3,606 results match your criteria cinnamic acid


Small Intrahepatic Vein Budd-Chiari Syndrome Complicated by Peritonitis.

ACG Case Rep J 2019 Jul 2;6(7):e00121. Epub 2019 Jul 2.

Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

Budd-Chiari syndrome is a rare disorder with significant liver-related complications. We present a 28-year-old woman with a 1-month history of weight loss and ascites. Hepatic venogram showed patent hepatic veins and inferior vena cava; however, there was an increased hepatic venous pressure gradient, which is clinically significant for portal hypertension. Read More

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http://dx.doi.org/10.14309/crj.0000000000000121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722369PMC
July 2019
2 Reads

Microwave-assisted single step cinnamic acid derivatization to mimic vanillin isomer and their cytotoxic potential.

Curr Pharm Biotechnol 2019 Oct 15. Epub 2019 Oct 15.

Molecular Bioprospection Department, CSIR-CIMAP Lucknow-226015. India.

Background: Cinnamic acid, a phenolic compound plays a crucial role in the formation of the secondary metabolites in plants using different pathways. Decalepis arayalpathra have plenty of secondary metabolite 2-hydroxy 4-methoxybenzaldehyde (HMB) present in its roots.

Objective: The study is conducted to confirm the presence of HMB and its precursor, i. Read More

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http://dx.doi.org/10.2174/1389201020666191015161429DOI Listing
October 2019

Cu-Catalysed oxidative amidation of cinnamic acids/arylacetic acids with 2° amines: an efficient synthesis of α-ketoamides.

Org Biomol Chem 2019 Oct 15. Epub 2019 Oct 15.

Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.

A new and convenient copper-catalysed synthesis of α-ketoamides has been accomplished using readily available cinnamic acids/arylacetic acids and 2° amines in an open atmosphere. The reaction between cinnamic acid and amine involves the formation of enamine followed by its aerobic oxidation, whereas the reaction of arylacetic acid with amine involves amide formation followed by benzylic methylene oxidation. Read More

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http://dx.doi.org/10.1039/c9ob02045dDOI Listing
October 2019

Cinnamic Acid and Sorbic acid Conversion Are Mediated by the Same Transcriptional Regulator in .

Front Bioeng Biotechnol 2019 27;7:249. Epub 2019 Sep 27.

Fungal Physiology, Westerdijk Fungal Biodiversity Institute and Fungal Molecular Physiology, Utrecht University, Utrecht, Netherlands.

Cinnamic acid is an aromatic compound commonly found in plants and functions as a central intermediate in lignin synthesis. Filamentous fungi are able to degrade cinnamic acid through multiple metabolic pathways. One of the best studied pathways is the non-oxidative decarboxylation of cinnamic acid to styrene. Read More

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http://dx.doi.org/10.3389/fbioe.2019.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776626PMC
September 2019

Apoptosis of Leukemia Cells by Ocimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3.

Curr Pharm Des 2019 Oct 10. Epub 2019 Oct 10.

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad. Pakistan.

Purpose: Leukemia, one of the major cancers, affects a large proportion of people around the world. Better treatment options for leukemia are required due to large number of side effects associated with current therapeutic regimens. In the present study, we sought to determine the pathway of triggering apoptosis of leukemic cells by Ocimum basilicum plant extract. Read More

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http://www.eurekaselect.com/175566/article
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http://dx.doi.org/10.2174/1381612825666191011100826DOI Listing
October 2019
4 Reads
3.452 Impact Factor

[Quality evaluation of Styrax based on quantitative determination of 7 chemical components using HPLC wavelength switching method and chemometrics].

Zhongguo Zhong Yao Za Zhi 2019 Jul;44(14):3070-3077

Chengdu Institute for Food and Drug Control Chengdu 610045,China.

In order to evaluate the quality of Styrax more comprehensively,this study attempted to establish an HPLC wavelength switching method to simultaneously determine the content of seven compounds in Styrax,and chemometrics were used to analyze the quality difference between different sources of Styrax,and finally establish a characteristic chromatogram of Styrax. The column was Agilent ZORBAX Extend C18( 4. 6 mm×250 mm,5 μm) with phase a mixture of acetonitrile-0. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190423.201DOI Listing

[Spectrum-effect relationship between HPLC fingerprint and free radicals scavenging in Guizhi Shaoyao Zhimu Decoction].

Zhongguo Zhong Yao Za Zhi 2019 Jul;44(14):3042-3048

Good Doctor Pharmaceutical Group Co.,Ltd. Chengdu 610073,China.

