78,441 results match your criteria clamping

Suppressive effect erythropoietin on oxidative stress by targeting AMPK/Nox4/ROS pathway in renal ischemia reperfusion injury.

Transpl Immunol 2022 Jan 11:101537. Epub 2022 Jan 11.

Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang 330006, China. Electronic address:

Objective: To explore the effect of erythropoietin (EPO) on the AMP-activated protein kinase (AMPK)/nicotinamide adenine dinucleotide phosphatase oxidase 4 (NOX4) signaling pathway during renal ischemia reperfusion injury (RIRI) in rats.

Methods: A rat model of RIRI was established by clamping the left renal pedicle and removing the right kidney. The rats in the sham group did not have their left renal pedicle clamped. Read More

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January 2022

A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury.

Bioengineered 2022 Feb;13(2):2058-2075

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.

The anterior cingulate cortex (ACC) is a core brain region processing pain emotion. In this study, we performed RNA sequencing analysis to reveal transcriptomic profiles of the ACC in a rat chronic constriction injury (CCI) model. A total of 1628 differentially expressed genes (DEGs) were identified by comparing sham-operated rats with rats of 12 hours, 1, 3, 7, and 14 days after surgery, respectively. Read More

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February 2022

Squeezing multiple soft particles into a constriction: Transition to clogging.

Phys Rev E 2021 Dec;104(6-2):065101

Biomechanics and Bioengineering Laboratory, CNRS, Université de Technologie de Compiègne, 60200 Compiègne, France.

We study numerically how multiple deformable capsules squeeze into a constriction. This situation is largely encountered in microfluidic chips designed to manipulate living cells, which are soft entities. We use fully three-dimensional simulations based on the lattice Boltzmann method to compute the flow of the suspending fluid and on the immersed boundary method to achieve the two-way fluid-structure interaction. Read More

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December 2021

Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD.

J Exp Neurol 2021 ;2(4):149-153

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension. In addition to the classical pathological findings of AD, such as beta-amyloid (Aβ) accumulation and tau hyperphosphorylation, vascular dysfunction is also associated with the progression of the disease. Vascular dysfunction in AD is associated with decreased cerebral blood flow (CBF). Read More

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January 2021

Endovascular reconstruction of aortoiliac occlusive disease in a case with claudication and an ectopic pelvic kidney.

Ann Med Surg (Lond) 2022 Jan 21;73:103205. Epub 2021 Dec 21.

Department of General Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction And Importance: Ectopic kidney is a rare anomaly with an incidence of about 1 in 2500 birth in the population. Concurrency of pelvic kidney and iliac occlusion is rare, and the treatment is challenging because the pelvic kidney is associated with an atypical blood supply.

Case Presentation: We reported a 68-year-old man with aortoiliac stenosis, right pelvic kidney, and high-risk cardiovascular comorbidities. Read More

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January 2022

Damage control in abdominal vascular trauma.

Colomb Med (Cali) 2021 Apr-Jun;52(2):e4064808. Epub 2021 Jun 30.

University of Pittsburgh. Critical Care Medicine. Pittsburgh, PA, USA. University of Pittsburgh University of Pittsburgh Critical Care Medicine PittsburghPA USA.

In patients with abdominal trauma who require laparotomy, up to a quarter or a third will have a vascular injury. The venous structures mainly injured are the vena cava (29%) and the iliac veins (20%), and arterial vessels are the iliac arteries (16%) and the aorta (14%). The initial approach is performed following the ATLS principles. Read More

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An unusual presentation of thymoma: dysgeusia, ulcerative colitis, keratoconjunctivitis sicca, autoimmune retinopathy and myasthenia gravis.

BMJ Case Rep 2022 Jan 13;15(1). Epub 2022 Jan 13.

Department of Neuro-Ophthalmology, National Hospital for Neurology and Neurosurgery, London, UK.

