33,372 results match your criteria chronic recurrent


Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events.

Cochrane Database Syst Rev 2021 Apr 14;4:CD007694. Epub 2021 Apr 14.

Cochrane Airways, Population Health Research Institute, St George's, University of London, London, UK.

Background: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness, and cough. Treatment with inhaled steroids and bronchodilators can result in good control of symptoms, prevention of further morbidity, and improved quality of life. However, an increase in serious adverse events with the use of both regular formoterol and regular salmeterol (long-acting beta₂-agonists) compared with placebo for chronic asthma has been demonstrated in previous Cochrane Reviews. Read More

View Article and Full-Text PDF

Antibiotics and Imiquimod for CTCL in Veterans: A Patient Population with Agent Orange Exposure.

Oncologist 2021 Apr 14. Epub 2021 Apr 14.

Department of Dermatology, Columbia University Medical Center, New York, NY.

Lessons Learned: Staphylococcus aureus infection in CTCL is thought to contribute to disease progression; thus, adjunctive treatment with antibiotics warrants further investigation. This trial of antibiotic therapy followed by imiquimod in early stage CTCL was not completed due to difficulties with patient accrual.

Background: Cutaneous T-cell lymphoma (CTCL), a form of Non-Hodgkin lymphoma, is a heterogeneous group of malignancies of mature memory T lymphocytes. Read More

View Article and Full-Text PDF

Clinicopathologic features of Good's syndrome: Two cases and literature review.

Open Med (Wars) 2021 1;16(1):532-539. Epub 2021 Apr 1.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Background: Good's syndrome (GS) is an immunodeficiency disease, causing thymoma, low or absent B-cells, hypogammaglobulinemia, and defects in cell-mediated immunity. The most common clinical presentation is recurrent infection, followed by refractory diarrhea, due to the immunodeficiency. However, there are only few reports on intestinal endoscopy and pathology. Read More

View Article and Full-Text PDF

Towards enhanced understanding of idiopathic ketotic hypoglycemia: a literature review and introduction of the patient organization, Ketotic Hypoglycemia International.

Orphanet J Rare Dis 2021 Apr 13;16(1):173. Epub 2021 Apr 13.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Background: Idiopathic Ketotic hypoglycemia (IKH) is a diagnosis of exclusion. Although considered as the most frequent cause of hypoglycemia in childhood, little progress has been made to advance the understanding of IKH since the medical term was coined in 1964. We aimed to review the literature on ketotic hypoglycemia (KH) and introduce a novel patient organization, Ketotic Hypoglycemia International (KHI). Read More

View Article and Full-Text PDF

A systematic literature review of the disease burden in patients with recessive dystrophic epidermolysis bullosa.

Orphanet J Rare Dis 2021 Apr 13;16(1):175. Epub 2021 Apr 13.

Abeona Therapeutics Inc, 1330 Avenue of the Americas, New York, NY, 10019, USA.

Background/objective: Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic collagen disorder characterized by skin fragility leading to blistering, wounds, and scarring. There are currently no approved curative therapies. The objective of this manuscript is to provide a comprehensive literature review of the disease burden caused by RDEB. Read More

View Article and Full-Text PDF

Macular Mobilization with a Flexible Nitinol Loop for Chronic or Recurrent Macular Holes.

Ophthalmol Retina 2021 Apr 10. Epub 2021 Apr 10.

Retina Service, Wills Eye Hospital, Philadelphia, PA. Electronic address:

View Article and Full-Text PDF

Vulnerability to recurrent episodes of acute decompensation/acute-on-chronic liver failure characterizes those triggered by indeterminate precipitants in patients with liver cirrhosis.

PLoS One 2021 13;16(4):e0250062. Epub 2021 Apr 13.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Background: Acute decompensation (AD) of liver cirrhosis (LC) and subsequent acute-on-chronic liver failure (ACLF) are fatal and impair quality of life. Insufficient knowledge of the highly heterogeneous natural history of LC, including decompensation, re-compensation, and possible recurrent decompensation, hinders the development and application of novel therapeutics. Approximately 10%-50% of AD/ACLF is reported to be precipitated by any indeterminate (unidentifiable, cryptogenic, or unknown) acute insults; however, its clinical characteristics are unclear. Read More

View Article and Full-Text PDF

Effectiveness of different types of skin grafting for treating venous leg ulcers: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25597

Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.

Background: Venous leg ulcers (VLUs) are the most common ulcer on the lower extremity, with 4% of patients over the age of 65 suffering from VLUs worldwide. As a recurrent, chronic, disabling disease, VLUs are associated with prolonged disability, substantial socioeconomic impact, and significant psychosocial morbidity. At present, Skin grating is one of the most effective treatments for non-healing ulcers. Read More

View Article and Full-Text PDF

Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP.