To establish the spectrum-effect relationship between HPLC fingerprint and free radicals activity scavenging in Guizhi Shaoyao Zhimu Decoction( GSZD),and provide a basis for the quality evaluation and modernization of classical prescriptions. Shimadsu GL-science C18 column( 4. 6 mm×250 mm,5 μm) was used with acetonitrile-0. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190410.305DOI Listing

Isolation, Identification and Synthesis of a New Prenylated Cinnamic Acid Derivative from Brazilian Green Propolis and Simultaneous Quantification of Bioactive Components by LC-MS/MS.

J Agric Food Chem 2019 Oct 9. Epub 2019 Oct 9.

A new cinnamic acid derivative, ()-3-[4-hydroxy-3-(()-3-formyl-2-butenyl)phenyl]-2- propenoic acid () has been isolated from the ethanol extract of Brazilian green propolis along with three known cinnamic acid derivatives, 3,4-dihydroxy-5-prenyl-()-cinnamic acid (), capillartemisin A () and 2,2-dimethylchromene-6-()-propenoic acid (), and a flavonoid, dihydrokaempferide () by liquid-liquid participation, a series of column chromatography and preparative HPLC. Their structures have been determined by spectroscopic analyses and chemical synthesis of compound . The simultaneous quantification of 20 constituents, including 10 cinnamic acid derivatives, 7 flavonoids and 3 caffeoylquinic acid derivatives, has also been developed and validated using LC-MS/MS. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b04835DOI Listing
October 2019

Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues.

Bioorg Chem 2019 Sep 26;93:103316. Epub 2019 Sep 26.

School of Pharmacy, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an, China. Electronic address:

This study aimed to synthesize and screen tyrosinase inhibitors for delay fruit browning. A series of vanillyl cinnamate analogues were designed and synthesized by simple processes, and the inhibitory effects of all the synthesized derivatives on mushroom tyrosinase were evaluated. In the enzymatic activity test, compounds 21, 22, and 26 had significant (P < 0. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.103316DOI Listing
September 2019
2.152 Impact Factor

Purification and Characterization of Phenylalanine Ammonia-Lyase as a Novel Approach for Myristicin Biotransformation.

J Microbiol Biotechnol 2019 Sep 30. Epub 2019 Sep 30.

Enzymology and Fungal Biotechnology Lab (EFBL), Botany and Microbiology Department, Faculty of Science, Zagazig University, 44519, Zagazig, Egypt.

Phenylalanine ammonia-lyase (PAL) catalyzes the reversible deamination of phenylalanine to cinnamic acid and ammonia. Algae have been considered as biofactories for PAL production, however, biochemical characterization of PAL and its potency for myristicin biotransformation into MMDA (3-methoxy-4, 5-methylenedioxyamphetamine) has not been studied yet. Thus, PAL from and has been purified, comparatively characterized and its affinity to transform myristicin was assessed. Read More

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http://dx.doi.org/10.4014/jmb.1908.08009DOI Listing
September 2019

Effect of Methyl Jasmonate on Phenolic Accumulation in Wounded Broccoli.

Molecules 2019 Sep 30;24(19). Epub 2019 Sep 30.

School of Bioengineering, Dalian University of Technology, Dalian 116024, China.

In order to find an efficient way for broccoli to increase the phenolic content, this study intended primarily to elucidate the effect of methyl jasmonate (MeJA) treatment on the phenolic accumulation in broccoli. The optimum concentration of MeJA was studied first, and 10 μM MeJA was chosen as the most effective concentration to improve the phenolic content in wounded broccoli. Furthermore, in order to elucidate the effect of methyl jasmonate (MeJA) treatment on phenolic biosynthesis in broccoli, the key enzyme activities of phenylpropanoid metabolism, the total phenolic content (TPC), individual phenolic compounds (PC), antioxidant activity (AOX) and antioxidant metabolism-associated enzyme activities were investigated. Read More

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http://dx.doi.org/10.3390/molecules24193537DOI Listing
September 2019

Organophosphane-Promoted Synthesis of Functionalized α,β-Unsaturated Alkenes and Furanones via Direct β-Acylation.

Org Lett 2019 Oct 30;21(20):8339-8343. Epub 2019 Sep 30.

Department of Chemistry , National Taiwan Normal University , 88, Sec. 4, Tingchow Road , Taipei 11677 , Taiwan, R.O.C.

