23,114 results match your criteria class indicated


Molecular insights of a novel fish Toll-like receptor 9 homologue in Nibea albiflora to reveal its function as PRRs.

Fish Shellfish Immunol 2021 Sep 20. Epub 2021 Sep 20.

National and Provincial Joint Laboratory of Exploration and Utilization of Marine Aquatic Genetic Resources, National Engineering Research Center of Marine Facilities Aquaculture, Zhejiang Ocean University, Zhoushan, 316022, PR China.

Toll-like receptors (TLRs) are an important class of molecules involved in non-specific immunity, and they are also the bridge connecting between non-specific immunity and specific immunity. As a vital member of TLR family TLR9 can be activated by bacterial DNA and induce the production of inflammatory cytokines. In this study, a full length of TLR9 homologue of 3677 bp in Nibea albiflora (named as NaTLR9, GenBank accession no: MN125017. Read More

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September 2021

An Example of Functional Integration and Application of Diversity, Inequities and Social Determinants of Health in an Applied Physiology Course.

Adv Physiol Educ 2021 Sep 23. Epub 2021 Sep 23.

Lincoln LGBTQ+ Resource Center, Gonzaga University, Spokane, WA, United States.

Increasing diversity, and including diverse perspectives in STEM classrooms and teaching practices is recognized as a current higher education priority. Resources to assist institutions and instructors are growing, however many STEM instructors still hesitate to implement diverse teaching practices and discussions of diversity issues in their courses for a variety of reasons. This paper describes an example of the incorporation and discussion of diversity and social justice issues as part of an upper-level physiology of aging course. Read More

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September 2021

Synthesis and fluorescence properties of red-to-near-infrared-emitting push-pull dyes based on benzodioxazole scaffolds.

J Mater Chem B 2021 Sep 23. Epub 2021 Sep 23.

Department of Chemistry and COSDAF (Centre of super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.

Fluorescence imaging with high temporal and spatial resolution has emerged as one of the most promising techniques to monitor biomolecules and biological processes in living systems. Among many kinds of small molecular fluorescent dyes, 2,1,3-benzoxadiazole (BD) derivatives have been widely applied in many chemical and biological applications due to their excellent photophysical properties. However, only a limited number of BD dyes with long emission wavelengths were reported. Read More

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September 2021

Chlorpyrifos in environment and food: a critical review of detection methods and degradation pathways.

Environ Sci Process Impacts 2021 Sep 23;23(9):1255-1277. Epub 2021 Sep 23.

Applied and Industrial Microbiology Lab, Department of Biotechnology, Indian Institute of Technology Madras, Chennai-600036, India.

Chlorpyrifos (CP) is a class of organophosphorus (OP) pesticides, which find extensive applications as acaricide, insecticide and termiticide. The use of CP has been indicated in environmental contamination and disturbance in the biogeochemical cycles. CP has been reported to be neurotoxic and has a detrimental effect on immunological and psychological health. Read More

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September 2021

Bioinformatics analyses of gene expression profile identify key genes and functional pathways involved in cutaneous lupus erythematosus.

Clin Rheumatol 2021 Sep 23. Epub 2021 Sep 23.

Department of Rheumatology and Immunology, The Affiliated Hospital of Hubei Minzu University, Enshi, Hubei Province, China.

Background: Lupus erythematosus is an autoimmune disease that causes damage to multiple organs ranging from skin lesions to systemic manifestations. Cutaneous lupus erythematosus (CLE) is a common type of lupus erythematosus (LE), but its molecular mechanisms are currently unknown. The study aimed to explore changes in the gene expression profiles and identify key genes involved in CLE, hoping to uncover its molecular mechanism and identify new targets for CLE. Read More

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September 2021

Social Determinants Do Not Determine Me.

Authors:
Haleigh Prather

Pediatrics 2021 Sep 22. Epub 2021 Sep 22.

