15,640 results match your criteria circulating values

Associations of D-dimer with CT Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study.

Ann Am Thorac Soc 2021 Apr 16. Epub 2021 Apr 16.

Weill Cornell Medical College, 12295, Department of Medicine, New York, New York, United States.

Rationale: The coagulation cascade may play a role in the pathogenesis of interstitial lung disease through increased production of thrombin and fibrin deposition. Whether circulating coagulation cascade factors are linked to lung inflammation and scarring among community-dwelling adults is unknown.

Objective: To test the hypothesis that higher baseline D-dimer levels are associated with markers of early lung injury and scarring. Read More

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Reliability of Serological Prestin Levels in Humans and its Relation to Otoacoustic Emissions, a Functional Measure of Outer Hair Cells.

Ear Hear 2021 Apr 15. Epub 2021 Apr 15.

Department of Speech, Language, and Hearing Sciences, University of Connecticut, Storrs, CT Connecticut Institute for Brain and Cognitive Sciences, University of Connecticut, Storrs, CT Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Connecticut Health, Farmington, CT.

Objectives: Serological biomarkers, common to many areas of medicine, have the potential to inform on the health of the human body and to give early warning of risk of compromised function or illness before symptoms are experienced. Serological measurement of prestin, a motor protein uniquely produced and expressed in outer hair cells, has recently been identified as a potential biomarker to inform on the health of the cochlea. Before any test can be introduced into the clinical toolkit, the reproducibility of the measurement when repeated in the same subject must be considered. Read More

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Identification of blood immune and metabolic indicators explaining the variability of growth of pigs under contrasted sanitary conditions.

BMC Vet Res 2021 Apr 15;17(1):166. Epub 2021 Apr 15.

PEGASE, INRAE, Institut Agro, 35590, Saint Gilles, France.

Background: Health and growth of pigs are affected by the hygiene of housing. Lower growth performance observed in poor hygiene of housing conditions is explained by reduced feed intake and metabolic changes caused by the activation of body defences. In a previous experiment, we reported contrasted average values of body weight gain, concentrations of circulating metabolites, redox and immune indicators in blood of pigs housed in good or poor hygiene conditions during the growing period. Read More

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Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.

Objectives: Sclerostin is an important regulator of bone mass involving the Wnt/β-catenin signalling pathway. Relatively few studies have investigated the relationships of circulating sclerostin levels with adiposity-related and muscle-related biochemical factors in individuals with increased energy metabolism. The aim of this study was to investigate the associations of circulating sclerostin with adipokines, myokines, osteokines and body composition values in lean adolescent females with increased physical activity. Read More

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Red blood cell distribution width as a novel prognostic marker after myocardial revascularization or cardiac valve surgery.

Sci Rep 2021 Apr 12;11(1):7889. Epub 2021 Apr 12.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

The red blood cell distribution width (RDW) measures the variability in the size of circulating erythrocytes. Previous studies suggested a powerful correlation between RDW obtained from a standard complete blood count and cardiovascular diseases in both primary and secondary cardiovascular prevention. The current study aimed to evaluate the prognostic role of RDW in patients undergoing cardiac rehabilitation after myocardial revascularization and/or cardiac valve surgery. Read More

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Molecular characterization of advanced non-small cell lung cancer patients by cfDNA analysis: experience from routine laboratory practice.

J Thorac Dis 2021 Mar;13(3):1658-1670

Thoracic Oncology Unit, Hospital Clínic, Barcelona, Spain.

Background: Analysis of circulating free DNA (cfDNA) by the real-time PCR cobas EGFR Mutation Test v2 (cobas EGFR Test) is a diagnostic approach used in clinical practice for the characterization of advanced non-small cell lung cancer (NSCLC) patients. The test additionally outputs a semiquantitative index (SQI) which reflects the proportion of mutated versus wild-type copies of the gene in cfDNA with potential use as a biomarker. CfDNA concentration and cfDNA fragmentation pattern have also shown potential utility as biomarkers for cancer patients. Read More

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United States internet searches for "infertility" following COVID-19 vaccine misinformation.

J Osteopath Med 2021 Apr 12. Epub 2021 Apr 12.

