14,510 results match your criteria chronic temporal


Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.

J Biol Chem 2021 Jul 31:101023. Epub 2021 Jul 31.

Departments of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis, heart failure and chronic obstructive pulmonary disease, initiates a hyperammonemic stress response (HASR) in tissues including skeletal muscle and in myotubes. Perturbations in levels of specific regulatory molecules have been reported, but the global responses to hyperammonemia are unclear. Read More

View Article and Full-Text PDF

Sleep and circadian rhythms: pillars of health-a Keystone Symposia report.

Ann N Y Acad Sci 2021 Aug 2. Epub 2021 Aug 2.

Sleep Center of Excellence, Columbia University Irving Medical Center, New York, New York.

The human circadian system consists of the master clock in the suprachiasmatic nuclei of the hypothalamus as well as in peripheral molecular clocks located in organs throughout the body. This system plays a major role in the temporal organization of biological and physiological processes, such as body temperature, blood pressure, hormone secretion, gene expression, and immune functions, which all manifest consistent diurnal patterns. Many facets of modern life, such as work schedules, travel, and social activities, can lead to sleep/wake and eating schedules that are misaligned relative to the biological clock. Read More

View Article and Full-Text PDF

Metabolic stringent response in intracellular stages of Leishmania.

Curr Opin Microbiol 2021 Jul 30;63:126-132. Epub 2021 Jul 30.

Department of Biochemistry and Pharmacology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

Leishmania are unusual in being able to survive long-term in the mature phagolysosome compartment of macrophages and other phagocytic cells in their mammalian hosts. Key to their survival in this niche, Leishmania amastigotes switch to a slow growth state and activate a stringent metabolic response. The stringent metabolic response may be triggered by multiple stresses and is associated with decreased metabolic fluxes, restricted use of sugars and fatty acids as carbon sources and increased dependence on metabolic homeostasis pathways. Read More

View Article and Full-Text PDF

Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study.

Neuroimage Clin 2021 Jul 24;31:102765. Epub 2021 Jul 24.

Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany; Institute for Diagnostic and Interventional Radiology, Pediatric and Neuroradiology, University Medical Centre Rostock, Rostock, Germany.

Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for patients with temporal lobe epilepsy (TLE). The role of machine learning and artificial intelligence to increase detection of brain abnormalities in TLE remains inconclusive. Read More

View Article and Full-Text PDF

Preeclampsia is a valuable opportunity to diagnose chronic kidney disease: a multicentre study.

Nephrol Dial Transplant 2021 Aug 2. Epub 2021 Aug 2.

Nephrology, Centre Hospitalier, Le Mans, France.

Background: Preeclampsia (PE) and chronic kidney disease (CKD) are known to be associated. Our objective was to assess the prevalence CKD in a large multicenter cohort of women without acknowledged CKD who experienced a PE episode.

Methods: Setting: France (Le Mans, Central France) and Italy (Cagliari, Sardinia). Read More

View Article and Full-Text PDF

National Health Systems and COVID-19 Death Toll Doubling Time.

Front Public Health 2021 15;9:669038. Epub 2021 Jul 15.

Facultad de Ingeniería y Tecnología, Universidad San Sebastián, Santiago, Chile.

Coronavirus disease 2019 (COVID-19) has placed stress on all National Health Systems (NHSs) worldwide. Recent studies on the disease have evaluated different variables, namely, quarantine models, mitigation efforts, damage to mental health, mortality of the population with chronic diseases, diagnosis, use of masks and social distancing, and mortality based on age. This study focused on the four NHSs recognized by the WHO. Read More

View Article and Full-Text PDF

A case of inflammatory myopathy in graft vs host disease - A potential role for ibrutinib.

Neuromuscul Disord 2021 Jul 4. Epub 2021 Jul 4.

Consultant Rheumatologist, Royal Adelaide Hospital, Associate Professor of Rheumatology, Discipline of Medicine, University of Adelaide, Australia.