A 41-year-old female presented with dysgeusia, dry eyes, nyctalopia with progressive visual field constriction (due to autoimmune retinopathy) and gastrointestinal symptoms (due to ulcerative colitis). She was subsequently admitted to intensive care with a myasthenic crisis, and CT of the thorax demonstrated a thymoma.Following thymectomy and adjuvant radiotherapy, she has remained in complete remission from her ulcerative colitis and myasthenia gravis, her retinopathy has stabilised and there has been no thymoma recurrence over a 10-year postoperative period. Read More

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January 2022

Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns.

Am J Perinatol 2022 Jan 13. Epub 2022 Jan 13.

Biochemistry, Gaziantep University, Gaziantep, Turkey.

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. Read More

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January 2022

Limonene, a citrus monoterpene, non-complexed and complexed with hydroxypropyl-β-cyclodextrin attenuates acute and chronic orofacial nociception in rodents: Evidence for involvement of the PKA and PKC pathway.

Phytomedicine 2021 Dec 18;96:153893. Epub 2021 Dec 18.

Department of Physiology, Laboratory of Neuroscience and Pharmacological Assays (LANEF), Federal University of Sergipe, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil.

Background: Chronic orofacial pain is a serious public health problem with a prevalence of 7-11% in the population. This disorder has different etiologies and characteristics that make pharmacological treatment difficult. Natural products have been shown to be a promising source of treatments for the management of chronic pain, as an example the terpenes. Read More

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December 2021

Nerve injury induces transient locus coeruleus activation over time: role of the locus coeruleus-dorsal reticular nucleus pathway.

Pain 2021 Aug 20. Epub 2021 Aug 20.

Neuropsychopharmacology and Psychobiology Research Group, Department of Psychology, University of Cadiz, Cadiz, Spain.

The transition from acute to chronic pain results in maladaptive brain remodeling, as characterized by sensorial hypersensitivity and the ensuing appearance of emotional disorders. Using the chronic constriction injury of the sciatic nerve as a model of neuropathic pain in male Sprague-Dawley rats, we identified time-dependent plasticity of locus coeruleus (LC) neurons related to the site of injury, ipsilateral (LCipsi) or contralateral (LCcontra) to the lesion, hypothesizing that the LC->dorsal reticular nucleus (DRt) pathway is involved in the pathological nociception associated with chronic pain. LCipsi inactivation with lidocaine increased cold allodynia 2 days after nerve injury but not later. Read More

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Achievement of textbook outcomes and comparisons with benchmark values after laparoscopic left lateral sectionectomy.

Updates Surg 2022 Jan 13. Epub 2022 Jan 13.

Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.

Laparoscopic left lateral sectionectomy (LLLS) is considered a standard approach for patients. Textbook outcomes (TOs) with benchmark values have been developed to help centers assess their outcomes of LLLS. The aim of our study was to identify factors associated with achieving TOs after LLLS. Read More

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January 2022

Piezoelectric energy harvester with double cantilever beam undergoing coupled bending-torsion vibrations by width-splitting method.

Sci Rep 2022 Jan 12;12(1):583. Epub 2022 Jan 12.

School of Mechanical Engineering, Engineering Research Center of Complex Tracks Processing Technology and Equipment of MoE, Key Laboratory of Welding Robot and Application Technology of Hunan Province, Xiangtan University, Xiangtan, 411105, People's Republic of China.

We propose piezoelectric energy harvester (PEH) with double-cantilever-beam (DCB) undergoing coupled bending-torsion vibrations by combining width-splitting method and asymmetric mass, in order that more ambient energy could be harvested from environmental vibration with multiple-frequency excitation. The geometrical dimensions are optimized for PEHDCB, when the maximum of output peak voltages U and resonance frequency difference (Δf) between the first and second modes are chosen as optimization objectives based on orthogonal test method. The energy harvesting efficiency is evaluated by the proportion of half-power bandwidth and quality factor, and the experimental and simulation results are compared to verify reliability. Read More

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January 2022

TRPV1 in arteries enables a rapid myogenic tone.