Rhinology 2021 Apr 13. Epub 2021 Apr 13.

Ghent University, Ghent, Belgium.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease with a high symptom burden and poor quality of life. Treatment options include recurrent surgeries and/or frequent systemic corticosteroids (SCS). Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2-mediated inflammation. Read More

View Article and Full-Text PDF

[Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension:a paradigmatic case report].

G Ital Cardiol (Rome) 2021 Mar;22(3):12-16

Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università degli Studi, Bologna - U.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola, Bologna.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complex disease where organized pulmonary thrombi and progressive vascular remodeling of the pulmonary arterial tree act synergistically to increase pulmonary vascular resistance and cause pulmonary hypertension. Balloon pulmonary angioplasty (BPA) has gained a renewed interest for the treatment of patients with CTEPH who are not undergoing surgery with pulmonary endarterectomy (PEA) or with persistent/recurrent pulmonary hypertension after PEA and has shown promising results in several observational studies conducted to date. We describe the case of a 42-year-old man with inoperable CTEPH in NYHA functional class III who normalized functional capacity, hemodynamic profile and main hemodynamic parameters after three BPA sessions. Read More

View Article and Full-Text PDF

[Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: 5 years of experience in Italy].

G Ital Cardiol (Rome) 2021 Mar;22(3):5-11

U.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola, Bologna - Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università degli Studi, Bologna.

Background: Balloon pulmonary angioplasty (BPA) represents a therapeutic option for the treatment of chronic thromboembolic pulmonary hypertension (CTEPH) in patients who are not eligible for surgical pulmonary endarterectomy (PEA) or with persistent/recurrent symptomatic pulmonary arterial hypertension after PEA. This study evaluated the safety of BPA during 5 years of experience of the only Italian center systematically performing this procedure.

Methods: The BPA program was activated at the S. Read More

View Article and Full-Text PDF

Tracheobronchopathia osteochondroplastica: a cause of chronic cough and haemoptysis.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Pathology and Microbiology, Aga Khan University, Karachi, Pakistan.

Tracheobronchopathia osteochondroplastica (TPO) is a rare disorder of the tracheopulmonary tree characterised by osseous and cartilaginous submucosal nodules projecting into the tracheal lumen, sparing the posterior tracheal membranous wall. Symptoms are non-specific and may include dry cough, hoarseness, dyspnoea, recurrent pneumonia and occasionally haemoptysis. A fibreoptic bronchoscopy showing multiple tracheal nodules followed by pathological biopsy is required to reach the final diagnosis. Read More

View Article and Full-Text PDF

An Eschar-like souvenir from a journey to Colombia: Ecthyma gangrenosum as a differential diagnosis of tropical diseases in immunocompromised patients - a case report.

BMC Infect Dis 2021 Apr 12;21(1):344. Epub 2021 Apr 12.

German Center for Infection Research (DZIF), partner site Munich, Munich, Germany.

Background: Ecthyma gangrenosum (EG) is a cutaneous infectious disease characterized by eschar-like skin ulcers typically caused by Pseudomonas aeruginosa. Here, we report a case of relapsing EG in a patient who had returned from a trip to Colombia, thus establishing EG as an important differential diagnosis of tropical diseases, and demonstrating that even long-term antibiotic treatment can result in only partial remission of EG.

Case Presentation: A 77-year-old man with underlying chronic lymphocytic leukemia (CLL) on ibrutinib treatment was admitted because of a superinfected mosquito bite on the left ear and multiple partially necrotic skin lesions disseminated all over the entire body five days after returning from a trip to Colombia. Read More

View Article and Full-Text PDF

Golimumab improves work productivity in patients suffering from moderate to severe ulcerative colitis: results of a prospective study over 24 months.

BMC Gastroenterol 2021 Apr 12;21(1):161. Epub 2021 Apr 12.

Medical Affairs, MSD Sharp & Dohme GmbH, Lindenplatz 1, 85540, Haar, Germany.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with recurrent episodes of debilitating symptoms negatively affecting work productivity and health-related quality of life (HRQoL). The use of biologics in UC treatment improves work and HRQoL but prospective long-term data concerning the treatment with TNFα inhibitor golimumab in UC patients are still rare. Therefore, our study aimed to evaluate the change in work productivity, capacity for daily activities and HRQoL in UC patients treated with golimumab in Germany. Read More

View Article and Full-Text PDF

Classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

the Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis DESIGN: Machine learning of cases with spondyloarthritis/HLA-B27-associated anterior uveitis and 8 other anterior uveitides.

Methods: Cases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Read More

View Article and Full-Text PDF

Effects of using montelukast during acute wheezing attack in hospitalized preschool children on the discharge rate and the clinical asthma score.

Pediatr Pulmonol 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatric Endocrinology, Güven Hospital, Ankara, Turkey.

