10,531 results match your criteria chronic periodontitis


Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes.

Head Face Med 2021 Apr 8;17(1):12. Epub 2021 Apr 8.

Department of Periodontology, Qingdao Stomatological Hospital, No. 17 Dexian Road, Qingdao, 266000, Shandong, China.

Background: Our study attempted to observe the value of periodontal curettage combined with root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes.

Methods: There involved 72 patients with type 2 diabetes mellitus complicated with moderate-to-severe chronic periodontitis who were diagnosed and treated in our hospital from January 2019 to December 2019. The patients enrolled were randomly divided into four groups using a computer-generated table: root planing and periodontal curettage combined group (n = 18), root planning group (n = 18), periodontal curettage group (n = 18) and cleansing group (n = 18). Read More

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[Research progress on the role of extracellular vesicles in the diagnosis and treatment of chronic periodontitis].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Apr;56(4):385-389

Department of Periodontology, Shanxi Medical University School and Hospital of Stomatology & Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, China.

Chronic periodontitis is a disease of periodontal supporting tissue infection caused by various causes. It was believed that the oral bacteria were the initiator of chronic periodontitis, and the host immune factors would affect the developing process and outcome of periodontitis, although the specific regulatory mechanism was not completely clear. Extracellular vesicles, subcellular components produced by cell paracrine, may carry a variety of genetic information to mediate intercellular communication. Read More

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Dysregulation of metallothionein and zinc aggravates periodontal diseases.

J Trace Elem Med Biol 2021 Apr 3;66:126754. Epub 2021 Apr 3.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, 50603, Malaysia.

Background: Periodontitis (PD) is a multifaceted inflammatory disease connected to bacterial infection that results in the destruction of tooth supporting structures and eventually tooth loss. Given their involvement in infection and inflammation, both metallothionein (MT) and zinc (Zn) might play vital roles in the development and progression of PD. More specifically, both MT and Zn are heavily involved in regulating immune functions, controlling bacterial infection, balancing inflammatory responses, and reducing oxidative stress, all of which are associated with the pathogenesis of PD. Read More

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[Motivational interviewing : a useful technique for both smoking cessation and periodontal interventions].

Rev Med Liege 2021 Apr;76(4):287-291

Université Paris-Saclay, Hôpitaux Universitaires Paris-Sud, Villejuif, France.

Tobacco is a risk factor for many chronic diseases and is the leading cause of preventable death. In the same way, periodontal diseases are one of the main chronic inflammatory diseases. The significant positive association between smoking and a higher risk of periodontitis is not any more to show and it appears that if smoking would be eliminated in this population, the risk of periodontitis would be reduced by approximately 14 %. Read More

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The Oral Microbiome in Periodontal Health.

Front Cell Infect Microbiol 2021 22;11:629723. Epub 2021 Mar 22.

Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czechia.

The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. Read More

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Molecular subgroup of periodontitis revealed by integrated analysis of the microbiome and metabolome in a cross-sectional observational study.

J Oral Microbiol 2021 Mar 25;13(1):1902707. Epub 2021 Mar 25.

Department of Oral Microbiology, School of Dentistry, Pusan National University, Busan, South Korea.

: Periodontitis (PT) is a multifactorial, chronic inflammatory disease that can have heterogeneous clinical presentations. The oral microbiome and its metabolites have been implicated as the causes and regulators of PT pathogenesis. In this study, we assessed the oral microbiome and its metabolome in PT patients to clarify the interactions between the microbiome and its metabolites. Read More

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Atypical presentation of lateral periodontal cyst associated with impacted teeth: two case reports.

BMC Oral Health 2021 Apr 7;21(1):178. Epub 2021 Apr 7.

Oral Medicine and Maxillofacial Pathology Unit, Division of Oral and Maxillofacial Surgery, Department of Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.