Myositis is a known complication of chronic graft-vs-host disease (cGVHD) following allogeneic haematopoietic stem cell transplantation, but can be difficult to diagnose and manage. We present the case of a 57 year old man with cGVHD in whom the full manifestations of myositis were suppressed for some time, likely due to partial treatment of his condition with immunosuppression including ibrutinib. Though initial muscle biopsy showed necrotising myopathy without significant inflammation, on cessation of ibrutinib he developed increasing weakness and creatine kinase levels, with repeat muscle biopsy showing histological changes more in keeping with dermatomyositis. Read More

View Article and Full-Text PDF

Clinical observation of macular choroidal thickness in primary chronic angle-closure glaucoma.

Int Ophthalmol 2021 Jul 31. Epub 2021 Jul 31.

Department of Ophthalmology, Shijiazhuang People's Hospital, No. 365 Jianhua Street, Shijiazhuang city, Hebei Province, People's Republic of China.

Purpose: To comparatively analyze differences in macular choroidal thickness and volume in primary chronic angle-closure glaucoma (PACG) eyes.

Methods: Thirty-one PACG patients were sequentially selected for this case-control study. Thirty-one eyes with PACG were included in group A, 31 fellow eyes were included in group B, and group C included 67 normal eyes. Read More

View Article and Full-Text PDF

Temporal trends of concentrations of per- and polyfluoroalkyl substances among adults with overweight and obesity in the United States: Results from the Diabetes Prevention Program and NHANES.

Environ Int 2021 Jul 29;157:106789. Epub 2021 Jul 29.

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA. Electronic address:

Background: Understanding the temporal trends and change of concentrations of per- and polyfluoroalkyl substances (PFAS) is important to evaluate the health impact of PFAS at both the individual- and population-level, however, limited information is available for pre-diabetic adults in the U.S.

Objectives: Determine trends and rate of change of plasma PFAS concentrations in overweight or obese U. Read More

View Article and Full-Text PDF

Pathology-pain relationships in different osteoarthritis animal model phenotypes: it matters what you measure, when you measure, and how you got there.

Osteoarthritis Cartilage 2021 Jul 28. Epub 2021 Jul 28.

Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, University of Sydney Faculty of Medicine and Health, At Royal North Shore Hospital, Australia. Electronic address:

Objective: To determine whether osteoarthritis (OA) pain characteristics and mechanistic pathways in pre-clinical models are phenotype-specific.

Design: Male 11-week-old C57BL6 mice had unilateral medial-meniscal-destabilization (DMM) or antigen-induced-arthritis (AIA), versus sham-surgery/immunised-controls (Sham/Im-CT). Pain-behaviour (allodynia, mechanical- and thermal-hyperalgesia, hindlimb static weight-bearing, stride-length) and lumbar dorsal-root-ganglia (DRG) gene-expression were measured at baseline, day-3, week-1/-2/-4/-8/-16, and pain-behaviour:gene-expression:joint-pathology associations investigated. Read More

View Article and Full-Text PDF

Eight fold increase in the dietary supplement related liver failure leading to transplant waitlisting over the last quarter century in the US.

Liver Transpl 2021 Jul 31. Epub 2021 Jul 31.

Transplant Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Introduction: We investigated the trends in listing and outcomes of drug induced acute liver failure (DIALF) over the last quarter century in the United States using the United Network for Organ Sharing (UNOS) database.

Methods: We examined waitlisted patients in the UNOS database between 1995 and 2020 with a diagnosis of DIALF, and assessed trends in etiologies, demographic and clinical characteristics, and outcomes over 3 periods, 1995-2003, 2004-2012 and 2013-2020. Patients with DIALF and cirrhosis were classified as drug induced acute on chronic liver failure (DI-ACLF). Read More

View Article and Full-Text PDF

Narrative arcs and shaping influences in long-term medication adherence.

Soc Sci Med 2021 Jul 24;285:114264. Epub 2021 Jul 24.

Department of Marketing, University of Tennessee, 321 Stokely Management Center, 916 Volunteer Boulevard, Knoxville, TN, 37996-0530, USA. Electronic address:

Long-term adherence to medications is not well understood and poses a significant challenge for many chronically ill persons. Past research provides insights on adherence in short durations such as a day or several weeks, even though chronically ill patients are required to take medications for periods as long as a lifetime. To fill this important knowledge gap, we study the temporal unfolding of prolonged medication-taking experiences among thirty adults, mostly African American, with chronic hypertension in the U. Read More

View Article and Full-Text PDF

Disease Burden Affects Aging Brain Function.