J Physiol 2022 Jan 12. Epub 2022 Jan 12.

Department of Pharmacology and Physiology, Georgetown University, Washington, DC, USA.

Key Points: We explored the physiological role of TRPV1 in vascular smooth muscle. TRPV1 antagonists dilated skeletal muscle arterioles both ex vivo and in vivo, increased coronary perfusion and decreased systemic blood pressure. Stretch of arteriolar myocytes and increases in intraluminal pressure in arteries triggered rapid Ca signaling and vasoconstriction respectively. Read More

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January 2022

Spectral dependency of the human pupillary light reflex. Influences of pre-adaptation and chronotype.

PLoS One 2022 12;17(1):e0253030. Epub 2022 Jan 12.

Institute of Medical Psychology, Ludwig-Maximilians-Universität, Munich, Germany.

Non-visual photoreceptors (ipRGCs) and rods both exert a strong influence on the human pupil, yet pupil models regularly use cone-derived sensitivity as their basis. This inconsistency is further exacerbated by the fact that circadian effects can modulate the wavelength sensitivity. We assessed the pupillary reaction to narrowband light stimuli in the mesopic range. Read More

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January 2022

Sphingomyelin-Sequestered Cholesterol Domain Recruits Formin-Binding Protein 17 for Constricting Clathrin-Coated Pits in Influenza Virus Entry.

J Virol 2022 Jan 12:JVI0181321. Epub 2022 Jan 12.

College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, and The Institute for Advanced Studies, Wuhan University, Wuhan 430072, PR China.

Influenza A virus (IAV) is a global health threat. The cellular endocytic machineries harnessed by IAV remain elusive. Here, by tracking single IAV particles and quantifying the internalized IAV, we found that the sphingomyelin (SM)-sequestered cholesterol, but not the accessible cholesterol, is essential for the clathrin-mediated endocytosis (CME) of IAV. Read More

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January 2022

Fabrication of voltage-gated spin Hall nano-oscillators.

Nanoscale 2022 Jan 12. Epub 2022 Jan 12.

Applied Spintronics Group, Department of Physics, University of Gothenburg, 412 96 Gothenburg, Sweden.

We demonstrate an optimized fabrication process for electric field (voltage gate) controlled nano-constriction spin Hall nano-oscillators (SHNOs), achieving feature sizes of <30 nm with easy to handle ma-N 2401 e-beam lithography negative tone resist. For the nanoscopic voltage gates, we utilize a two-step tilted ion beam etching approach and through-hole encapsulation using 30 nm HfO. The optimized tilted etching process reduces sidewalls by 75% compared to no tilting. Read More

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January 2022

Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.

Cardiovasc Res 2022 Jan 9. Epub 2022 Jan 9.

Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Aims: Well-controlled mitochondrial homeostasis, including a mitochondria-specific form of autophagy (hereafter referred to as mitophagy), is essential for maintaining cardiac function. The molecular mechanism mediating mitophagy during PO is poorly understood. We have shown previously that mitophagy in the heart is mediated primarily by Atg5/Atg7-independent mechanisms, including Unc-51-like kinase1 (Ulk1)-dependent alternative mitophagy, during myocardial ischemia. Read More

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January 2022

A Quality Improvement Project to Delay Umbilical Cord Clamping Time.

Pediatr Qual Saf 2021 Sep-Oct;6(5):e452. Epub 2021 Sep 24.

Department of Pediatrics, Joan C Edwards School of Medicine, Marshall University, Huntington, W.Va.

Delayed cord clamping (DCC) has numerous benefits to the neonate, including increased hemoglobin levels, decreased need for red blood cell transfusions, and decreased incidence of necrotizing enterocolitis and intraventricular hemorrhage. A preliminary observational study at our institution demonstrated 12% of the observed deliveries met the DCC standard, defined as umbilical cord clamping at least 30-60 seconds after birth. Therefore, we designed a quality improvement project to increase the percentage of deliveries using DCC. Read More

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September 2021

Biomechanical and morphological evaluation of aortic wall changes related to the cross-clamping method in different surgical techniques.

