759,026 results match your criteria city


Engineered s-Triazine-based dendrimer-honokiol conjugates as targeted MMP-2/9 inhibitors for halting hepatocellular carcinoma.

ChemMedChem 2021 Sep 21. Epub 2021 Sep 21.

Alexandria University, Department of Physics and Chemistry, Faculty of Education, Alexandria University, Egypt., Alexandria, EGYPT.

Despite the advances in developing MMP-2/9 inhibitors, off-target side effects and pharmacokinetics problems remain major challenges hindering their clinical success in cancer therapy. However, recent targeting strategies obviously revitalized MMP research. Herein, we introduce new s-triazine-based dendrimers endowed with intrinsic MMP-2/9 inhibitory potential and tetherable to hepatocellular carcinoma-specific targeting ligands and anticancer agents via biodegradable linkages for targeted therapy. Read More

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September 2021

Flexible sigmoidoscopy may be sufficient for initial evaluation of suspected immunotherapy-mediated colitis: a cross-sectional study.

J Gastroenterol Hepatol 2021 Sep 21. Epub 2021 Sep 21.

Division of Gastroenterology, Department of Medicine, City of Hope Medical Center.

Background And Aim: Immune checkpoint inhibitors (ICIs) have shown promise in treating a variety of cancers. Their increased use coincides with increased incidence of immunotherapy-mediated colitis (IMC), a common adverse effect. Optimal strategy for endoscopic evaluation of IMC (full colonoscopy or flexible sigmoidoscopy) is not well-defined. Read More

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September 2021

CBFB-MYH11 Fusion Transcripts Distinguish Acute Myeloid Leukemias with Distinct Molecular Landscapes and Outcomes.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

Fred Hutchinson Cancer Research Center, seattle, Washington, United States.

Patients with inv(16)/CBFB-MYH11 AML are considered favorable risk, however, nearly one-third relapse despite intensive therapy. Despite efforts to define risk groups within this favorable risk cohort, CBFB-MYH11 AML patients continue to be treated as a uniform cohort. Through transcriptome sequencing of 186 patients with inv(16) AML, we demonstrate that fusion junction breakpoints (exon 5-exon 33 versus other) are highly associated with outcome. Read More

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September 2021

Haploidentical vs. sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

University of Virginia, Charlottesville, Virginia, United States.

The role of haploidentical hematopoietic cell transplantation (HCT) using post-transplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariate analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) between haploidentical HCT using PTCy and HLA-matched sibling donor (MSD), 8/8 HLA-matched unrelated donor (MUD) , 7/8 HLA-matched UD, or umbilical cord blood (UCB) HCT. Read More

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September 2021

Changes in PPAR-γ Expression Are Associated with microRNA Profiles during Fetal Programming due to Maternal Overweight and Obesity.

Gynecol Obstet Invest 2021 Sep 21:1-12. Epub 2021 Sep 21.

Biochemistry Department, University Autonomous of San Luis Potosí, San Luis Potosi, Mexico.

Background: There has been a global increase in the prevalence of obesity in pregnant women in recent years. Animal studies have shown that intrauterine environment associated with maternal obesity leads to epigenetic changes. However, the effects of epigenetic changes occurring before birth in response to maternal conditions have not been clearly characterized in humans. Read More

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September 2021

Synthesis and characterization of gold nanorods coated by mesoporous silica MCM-41 as a platform bioapplication in photohyperthermia.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

Ciencia e Tecnologia de Materiais, Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte City, Minas Gerais State, Caixa Postal 941, CEP 30123-970, Belo Horizonte, 31323970, BRAZIL.

Gold nanoparticles have been widely investigated for biomedical applications due to their optical properties. These particles present the interesting feature of absorbing light when stimulated with laser radiation to generate heating. Among the possible morphologies for synthetic gold nanoparticles, gold nanorods have properties of great interest for applications in the photohyperthermia processes. Read More

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September 2021

Low-temperature grown vertically aligned carbon nanotube array for an optimal infrared bolometer.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

Santa Clara University, 500 El Camino Real, Santa Clara, California, 95053-4345, UNITED STATES.

Vertically aligned carbon nanotube (VACNT) arrays have been explored as an absorber of thermal-type photodetectors. A long and dense VACNT array absorbs a wide spectral range of incident light with high absorption rate, but has a high thermal mass that results in a low response speed. To achieve a small thermal mass, a shorter and less dense VACNT array is needed. Read More

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September 2021

Increased dielectric performance of PVDF-based composites by electrochemical exfoliated graphite additives.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

School of mechanical engineering, Jiangsu University, #301 Xuefu Road, PR CHINA, Zhenjiang, 212013, CHINA.