Background: Lateral periodontal cyst (LPC) is an uncommon form of developmental odontogenic cyst. LPC can be suspected when there is a round, well-circumscribed radiolucency, usually of small diameter, along the lateral surface of vital erupted teeth, predominantly in the mandibular premolar region. Histopathological analysis allows LPC to be diagnosed based on its characteristic features such as a thin cuboidal to stratified squamous non-keratinizing epithelium containing epithelial plaques and glycogen-rich clear cells. Read More

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Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide from .

J Biomed Res 2020 Aug 31:1-10. Epub 2020 Aug 31.

Department of Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China. E-mail:

Periodontitis is a highly prevalent, chronic, non-specific, and immunologically devastating disease of periodontal tissues, caused by microbial infection. This study aims to examine the efficacy and protective mechanism of triclosan (TCS), a bisphenolic, non-cationic component of oral care products, against periodontal inflammation induced by lipopolysaccharide purified from (LPS-PG). TCS markedly downregulated IL-6, IL-8, and IL-15 in human periodontal ligament fibroblasts (HPDLFs) treated with LPS-PG. Read More

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Structural and kinetic characterization of glutaminyl cyclase.

Biol Chem 2021 Apr 7. Epub 2021 Apr 7.

Department of Biological Sciences, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu215123, China.

is a bacterial species known to be involved in the pathogenesis of chronic periodontitis, that more recently has been as well associated with Alzheimer's disease. expresses a glutaminyl cyclase (PgQC) whose human ortholog is known to participate in the beta amyloid peptide metabolism. We have elucidated the crystal structure of PgQC at 1. Read More

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Self-reported periodontitis and fecundability in a population of pregnancy planners.

Hum Reprod 2021 Apr 3. Epub 2021 Apr 3.

Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

Study Question: Is a history of periodontitis among women associated with reduced fecundability?

Summary Answer: A history of periodontitis, as assessed by three different self-reported measures, may be associated with reduced fecundability.

What Is Known Already: Periodontitis is a chronic inflammatory condition affecting the hard and soft tissues surrounding the teeth. Few studies have evaluated the association between periodontitis and time to pregnancy, and findings are mixed. Read More

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Development and optimization of a rapid colorimetric membrane immunoassay for .

J Microbiol Biotechnol 2021 Apr 5. Epub 2021 Apr 5.

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

) is a major bacterial pathogen that causes periodontitis, a chronic inflammatory disease of tissues around the teeth. Periodontitis is known to be related to other diseases, such as oral cancer, Alzheimer's disease, and rheumatism. Thus, a precise and sensitive test to detect is necessary for the early diagnosis of periodontitis. Read More

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The recent advances in scaffolds for integrated periodontal regeneration.

Bioact Mater 2021 Oct 18;6(10):3328-3342. Epub 2021 Mar 18.

Center for Dental and Craniofacial Research, Columbia University Medical Center, 630 W. 168 St., VC12-212, New York, NY, 10032, USA.

The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Read More

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October 2021

The Role of Neutrophil Extracellular Traps in Periodontitis.

Front Cell Infect Microbiol 2021 18;11:639144. Epub 2021 Mar 18.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

Periodontitis is a chronic, destructive disease of periodontal tissues caused by multifaceted, dynamic interactions. Periodontal bacteria and host immunity jointly contribute to the pathological processes of the disease. The dysbiotic microbial communities elicit an excessive immune response, mainly by polymorphonuclear neutrophils (PMNs). Read More

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Lipopolysaccharide Preparation Derived From Induces a Weaker Immuno-Inflammatory Response in BV-2 Microglial Cells Than by Differentially Activating TLR2/4-Mediated NF-κB/STAT3 Signaling Pathways.

Front Cell Infect Microbiol 2021 18;11:606986. Epub 2021 Mar 18.

Department of Periodontology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Alzheimer's disease (AD) is a degenerative disease of the central nervous system with unclear etiology and pathogenesis. In recent years, as the infectious theory and endotoxin hypothesis of AD has gained substantial attention, several studies have proposed that (), one of the main pathogenic bacteria of chronic periodontitis, and the lipopolysaccharide (LPS) of may lead to AD-like pathological changes and cognition impairment. However, research on the relationship between -LPS and neuroinflammation is still lacking. Read More

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Two Zn(II)-based Coordination Polymers: Treatment Activity on Chronic Periodontitis by Inhibiting the Relative Expression of the Porphyria gingivalis Survival Gene.