J Vasc Bras 2021 1;20:e20200204. Epub 2021 Dec 1.

Universidade Federal de São Paulo - UNIFESP, Escola Paulista de Medicina, São Paulo, SP, Brasil.

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December 2021

Dynamics of the Catalytic Active Site of Isoleucyl tRNA Synthetase from bound with Adenylate and Mupirocin.

J Phys Chem B 2022 Jan 11. Epub 2022 Jan 11.

Department of Chemistry Kalyani University Kalyani, West Bengal 741235, India.

The development of new antimicrobial drugs is critically needed due to the alarming increase in antibiotic resistance in bacterial pathogens. The active sites of different bacterial aminoacyl tRNA synthetases (aaRS) are validated targets of antibiotics. At present, the only aaRS inhibitor approved is mupirocin (MRC) which targets bacterial isoleucyl tRNA synthetase (IleRS). Read More

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January 2022

Surgical outcomes of total arch replacement with modified elephant trunk technique in type A aortic dissection: insights from single-center experience.

Asian Cardiovasc Thorac Ann 2022 Jan 11:2184923211070115. Epub 2022 Jan 11.

Department of Thoracic and Cardiovascular Surgery, 385685Nanjing First Hospital, 385685Nanjing Medical University, P.R. China.

Background: Total arch replacement with modified elephant trunk technique plays an important role in treating acute type A aortic dissection in China. We aim to summarize the therapeutic effects of this procedure in our center over a 17-year period.

Methods: Consecutive patients treated at our hospital due to type A aortic dissection from January 2004 to January 2021 were studied. Read More

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January 2022

Fluorescent Nanohybrids from ZnS/CdSe Quantum Dots Functionalized with Triantennary, -Hydroxy--(4-arylbutanamido)benzamide/Gallamide Dendrons That Act as Inhibitors of Histone Deacetylase for Lung Cancer.

ACS Appl Bio Mater 2021 Mar 9;4(3):2475-2489. Epub 2021 Feb 9.

Department of Pharmacology, National Cheng Kung University, Tainan 70101, Taiwan.

-Hydroxy--(4-arylbutanamido)benzamides (HABAB) belong to one class of histone deacetylase inhibitors (HDACi), which regulate deacetylation of lysine residue's amino group in histone, which results in chromatin constriction. In addition, transcriptional knockdown of the genetic loci possessing the suppressor genes of tumor occurs. A tripodal, HABAB-capped gallamide dendron possessing thiol anchoring unit was prepared by the click method. Read More

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Metoclopramide and Propofol to Prevent Nausea and Vomiting during Cesarean Section under Spinal Anesthesia: A Randomized, Placebo-Controlled, Double-Blind Trial.

J Clin Med 2021 Dec 26;11(1). Epub 2021 Dec 26.

Department of Emergency, SS.ma Annunziata University Hospital, Via dei Vestini, 66100 Chieti, Italy.

Background: Intra-operative nausea, vomiting and retching (NVR) are frequently associated with subarachnoid anesthesia (SA) in women undergoing cesarean section (CS). In this study performed in women undergoing CS under SA with a risk factor control strategy, we compared saline (placebo), propofol, metoclopramide and both drugs to prevent NVR.

Methods: We recorded NVR events in 110 women undergoing CS who were randomized after umbilical cord clamping to receive saline (S; = 27), metoclopramide 10 mg (M; = 28), propofol 1 mg/kg/h (P; = 27) or both drugs (PM; = 28). Read More

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December 2021

Lead Dependent Tricuspid Valve Dysfunction-Risk Factors, Improvement after Transvenous Lead Extraction and Long-Term Prognosis.

J Clin Med 2021 Dec 24;11(1). Epub 2021 Dec 24.