Oregon Health & Science University, Portland, Oregon

The following is the winning submission from the fifth annual Section on Pediatric Trainees Monthly Feature essay competition. For this year's competition, we asked trainees to reflect on and share how their unique identity, or identities, informs their advocacy work on behalf of children and families. We asked writers to consider how their personal histories and backgrounds, including sex, sexual orientation, race, ethnicity, religion, geographic area, and life experiences improve equity in pediatric health care. Read More

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September 2021

CircRNA-1967 participates in the differentiation of goat SHF-SCs into hair follicle lineage by sponging miR-93-3p to enhance LEF1 expression.

Anim Biotechnol 2021 Sep 22:1-13. Epub 2021 Sep 22.

College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.

Circular RNAs (circRNAs), a novel class of non-coding RNAs, can interact with miRNAs through a sequence-driven sponge mechanism, thereby regulating the expression of their downstream target genes. CircRNA-1967 was found in secondary hair follicles (SHFs) of cashmere goats, but its functions are not clear. Here, we showed that both circRNA-1967 and its host gene BNC2 had significantly higher expression in SHF bulge at anagen than those at telogen of cashmere goats. Read More

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September 2021

Early adolescent psychological adaptation differences by stress-coping profiles: a latent transition analysis.

Anxiety Stress Coping 2021 Sep 22:1-18. Epub 2021 Sep 22.

Graduate School of Education, The University of Tokyo, Tokyo, Japan.

Background & Objectives: This study sought to reveal adolescent coping profiles by focusing on the combination of help-seeking and active/passive coping styles, and to compare affective and school adaptation levels across different profiles.

Design: One-year longitudinal data were collected from 695 Japanese secondary-school students (359 males, 330 females, and 6 unknowns) every semester. All participants reported their positive/negative affect and school adaptation. Read More

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September 2021

Anti-interleukin-5 in the Management of Eosinophilic Asthma: A Review of Effectiveness, Safety, and Budgetary Impact From the Perspective of the Brazilian Health System.

Value Health Reg Issues 2021 Sep 18;26:169-181. Epub 2021 Sep 18.

Universidade Federal de Mato Grosso - UFMT/Universidade de Várzea Grande-MT, Cuiabá-MT, Brasil.

Objectives: To evaluate the efficacy and safety of anti-interleukin-5 class therapy agents in the treatment of eosinophilic asthma and the financial impact of these drugs on the Brazilian and Mato Grosso public health systems.

Methods: The literature review in important databases was guided by a structured research question including patient or population, intervention, comparator, outcome and type of study. The retrieved studies went through a screening, selection, data extraction, and methodological quality assessment process. Read More

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September 2021

Single and simultaneous effects of naphthalene and salinity on anaerobic digestion: Response surface methodology, microbial community analysis and potential functions prediction.

Environ Pollut 2021 Sep 16;291:118188. Epub 2021 Sep 16.

School of Environmental Science and Engineering, China-America CRC for Environment & Health, Shandong University, 72#Jimo Binhai Road, Qingdao, Shandong Province, 266237, China. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) are a persistent and prevalent class of pollutants in petroleum-contaminated saline environment, which pose potential harm to organisms. Researches on anaerobic biodegradation of PAHs are gradually emerging, but the response of anaerobic microorganisms to salinity changes and the co-effects of salinity and PAHs in anaerobic digestion (AD) system have seldom been reported. Thus, we investigated the variations of AD system performance and anaerobic microbial community caused by different concentrations of naphthalene (Nap) or/and NaCl based on Box-Behnken Design (0 mg/L ≤ Nap ≤150 mg/L, 0 g/L ≤ NaCl ≤25 g/L). Read More

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September 2021

Way to Enforce Selectivity via Steric Hindrance: Improvement of Am(III)/Eu(III) Solvent Extraction by Loaded Diphosphonic Acid Esters.

Inorg Chem 2021 Sep 21. Epub 2021 Sep 21.

Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, Building 3, Moscow 119991, Russian Federation.