J Oleo Sci 2021 ;70(4):541-548

Department of Periodontology, Qingdao Stomatological Hospital.

Two mixed-ligand complexes on the basis of L ligand [L = 3,6-bis(imidazol-1-yl)pyridazine] have been prepared under the solvothermal reaction conditions via the Zn(II) salts reacting with the ligands of L in the existence of two positional isomerous carboxylic acid ligands and their chemical formula respectively are [Zn(L)(1,2-BDC)(μ-OH)] (1, 1,2-HBDC = 1,2-benzenedicarboxylic acid ) and {[Zn(L)(1,3-HBDC) (1,3-BDC)(μ-OH)]·ClO·3HO} (2, 1,3-HBDC = 1,3-benzenedicarboxylic acid). The inhibitory influence of the two compounds against the inflammatory response in periodontium was evaluated by measuring the inflammatory cytokines releasing with ELISA detection kit. The results of ELISA assay indicated that compound 1 showed much stronger inhibitory influences than compound 2 against the inflammatory cytokines releasing. Read More

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January 2021

ASSESSMENT OF LASER AND ANTIOXIDANT THERAPY EFFICACY IN TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS.

Georgian Med News 2021 Feb(311):54-57

1Saint Petersburg State University, Department of Clinical Dentistry SPbU; Russian Federation.

Chronic generalized parodontitis is one of the most prevalent disorders among diseases of oral cavity, making the search for optimal treatment modalities of this disorder one of the mostressing matters to this day.  The purpose of this study was to assess outcomes of conventional therapy and secondary prevention of chronic generalized parodontitis with in combination with use of laser therapy and antioxidant drug treatment.   The study is presented as a joint multi-site investigation conducted by the group of authors from St. Read More

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February 2021

Serum proteins associated with periodontitis relapse post-surgery: A pilot study.

J Periodontol 2021 Apr 4. Epub 2021 Apr 4.

Umeå University, Department of Molecular Periodontology, Umeå, Sweden.

Background: The knowledge of which genes and proteins that are connected to the susceptibility to gingivitis with subsequent local tissue degradation seen in periodontitis is insufficient. Changes of serum proteins associated with recurrence of bleeding on probing (BOP) and increased periodontal pocket depths (PPD) after surgical treatment of periodontitis could reveal molecules that could be early signals of tissue destruction and/or of importance for systemic effects in other tissues or organs.

Methods:  We performed a longitudinal pilot study and followed 96 inflammation-related proteins over time in serum from patients who underwent surgical treatment of periodontitis (n = 21). Read More

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Periodontal disease and risk of mortality and kidney function decline in advanced chronic kidney disease: a nationwide population-based cohort study.

Clin Oral Investig 2021 Apr 4. Epub 2021 Apr 4.

Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan.

Objectives: Periodontal disease is prevalent in patients with chronic kidney disease (CKD) and potentially associated with kidney function decline. However, it is uncertain whether periodontal disease affects the risk of mortality and morbidity in patients with advanced CKD.

Materials And Methods: Taiwan's National Health Insurance Research Database was used to conduct a nationwide population-based cohort study. Read More

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Validation of a search strategy for randomized clinical trials related to periodontitis.

Arch Public Health 2021 Apr 3;79(1):43. Epub 2021 Apr 3.

Faculty of Health Sciences, University of Brasilia, Brasília, Distrito Federal, Brazil.

Background: Systematic reviews, considered the gold standard for the assessment of scientific evidence, may present conflicting findings for the same clinical issue, and such dissent may be justified by the forms of elaboration of the electronic search strategy. This paper aims to validate a search strategy to identify randomized clinical trials related to periodontitis. A gold standard reference set was developed to validate the identified clinical trials using the relative recall method. Read More

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Impact of the Diet on the Formation of Oxidative Stress and Inflammation Induced by Bacterial Biofilm in the Oral Cavity.

