748 results match your criteria class iiia


The first reported case of neonatal alloimmune thrombocytopenia due to low-frequency human platelet antigen-6b antibodies in the United Kingdom.

Transfusion 2021 Jun 22. Epub 2021 Jun 22.

H&I Department, NHSBT, Filton, United Kingdom.

Background: Neonatal alloimmune thrombocytopenia (NAIT) is a potentially serious clinical condition caused by maternal alloantibodies directed to human platelet antigens (HPA), inherited from the father and expressed on fetal/neonatal platelets. We report a case of an otherwise well, full term child, with a profound thrombocytopenia (33 x 109/L). There was no bleeding or obvious explanation for the low platelet count. Read More

View Article and Full-Text PDF

Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients.

World J Gastroenterol 2021 May;27(19):2376-2393

Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.

Background: Sepsis is a common disease in intensive care units, with high morbidity and mortality. Intestinal microecology plays a vital part in the development and progression of this disease, possibly because sepsis and its treatment cause specific changes in the composition of the intestinal flora.

Aim: To investigate the characteristics of intestinal flora disturbance in sepsis patients treated with antibiotics. Read More

View Article and Full-Text PDF

Clinical and Radiographic Predictors of Nonunion in Open Tibial Shaft Fractures.

Orthopedics 2021 May-Jun;44(3):142-147. Epub 2021 May 1.

Open fracture is a risk factor for nonunion of diaphyseal tibia fractures. Compared with closed injuries, there is a relative lack of scientific knowledge regarding the healing of open tibia fractures. The objective of this study was to investigate which patient, injury, and surgeon-related factors predict nonunion in open tibial shaft fractures. Read More

View Article and Full-Text PDF

Occurrence of multidrug-resistant Enterococcus faecium isolated from environmental samples.

Lett Appl Microbiol 2021 Aug 24;73(2):237-246. Epub 2021 May 24.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Enterococcus species are present in the microbiota of humans and animals and have also been described in the environment. Among the species, Enterococcus faecium is one of the main pathogens associated with nosocomial infections worldwide. Enterococcus faecium isolates resistant to different classes of antimicrobials have been increasingly reported, including multidrug-resistant (MDR) isolates in environmental sources, which is worrying. Read More

View Article and Full-Text PDF

Multifunctional pathology-mapping theranostic nanoplatforms for US/MR imaging and ultrasound therapy of atherosclerosis.

Nanoscale 2021 May 30;13(18):8623-8638. Epub 2021 Apr 30.

Department of Ultrasound, Laboratory of Ultrasound Imaging and Drug, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Atherosclerotic thrombosis is the leading cause of most life-threatening cardiovascular diseases (CVDs), particularly as a result of rupture or erosion of vulnerable plaques. Rupture or erosion-prone plaques are quite different in cellular composition and immunopathology, requiring different treatment strategies. The current imaging technology cannot distinguish the types of vulnerable plaques, and thus empirical treatment is still applied to all without a tailored and precise treatment. Read More

View Article and Full-Text PDF

Multicenter global early feasibility study to evaluate total endovascular arch repair using three-vessel inner branch stent-grafts for aneurysms and dissections.

J Vasc Surg 2021 Apr 16. Epub 2021 Apr 16.

Aortic Center, Hôpital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph, Université Paris Saclay, Gif-sur-Yvette, France.

Objective: We evaluated the outcomes of total endovascular aortic arch repair using three-vessel inner branch stent-grafts for aneurysms and chronic dissections.

Methods: We reviewed the clinical data and outcomes of consecutive patients treated by total endovascular aortic arch repair at eight academic centers using three-vessel inner branch stent-grafts (William Cook Europe, Bjaeverskov, Denmark) from 2016 to 2019. All patients received three-vessel designs with two antegrade and one retrograde inner branch, which was used to incorporate the innominate, left common carotid, and left subclavian arteries. Read More

View Article and Full-Text PDF

Multiple retrospective analysis of survival and evaluation of cardiac death predictors in a population of dogs affected by degenerative mitral valve disease in ACVIM class C treated with different therapeutic protocols.

Pol J Vet Sci 2021 Mar;24(1):109-118

University of Milan, University Veterinary Teaching Hospital, Via dell'Università n. 6, 26900 Lodi (LO), Italy.