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Context: On December 1, 2020, Drs. Wolfgang Wodarg and Micheal Yeadon petitioned to withhold emergency use authorization of the BNT162b2 messenger ribonucleic acid vaccine for coronavirus disease 2019 (COVID-19) manufactured by BioNTech and Pfizer, raising concern for female infertility risks but acknowledging the lack of evidence. The European Medicines Agency and the US Food and Drug Administration ultimately issued emergency use authorizations, but misinformation claiming that COVID-19 vaccines cause female infertility began circulating on social media, potentially influencing public perception and medical decision making among pregnant patients or those seeking to become pregnant. Read More

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Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system.

Burns Trauma 2021 Jan 1;9:tkab001. Epub 2021 Apr 1.

Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, United Kingdom.

Background: Traumatic injury is associated with increased concentrations of cell-free DNA (cfDNA) in the circulation, which contribute to post-injury complications. The endonuclease deoxyribonuclease 1 (DNase-1) is responsible for removing 90% of circulating cfDNA. Recently, DNase activity was reported to be significantly reduced following major non-traumatic brain injury (TBI), but the processes responsible were not investigated. Read More

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January 2021

Can a Higher Protein/Low Glycemic Index vs. a Conventional Diet Attenuate Changes in Appetite and Gut Hormones Following Weight Loss? A 3-Year PREVIEW Sub-study.

Front Nutr 2021 22;8:640538. Epub 2021 Mar 22.

School of Human Sciences, Faculty of Science, The University of Western Australia, Crawley, WA, Australia.

Previous research showed that weight-reducing diets increase appetite sensations and/or circulating ghrelin concentrations for up to 36 months, with transient or enduring perturbations in circulating concentrations of the satiety hormone peptide YY. This study assessed whether a diet that is higher in protein and low in glycemic index (GI) may attenuate these changes. 136 adults with pre-diabetes and a body mass index of ≥25 kg/m underwent a 2-month weight-reducing total meal replacement diet. Read More

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Alterations of PTEN and SMAD4 methylation in diagnosis of breast cancer: implications of methyl II PCR assay.

J Genet Eng Biotechnol 2021 Apr 6;19(1):54. Epub 2021 Apr 6.

Surgical Oncology Department, Mansoura Oncology Centre, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Background: Diagnosis of breast cancer is more complicated due to lack of minimal invasive biomarker with sufficient precision. DNA methylation is a promising marker for cancer diagnosis. In this study, authors evaluated methylation patterns for PTEN and SMAD4 in blood samples using EpiTect Methyl II QPCR assay quantitative PCR technology. Read More

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Circulating NK and NKT cells in the diagnosis and treatment of immunological causes of female infertility - retrospective data analysis from the tertiary clinical center.

Cas Lek Cesk 2021 ;160(1):27-32

Immune dysregulation can cause embryo implantation failure, possibly due to mechanisms of innate non-adaptive immunity, including natural killer (NK) and natural killer T (NKT) cells. Retrospective analysis of relative counts and functional properties of NK and NKT peripheral blood cells in women with cellular immunopathology before and after immunomodulatory treatment was realized to evaluate these values in a proportion of clinical post-treatment pregnancies. For retrospective analysis, data were collected from 184 infertile women treated for abnormal functional properties and/or numbers of NK and NKT cells after stimulation with sperm and trophoblast antigens. Read More

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A comparative study of two immunoassays of maternal placental growth factor.

Scand J Clin Lab Invest 2021 Apr 6:1-6. Epub 2021 Apr 6.

National Perinatal Epidemiology Centre, University College Cork, Cork, Ireland.

Circulating maternal levels of placental growth factor correlates well with placental function and numerous studies advocate its role to help rule-out preterm pre-eclampsia. A number of automated immunoassay platforms to quantify placental growth factors are currently available. The aim of this study was to highlight the importance of developing and validating appropriate reference ranges and clinical cut-offs for immunoassays, by comparing the results obtained from two different immunoassays of placental growth factor; the Quantikine ELISA and the automated Triage test. Read More

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Ecdysteroid metabolism in mammals: The fate of ingested 20-hydroxyecdysone in mice and rats.

