and Anomaly Detection in Photovoltaic Plants.

Sensors (Basel) 2021 May 27;21(11). Epub 2021 May 27.

SAL Silicon Austria Labs GmbH, Europastr. 12, 9524 Villach, Austria.

Photovoltaic (PV) plants typically suffer from a significant degradation in performance over time due to multiple factors. Operation and maintenance systems aim at increasing the efficiency and profitability of PV plants by analyzing the monitoring data and by applying data-driven methods for assessing the causes of such performance degradation. Two main classes of degradation exist, being it either gradual or a sudden anomaly in the PV system. Read More

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Small RNA-Sequencing: Approaches and Considerations for miRNA Analysis.

Diagnostics (Basel) 2021 May 27;11(6). Epub 2021 May 27.

Laboratory of Gene Expression, Institute of Biotechnology, CAS, BIOCEV, 252 50 Vestec, Czech Republic.

MicroRNAs (miRNAs) are a class of small RNA molecules that have an important regulatory role in multiple physiological and pathological processes. Their disease-specific profiles and presence in biofluids are properties that enable miRNAs to be employed as non-invasive biomarkers. In the past decades, several methods have been developed for miRNA analysis, including small RNA sequencing (RNA-seq). Read More

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