Hybrid donor extractants are a promising class of compounds for the separation of trivalent actinides and lanthanides. Here, we investigated a series of sterically loaded diphosphonate ligands based on bipyridine (BiPy-PO-iPr and BiPy-PO-cHex) and phenanthroline (Phen-PO-iPr and Phen-PO-cHex). We studied their complex formation with nitrates of trivalent f-elements in solvent extraction systems (Am and Eu) and homogeneous acetonitrile solutions (Nd, Eu, and Lu). Read More

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September 2021

The pattern of romantic and sexual related experiences among Chinese young adolescents: an exploration with multi-group latent class analysis.

Reprod Health 2021 Sep 20;18(1):184. Epub 2021 Sep 20.

NHC Key Lab. of Reproductive Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, 779 Old Hu Min Road, 200237, Shanghai, People's Republic of China.

Background: Studies on very young adolescents' romantic and sexual experiences would help inform the context in which early sex arises. However, such studies are scant in China due to sparse data and cultural issues.

Method: This study used the GEAS baseline data conducted among1776 adolescents in Shanghai. Read More

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September 2021

pQLyCar: Peptide-based dynamic query-driven sample rescaling strategy for identifying carboxylation sites combined with KNN and SVM.

Anal Biochem 2021 Sep 17:114386. Epub 2021 Sep 17.

School of Information Science and Technology, Northeast Normal University, Changchun, 130117, China.

Lysine carboxylation is one of the most crucial type of post-translation modification, which plays a significant role in catalytic mechanisms. Therefore, it is essential to study lysine carboxylation and explore its biological mechanism. Compared with traditional experimental methods that are labor-intensive and time-consuming, computational methods are much more convenience and faster. Read More

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September 2021

Family Socioeconomic Status and Learning Engagement in Chinese Adolescents: The Multiple Mediating Roles of Resilience and Future Orientation.

Front Psychol 2021 2;12:714346. Epub 2021 Sep 2.

Nanjing Zhonghua High School, Nanjing, China.

This study explored the mediating effects of resilience and future orientation on the relationship between family socioeconomic status (SES) and learning engagement within the context of Chinese culture based on the cognitive theory of social class. A total of 1,245 junior high school students were recruited to complete anonymous questionnaires regarding the objective and subjective SES of their families, resilience, future orientation, and learning engagement. The mediating effects were tested by stepped multiple linear regression. Read More

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September 2021

Computational Design and Analysis of a Multi-epitope Against Influenza A virus.

Int J Pept Res Ther 2021 Sep 12:1-14. Epub 2021 Sep 12.

Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, 69, P.O.Box: 1316943551, Tehran, Iran.

Influenza A viruses are among the most studied viruses, however no effective prevention against influenza infection has been developed. So, designing an effective vaccine against Influenza A virus is a critical issue in the field of medical biotechnology. For this reason, to combat this disease, we have designed a novel multi-epitope vaccine candidate based on the several conserved and potential linear B-cell and T-cell binding epitopes by using the in silico approach. Read More

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September 2021

Analysis of influencing factors on the duration of pediatric peripheral intravenous catheter.

J Vasc Access 2021 Sep 18:11297298211044024. Epub 2021 Sep 18.

The First Hospital of Hunan University of Chinese Medicine, The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Background: The application of peripheral intravenous catheter has been an effective guarantee for the success of pediatric therapy. We aimed to investigate the correlative factors that impacting the duration of pediatric peripheral intravenous catheter.

Methods: From January 2017 to October 2017, 370 cases of pediatric patients in the First Hospital of Hunan University of Chinese Medicine were collected as the research object. Read More

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September 2021

Pediatric hemispherectomy outcome: Adaptive functioning, intelligence, and memory.

Epilepsy Behav 2021 Sep 16;124:108298. Epub 2021 Sep 16.

Neurosciences, Seattle Children's Hospital, United States; Center for Integrated Brain Research, Seattle Children's Hospital, United States; Department of Neurology, University of Washington School of Medicine, United States; Division of Pediatric Neurology, Seattle Children's Hospital, United States.

Objective: Our purpose was to characterize neuropsychological evaluation (NP) outcome following functional hemispherectomy in a large, representative cohort of pediatric patients.