Background: In chronic asthma treatment, leukotriene receptor antagonists have been recommended, but it is not clear whether montelukast can be used in acute recurrent wheezing attacks in children.

Objective: To investigate the safety and effectiveness of oral montelukast in addition to standard treatment in hospitalized children aged between 6 and 72 months with acute recurrent wheezing attacks.

Method: One hundred patients aged between 6 and 72 months who had wheezing attacks with clinical asthma scores (CAS) ≥3 and were hospitalized were included in this randomized, double-blind, placebo-controlled, parallel-group clinical trial. Read More

View Article and Full-Text PDF

Nephrological factors may cause kidney dysfunction in patients with Common Variable Immunodeficiency.

Turk J Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Background/aim: Common variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, an increased risk of autoimmune disease, malignancy, and chronic inflammation. Proteinuria is one of the most important prognostic factors causing progression in kidney disease. Proteinuria causes tubulotoxicity, activates inflammatory markers that cause fibrosis, and consequently nephropathy progression. Read More

View Article and Full-Text PDF

Disk Battery as a Vaginal Foreign Body in a Five-Year-Old Preadolescent Child.

Cureus 2021 Mar 6;13(3):e13727. Epub 2021 Mar 6.

College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, USA.

The self-introduction of batteries into the vagina is exceedingly infrequent among preadolescents, with only six cases have been recorded in the English-language PubMed-indexed literature. Herein, we present the case of a five-year-old female child who presented with an 18-month history of recurrent ill-smelling vaginal discharge. Pelvic radiograph displayed a radio-opaque object, most likely representing a disk battery inside her vagina. Read More

View Article and Full-Text PDF

Effect of OM-85 BV on reducing bronchiectasis exacerbation in Chinese patients: the iPROBE study.

J Thorac Dis 2021 Mar;13(3):1641-1651

Division of Pulmonary Medicine and Critical Care, Chapel Hill, NC, USA.

Background: Bronchiectasis is characterized by recurrent infectious exacerbations. No existing data inform preventive strategy for exacerbations beyond chronic macrolides. OM-85 BV, an immunostimulant, has been shown to prevent recurrent respiratory infections. Read More

View Article and Full-Text PDF

Early onset bioprosthetic tricuspid valve stenosis in a case with cardiac sarcoidosis: Pathological findings based on autopsy.

J Cardiol Cases 2021 Apr 8;23(4):173-176. Epub 2021 Feb 8.

Division of Cardiovascular Surgery, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.

A 60-year-old woman with cardiac sarcoidosis developed recurrent and refractory right heart failure 26 months after tricuspid valve replacement. Echocardiography revealed thickened and immobile cusp with increased diastolic tricuspid gradient of 8-10 mmHg, consistent with bioprosthetic tricuspid stenosis (TS). Prolonged intravenous injection of dobutamine and carperitide, with intermittent intravenous furosemide, was necessary at multiple times. Read More

View Article and Full-Text PDF

Plasma Biomarkers of Risk of Tuberculosis Recurrence in HIV Co-Infected Patients From South Africa.

Front Immunol 2021 25;12:631094. Epub 2021 Mar 25.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.

There is an urgent need to identify immunological markers of tuberculosis (TB) risk in HIV co-infected individuals. Previously we have shown that TB recurrence in HIV co-infected individuals on ART was associated with markers of systemic inflammation (IL-6, IL1β and IL-1Rα). Here we examined the effect of additional acute inflammation and microbial translocation marker expression on risk of TB recurrence. Read More

View Article and Full-Text PDF

Heterogeneous Individual Risk Modeling of Recurrent Events.

Biometrika 2021 Mar 19;108(1):183-198. Epub 2020 Nov 19.

Eli Lilly and Company, Indianapolis 46285, U.S.A.

Progression of chronic disease is often manifested by repeated occurrences of disease-related events over time. Delineating the heterogeneity in the risk of such recurrent events can provide valuable scientific insight for guiding customized disease management. In this paper, we propose a new sensible measure of individual risk of recurrent events and present a dynamic modeling framework thereof, which accounts for both observed covariates and unobservable frailty. Read More

View Article and Full-Text PDF

Noninvasive Intracranial Pressure Monitoring in Chronic Stroke Patients with Sedentary Behavior: A Pilot Study.

Acta Neurochir Suppl 2021 ;131:55-58

Department of Physical Therapy, Federal University of São Carlos-UFSCar, São Carlos, São Paulo, Brazil.

Objective: This study aimed to correlate the P2/P1 ratio of intracranial pressure waveforms with sedentary behavior during the chronic stage of stroke.