Clinical records of dogs with spontaneous degenerative mitral valve disease (DMVD) with clinical signs related to congestive heart failure (CHF) recruited during routine clinical practice between 2001 and 2018 at the Cardiology Unit of the Veterinary Teaching Hospital (University of Milan) were included in this retrospective cohort study. Baseline echocardiographic data were evaluated. Median survival time (MST) was calculated. Read More

View Article and Full-Text PDF

A New Classification System to Predict Functional Outcome after Laryngectomy and Laryngopharyngectomy.

Cancers (Basel) 2021 Mar 23;13(6). Epub 2021 Mar 23.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria.

(1) Objective: To evaluate long-term functional outcome in patients who underwent primary or salvage total laryngectomy (TL), TL with partial (TLPP), or total pharyngectomy (TLTP), and to establish a new scoring system to predict complication rate and long-term functional outcome; (2) Material and Methods: Between 1993 and 2019, 258 patients underwent TL ( = 85), TLPP ( = 101), or TLTP ( = 72). Based on the extent of tumor resection, all patients were stratified to (i) localization I: TL; II: TLPP; III: TLTP and (ii) surgical treatment (A: primary resection; B: salvage surgery). Type and rate of complication and functional outcome, including oral nutrition, G-tube dependence, pharyngeal stenosis, and voice rehabilitation were evaluated in 163 patients with a follow-up ≥ 12 months and absence of recurrent disease; (3) Results: We found 61 IA, 24 IB, 63 IIA, 38 IIB, 37 IIIA, and 35 IIIA patients. Read More

View Article and Full-Text PDF

Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy.

Auris Nasus Larynx 2021 Mar 6. Epub 2021 Mar 6.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1, Shinjuku-ku, Tokyo, Nishishinjuku 160-0023, Japan.

A 30-year-old man presented with swelling in the lower left ear. Close examination led to a diagnosis of parotid gland cancer, T4N0M0 Stage IVA, so total resection of the left parotid gland and left neck dissection were performed. Pathological examination led to a diagnosis of high-grade malignant-type mucoepidermoid, and chemoradiotherapy was performed as postoperative treatment. Read More

View Article and Full-Text PDF

Surgical Treatment and Proposed Modified Classification for Harrington Class III Periacetabular Metastases.

Orthop Surg 2021 Apr 4;13(2):553-562. Epub 2021 Mar 4.

Musculoskeletal Tumor Center, Beijing Key Laboratory of Musculoskeletal Tumor, Peking University People's Hospital, Beijing, China.

Objectives: This study aims to: (i) evaluate the outcome of patients with Harrington class III lesions who were treated according to Harrington classification; (ii) propose a modified surgical classification for Harrington class III lesions; and (iii) assess the efficiency of the proposed modified classification.

Methods: This study composes two phases. During phase 1 (2006 to 2011), the clinical data of 16 patients with Harrington class III lesions who were treated by intralesional excision followed by reconstruction of antegrade/retrograde Steinmann pins/screws with cemented total hip arthroplasty (Harrington/modified Harrington procedure) were retrospectively reviewed and further analyzed synthetically to design a modified surgical classification system. Read More

View Article and Full-Text PDF

Endovascular Treatment of Ruptured Wide-Necked Anterior Communicating Artery Aneurysms Using a Low-Profile Visualized Intraluminal Support (LVIS) Device.

Front Neurol 2020 28;11:611875. Epub 2021 Jan 28.

Department of Neurosurgery, Changhai Hospital, Navy Medical University, Shanghai, China.

To evaluate the safety and efficacy of low-profile visualized intraluminal support (LVIS) stent-assisted coiling for the treatment of ruptured wide-necked anterior communicating artery (ACoA) aneurysms. The clinical and angiographic data of 31 acutely ruptured wide-necked ACoA aneurysms treated with LVIS stent-assisted coiling between January 2014 and December 2018 were retrospectively reviewed. All stents were successfully deployed. Read More

View Article and Full-Text PDF
January 2021

Modulators of Mortality Benefit From Peri-Angioplasty Adjunctive Tirofiban in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Circ J 2021 01 14;85(2):166-174. Epub 2021 Jan 14.

Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital.

Background: Studies investigating the modulators of mortality benefit conferred by peri-angioplasty glycoprotein IIb/IIIa inhibitors in ST-elevation myocardial infarction (STEMI) are still lacking.Methods and Results:A prospective database (n=1,025) of consecutive cases undergoing primary percutaneous coronary intervention for STEMI was retrospectively analyzed. For patients in Killip class I, II or III, IV, the multivariate-adjusted hazard ratios of 30-day all-cause mortality associated with adjunctive tirofiban were 3. Read More

View Article and Full-Text PDF
January 2021

Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors.