Adding conductive graphene into polyvinylidene fluoride (PVDF) is an effective method to improve the dielectric properties. However, the high conductivity and uniform distribution of graphene in PVDF matrix still meet challenges. In this work, electrochemical exfoliated graphite (EEG) with good conductivity and solution dispersion is used to prepare PVDF/EEG films. Read More

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September 2021

Magnetic enhancement of oxygen evolution reaction performance of NiCo-spinel oxides.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

Hunan University, Lushan Road (S), Yuelu District, Changsha, Hunan Province, Changsha, 410082, CHINA.

Low-cost and high-efficiency transition metal oxide catalysts are desired for high-efficiency water splitting technology. An applying magnetic field (MF) enhancement method is presented to improve the oxygen evolution reaction (OER) performance of NiCo-spinel magnetic catalysts, the enhancement of OER performance depends on the applied magnetic field strength and magnetic properties of catalysts. The maximum enhanced current density percentage of about 90. Read More

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September 2021

A breakthrough dynamic-osmotic membrane bioreactor/nanofiltration hybrid system for real municipal wastewater treatment and reuse.

Bioresour Technol 2021 Sep 13;342:125930. Epub 2021 Sep 13.

Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology, Sydney, Broadway, NSW 2007, Australia. Electronic address:

This study designed a Dynamic-Osmotic membrane bioreactor/nanofiltration (OsMBR/NF) system for municipal wastewater treatment and reuse. Results indicated that a continuously rotating FO module with 60 RPM in Dynamic-OsMBR system could enhance shear stress and reduce cake layer of foulants, leading to higher flux (50%) compared to Traditional-OsMBR during a 40-operation day. A negligible specific reverse salt flux (0. Read More

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September 2021

Association between perioperative intravenous lidocaine and subjective quality of recovery: A meta-analysis of randomized controlled trials.

J Clin Anesth 2021 Sep 18;75:110521. Epub 2021 Sep 18.

Department of Emergency Medicine, E-Da Hospital, Kaohsiung city, Taiwan; College of Medicine, I-Shou University, Kaohsiun cityg, Taiwan. Electronic address:

Study Objective: To evaluate the impact of perioperative intravenous lidocaine on the quality of recovery (QoR) following surgery.

Design: Meta-analysis of randomized controlled trials (RCTs).

Setting: Postoperative care. Read More

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September 2021

An evaluation model for the development of more humane correctional institutions: Evidence from Penghu Prison.

Eval Program Plann 2021 Sep 17;89:102013. Epub 2021 Sep 17.

Penghu Prison, Agency of Corrections, Ministry of Justice, No. 1-1, Dingwan Village, Husi Township, Penghu County, 88592, Taiwan. Electronic address:

Over time, correctional institutions have actively implemented innovations in prison administration. Most correctional institutions constitute conservative and closed societies. Generally, people do not have sufficient knowledge or understanding of penal correction. Read More

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September 2021

Novel biogenic silver and gold nanoparticles for multifunctional applications: Green synthesis, catalytic and antibacterial activity, and colorimetric detection of Fe(III) ions.

Chemosphere 2021 Sep 16;287(Pt 3):132271. Epub 2021 Sep 16.

Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City, Ho Chi Minh City, 70000, Viet Nam. Electronic address:

In this study, novel biogenic silver (AgNPs) and gold nanoparticles (AuNPs) were developed using a green approach with Ganoderma lucidum (GL) extract. The optimization of synthesis conditions for the best outcomes was conducted. The prepared materials were characterized and their applicability in catalysis, antibacterial and chemical sensing was comprehensively evaluated. Read More

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September 2021

Colloidal transport and deposition through dense vegetation.

Chemosphere 2021 Sep 7;287(Pt 3):132197. Epub 2021 Sep 7.

State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, College of Hydrology and Water Resources, Nanjing, Jiangsu, 210098, China.

The effectiveness of submerged synthetic aquatic vegetation on removal of colloids from flowing water was investigated to explore retention of particulate nonpoint source pollutants in aquatic systems. In colloid transport experiments, the deposition rate coefficient of colloids in dense vegetation is often taken as spatially constant. This assumption was tested by experiments and modeling aimed at quantifying changes in colloid retention with travel distance in submerged synthetic aquatic vegetation. Read More

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September 2021

Feed restriction and type of forage influence performance and behaviour of outdoor gestating sows.

Animal 2021 Sep 18;15(10):100346. Epub 2021 Sep 18.

Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada, Sherbrooke, 2000 College Street, Sherbrooke J1M 1Z3, QC, Canada.

Forages can contribute to the nutrient supply for sows but the extent to which they can replace concentrate feeding is not well known. The objective of this study was to assess the effect of level of feed restriction and type of forage on the performance and activity of gestating sows under outdoor conditions. A total of 45 sows were distributed among three treatments, with five replicates of three sows/treatment, from week 5 of gestation until farrowing. Read More

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September 2021

Associations Between Anxiety, Self-efficacy, and Self-care in Rural Adolescents with Poorly Controlled Asthma.

Ann Allergy Asthma Immunol 2021 Sep 18. Epub 2021 Sep 18.

Columbia University School of Nursing. Electronic address:

Background: Rural adolescents are vulnerable to asthma; good self-care can reduce morbidity. Sub-types of anxiety (e.g. Read More

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September 2021

Healthy Lifestyle and Mortality Among Adults Receiving Hemodialysis: The DIET-HD Study.

Am J Kidney Dis 2021 Sep 18. Epub 2021 Sep 18.

Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Edward Ford Building A27, NSW 2006, Australia; Department of Emergency and Organ Transplantation, University of Bari, Bari, Piazza Giulio Cesare, 70124 Bari, Italy. Electronic address:

Rationale & Objective: A healthy lifestyle promotes cardiovascular health and reduces cardiac-related mortality in the general population but its benefits for people receiving maintenance hemodialysis are uncertain.

Study Design: Prospective cohort study.

Setting & Participants: 5,483 of 9,757 consecutive adults receiving maintenance hemodialysis (January 2014 to June 2017, median dialysis vintage: 3. Read More

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September 2021

Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production.

Eur J Pharm Sci 2021 Sep 18:106013. Epub 2021 Sep 18.

Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, 550004, P. R. China.

Background: Doxorubicin (DOX) is widely used as an effective chemotherapy agent in human cancer. Our study aimed to explore the specific mechanism of DOX in osteoarthritis (OA).

Methods: A mouse OA model was established by destabilizing the medial meniscus (DMM), and the role of DOX was determined by intraperitoneally injecting 5 or 10 mg/kg DOX. Read More

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September 2021

Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.

Diabetes Res Clin Pract 2021 Sep 18:109063. Epub 2021 Sep 18.

Faculty of Biology, Medicine and Health, University of Manchester and Manchester University Foundation Trust, Manchester, UK.

Diabetic sensorimotor polyneuropathy (DSPN) affects around one third of people with diabetes and accounts for considerable morbidity, increased risk of mortality, reduced quality of life, and increased health care costs resulting particularly from neuropathic pain and foot ulcers. Painful DSPN is encountered in 13-26% of diabetes patients, while up to 50% of patients with DSPN may be asymptomatic. Unfortunately, DSPN still remains inadequately diagnosed and treated. Read More

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September 2021

Retrospective analysis of interventions to epidemics using dynamic simulation of population behavior.

Math Biosci 2021 Sep 18:108712. Epub 2021 Sep 18.

Division of Applied Mechanics, U.S. FDA/CDRH Silver Spring, MD 20993, USA. Electronic address:

Retrospective analyses of interventions to epidemics, in which the effectiveness of strategies implemented are compared to hypothetical alternatives, are valuable for performing the cost-benefit calculations necessary to optimize infection countermeasures. SIR (susceptible-infected-removed) models are useful in this regard but are limited by the challenge of deciding how and when to update the numerous parameters as the epidemic changes in response to population behaviors. Behaviors of particular interest include facemasks adoption (at various levels) and social distancing. Read More

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September 2021

Sleep, psychiatric and socioeconomic factors associated with substance use in a large population sample: A cross-sectional study.

Pharmacol Biochem Behav 2021 Sep 18:173274. Epub 2021 Sep 18.

Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, São Paulo 04024-002, Brazil.

Multiple elements modulate drug use, including sleep, which is increasingly being considered as an important contributor to substance use and abuse. The present study aimed to evaluate the association between sleep, psychiatric and socioeconomic/demographic factors and substance use in a large-scale representative sample from the city of São Paulo, Brazil. Data from the 2007 São Paulo Epidemiological Sleep Study (EPISONO) database were used. Read More

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September 2021

Airborne magnetic nanoparticles may contribute to COVID-19 outbreak: Relationships in Greece and Iran.

Environ Res 2021 Sep 18:112054. Epub 2021 Sep 18.