J Steroid Biochem Mol Biol 2021 Apr 2:105896. Epub 2021 Apr 2.

Biophytis, Sorbonne Université - BC9, 4 place Jussieu, 75005, Paris, France; Sorbonne Université, CNRS - Institut de Biologie Paris Seine (BIOSIPE), 75005, Paris, France. Electronic address:

Phytoecdysteroids are molecules derived from sterol metabolism and found in many plants. They display a wide array of pharmacological effects on mammals (e.g. Read More

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Assessing the values of circulating immune complexes in multiple sclerosis patients following immunomodulator or corticosteroid treatment.

Exp Ther Med 2021 May 23;21(5):542. Epub 2021 Mar 23.

Department of Sports, Faculty of Physical Education and Sports, 'Ovidius' University of Constanta, 900470 Constanta, Romania.

Multiple sclerosis is defined as an immune-mediated disease that affects the central nervous system, and also is characterized by the presence of immune cells and mediators which contribute to the subsidiary neuroinflammation associated with multiple sclerosis. Throughout the evolution of multiple sclerosis, it has been observed that circulating immune complexes (CICs) have higher values in these patients, especially in the acute phase of the disease. Thus, the aim of the present study was to observe, if in acute attack, relapsing-remitting multiple sclerosis patients still present high values of CICs after treatment with glatiramer and prednisone. Read More

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Circulating microRNA signatures that predict liver fibrosis progression in patients with HIV-1/HCV co-infections.

AIDS 2021 Mar 31. Epub 2021 Mar 31.

IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Badalona, Spain Internal Medicine Department, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Badalona, Spain.

Objective: The lack of available biomarkers for diagnosing and predicting different stages of liver disease with a non-invasive strategy is currently one of the main challenges that clinicians are facing. Recent evidence indicates that the plasma levels of specific microRNAs (miRNAs) may be significantly altered in patients with liver injury, including those with human immunodeficiency virus type 1 (HIV-1) infections.

Design/methods: Large-scale deep sequencing analysis of small RNA expression was performed on plasma samples from 46 patients with HIV-1/hepatitis C virus (HCV) co-infections that did not exhibit liver fibrosis at the time of sampling. Read More

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Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data.

EBioMedicine 2021 Apr 1;66:103318. Epub 2021 Apr 1.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background: Biomarker-disease relationships are extensively investigated. However, associations between common clinical biomarkers and healthspan, the disease-free lifespan, are largely unknown. We aimed to explore the predictive values of ten biomarkers on healthspan and lifespan, and to identify putative causal mechanisms. Read More

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Changes in the profile of circulating HDL subfractions in severe obese adolescents following a weight reduction program.

Nutr Metab Cardiovasc Dis 2021 Feb 10. Epub 2021 Feb 10.

Institute of Bioengineering and Department of Applied Biology-Nutrition, University Miguel Hernandez, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. Electronic address:

Background And Aims: Epidemiological studies show that obese adolescents are candidates to suffer cardiovascular pathologies in adulthood. In order to detect subfractions with a diagnostic value for future cardiovascular disorders, we analyzed the complete lipoprotein profile of severely obese adolescents.

Methods And Results: Twenty-eight obese adolescents free from comorbidities were admitted into a weight reduction program. Read More

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February 2021

Early, On-Treatment Levels and Dynamic Changes of Genomic Instability in Circulating Tumor DNA Predict Response to Treatment and Outcome in Metastatic Breast Cancer Patients.

Cancers (Basel) 2021 Mar 16;13(6). Epub 2021 Mar 16.

Lady Davis Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Background: Circulating tumor DNA (ctDNA) offers high sensitivity and specificity in metastatic cancer. However, many ctDNA assays rely on specific mutations in recurrent genes or require the sequencing of tumor tissue, difficult to do in a metastatic disease. The purpose of this study was to define the predictive and prognostic values of the whole-genome sequencing (WGS) of ctDNA in metastatic breast cancer (MBC). Read More

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Baseline and Kinetic Circulating Tumor Cell Counts Are Prognostic Factors in a Prospective Study of Metastatic Colorectal Cancer.