We report a phosphine-mediated direct β-acylation of α,β-unsaturated 1,3-diketones with acyl chlorides and a base. Functionalized furanones were also prepared by the reaction of cinnamic acid and acyl chloride according to our protocol via β-acylation. Our studies revealed that α,β-unsaturated 1,3-diketones with an electron-donating group at the second position favor the formation of β-acylated products, whereas those with oxygen, such as anhydrides, favor furanones via an unprecedented C-acylation/cyclization sequence. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b03116DOI Listing
October 2019

-alkylimidazolium Salts Functionalized with -Coumaric and Cinnamic Acid: A Study of Their Antimicrobial and Antibiofilm Effects.

Molecules 2019 Sep 26;24(19). Epub 2019 Sep 26.

Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca 3460000, Chile.

The bacterial resistance to antibiotics has compromised the therapies used for bacterial infections. Nowadays, many strategies are being carried out to address this problem. Among them, the use of natural compounds like cinnamic and -coumaric acids stands out. Read More

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http://dx.doi.org/10.3390/molecules24193484DOI Listing
September 2019

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR.

Bioorg Chem 2019 Nov 13;92:103253. Epub 2019 Sep 13.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 2A Nan Wei Road, Beijing 100050, PR China. Electronic address:

Two β-secreatase (BACE1) inhibitors from natural products (cinnamic acid and flavone) were linked to furnish potent, cell permeable BACE1 inhibitors with noncompetitive mode of inhibition, with the assistance of saturated transfer difference (STD)-NMR technique. Some of these conjugates also exhibited selective BACE1 inhibition over other aspartyl proteases such as BACE-2 and renin, as well as poor cytotoxicity. Taken together, conjugates 4 represent a new series of BACE inhibitors warrants further investigation for their potential in Alzheimier's disease therapy. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.103253DOI Listing
November 2019

Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms.

Eur J Med Chem 2019 Sep 20;183:111723. Epub 2019 Sep 20.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova 32, Moscow, 119991, Russia.

A set of ortho-, meta- and para-substituted cinnamic hydroxamic acids (CHAs) was synthesized. In each series of structural isomers, a phenyl substituent was linked to an aromatic ring of the parent cinnamic acid via a linker of one to four atoms in length. Using a cell test system with the full-length replicon of hepatitis C virus (HCV), we established a relationship between the suppression of HCV replicon propagation and the inhibition of class I/IIb histone deacetylases (HDACs). Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.111723DOI Listing
September 2019
2 Reads

Synthesis of cinnamic acid derivatives and leishmanicidal activity against Leishmania braziliensis.

Eur J Med Chem 2019 Sep 9;183:111688. Epub 2019 Sep 9.

Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG, Brazil. Electronic address:

Leishmania braziliensis is one of the pathogenic agents of cutaneous and mucocutanoeous leishmaniasis. There are no validated vaccines to prevent the infection and the treatment relies on drugs that often present severe side effects, which justify the efforts to find new potential antileishmanial drugs. An alternative to promote the discovery of new drugs would be the association of different chemical groups of bioactive compounds. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.111688DOI Listing
September 2019
3 Reads

Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect.

Eur J Med Chem 2019 Sep 13;183:111695. Epub 2019 Sep 13.

School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address:

As for complex brain diseases involved with multiple pathogenic factors, it is extremely difficult to achieve curative effect by acting on a single target. Multi-approach drugs provide a promising prospect in the treatment of complex brain diseases and have been attracting more and more interest. Enlightened by synergetic effect of combination in traditional herb medicines, forty-two novel cinnamic acid derivatives were designed and synthesized by introducing capsaicin and/or ligustrazine moieties to enhance biological activities in both neurological function and neurovascular protection. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.111695DOI Listing
September 2019
1 Read

Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study.

Eur J Med Chem 2019 Sep 6;183:111650. Epub 2019 Sep 6.

Northwest University, Xi'an, 710069, China. Electronic address:

Inspired by the traditional Chinese herbal pair of Polygala tenuifolia-Acori Tatarinowii for treating epilepsy, 33 novel substituted cinnamic α-asaronol esters and analogues were designed by Combination of Traditional Chinese Medicine Molecular Chemistry (CTCMMC) strategy, synthesized and tested systematically not only for anticonvulsant activity in three mouse models but also for LDH inhibitory activity. Thereinto, 68-70 and 75 displayed excellent and broad spectra of anticonvulsant activities with modest ability in preventing neuropathic pain, as well as low neurotoxicity. The protective indices of these four compounds compared favorably with stiripentol, lacosamide, carbamazepine and valproic acid. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193079
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http://dx.doi.org/10.1016/j.ejmech.2019.111650DOI Listing
September 2019
3 Reads
3.447 Impact Factor

New cinnamic acid-pregenolone hybrids as potential antiproliferative agents: Design, synthesis and biological evaluation.