Ecoresources P.C, Giannitson-Santaroza Str. 15-17, 54627, Thessaloniki, Greece; Department of Physics, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. Electronic address:

This work attempts to shed light on whether the COVID-19 pandemic rides on airborne pollution. In particular, a two-city study provides evidence that PM contributes to the timing and severity of the epidemic, without adjustment for confounders. The publicly available data of deaths between March and October 2020, updated it on May 30, 2021, and the average seasonal concentrations of PM pollution over the previous years in Thessaloniki, the second-largest city of Greece, were investigated. Read More

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September 2021

Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene.

Am J Hum Genet 2021 Sep 14. Epub 2021 Sep 14.

Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA.

Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly that is often accompanied by other anomalies. Although the role of genetics in the pathogenesis of CDH has been established, only a small number of disease-associated genes have been identified. To further investigate the genetics of CDH, we analyzed de novo coding variants in 827 proband-parent trios and confirmed an overall significant enrichment of damaging de novo variants, especially in constrained genes. Read More

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September 2021

Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress.

Mol Cell 2021 Sep;81(18):3786-3802.e13

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address:

Amino acids are essential building blocks of life. However, increasing evidence suggests that elevated amino acids cause cellular toxicity associated with numerous metabolic disorders. How cells cope with elevated amino acids remains poorly understood. Read More

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September 2021

Role of hepatosteatosis in HBsAg seroconversion in HBeAg-negative chronic hepatitis B patients.

Int J Clin Pract 2021 Sep 21:e14899. Epub 2021 Sep 21.

Ankara City Hospital, Department of Gastroenterology, Ankara, Turkey.

Background: In chronic HBV infection, certain individual and viral characteristics such as advanced age, presence of hepatic steatosis (HS), normal ALT levels, initially negative HBeAg and HBV DNA, and genotype of the virus are associated with HBsAg seroclearance and seroconversion. Herein, we report the results of our study evaluating the association between hepatosteatosis and HbsAg seroconversion.

Methods: The clinical and biochemical data of patients with CHB and hepatosteatosis (HS) (HBsAg seroconversion, n:52, and non-HbsAg seroconversion, n:352), and the rate of development HBsAg seroconversion were evaluated. Read More

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September 2021

Comparing the performance of machine learning algorithms for remote and in situ estimations of chlorophyll-a content: a case study in the Tri An Reservoir, Vietnam.

Water Environ Res 2021 Sep 21. Epub 2021 Sep 21.

Ho Chi Minh City University of Technology (HUTECH), Binh Thanh District, Ho Chi Minh City, Vietnam.

Chlorophyll-a (Chl-a) is one of the most important indicators of the trophic status of inland waters, and its continued monitoring is essential. Recently, the operated Sentinel-2 MSI satellite offers high spatial resolution images for remote water quality monitoring. In this study, we tested the performance of the three well-known machine learning (ML) [random forest (RF), support vector machine (SVM), Gaussian process (GP)] and the two novel ML [extreme gradient boost (XGB), CatBoost (CB)] models for estimation a wide-range of Chl-a concentration (10. Read More

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September 2021

SARS-CoV-2 mRNA Vaccine Injection Site Pseudolymphoma.

J Eur Acad Dermatol Venereol 2021 Sep 21. Epub 2021 Sep 21.

Department of Pathology, Division of Histopathology, Mater Dei Hospital, Malta.

A healthy 68-year-old female presented with an erythematous nodule on the outer aspect of her left arm (Figure 1A&B). The location of the nodule coincided with the injection site of the second dose of the Pfizer-BioNTech (Pfizer Inc. New York City, NY, USA) SARS-CoV-2 mRNA vaccine, administered three months before. Read More

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September 2021

Disease mechanisms of X-linked cone dystrophy caused by missense mutations in the red and green cone opsins.

FASEB J 2021 Oct;35(10):e21927

Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.

Cone photoreceptors are responsible for the visual acuity and color vision of the human eye. Red/green cone opsin missense mutations N94K, W177R, P307L, R330Q, and G338E have been identified in subjects with congenital blue cone monochromacy or color-vision deficiency. Studies on disease mechanisms due to these cone opsin mutations have been previously carried out exclusively in vitro, and the reported impairments were not always consistent. Read More

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October 2021

CRYPTOSPORIDIUM SPP. IN PET DWARF WINTER WHITE RUSSIAN HAMSTERS (PHODOPUS SUNGORIS SUNGORIS) IN CHINA.

J Parasitol 2021 Sep;107(5):770-777

The Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.

Cryptosporidium spp. have been identified in a wide range of hosts, such as humans and domestic and wild animals, while less information about the prevalence of Cryptosporidium spp. in pet hamsters is documented. Read More

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September 2021