Methods: We evaluated seizure and NP outcomes and medical variables for all post-hemispherectomy patients from Seattle Children's Hospital epilepsy surgery program between 1996 and 2020. Neuropsychological evaluation outcome tests used were not available on all patients due to the diversity of patient ages and competency that is typical of a representative pediatric cohort; all patients had at least an adaptive functioning or intelligence measure, and a subgroup had memory testing. Read More

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September 2021

The efficacy and safety of novel classes of glucose-lowering drugs for cardiovascular outcomes: a network meta-analysis of randomised clinical trials.

Diabetologia 2021 Sep 18. Epub 2021 Sep 18.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Aims/hypothesis: Several cardiovascular outcome trials on sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been released recently, including trials enrolling patients with congestive heart failure (CHF) and chronic kidney disease (CKD). Comparisons of the efficacy and safety of SGLT2i, glucagon-like peptide-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i) thus require an update. Assessments in patient subgroups, i. Read More

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September 2021

Can mental health competence reduce the higher risk of smoking initiation among teenagers with parents who smoke?

Eur J Public Health 2021 Sep 18. Epub 2021 Sep 18.

Population, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.

Background: Parental smoking strongly influences adolescent smoking, yet few studies have examined factors that may protect against this. We investigated whether skills-based components of positive mental health ('mental health competence', MHC) modified the association between parental and teenager smoking, in the UK-representative Millennium Cohort Study (approximately 18 000 children, born 2000-02; analytic sample: n = 10 133).

Methods: Cohort members (CMs) reported at 14 years (y) whether they had ever smoked cigarettes. Read More

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September 2021

Investigation on Potential of Chitosan Nanoparticles for Oral Bioavailability Enhancement of Risedronate Sodium.

AAPS PharmSciTech 2021 Sep 17;22(7):236. Epub 2021 Sep 17.

Centre for Post Graduate Studies and Research in Pharmaceutical Sciences, Shri G.H.Patel Pharmacy Building, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, 390002, India.

Risedronate sodium (RS) is used in osteoporosis for bone reabsorption. It is a BCS class III drug having poor oral bioavailability (<0.63%) due to low permeability. Read More

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September 2021

Indomethacin-based PROTACs as pan-coronavirus antiviral agents.

Eur J Med Chem 2021 Sep 4;226:113814. Epub 2021 Sep 4.

Department of Chemistry, Biology, and Biotechnology, University of Perugia, Italy. Electronic address:

Indomethacin (INM), a well-known non-steroidal anti-inflammatory drug, has recently gained attention for its antiviral activity demonstrated in drug repurposing studies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Although the mechanism of action of INM is not yet fully understood, recent studies have indicated that it acts at an early stage of the coronaviruses (CoVs) replication cycle. In addition, a proteomic study reported that the anti-SARS-CoV-2 activity of INM could be also ascribed to its ability to inhibit human prostaglandin E synthase type 2 (PGES-2), a host protein which interacts with the SARS-CoV-2 NSP7 protein. Read More

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September 2021

Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets.

J Cell Physiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi, India.

Glioblastoma (GBM) is the most aggressive, malignant, and therapeutically challenging Grade IV tumor of the brain. Although the possibility of distant metastasis is extremely rare, GBM is known to cause intracranial metastasis forming aggressive secondary lesions resulting in a dismal prognosis. Metastasis also plays an important role in tumor dissemination and recurrence making GBM largely incurable. Read More

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September 2021

CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer.

Ann Transl Med 2021 Aug;9(15):1236

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer (BC) subtypes. Circular ribonucleic acids (circRNAs) are a class of novel stable and conserved forms of ribonucleic acids (RNAs). circRNAs have been documented to be involved in multiple diseases, especially malignancies, through a competing endogenous RNA (ceRNA) mechanism. Read More

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Relationship Between Sleep-Wake Disturbance and Risk of Malnutrition in Hospitalized Patients With Cirrhosis.

Front Nutr 2021 31;8:719176. Epub 2021 Aug 31.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

Both sleep-wake disturbance and malnutrition are common in cirrhosis and might be associated with similar adverse outcomes, such as impaired health-related quality of life, hepatic encephalopathy, and sarcopenia, but there is no study investigating the relationship between these two. We aimed to explore the relationship between sleep-wake disturbance [estimated by the Pittsburgh Sleep Quality Index (PSQI)] and malnutrition risk [estimated by the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT)]. About 150 patients with cirrhosis were prospectively recruited. Read More

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A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy.