Steroids 2019 Sep 16;152:108499. Epub 2019 Sep 16.

School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address:

A series of new cinnamic acid-pregenolone hybrids (5a-5o) was designed, synthesized and evaluated for their in vitro antiproliferative activity. Some of them showed potential antiproliferative activity and selectivity towards a panel of cancer cell lines, including A549, H157, HepG2, MCF-7, and HL-60. Among these analogs, compound 5f showed the most promising activity with IC values ranging from 3. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.108499DOI Listing
September 2019

Identification of Cinnamaldehyde as Most Effective Fatty Acid Uptake Reducing Cinnamon-Derived Compound in Differentiated Caco-2 Cells Compared to Its Structural Analogues Cinnamyl Alcohol, Cinnamic Acid, and Cinnamyl Isobutyrate.

J Agric Food Chem 2019 Oct 14. Epub 2019 Oct 14.

Symrise AG , Muehlenfeldstraße 1 , Holzminden 37603 , Germany.

Naturally occurring cinnamon compounds such as cinnamaldehyde (CAL) and structurally related constituents have been associated with antiobesity activities, although studies regarding the impact on intestinal fatty acid uptake are scarce. Here, we demonstrate the effects of CAL and structural analogues cinnamyl alcohol (CALC), cinnamic acid (CAC), and cinnamyl isobutyrate on mechanisms regulating intestinal fatty acid uptake in differentiated Caco-2 cells. CAL, CALC, and CAC (3000 μM) were found to decrease fatty acid uptake by 58. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b04274DOI Listing
October 2019

Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase.

Nat Chem 2019 Sep 16. Epub 2019 Sep 16.

Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.

The UbiD enzyme plays an important role in bacterial ubiquinone (coenzyme Q) biosynthesis. It belongs to a family of reversible decarboxylases that interconvert propenoic or aromatic acids with the corresponding alkenes or aromatic compounds using a prenylated flavin mononucleotide cofactor. This cofactor is suggested to support (de)carboxylation through a reversible 1,3-dipolar cycloaddition process. Read More

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http://dx.doi.org/10.1038/s41557-019-0324-8DOI Listing
September 2019

Comprehensive identification of minor components and bioassay-guided isolation of an unusual antioxidant from Azolla imbricata using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with multicomponent knockout and bioactivity evaluation.

J Chromatogr A 2019 Aug 7:460435. Epub 2019 Aug 7.

School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address:

Azolla imbricata (Roxb.) Nakai is used as a traditional Chinese medicine. However, very limited information is available on its effective components. Read More

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http://dx.doi.org/10.1016/j.chroma.2019.460435DOI Listing
August 2019
2 Reads

cis-Cinnamic acid is a natural plant growth-promoting compound.

J Exp Bot 2019 Aug 30. Epub 2019 Aug 30.

Ghent University, Department of Plant Biotechnology and Bioinformatics, Gent, Belgium.

Agrochemicals provide vast potential to improve plant productivity, because they are easy to implement at low cost while not being restricted by species barriers as compared to breeding strategies. Despite the general interest, only few compounds with growth-promoting activity have been described so far. Here, we add cis-cinnamic acid (c-CA) to the small portfolio of existing plant growth stimulators. Read More

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http://dx.doi.org/10.1093/jxb/erz392DOI Listing
August 2019
2 Reads

Antioxidant Effects of Tea Extracts on d-Galactose-Induced Aging Model in Mice.

Antioxidants (Basel) 2019 Sep 8;8(9). Epub 2019 Sep 8.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.

As a traditional Chinese medicinal drink, , a local tea from Xinjiang, China, is favored for its rich flavor and biological functionality. This study looked at aging mice induced by d-galactose to determine the in vivo anti-aging effect of tea extracts (AVTEs) and its bioactive components. We evaluated the weight of major organs (via organ index) and pathological changes in the liver. Read More

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http://dx.doi.org/10.3390/antiox8090381DOI Listing
September 2019
2 Reads

In vitro antitumor activity, ADME-Tox and 3D-QSAR of synthesized and selected natural styryl lactones.

Comput Biol Chem 2019 Aug 23;83:107112. Epub 2019 Aug 23.

University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia; Serbian Academy of Sciences and Arts, Knez Mihajlova 35, 11000 Belgrade, Serbia.