Int J Mol Sci 2020 Dec 17;21(24). Epub 2020 Dec 17.

Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.

The long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in treatment of different chronic inflammatory disorders is strongly restricted by their serious gastrointestinal adverse effects. Therefore, there is still an urgent need to search for new, safe, and efficient anti-inflammatory agents. Previously, we have reported the Mannich base-type derivatives of pyrrolo[3,4-]pyridazinone which strongly inhibit cyclooxygenase, have better affinity to COX-2 isoenzyme and exert promising anti-oxidant activity. Read More

View Article and Full-Text PDF
December 2020

Improved Mortality, Morbidity and Long-term Outcome after Anatomical Hepatectomy with the Glissonean Pedicle Approach in Patients with Hepatocellular Carcinoma: 30 years' Experience at a Single Institute.

Ann Surg 2020 Dec 2. Epub 2020 Dec 2.

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University.

Objective: We evaluated the morbidity and mortality after anatomical hepatectomy with the Glissonean pedicle approach, and long-term outcomes in relation to the morbidity in patients with hepatocellular carcinoma (HCC).

Summary Background Data: The mortality, morbidity, and long-term outcomes were evaluated retrospectively.

Methods: 1953 patients with HCC underwent various anatomical hepatectomies with the Glissonean pedicle approach between 1985 and 2014. Read More

View Article and Full-Text PDF
December 2020

Residual platelet reactivity in low-dose aspirin-treated patients with class 1 obesity.

Vascul Pharmacol 2021 02 15;136:106819. Epub 2020 Nov 15.

Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Department of Internal Medicine I, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria. Electronic address:

Background: Recent data suggest a decreased clinical efficacy of low-dose aspirin in patients weighing ≥70 kg. We therefore investigated the impact of body weight and class 1 obesity on thromboxane generation and platelet reactivity to arachidonic acid (AA) in 316 patients on dual antiplatelet therapy following angioplasty and stenting.

Methods: Platelet surface expression of P-selectin and activated glycoprotein (GP) IIb/IIIa in response to AA were determined by flow cytometry as sensitive markers of platelet activation. Read More

View Article and Full-Text PDF
February 2021

Nuss Procedure for Pectus Excavatum: A Comparison of Complications Between Young and Adult Patients.

Ann Thorac Surg 2020 Nov 9. Epub 2020 Nov 9.

Division of General Thoracic Surgery, Department of Surgery, Zuyderland Medical Center, Heerlen, the Netherlands.

Background: The Nuss procedure is the gold standard surgical treatment for pectus excavatum in young patients. Its use in adults has also been described, although it may be associated with increased postoperative morbidity resulting from higher chest wall rigidity. This study aimed to examine the risk of complications after the Nuss procedure in adult patients compared with young patients with pectus excavatum. Read More

View Article and Full-Text PDF
November 2020

Uncemented or cemented stems in first-time revision total hip replacement? An observational study of 867 patients including assessment of femoral bone defect size.

Acta Orthop 2021 04 12;92(2):143-150. Epub 2020 Nov 12.

Section of Orthopaedics, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden.

Background and purpose - Uncemented stems are gradually replacing cemented stems in hip revision surgery. We compared the risk of re-revision between uncemented and cemented revision stems and assessed whether the different fixation methods are used in similar femoral bone defects.Patients and methods - 867 patients operated on with uncemented or cemented stems in first-time hip revision surgery due to aseptic loosening performed 2006-2016 were identified in the Swedish Hip Arthroplasty Register. Read More

View Article and Full-Text PDF

In-hospital outcomes of COVID-19 ST-elevation myocardial infarction patients.

EuroIntervention 2021 04;16(17):1426-1433

Institut del Cor, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Aims: The aim of this study was to assess clinical and prognosis differences in patients with COVID-19 and STEMI.

Methods And Results: Using a nationwide registry of consecutive patients managed within 42 specific STEMI care networks, we compared patient and procedure characteristics and in-hospital outcomes in two different cohorts, according to whether or not they had COVID-19. Among 1,010 consecutive STEMI patients, 91 were identified as having COVID-19 (9. Read More

View Article and Full-Text PDF

The sodium-glucose cotransporter-2 (SGLT2) inhibitors synergize with nitric oxide and prostacyclin to reduce human platelet activation.