J Gerontol A Biol Sci Med Sci 2021 Jul 30. Epub 2021 Jul 30.

Intramural Research Program, National Institute on Aging, NIH.

Background: Most older adults live with multiple chronic disease conditions, yet the effect of multiple diseases on brain function remains unclear.

Methods: We examine the relationship between disease multimorbidity and brain activity using regional cerebral blood flow (rCBF) 15O-water PET scans from 97 cognitively normal participants (mean baseline age 76.5) in the Baltimore Longitudinal Study of Aging (BLSA). Read More

View Article and Full-Text PDF

[Intervertebral disc-related occupational diseases of the lumbar and cervical spines].

Internist (Berl) 2021 Jul 30. Epub 2021 Jul 30.

Zentrum für Orthopädie, Unfallchirurgie und Paraplegiologie, Konservative Orthopädie und Gutachtenambulanz, Universitätsklinikum Heidelberg, Schlierbacher Landstr. 200a, 69118, Heidelberg, Deutschland.

Intervertebral disc-related diseases of the cervical and lumbar spine are considered to be occupational diseases, if the occupational and medical prerequisites are fulfilled and the causal connection between the prerequisites is likely. The working conditions include occupational burdens with long-term lifting and carrying of heavy loads or long-term activities in an extremely bent position of the torso, long-term carrying of heavy loads on the shoulders and long-term effects of whole-body vibration in a sitting position. A medical prerequisite is fulfilled by a damage pattern with chronic lower back or neck pain and damage of the cervical or lumbar vertebrae in a conform manner. Read More

View Article and Full-Text PDF

Structural Brain Changes Associated with Overweight and Obesity.

J Obes 2021 16;2021:6613385. Epub 2021 Jul 16.

Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Mexico.

Obesity is a global health problem with a broad set of comorbidities, such as malnutrition, metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This review describes recent findings of neuroimaging and two studies of cell density regarding the roles of overnutrition-induced hypothalamic inflammation in neurodegeneration. These studies provided consistent evidence of smaller cortical thickness or reduction in the gray matter volume in people with overweight and obesity; however, the investigated brain regions varied across the studies. Read More

View Article and Full-Text PDF

Psychiatric outcome of temporal lobe epilepsy surgery: A prospective, 2-year follow-up study.

Epilepsy Behav 2021 Jul 26;122:108216. Epub 2021 Jul 26.

National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.

Objective: We performed a prospective, longitudinal, 2-year follow-up study to clarify psychiatric courses and outcomes after temporal lobe epilepsy surgery.

Methods: We assessed 141 patients (68 men, 73 women) aged 16 or older with structured interviews and psychiatric rating scales before surgery and 3 months, 1 year, and 2 years afterward.

Results: Fifty-two patients (36. Read More

View Article and Full-Text PDF

Temporal trends of COVID-19 related in-hospital mortality and demographics in Switzerland - a retrospective single centre cohort study.

Swiss Med Wkly 2021 07 19;151:w20572. Epub 2021 Jul 19.

Division of infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland.

Aims: The aim of this study was to analyse the demographics, risk factors and in-hospital mortality rates of patients admitted with coronavirus disease 2019 (COVID-19) to a tertiary care hospital in Switzerland.

Methods: In this single-centre retrospective cohort study at the University Hospital Basel, we included all patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection hospitalised from 27 February 2020 to 10 May 2021. Patients’ characteristics were extracted from the electronic medical record system. Read More

View Article and Full-Text PDF

Altered Neurovascular Coupling in Patients with Chronic Myofascial Pain.

Pain Physician 2021 Aug;24(5):E601-E610

Department of Anatomy, Zunyi Medical College, Zunyi, Guizhou, China.

Background: Despite previous reports on cerebral structures and functional connectivity in patients with myofascial pain (MFP), it is not clear whether alterations in neurovascular coupling occur in these patients.

Objectives: We analyzed the coupling between resting-state cerebral blood flow (CBF) and functional connectivity strength (FCS) for observation of neurovascular coupling in patients with chronic MFP.

Study Design: Observational study. Read More

View Article and Full-Text PDF

Traditional medicines prescribed for prevention of COVID-19: Use with caution.