Prostate cancer is a common cause of death in men and a novel treating methods should be developed. In order to find a new drug for prostate cancer, a series of novel conformationally constrained analogues of (+)-goniofufurone and 7-epi-(+)-goniofufurone, as well as the newly synthesized styryl lactones containing the cinnamic acid ester groups were evaluated for in vitro cytotoxicity against prostate cancer cell (PC-3). Furthermore, prediction of physicochemical characteristics and drugability as well as in silico ADME-Tox tests of investigated compounds were performed. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.107112DOI Listing
August 2019
1 Read

Cinnamic acid rescues behavioral deficits in a mouse model of traumatic brain injury by targeting miR-455-3p/HDAC2.

Life Sci 2019 Aug 29;235:116819. Epub 2019 Aug 29.

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.

Aims: Traumatic brain injury (TBI) not only induces physiological disabilities but also leads to cognitive impairment. However, no effective therapeutic approach for TBI-related memory decline exists. In this study, we treated TBI mice with cinnamic acid (CNA) to detect whether CNA is able to rescue the memory deficits induced by TBI and to explore the potential mechanisms. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.116819DOI Listing

Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model.

Nutr Res 2019 Jul 30;69:30-41. Epub 2019 Jul 30.

Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan; Program of Food and AgriLife Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan. Electronic address:

Brazilian propolis is rich in cinnamic acid derivatives and reportedly reduces intestinal inflammation in rodents; however, the underlying mechanisms remain unclear. We hypothesized that the regulation of tight junction (TJ) barrier, Th17 cell differentiation, and/or, macrophage activation by cinnamic acid derivatives were involved in the propolis-mediated anti-inflammatory effect. Mice were orally administered 2% dextran sodium sulfate (DSS) in combination with either the feeding control or a diet containing 0. Read More

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http://dx.doi.org/10.1016/j.nutres.2019.07.003DOI Listing

Antinociceptive Activity of Petroleum Ether Fraction of Leaves Methanolic Extract: Roles of Nonopioid Pain Modulatory Systems and Potassium Channels.

Biomed Res Int 2019 5;2019:6593125. Epub 2019 Aug 5.

Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.

Methanolic extract of Lindau leaves (MECN) has been reported to exert antinociceptive activity. The present study aimed to elucidate the possible antinociceptive mechanisms of a lipid-soluble fraction of MECN, which was obtained after sequential extraction in petroleum ether. The petroleum ether fraction of (PECN), administered orally to mice, was (i) subjected to capsaicin-, glutamate-, phorbol 12-myristate 13-acetate-, bradykinin-induced nociception model; (ii) prechallenged (intraperitoneal (i. Read More

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http://dx.doi.org/10.1155/2019/6593125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699298PMC

Chiral nanostructures self-assembled from nitrocinnamic amide amphiphiles: substituent and solvent effects.

Beilstein J Nanotechnol 2019 5;10:1608-1617. Epub 2019 Aug 5.

Beijing National Laboratory for Molecular Science (BNLMS), CAS Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Chiral nanostructures, such as α-helical proteins and double helix DNA, are widely found in biological systems and play a significant role in the biofunction of life. These structures are essentially fabricated through the covalent or noncovalent bonds between small chiral molecules. It is thus an important issue to understand how small chiral molecules can form chiral nanostructures. Read More

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http://dx.doi.org/10.3762/bjnano.10.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693415PMC
August 2019
1 Read

Phenylpropanoid Glycerol Glucosides Attenuate Glucose Production in Hepatocytes.

ACS Omega 2019 Jun 19;4(6):10670-10676. Epub 2019 Jun 19.

Department of Food Science, University of Tennessee Institute of Agriculture, Knoxville, Tennessee 37996, United States.

An activity-guided fractionation approach revealed several phenylpropanoid glycerol glucosides isolated from the bulbs of Thunb. (Easter lily) with gluconeogenesis inhibitory activities. The strongest activity was observed for (2)-1---coumaroyl-2--β-d-glucopyranosylglycerol (), (2)-1--caffeoyl-2--β-d-glucopyranosylglycerol (), and (2)-1--β-d-glucopyranosyl-2-coumaroylglycerol () with inhibitions of 51. Read More

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http://dx.doi.org/10.1021/acsomega.9b00751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648405PMC

Synthesis, computational studies, tyrosinase inhibitory kinetics and antimelanogenic activity of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives.

J Enzyme Inhib Med Chem 2019 Dec;34(1):1-11

Department of Chemistry, Siedlce University of Natural Sciences and Humanities , Siedlce , Poland.