Biochem Pharmacol 2020 12 8;182:114276. Epub 2020 Oct 8.

Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, Sao Paulo, Brazil. Electronic address:

Gliflozins (canagliflozin, dapagliflozin and empagliflozin) are the newest anti-hyperglycemic class and have offered cardiovascular and renal benefits. Because platelets are involved in the atherothrombosis process, this study is aimed to evaluate the direct effect of gliflozins on platelet reactivity. Platelet-rich plasma (PRP) or washed platelets (WP) were obtained from healthy volunteers. Read More

View Article and Full-Text PDF
December 2020

Women Who Are Young, Non-White, and with Lower Socioeconomic Status Report Higher Financial Toxicity up to 1 Year After Breast Cancer Surgery: A Mixed-Effects Regression Analysis.

Oncologist 2021 01 12;26(1):e142-e152. Epub 2020 Oct 12.

The Dartmouth Institute for Health Policy & Clinical Practice, Dartmouth College, Lebanon, New Hampshire, USA.

Purpose: We examined self-reported financial toxicity and out-of-pocket expenses among adult women with breast cancer.

Methods: Patients spoke English, Spanish, or Mandarin Chinese, were aged 18+ years, had stage I-IIIA breast cancer, and were eligible for breast-conserving and mastectomy surgery. Participants completed surveys about out-of-pocket costs and financial toxicity at 1 week, 12 weeks, and 1 year postsurgery. Read More

View Article and Full-Text PDF
January 2021

Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia.

Platelets 2020 Sep 23:1-8. Epub 2020 Sep 23.

Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Hepatitis C virus-associated immune thrombocytopenia (HCV-ITP) has been assumed to be one of secondary ITP and associated with antiplatelet antibodies. This study was to clarify the antibody profile in HCV-ITP compared with primary ITP. We enrolled 55 HCV-ITP, 30 primary ITP, 11 -ITP, 21 HCV control, and 16 healthy volunteers. Read More

View Article and Full-Text PDF
September 2020

Application of lyophilised human platelets for antibody detection in solid phase red cell adherence assay.

J Immunol Methods 2020 12 15;487:112868. Epub 2020 Sep 15.

Suzhou Institute of Biomedical Engineering and Technology (SIBET), Chinese Academy of Sciences (CAS), Suzhou, PR China. Electronic address:

Antibodies against human platelets cause a variety of thrombocytopenic disorders, which lead to potentially fatal haemorrhage. Therefore, their prompt detection is mandatory for successful patient treatment. Solid phase red cell adherence (SPRCA) assay allows for platelet antibody detection widely. Read More

View Article and Full-Text PDF
December 2020

Focal Cortical Dysplasia IIIa in Hippocampal Sclerosis-Associated Epilepsy: Anatomo-Electro-Clinical Profile and Surgical Results From a Multicentric Retrospective Study.

Neurosurgery 2021 01;88(2):384-393

Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children Hospital, Rome, Italy.

Background: Hippocampal sclerosis (HS) may be associated with focal cortical dysplasia IIIa (FCD IIIa) in patients undergoing surgery for temporal lobe epilepsy (TLE).

Objective: To investigate whether the anatomo-electro-clinical profile and surgical outcome in patients with HS-related TLE are affected by coexisting FCD IIIa.

Methods: A total of 220 patients, operated in 5 centers, with at least 24 mo follow-up (FU), were retrospectively studied. Read More

View Article and Full-Text PDF
January 2021

Which Functional Classification Scale is Optimal for Children with Pulmonary Hypertension (PAH)?

Pediatr Cardiol 2020 Dec 9;41(8):1725-1729. Epub 2020 Aug 9.

Department of Cardiology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730, Warsaw, Poland.

Functional status assessed by the WHO-FC scale derived from adults is a known prognostic factor for pulmonary hypertension. Data on the usefulness of the Panama-FC scale in assessing children with pulmonary hypertension are limited. The study was performed to compare functional status results (WHO-FC and Panama-FC) and to assess the usefulness of these scales in various clinical situations. Read More

View Article and Full-Text PDF
December 2020

An Unusual Case of Drug-Induced Thrombocytopenia.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620947891

White River Health System, Batesville, AR, USA.