Diagnostics (Basel) 2021 Mar 12;11(3). Epub 2021 Mar 12.

International Research Center, A.C. Camargo Cancer Center, São Paulo 01508-010, Brazil.

The discovery of predictive biomarkers in metastatic colorectal cancer (mCRC) is essential to improve clinical outcomes. Recent data suggest a potential role of circulating tumor cells (CTCs) as prognostic indicators. We conducted a follow-on analysis from a prospective study of consecutive patients with mCRC. Read More

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miR-30b-5p Downregulation as a Predictive Biomarker of Coronary In-Stent Restenosis.

Biomedicines 2021 Mar 30;9(4). Epub 2021 Mar 30.

Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío, University of Seville, CSIC, 41013 Seville, Spain.

In-stent restenosis (ISR) is one of the main limitations of percutaneous coronary intervention (PCI) therapy with drug-eluting stents (DES) implantation. The aim of this study was to determine if circulating microRNAs (miRNAs) have diagnostic capability for determining ISR in a cohort of matched patients. Blood samples were collected from 55 patients who underwent previously PCI and were readmitted for a new coronary angiography. Read More

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Effects of Christian Orthodox Fasting Versus Time-Restricted Eating on Plasma Irisin Concentrations Among Overweight Metabolically Healthy Individuals.

Nutrients 2021 Mar 25;13(4). Epub 2021 Mar 25.

First Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.

Irisin has been recently identified as an adipomyokine produced during physical activity and involved in the browning of adipose tissue. Despite the emerging evidence suggesting an inverse relationship between irisin plasma concentrations and adverse metabolic outcomes, the exact impact of diet on irisin levels remains obscure. Thus, we aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on circulating irisin levels among overweight, metabolically healthy, adults. Read More

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Performance, Correlation and Kinetic Profile of Circulating Serum Fungal Biomarkers of Invasive Aspergillosis in High-Risk Patients with Hematologic Malignancies.

J Fungi (Basel) 2021 Mar 13;7(3). Epub 2021 Mar 13.

Clinical Microbiology Laboratory, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.

As conventional microbiological documentation of invasive aspergillosis (IA) is difficult to obtain, serum fungal biomarkers are important adjunctive diagnostic tools. Positivity rates and the kinetic profiles of galactomannan (GM), 1,3-β-D-glucan (BDG) and DNA (PCR) were studied in high-risk patients with hematologic malignancies. GM, BDG and PCR data from serial serum specimens ( = 240) from 93 adult hematology patients with probable ( = 8), possible ( = 25) and no ( = 60) IA were retrospectively analyzed. Read More

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New Insights into the Metabolism of the Flavanones Eriocitrin and Hesperidin: A Comparative Human Pharmacokinetic Study.

Antioxidants (Basel) 2021 Mar 11;10(3). Epub 2021 Mar 11.

Laboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department Food Science and Technology, Campus de Espinardo, CEBAS-CSIC, P.O. Box 164, 30100 Murcia, Spain.

The intake of hesperidin-rich sources, mostly found in orange juice, can decrease cardiometabolic risk, potentially linked to the gut microbial phase-II hesperetin derivatives. However, the low hesperidin solubility hampers its bioavailability and microbial metabolism, yielding a high inter-individual variability (high vs. low-producers) that prevents consistent health-related evidence. Read More

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Arginine Metabolites as Biomarkers of Myocardial Ischaemia, Assessed with Cardiac Magnetic Resonance Imaging in Chronic Kidney Disease.

Biomolecules 2021 Mar 11;11(3). Epub 2021 Mar 11.

Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia.

(1) Background: Cardiovascular disease (CVD) is the major cause of morbidity and mortality in patients with chronic kidney disease (CKD). Myocardial oxygenation and perfusion response to stress, using oxygen-sensitive cardiovascular magnetic resonance (OS-CMR) and stress T1 mapping respectively, are impaired in CKD patients with and without known coronary artery disease (CAD). Endothelial dysfunction, assessed by circulating levels of asymmetric dimethylarginine (ADMA) and homoarginine (HMA), promotes atherosclerosis. Read More

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Prognostic Stratification of Metastatic Prostate Cancer Patients Treated With Abiraterone and Enzalutamide Through an Integrated Analysis of Circulating Free microRNAs and Clinical Parameters.