The over expression of melanogenic enzymes like tyrosinase caused many hyperpigmentaion disorders. The present work describes the synthesis of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives and as antimelanogenic agents. The tyrosinase inhibitory activity of synthesized derivatives and was determined and it was found that derivative possesses excellent activity with IC = 0. Read More

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http://dx.doi.org/10.1080/14756366.2019.1654468DOI Listing
December 2019
1 Read
2.383 Impact Factor

Identification of phenylamide phytoalexins and characterization of inducible phenylamide metabolism in wheat.

Phytochemistry 2019 Nov 23;167:112098. Epub 2019 Aug 23.

Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan. Electronic address:

Changes in specialized metabolites were analyzed in wheat leaves inoculated with Bipolaris sorokiniana, the causal agent of spot blotch of Poaceae species. HPLC analysis detected the accumulation of six compounds in B. sorokiniana-infected leaves. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.112098DOI Listing
November 2019
1 Read

Low-molecular-weight-heparin increases Th1- and Th17-associated chemokine levels during pregnancy in women with unexplained recurrent pregnancy loss: a randomised controlled trial.

Sci Rep 2019 Aug 23;9(1):12314. Epub 2019 Aug 23.

Department of Clinical Immunology and Transfusion Medicine, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Low-molecular-weight heparin (LMWH) is widely used to treat recurrent pregnancy loss (RPL) because of its anti-coagulant effects. Although in vitro studies have suggested additional immunological effects, these are debated. We therefore investigated whether LMWH could modulate immune responses in vivo during pregnancy of women with unexplained RPL. Read More

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http://dx.doi.org/10.1038/s41598-019-48799-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707182PMC

Cinnamate-CoA ligase is involved in biosynthesis of benzoate-derived biphenyl phytoalexin in Malus × domestica 'Golden Delicious' cell cultures.

Plant J 2019 Aug 22. Epub 2019 Aug 22.

Plant Molecular Biology Group, Biotechnology Department, Indian Institute of Technology Roorkee, Roorkee, 247667, India.

Apple (Malus sp.) and other genera belonging to the sub-tribe Malinae of the Rosaceae family produce unique benzoic acid-derived biphenyl phytoalexins. Cell cultures of Malus domestica cv. Read More

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http://dx.doi.org/10.1111/tpj.14506DOI Listing
August 2019
5.972 Impact Factor

Safety and Efficacy of Tinzaparin Anticoagulation during Nocturnal Hemodialysis.

Am J Nephrol 2019 21;50(4):255-261. Epub 2019 Aug 21.

Division of Nephrology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

Background: The safety and efficacy of low-molecular-weight heparin in the prevention of extracorporeal dialysis circuit clotting among in-center extended duration nocturnal hemodialysis (INHD) patients are unknown. The aim of this study was to determine the safety and efficacy of 2 doses of tinzaparin, among INHD patients receiving 6-8 h hemodialysis, 3 times per week.

Methods: We conducted a retrospective cohort study to examine antifactor Xa levels at time 0, 2 h, 4 h mid-hemodialysis (mid-HD), 6 h, and at end of each INHD session for 4 weeks and to determine extracorporeal dialysis circuit clotting and bleeding events after switching from unfractionated heparin to tinzaparin, using a standard protocol of tinzaparin delivery at the initiation and midpoint of HD. Read More

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http://dx.doi.org/10.1159/000502506DOI Listing
August 2019
1 Read

The Snapdragon LATE ELONGATED HYPOCOTYL Plays A Dual Role in Activating Floral Growth and Scent Emission.

Cells 2019 Aug 17;8(8). Epub 2019 Aug 17.

Genética Molecular, Instituto de Biotecnología Vegetal, Edificio I+D+I, Plaza del Hospital s/n, Universidad Politécnica de Cartagena, 30202 Cartagena, Spain.

The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down in affects growth and scent emission. Read More

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http://dx.doi.org/10.3390/cells8080920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721690PMC

Discovery of carboxylic acid reductase (CAR) from Thermothelomyces thermophila and its evaluation for vanillin synthesis.

J Biotechnol 2019 Oct 13;304:44-51. Epub 2019 Aug 13.

Austrian Center of Industrial Biotechnology, Petersgasse 14, Graz, Austria; Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, Petersgasse 14, Graz, Austria. Electronic address:

A novel type III fungal CAR was identified from the organism Thermothelomyces thermophila. High expression levels were observed in E. coli using the pETDuet-1 plasmid system in combination with an autoinduction protocol. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.08.007DOI Listing
October 2019

- and Methyl Jasmonate-Induced Resistance to Through Enhanced Phenylpropanoid Activities in Bread Wheat ( L.).