Nephrology (Carlton) 2021 Jul 28. Epub 2021 Jul 28.

Department of Nephrology, The Madras Medical Mission, Chennai, India.

Acute interstitial nephritis can result due to exposure to any medication, toxins, infections or malignancy. In the midst of this Coronavirus (COVID-19) pandemic, there has been a race for finding remedies to prevent the spread of and control the complications due to Severe Acute Respiratory Syndrome Coronavirus 2. Certain Indian medicinal herb concoctions like kabasura kudineer and nilavembu kudineer are being widely publicized to boost immunity and reduce the risk of developing COVID-19. Read More

View Article and Full-Text PDF

In vivo imaging of the microglial landscape after whole brain radiation therapy.

Int J Radiat Oncol Biol Phys 2021 Jul 24. Epub 2021 Jul 24.

Department of Radiation Oncology, University of Rochester, Rochester, NY. Electronic address:

Purpose: Whole brain radiation therapy (WBRT) is an important treatment for patients with multiple brain metastases, but can also cause cognitive deterioration. Microglia, the resident immune cells of the brain, promote a pro-inflammatory environment and likely contribute to cognitive decline after WBRT. To investigate the temporal dynamics of the microglial reaction in individual mice to WBRT, we developed a novel in vivo experimental model using cranial window implants and longitudinal imaging. Read More

View Article and Full-Text PDF

Brain structural differences in temporal lobe and frontal lobe epilepsy patients: A voxel-based morphometry and vertex-based surface analysis.

Neuroradiol J 2021 Jul 27:19714009211034839. Epub 2021 Jul 27.

Department of Radiology, 6915Mayo Clinic, Mayo Clinic, USA.

Purpose: Exploration of the effect of chronic recurrent seizures in focal epilepsy on brain volumes has produced many conflicting reports. To determine differences in brain structure in temporal lobe epilepsy (TLE) and extratemporal epilepsy (using frontal lobe epilepsy (FLE) a surrogate) further, we performed a retrospective analysis of a large cohort of patients with seizure-onset zone proven by intracranial monitoring.

Methods: A total of 120 TLE patients, 86 FLE patients, and 54 healthy controls were enrolled in this study. Read More

View Article and Full-Text PDF

Variation in Evolving Optic Neuritis.

J Neuroophthalmol 2021 Jul 23. Epub 2021 Jul 23.

Department of Neurology, Beth Israel Deaconess Medical Center (MAB), Harvard Medical School, Boston, Massachusetts; Department of Surgery, Division of Ophthalmology (NT), Harvard Medical School, Boston, Massachusetts; Department of Neurology (RMM), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and Department of Ophthalmology (YJL), Byers Eye Institute, Stanford University, Palo Alto, California.

Background: The typical natural history of optic neuritis is subjected to important exceptions. Recognition of these exceptions has led to valuable insights regarding specific etiologies of optic neuritis. Exceptions to the natural history of recovering optic neuritis are well-defined (e. Read More

View Article and Full-Text PDF

Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.

Neuromodulation 2021 Jul 26. Epub 2021 Jul 26.

Headache and Orofacial Pain Effort (H.O.P.E.), Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

Objectives: Although primary motor cortex (M1) transcranial direct current stimulation (tDCS) has an analgesic effect in fibromyalgia (FM), its neural mechanism remains elusive. We investigated whether M1-tDCS modulates a regional temporal variability of blood-oxygenation-level-dependent (BOLD) signals, an indicator of the brain's flexibility and efficiency and if this change is associated with pain improvement.

Materials And Methods: In a within-subjects cross-over design, 12 female FM patients underwent sham and active tDCS on five consecutive days, respectively. Read More

View Article and Full-Text PDF

Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus.

Neurobiol Sleep Circadian Rhythms 2021 Nov 25;11:100070. Epub 2021 Jun 25.

Laboratory of Animal Physiology, School of Agriculture, Meiji University, Kawasaki, Kanagawa, 214-8571, Japan.