Department of Cardiac Surgery, Masovian Specialistic Hospital of Radom, 26-617 Radom, Poland.

Background: Lead-related tricuspid valve dysfunction (LDTVD) has not been studied in a large population and its management remains controversial.

Methods: An analysis of the clinical data of 2678 patients undergoing transvenous lead extraction (TLE) in years 2008-2021 was conducted, with a separate group of 119 patients with LDTVD. Potential risk factors for LDTVD, improvement in valve function, and long-term prognosis after TLE were assessed. Read More

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December 2021

Long-Term Follow-Up of Device-Assisted Clampless Off-Pump Coronary Artery Bypass Grafting Compared with Conventional On-Pump Technique.

Int J Environ Res Public Health 2021 Dec 27;19(1). Epub 2021 Dec 27.

Division of Cardiac Surgery, Tor Vergata University Hospital, Viale Oxford 81, 00133 Rome, Italy.

Study Objective: To evaluate the long-term outcomes of clampless off-pump coronary artery bypass grafting (C-OPCAB) compared with conventional on-pump double clamping coronary artery bypass grafting (C-CABG).

Methods: From October 2006 to December 2011, 366 patients underwent isolated coronary artery bypass grafting. After propensity score matching of preoperative variables, 143 pairs were selected who received C-OPCAB with the use of device-assisted PAS-Port proximal venous graft anastomoses or C-CABG, performed by the same surgeon experienced in both techniques. Read More

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December 2021

Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success?

Cancers (Basel) 2021 Dec 24;14(1). Epub 2021 Dec 24.

Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, 41092 Seville, Spain.

During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during migration through narrow pores and cell squeezing. However, little is known on the importance and consequences of mechanical stress for tumor progression and success in invading a new organ. Recently, several studies have shown that cell constriction can lead to nuclear envelope rupture (NER) during interphase. Read More

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December 2021

Mechanical and Electronic Cell-Chip Interaction of APTES-Functionalized Neuroelectronic Interfaces.

ACS Appl Bio Mater 2021 Aug 4;4(8):6326-6337. Epub 2021 Aug 4.

Institute of Biological Information Processing - Bioelectronics (IBI-3), Forschungszentrum Jülich, 52425 Jülich, Germany.

In this work, we analyze the impact of a chip coating with a self-assembled monolayer (SAM) of (3-aminopropyl)triethoxysilane (APTES) on the electronic and mechanical properties of neuroelectronic interfaces. We show that the large signal transfer, which has been observed for these interfaces, is most likely a consequence of the strong mechanical coupling between cells and substrate. On the one hand, we demonstrate that the impedance of the interface between Pt electrodes and an electrolyte is slightly reduced by the APTES SAM. Read More

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Discrete constriction locations describe a comprehensive range of vocal tract shapes in the Maeda model.

JASA Express Lett 2021 Dec 28;1(12):124402. Epub 2021 Dec 28.

Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California 94143, USA.

The Maeda model was used to generate a large set of vocoid-producing vocal tract configurations. The resulting dataset (a) produced a comprehensive range of formant frequencies and (b) displayed discrete tongue body constriction locations (palatal, velar/uvular, and lower pharyngeal). The discrete parameterization of constriction location across the vowel space suggests this is likely a fundamental characteristic of the human vocal tract, and not limited to any specific set of vowel contrasts. Read More

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December 2021

Late-onset Hem-o-Lok® migration into the bladder after robot-assisted radical prostatectomy.

IJU Case Rep 2022 Jan 11;5(1):49-52. Epub 2021 Nov 11.

Department of Urology St. Luke's International Hospital Tokyo Japan.

Introduction: Hem-o-Lok clips are widely used in robot-assisted radical prostatectomy because of their ease of application and secure clamping. Although there have been some reports of their migration into the urinary tract, this usually occurs a few months after robot-assisted radical prostatectomy. Late-onset cases of Hem-o-Lok clip migration, that is, after more than 1 year, are rare. Read More

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January 2022