Front Microbiol 2019 31;10:1697. Epub 2019 Jul 31.

Plant-Microbe Interaction and Rhizosphere Biology Lab, ICAR-National Bureau of Agriculturally Important Microorganisms, Mau, India.

The aim of the present study was to evaluate the impact of UBSTH-501- and methyl jasmonate-induced systemic resistance and their integration on the spot blotch pathogen, through enhanced phenylpropanoid activities in bread wheat ( L.). It was found that the application of MeJA (>100 mg L) inhibits the germination of spores under controlled laboratory conditions. Read More

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http://dx.doi.org/10.3389/fmicb.2019.01697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685482PMC
July 2019
3.941 Impact Factor

Metabolomic Profiling of the Host Response of Tomato ( Following Infection by .

Int J Mol Sci 2019 Aug 14;20(16). Epub 2019 Aug 14.

Centre for Plant Metabolomics Research, Department of Biochemistry, University of Johannesburg, P.O. Box 524, Auckland Park, Johannesburg 2006, South Africa.

Tomato () is an important dietary source of bioactive phytochemicals and active breeding programs constantly produce new cultivars possessing superior and desirable traits. The phytopathogenic , the causal agent of bacterial wilt, is a highly destructive bacterial disease with a high economic impact on tomato production. This study followed an untargeted metabolomic approach involving four tomato cultivars and aimed at the identification of secondary metabolites involved in plant defense after infection with . Read More

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http://dx.doi.org/10.3390/ijms20163945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720392PMC

New phenolic cinnamic acid derivatives as selective COX-2 inhibitors. Design, synthesis, biological activity and structure-activity relationships.

Bioorg Chem 2019 Oct 2;91:103179. Epub 2019 Aug 2.

Pharmaceutical Chemistry Laboratory, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CIEPQPF Centre for Chemical Processes Engineering and Forest Products, University of Coimbra, 3030-790 Coimbra, Portugal. Electronic address:

Selective inhibition of cyclooxygenase (COX)-2 enzyme is an important achievement when looking for potent anti-inflammatory agents, with fewer gastrointestinal side effects. In this work, a new series of cinnamic acid derivatives, namely hexylamides, have been designed, synthesized and evaluated in human blood for their inhibitory activity of COX-1 and COX-2 enzymes. From this, new structure-activity relationships were built, showing that phenolic hydroxyl groups are essential for both COX-1 and COX-2 inhibition. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.103179DOI Listing
October 2019

Antioxidant, Antidiabetic, and Anticholinesterase Activities and Phytochemical Profile of Wedd.

Plants (Basel) 2019 Aug 3;8(8). Epub 2019 Aug 3.

Department of Science, University of Basilicata, V.le dell'Ateneo Lucano 10, 85100 Potenza, Italy.

Oxidative stress is involved in different diseases, such as diabetes and neurodegenerative diseases. The genus includes about 70 species of flowering plant species; most of them are commonly used as food and in particular as a tea infusion in the Andean region of South America in folk medicine to treat various chronic diseases. Wedd. Read More

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http://dx.doi.org/10.3390/plants8080265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724412PMC

Site-directed mutagenesis and stability of the carboxylic acid reductase MAB4714 from Mycobacterium abscessus.

J Biotechnol 2019 Sep 2;303:72-79. Epub 2019 Aug 2.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3E5, Canada; Centre for Environmental Biotechnology, School of Natural Sciences, Bangor University, Bangor, Gwynedd LL57 2UW, UK. Electronic address:

Carboxylic acid reductases (CARs) catalyze ATP- and NADPH-dependent reduction of carboxylic acids to corresponding aldehydes. Although successful applications of these enzymes for the bioconversion of monocarboxylic acids have already been reported, their applicability for the reduction of dicarboxylic acids is not well understood. Here, we explored the possibility of engineering CARs for enhanced activity toward succinic acid for potential applications in 1,4-butanediol production. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.07.009DOI Listing
September 2019

Cinnamamide: An insight into the pharmacological advances and structure-activity relationships.

Eur J Med Chem 2019 Nov 26;181:111561. Epub 2019 Jul 26.

