Ann Surg 2021 Aug 4. Epub 2021 Aug 4.
Division of Colon & Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN Department of Surgery, Raleigh General Hospital, Beckley, WV Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX. Department of Surgery, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Objective: To evaluate the impact of neoadjuvant multi-agent systemic chemotherapy and radiation (TNT) vs neoadjuvant single-agent chemoradiation (nCRT) and multi-agent adjuvant chemotherapy on overall survival (OS), tumor downstaging, and circumferential resection margin (CRM) status in patients with locally advanced rectal cancer.
Summary Background Data: Outside of clinical trials and small institutional reports, there is a paucity of data regarding the short and long-term oncologic impact of TNT as compared to nCRT.
Methods: Adult patients with stage II-III rectal adenocarcinoma were identified in the National Cancer Database [2006-2015]. Read More