J Biomed Res 2020 Aug 31:1-10. Epub 2020 Aug 31.
Department of Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China. E-mail:
Periodontitis is a highly prevalent, chronic, non-specific, and immunologically devastating disease of periodontal tissues, caused by microbial infection. This study aims to examine the efficacy and protective mechanism of triclosan (TCS), a bisphenolic, non-cationic component of oral care products, against periodontal inflammation induced by lipopolysaccharide purified from (LPS-PG). TCS markedly downregulated IL-6, IL-8, and IL-15 in human periodontal ligament fibroblasts (HPDLFs) treated with LPS-PG. Read More