Department of Pharmaceutical Technology and Process Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), 40, Dilip Rd, Jinkalwada, Balanagar, Hyderabad, Telangana, 500037, India. Electronic address:

The cinnamamide (cinnamic acid amide and cinnamide) is a privileged scaffold present widely in a number of natural products. The scaffold acts as a useful template for designing and arriving at newly drug-like molecules with potential pharmacological activity. An attempt has been made to review the extensive occurrence of cinnamamide scaffold in many lead compounds reported for treating various diseases, their binding interactions with the therapeutic targets as well as mechanism of action and their structure-activity relationships. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.07.064DOI Listing
November 2019
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An NADH-Dependent Reductase from Eubacterium ramulus Catalyzes the Stereospecific Heteroring Cleavage of Flavanones and Flavanonols.

Appl Environ Microbiol 2019 Oct 17;85(19). Epub 2019 Sep 17.

Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

The human intestinal anaerobe is known for its ability to degrade various dietary flavonoids. In the present study, we demonstrate the cleavage of the heterocyclic C-ring of flavanones and flavanonols by an oxygen-sensitive NADH-dependent reductase, previously described as enoate reductase, from This flavanone- and flavanonol-cleaving reductase (Fcr) was purified following its heterologous expression in and further characterized. Fcr cleaved the flavanones naringenin, eriodictyol, liquiritigenin, and homoeriodictyol. Read More

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http://dx.doi.org/10.1128/AEM.01233-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752008PMC
October 2019
1 Read

[Pharmacokinetics of compatible effective components of Mahuang Decoction in febrile rats].

Zhongguo Zhong Yao Za Zhi 2019 May;44(10):2149-2155

Zhejiang Chinese Medical University Hangzhou 310053,China.

In the present paper,after the febrile rat model was prepared by injecting yeast,orthogonally compatible effective components from prescription drugs of Mahuang Decoction( Ephedra sinica total alkaloids,Cinnamomum cassia essential oil,amygdalin,Glycyrrhiza uralensis total flavonoids+G. uralensis total saponins) with nine different dosage ratios were given by gavage administration.The plasma concentrations of main active ingredients including ephedrine hydrochloride,pseudoephedrine hydrochloride,methylephedrine hydrochloride,cinnamic acid,amygdalin,liquritin and glycyrrhizin at different time points were analyzed by liquid chromatograph mass spectrometer( LC-MS). Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190125.002DOI Listing
May 2019
6 Reads

Potential of Colocasia leaves in human nutrition: Review on nutritional and phytochemical properties.

J Food Biochem 2019 Jul 26;43(7):e12878. Epub 2019 Apr 26.

Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, India.

Colocasia esculenta leaves possess vital nutritive and nonnutritive components in significant amounts, but are underutilized, and lesser explored. The chemical composition varies significantly depending upon climatic conditions and other agronomical factors of the location of cultivation and variety. Micronutrients, viz. Read More

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http://dx.doi.org/10.1111/jfbc.12878DOI Listing
July 2019
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Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats.

J Food Biochem 2019 Feb 28;43(2):e12704. Epub 2018 Oct 28.

Faculty of Agriculture, Agricultural Biochemistry Department, Zagazig University, Zagazig, Egypt.

Moringa oleifera gained importance as a medicinal plant. The current study assesses Moringa leaf ethanol extracts (MLE) against experimentally diclofenac sodium (DcNa)-induced liver toxicity in male rats. Leaves were extracted with different solvents differing in polarity. Read More

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http://dx.doi.org/10.1111/jfbc.12704DOI Listing
February 2019
2 Reads

Phytochemical profiling, polyphenol composition, and antioxidant activity of the leaf extract from the medicinal halophyte Thespesia populnea reveal a potential source of bioactive compounds and nutraceuticals.

J Food Biochem 2019 Feb 15;43(2):e12731. Epub 2018 Nov 15.

Division of Biotechnology & Phycology, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Bhavnagar, India.

The present study evaluated the phytochemical constituents, nutritional attributes, and the antioxidant capacity of the medicinal halophyte Thespesia populnea. The metabolite profiling by GC-QTOF-MS analysis identified 37 metabolites among which sucrose, malic acid, and turanose were the most abundant. A total of 18 polyphenols and 17 amino acids were identified by the HPLC-DAD analysis. Read More

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http://dx.doi.org/10.1111/jfbc.12731DOI Listing
February 2019
1 Read

Corrigendum to "Biosynthesis of methyl (E)-cinnamate in the liverwort Conocephalum salebrosum and evolution of cinnamic acid methyltransferase" [Phytochemistry 164 (2019) 50-59].

Phytochemistry 2019 10 25;166:112074. Epub 2019 Jul 25.

Department of Plant Sciences, University of Tennessee, Knoxville, TN, 37996, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2019.112074DOI Listing
October 2019