Drug-induced thrombocytopenia (DIT) is a differential diagnosis for consideration when acute thrombocytopenia is encountered in the outpatient or inpatient setting. The mechanism of thrombocytopenia induced by different antiplatelet therapies varies. DIT may occur due to antibody formation following the exposure to a drug, or naturally occurring preexisting antibodies may produce rapid-onset thrombocytopenia when a drug molecule binds to a platelet receptor inducing a conformational change thus rendering it to be an antigen target for naturally occurring antibodies. Read More

View Article and Full-Text PDF

New Determinants of Aminoglycoside Resistance and Their Association with the Class 1 Integron Gene Cassettes in .

Int J Mol Sci 2020 Jun 13;21(12). Epub 2020 Jun 13.

Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8 St., 02-786 Warsaw, Poland.

is an important opportunistic animal pathogen. Different antimicrobials, including aminoglycosides, are used to treat infections. The aim of the present study was to evaluate aminoglycoside susceptibility and to detect aminoglycoside resistance determinants in 86 isolates of different origin. Read More

View Article and Full-Text PDF

Predictors of Cerebral Aneurysm Rupture after Coil Embolization: Single-Center Experience with Recanalized Aneurysms.

AJNR Am J Neuroradiol 2020 05 7;41(5):828-835. Epub 2020 May 7.

From the Department of Neurosurgery (Y.F., H.I., S.T., H.A., R.F., T.S., Y.O., Y.M., N.Sasaki, T.F., R.A., K.H., S.K., M.S., N.Sakai), Kobe City Medical Center General Hospital, Kobe, Japan.

Background And Purpose: Recanalization after coil embolization is widely studied. However, there are limited data on how recanalized aneurysms rupture. Herein, we describe our experience with the rupture of recanalized aneurysms and discuss the type of recanalized aneurysms at greatest rupture risk. Read More

View Article and Full-Text PDF

Vascular injury biomarkers and stroke risk: A population-based study.

Neurology 2020 06 5;94(22):e2337-e2345. Epub 2020 May 5.

From the Divisions of Cancer Epidemiology (L.P.-B., M.G., A.H., M.-L.G., T.J., S.G.M., R.K., T.K.) and Clinical Epidemiology and Aging Research (M.H.), German Cancer Research Center (DKFZ), Heidelberg; Medical Faculty (L.P.-B., M.G.), Heidelberg University; Department of Preventive Oncology (M.-L.G.), National Center for Tumor Diseases, Heidelberg; Department of Neurology (M.K.), Heidelberg University; Institute of Transfusion Medicine and Immunology (P.B.), Medical Faculty Mannheim, Heidelberg University; and German Red Cross Blood Service Baden-Württemberg-Hessen (P.B.), Mannheim, Germany.

Objective: Because little is known about associations between biomarkers of vascular injury and stroke risk, we evaluated associations between plasma concentrations of 6 novel biomarkers of vascular injury and stroke risk in a population-based study.

Methods: A case-cohort subset of EPIC-Heidelberg (European Prospective Investigation for Cancer and Nutrition-Heidelberg) including incident stroke cases (n = 335) and a random subcohort (n = 2,418) was selected. Concentrations of intercellular adhesion molecule 3 (ICAM3), soluble E-selectin and P-selectin, soluble thrombomodulin (sTM), thrombopoietin, and glycoprotein IIb/IIIa were measured in baseline plasma samples. Read More

View Article and Full-Text PDF

Cingulate gyrus epilepsy: semiology, invasive EEG, and surgical approaches.

Neurosurg Focus 2020 04;48(4):E8

1School of Medicine and.

Objective: The semiology of cingulate gyrus epilepsy is varied and may involve the paracentral area, the adjacent limbic system, and/or the orbitofrontal gyrus. Invasive electroencephalography (iEEG) recording is usually required for patients with deeply located epileptogenic foci. This paper reports on the authors' experiences in the diagnosis and surgical treatment of patients with focal epilepsy originating in the cingulate gyrus. Read More

View Article and Full-Text PDF

Anti-platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications.

J Thromb Haemost 2020 05 12;18(5):1210-1220. Epub 2020 Apr 12.

Laboratory for Platelet and Leukocyte Serology, Department of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, the Netherlands.

Background: Anti-platelet antibody testing may be useful for the diagnosis and management of childhood immune thrombocytopenia (ITP).

Objectives: Here we aimed to assess the prevalence and prognostic significance of anti-platelet glycoprotein-specific IgM and IgG antibodies.

Methods: Children with newly diagnosed ITP were included at diagnosis and randomized to an intravenous immunoglobulins (IVIg) or careful observation group (TIKI trial). Read More

View Article and Full-Text PDF