Front Oncol 2021 16;11:626104. Epub 2021 Mar 16.

Oncology 1 Unit, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Androgen Receptor-Targeted Agents (ARTA) have dramatically changed the therapeutic landscape of metastatic Castration-Resistant Prostate Cancer (mCRPC), but 20-40% of these patients progress early after start of ARTA treatment. The present study investigated the potential utility of plasma cell-free microRNAs (cfmiRNAs) as prognostic markers by analyzing a prospective cohort of 31 mCRCP patients treated with abiraterone ( = 10) or enzalutamide ( = 21). Additional potential prognostic factors were extracted from clinical records and outcome was evaluated as overall survival (OS) and progression-free survival (PFS). Read More

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A prospective investigation of circulating metabolome identifies potential biomarkers for gastric cancer risk.

Cancer Epidemiol Biomarkers Prev 2021 Apr 1. Epub 2021 Apr 1.

Department of Medicine, Vanderbilt University Medical Center.

Background: Metabolomics is widely used to identify potential novel biomarkers for cancer risk. No investigation, however, has been conducted to prospectively evaluate the role of perturbation of metabolome in gastric cancer development.

Methods: Two hundred fifty incident cases diagnosed with primary gastric cancer were selected from the Shanghai Women's Health and the Shanghai Men's Health Study, and each was individually matched to one control by incidence density sampling. Read More

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Strenuous 12-h run elevates circulating biomarkers of oxidative stress, inflammation and intestinal permeability in middle-aged amateur runners: A preliminary study.

PLoS One 2021 1;16(4):e0249183. Epub 2021 Apr 1.

Department of Chemistry and Biochemistry, Institute for Basic Science, University of Physical Education, Krakow, Poland.

Given the solid evidence that prolonged strenuous exercise is a cause of metabolic stress, this study sought to determine whether a 12-h run would affect total oxidant status (TOS), total oxidant capacity (TOC), total antioxidant status (TAS), high-sensitivity C-reactive protein (hs-CRP) and the biomarkers of intestinal permeability (protein fatty acid-binding proteins (I-FABP) and zonulin) in middle-aged male subjects. Ten amateur long-distance runners (aged 52.0 ± 6. Read More

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Increased neutrophil-lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification.

BMC Surg 2021 Mar 31;21(1):176. Epub 2021 Mar 31.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Background: The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed the ability to predict the recurrence of such markers after curative resection in patients with these neoplasms.

Methods: Circulating/systemic neutrophil-lymphocyte, monocyte-lymphocyte, platelet-lymphocyte, and platelet-white cell ratios were evaluated in 120 patients who underwent curative resection for well-differentiated pancreatic neuroendocrine neoplasms without synchronous distant metastasis between 2001 and 2018. Read More

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High frequency of concurrent anti-C1q and anti-dsDNA but not anti-C3b antibodies in patients with Lupus Nephritis.

J Immunoassay Immunochem 2021 Mar 31:1-18. Epub 2021 Mar 31.

Department of Rheumatology, Iran University of Medical Sciences, Tehran, Iran.

Lupus Nephritis (LN) in patients with Systemic Lupus Erythematosus (SLE) is one of the most serious and prevalent manifestations. The procedure of renal biopsy is harmful and accompanied by potential hazards. Therefore, introducing reliable biomarkers to predict LN is exceedingly worthwhile. Read More

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Alterations in serum amino acid profiles in children with attention deficit/hyperactivity disorder.

Biomed Rep 2021 May 19;14(5):47. Epub 2021 Mar 19.

Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl 150000, Russia.

The objective of the present study was to evaluate the circulating serum amino acid levels in children with attention deficit/hyperactivity disorder (ADHD). A total of 71 children with untreated ADHD and 31 neurotypical controls aged 7-14 years old were examined. Serum amino acid levels were evaluated using high-performance liquid chromatography (HPLC) with UV-detection. Read More

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