Neurology 2020 06 5;94(22):e2337-e2345. Epub 2020 May 5.
From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.
Objective: Because little is known about associations between biomarkers of vascular injury and stroke risk, we evaluated associations between plasma concentrations of 6 novel biomarkers of vascular injury and stroke risk in a population-based study.
Methods: A case-cohort subset of EPIC-Heidelberg (European Prospective Investigation for Cancer and Nutrition-Heidelberg) including incident stroke cases (n = 335) and a random subcohort (n = 2,418) was selected. Concentrations of intercellular adhesion molecule 3 (ICAM3), soluble E-selectin and P-selectin, soluble thrombomodulin (sTM), thrombopoietin, and glycoprotein IIb/IIIa were measured in baseline plasma samples. Read More