Materials And Methods: Eight patients from São Carlos, Brazil, who had hemiparesis and stroke onset within the previous 6 months, participated in this study. To monitor their intracranial pressure, we used noninvasive Brain4Care intracranial pressure monitoring during a postural change maneuver involving 15 min in a supine position and 15 min in an orthostatic position. Read More

View Article and Full-Text PDF
January 2021

Identifying predictors of ventral hernia recurrence: systematic review and meta-analysis.

BJS Open 2021 Mar;5(2)

Centre of Medical Imaging, University College Hospital, London, UK.

Background: Ventra hernias are increasing in prevalence and many recur despite attempted repair. To date, much of the literature is underpowered and divergent. As a result there is limited high quality evidence to inform surgeons succinctly which perioperative variables influence postoperative recurrence. Read More

View Article and Full-Text PDF

Involvement of cytotoxic Eomes-expressing CD4 T cells in secondary progressive multiple sclerosis.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502 Japan;

Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes of peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to a chronic disease course with progressive neurological dysfunctions (secondary progressive MS, SPMS), with the progression rate varying between patients and over time. SPMS pathogenesis is now linked to immune-cell-mediated processes, although the mechanisms driving SPMS transition and progression remain elusive, and SPMS lacks biomarkers and effective treatments. Read More

View Article and Full-Text PDF

Predictors of sinonasal disease onset, progression, and severity in pediatric cystic fibrosis patients.

Am J Otolaryngol 2021 Mar 31;42(5):103016. Epub 2021 Mar 31.

Department of Otolaryngology, Division of Pediatric Otolaryngology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA, United States of America.

Purpose: Pediatric cystic fibrosis (CF) patients have a variable onset, severity, and progression of sinonasal disease. The objective of this study was to identify genotypic and phenotypic factors associated with CF that are predictive of sinonasal disease, recurrent nasal polyposis, and failure to respond to standard treatment.

Methods: A retrospective case series was conducted of 30 pediatric patients with CF chronic rhinosinusitis with and without polyps. Read More

View Article and Full-Text PDF

Hyperbaric oxygen management of recurrent cellulitis in poikiloderma with neutropenia.

Am J Med Genet A 2021 Apr 9. Epub 2021 Apr 9.

Department of Internal Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.

Poikiloderma with neutropenia (PN), is a rare autosomal recessive condition with many associated complications and manifestations. Here we present a patient with confirmed PN who is of one-quarter Chucktaw or Cherokee heritage with no known descent from the Navajo tribe. The patient's condition was complicated by chronic bilateral lower limb cellulitis and associated osteomyelitis which was unresponsive to extensive antibiotic regimens. Read More

View Article and Full-Text PDF

Adverse Events Associated With Therapeutic Endoscopic Retrograde Pancreatography.

Pancreas 2021 Mar;50(3):378-385

From the Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO.

Objectives: Data regarding the safety of endoscopic retrograde pancreatography (ERP) are limited compared with biliary endoscopic retrograde cholangiopancreatography. The aim of this study was to determine adverse events (AEs) associated with therapeutic ERP.

Methods: This single-center retrospective study examined consecutive therapeutic ERPs with the primary intention of cannulating the pancreatic duct. Read More

View Article and Full-Text PDF

The incisional hernia epidemic: evaluation of outcomes, recurrence, and expenses using the healthcare cost and utilization project (HCUP) datasets.

Hernia 2021 Apr 9. Epub 2021 Apr 9.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Background: Incisional hernias (IH) following abdominal surgery persist as morbid, costly, and multi-disciplinary surgical challenges. Using longitudinal, multi-state, administrative claims data (HCUP State Inpatient Databases (SID)); (HCUP State Ambulatory Surgery and Services Databases (SASD)), we aimed to characterize the epidemiology, outcomes, recurrence, and costs of IH.

Study Design: 529,108 patients undergoing abdominal surgery in 2010 across six specialties (colorectal, general/bariatric, hepatobiliary, obstetrics/gynecology, urology, and vascular) were identified within inpatient and ambulatory databases for Florida (FL), Iowa (IA), Nebraska (NE), New York (NY), and Utah (UT). Read More

View Article and Full-Text PDF

Popliteal Entrapment Syndrome as a Cause of Chronic Lower Extremity Pain in a 16-Year Old.

Cureus 2021 Mar 5;13(3):e13723. Epub 2021 Mar 5.

Internal Medicine-Pediatrics, Icahn School of Medicine at Mount Sinai, New York, USA.

Popliteal entrapment syndrome is an uncommon cause of intermittent claudication in young patients lacking atherosclerotic risk factors. ZS is a 16-year-old cisgender female with type 1 diabetes complicated by microalbuminuria, obesity (body mass index (BMI) = 45.86 kg/m²), and a history of perinatal stroke with residual right-sided hemiparesis, who presented with six months of worsening bilateral, exertional lower extremity pain. Read More

View Article and Full-Text PDF