8 results match your criteria circrna_100395

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CircRNA_100395 Carried by Exosomes From Adipose-Derived Mesenchymal Stem Cells Inhibits the Malignant Transformation of Non-Small Cell Lung Carcinoma Through the miR-141-3p-LATS2 Axis.

Front Cell Dev Biol 2021 25;9:663147. Epub 2021 Mar 25.

Department of Medical Oncology, Shulan (Hangzhou) Hospital, Affiliated to Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.

Objective: The specific purpose of this study is to investigate the impact exosomes from adipose-derived mesenchymal stem cell (AMSC) has on non-small cell lung carcinoma (NSCLC) and the relative applications.

Methods: circ_100395, miR-141-3p, and LATS2 were expressed and detected in NSCLC and paracancerous tissues as well as NSCLC cell lines. Pearson correlation analysis, Dual-Luciferase Reporter Assay and RNA pull-down assay were used to validate their expression and interaction, respectively. Read More

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Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis.

Oncol Lett 2021 May 28;21(5):419. Epub 2021 Mar 28.

Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China.

Gastric cancer (GC) has a high morbidity and mortality, hence it is very important to elucidate the molecular pathogenesis mechanism of GC progression in order to find new treatment strategies. The present study aimed to explore the biological function of circular RNA_100395 (circRNA_100395) in GC. The expression level of circRNA_100395 in GC tissues, as well as normal epithelial cells and various gastric cancer cell lines, was detected using reverse transcription-quantitative PCR. Read More

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Inhibitory role of circRNA_100395 in the proliferation and metastasis of prostate cancer cells.

J Int Med Res 2021 Feb;49(2):300060521992215

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Objective: Circular RNAs (circRNAs) are non-coding RNAs with high cancer-specific expression and the potential for regulating tumorigenesis. CircRNA_100395 is expressed at low levels in many cancers and is involved in the regulation of tumor cell proliferation and metastasis. However, its expression and function in prostate cancer remain unclear. Read More

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February 2021

Expression profile of circular RNAs in cystic echinococcosis pericystic tissue.

J Clin Lab Anal 2021 Mar 7;35(3):e23687. Epub 2021 Jan 7.

Department of Vascular and Hepatobilliry Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.

Objective: The aim of the present study was to investigate the expression profiles of circular RNAs (circRNAs) in the pericystic tissue of patients with cystic echinococcosis (CE).

Patients And Methods: CircRNA expression profiles were obtained by circRNA microarray of four matched pairs of pericystic tissues affected by CE and adjacent normal liver tissues. qRT-PCR was used to validate the differential expression of some circRNAs identified by the microarray analysis. Read More

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CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6.

Eur Rev Med Pharmacol Sci 2020 12;24(23):12216-12223

Secondary Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

Objective: This study aims to uncover the differential expression of circRNA_100395 in breast carcinoma specimens, and its regulatory effect on cancer cell phenotypes. The role of circRNA_100395 in affecting breast carcinoma progression and the molecular mechanism are explored as well.

Patients And Methods: CircRNA_100395 expressions in breast carcinoma and paracancerous tissues were detected. Read More

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December 2020

CircRNA_100395 inhibits cell proliferation and metastasis in ovarian cancer via regulating miR-1228/p53/epithelial-mesenchymal transition (EMT) axis.

J Cancer 2020 1;11(3):599-609. Epub 2020 Jan 1.

Department of Obstetrics and Gynaecology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China.

Circular RNAs (circRNAs) have been reported to regulate the incidence of tumor by regulating the transcriptional level and post-transcriptional level of tumor-related genes, and are significantly correlated with tumor metastasis and progression. CircRNA_100395 (circ_100395) has been reported to suppress lung cancer cell proliferation, and might act as an oncogene in deveopment of various cancers. However, the expression and function of circ_100395 in ovarian cancer has not been systematically researched. Read More

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January 2020

Role of CircRNAs_100395 in Proliferation and Metastases of Liver Cancer.

Med Sci Monit 2019 Aug 17;25:6181-6192. Epub 2019 Aug 17.

Department of Vascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Circular RNAs (circRNAs) are a kind of noncoding RNA with high cancer-specific expression, and great potential in regulating tumorigenesis. Among these, circRNA_100395 (circ_100395) has been reported to be downregulated in lung cancer, and participates in the process of tumor cell proliferation and metastasis. However, its expression and function in liver cancer remain unknown. Read More

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Microarray profiling of circular RNAs in human papillary thyroid carcinoma.

PLoS One 2017 13;12(3):e0170287. Epub 2017 Mar 13.

Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, China.

Background: Non-coding circular RNAs (circRNAs) have displayed dysregulated expression in several human cancers. Here, we profiled the circRNA expression of papillary thyroid carcinoma (PTC) tumors to improve our understanding of PTC pathogenesis.

Methods: Microarray profiling was performed on 18 thyroid samples, consisting of six PTC tumors, six matching contralateral normal samples, and six benign thyroid lesions. Read More

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September 2017
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