Urol Case Rep 2021 Nov 5;39:101834. Epub 2021 Sep 5.

Cleveland Clinic Akron General Urology Program, Akron, OH, 44307, USA.

Dapagliflozin (Farxiga), is an SGLT-2 inhibitor commonly indicated for the treatment of diabetes mellitus type 2 (DM 2), heart failure, and chronic kidney disease. One rare side effect associated with SGLT-2 inhibitors is bacterial infection of the genitalia. There are several case reports highlighting the incidence of Fournier's gangrene (FG) in patients who take medications within this drug class. Read More

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November 2021

Adaptation of the endemic coronaviruses HCoV-OC43 and HCoV-229E to the human host.

Virus Evol 2021 24;7(2):veab061. Epub 2021 Jun 24.

Scientific Institute IRCCS E. MEDEA, Bioinformatics, via don Luigi Monza, 23843 Bosisio Parini, Italy.

Four coronaviruses (HCoV-OC43, HCoV-HKU1, HCoV-NL63, and HCoV-229E) are endemic in human populations. All these viruses are seasonal and generate short-term immunity. Like the highly pathogenic coronaviruses, the endemic coronaviruses have zoonotic origins. Read More

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Direct synthesis of -methyl benzaldehyde from acetaldehyde via an organic amine-catalyzed dehydrogenation mechanism.

iScience 2021 Sep 23;24(9):103028. Epub 2021 Aug 23.

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

-Methyl benzaldehyde (-MBA) is a class of key chemical intermediates of pharmaceuticals. Conventional industrial processes for -MBA production involve the consecutive photochlorination, amination, and acid hydrolysis of petroleum-derived -xylene, while producing vast pollutants and waste water. Herein, we report a direct, green route for selective synthesis of -MBA from acetaldehyde using a diphenyl prolinol trimethylsilyl ether catalyst. Read More

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September 2021

Development and in vitro and in vivo evaluations of a microemulsion formulation for the oral delivery of oxaprozin.

Curr Drug Deliv 2021 Sep 13. Epub 2021 Sep 13.

College of pharmacy, China Medical University, Shenyang. China.

Background: Oxaprozin is labeled as a Class II drug in the biopharmaceutical classification system, and its poor solubility in the entire gastrointestinal tract may be the main reason for its poor oral absorption capacity.

Objective: The purpose of this study was to develop an oxaprozin formulation to enhance its oral absorption.

Method: Oxaprozin-loaded microemulsions were prepared using the titration method and pseudoternary phase diagram. Read More

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September 2021

Problematic internet use profiles and psychosocial risk among adolescents.

PLoS One 2021 14;16(9):e0257329. Epub 2021 Sep 14.

Angela Boškin Faculty of Health Care, Jesenice, Slovenia.

Objective: Although Problematic Internet Use (PIU) is an emerging area of study in psychology, little is known about the unique features of specific subgroups of internet users and their psychosocial vulnerabilities within robust and nationwide populations.

Methods: The aim of this study was to identify distinct latent groups of internet users based on their PIU risk and to compare their psychosocial outcomes. To achieve this, a nationally representative sample of adolescents of the same grade (N = 1,066, Meanage = 13. Read More

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September 2021

Comparative molecular evolution of chitinases in ascomycota with emphasis on mycoparasitism lifestyle.

Microb Genom 2021 Sep;7(9)

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.

Chitinases are involved in multiple aspects of fungal life cycle, such as cell wall remodelling, chitin degradation and mycoparasitism lifestyle. To improve our knowledge of the chitinase molecular evolution of Ascomycota, the gene family of 72 representatives of this phylum was identified and subjected to phylogenetic, evolution trajectory and selective pressure analyses. Phylogenetic analysis showed that the chitinase gene family size and enzyme types varied significantly, along with species evolution, especially for groups B and C. Read More

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September 2021