The dorsal striatum forms part of the basal ganglia circuit that is a major regulator of voluntary motor behavior. Dysfunction in this circuit is a critical factor in the pathology of neurological (Parkinson's and Huntington's disease) as well as psychiatric disorders. In this study, we employed real-time monitoring of multiple unit neural activity (MUA) in the dorsal striatum of freely moving mice. Read More

View Article and Full-Text PDF
November 2021

Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial.

Front Bioeng Biotechnol 2021 7;9:677541. Epub 2021 Jul 7.

Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Purpose: To determine the efficacy of autologous platelet- and extracellular vesicle-rich plasma (PVRP) to treat chronic postoperative temporal bone cavity inflammation (CPTBCI) after exhausting surgical and standard conservative therapies.

Materials And Methods: Patients were randomly allocated to treatment with PVRP (PVRP group) or standard conservative methods (control group) in a setting of four once-monthly checkups and subsequent follow-up. The treatment outcome was measured with the Chronic Otitis Media Questionnaire-12 (COMQ-12), CPTBCI focus surface area, and CPTBCI symptom-free time after the fourth checkup. Read More

View Article and Full-Text PDF

Management of Temporomandibular Joint Ankylosis Using Temporoparietal Fascia Flap.

World J Plast Surg 2021 May;10(2):93-97

Dental student at MUMS, Student Research Committee, Faculty of Denti-stry, Mashhad University of Medical Sciences, Mashhad, Iran.

The adhesion of mandibular condyle to the glenoid fossa by bone or fibroblastic tissue is called temporomandibular joint (TMJ) ankylosis. Trauma and infection are the main reasons for affecting TMJ ankylosis. TMJ arthroplasty is the treatment of choice for this situation. Read More

View Article and Full-Text PDF

A latent growth curve modelling approach to seasonal and spatial dynamics of food security heterogeneities in rural Lake Naivasha Basin, Kenya.

Food Secur 2021 Jul 17:1-15. Epub 2021 Jul 17.

Department of Economics and Management, University of Pavia, Via S. Felice, 5-27100, Pavia, Italy.

The increasing complexity of food insecurity, malnutrition, and chronic poverty faced by Sub-Saharan Africa warrants urgent categorisation and tracking of household food security along both temporal and spatial dimensions. This will help to effectively target, monitor and evaluate population-level programs and specific interventions aimed at addressing food insecurity. Traditional longitudinal analysis does not address the dynamics of inter- and intrahousehold heterogeneities within the seasonal and spatial context of household-level food security. Read More

View Article and Full-Text PDF

The Incidence and Predictors of Solid- and Hematological Malignancies in Patients with Giant Cell Arteritis: A Large Real-World Database Study.

Int J Environ Res Public Health 2021 07 16;18(14). Epub 2021 Jul 16.

Department of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat Gan 5265601, Israel.

Background: The association between giant cell arteritis (GCA) and malignancies had been widely investigated with studies reporting conflicting results. Therefore, in this study, we aimed to investigate this association using a large nationwide electronic database.

Methods: This study was designed as a retrospective cohort study including GCA patients first diagnosed between 2002-2017 and age, sex and enrollment time-matched controls. Read More

View Article and Full-Text PDF

Electrographic Features of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.

Cereb Cortex Commun 2021 22;2(1):tgab004. Epub 2021 Jan 22.

Krembil Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8.

Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures (SRS) and comorbidities. Kindling through repetitive brief stimulation of a limbic structure is a commonly used model of temporal lobe epilepsy. Particularly, extended kindling over a period up to a few months can induce SRS, which may simulate slowly evolving epileptogenesis of temporal lobe epilepsy. Read More

View Article and Full-Text PDF
January 2021

Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging.

Front Aging Neurosci 2021 6;13:695200. Epub 2021 Jul 6.

Cognitive and Affective Neuroscience and Clinical Psychology, Research Institute of Health Sciences (IUNICS) and Balearic Islands Health Research Institute (IdISBa), University of the Balearic Islands (UIB), Palma, Spain.

Alterations in the affective component of pain perception are related to the development of chronic pain and may contribute to the increased vulnerability to pain observed in aging. The present study analyzed age-related changes in resting-state brain activity and their possible relation to an increased pain perception in older adults. For this purpose, we compared EEG current source density and fMRI functional-connectivity at rest in older ( = 20, 66. Read More

View Article and Full-Text PDF