Materials (Basel) 2021 Mar 12;14(6). Epub 2021 Mar 12.

Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

The diet is related to the diversity of bacteria in the oral cavity, and the less diverse microbiota of the oral cavity may favor the growth of pathogenic bacteria of all bacterial complexes. Literature data indicate that disturbances in the balance of the bacterial flora of the oral cavity seem to contribute to both oral diseases, including periodontitis, and systemic diseases. If left untreated, periodontitis can damage the gums and alveolar bones. Read More

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Evaluation of Microcirculation, Cytokine Profile, and Local Antioxidant Protection Indices in Periodontal Health, and Stage II, Stage III Periodontitis.

J Clin Med 2021 Mar 18;10(6). Epub 2021 Mar 18.

Laboratory "Health Systemic Process", University Lyon 1, EA4129, 69008 Lyon, France.

Periodontitis, initiated by the subgingival biofilm and modified by the individual's inflammatory/immune response, has been associated with vascular dysfunction. To analyze microcirculation indices in periodontal tissues and determine the activity of the enzymatic component of antioxidant defense and humoral immunity factors, a single-blind non-invasive clinical trial was realized. Forty subjects, aged from 30 to 65 years, with moderate to severe chronic periodontitis (chronic generalized periodontitis, CGP) vs. Read More

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Comparative Analysis of Cytokine Expression in Oral Keratinocytes and THP-1 Macrophages in Response to the Most Prevalent Serotypes of .

Microorganisms 2021 Mar 17;9(3). Epub 2021 Mar 17.

Laboratory of Molecular Immunology, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepción, Concepción 4030000, Chile.

Background: Periodontitis is a chronic inflammatory disease associated with a dysbiotic biofilm. Many pathogens have been related with its progression and severity, one of which is , a Gram-negative bacteria with seven serotypes (a-g) according with the structure of its LPS, with serotype b defined as the most virulent compared with the other serotypes. The aim of this study was to evaluate the response of oral keratinocytes and macrophages to . Read More

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Influence of Micronutrient Intake, Sociodemographic, and Behavioral Factors on Periodontal Status of Adults Assisted by a Public Health Care System in Brazil: A Cross-Sectional Multivariate Analysis.

Nutrients 2021 Mar 17;13(3). Epub 2021 Mar 17.

Health Sciences Faculty, Universidade Federal de Lavras (UFLA), 37200-900 Lavras, Minas Gerais, Brazil.

The lack of access to a balanced diet, rich in vitamins and minerals, can predispose people to inflammatory diseases such as obesity, diabetes mellitus, and periodontitis. We aimed to evaluate the relationship between micronutrient intake, sociodemographic behavioral characteristics, and periodontal health in adults assisted by a public health care system. Participants ( = 450) answered a food frequency questionnaire and were submitted to anthropometric and oral clinical examinations. Read More

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Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis.

J Clin Med 2021 Mar 10;10(6). Epub 2021 Mar 10.

Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan.

Periodontal disease is a chronic inflammatory disease of the periodontal tissue. The periodontal inflamed surface area (PISA) is a proposed index for quantifying the inflammatory burden resulting from periodontitis lesions. This study aimed to investigate longitudinal changes in the periodontal status as evaluated by the PISA following the active periodontal treatment. Read More

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Management of the Sequelae of a Sport-Related Traumatic Dental Injury Using Ultrasound Examination in the Diagnosis and Follow-Up.

Dent J (Basel) 2021 Mar 2;9(3). Epub 2021 Mar 2.

Department of Conservative Dentistry and Endodontics, University of Cagliari, 09124 Cagliari, Italy.

About a quarter of all oral pathologies involving the oral cavity and dental apparatus are traumatic injuries, and a substantial number of these cases are the result of sports injuries affecting adolescents and young adults. Here, we report the case of a 25-year-old healthy female referred to the department of Endodontics for the evaluation and management of teeth 1.2 and 1. Read More

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Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review.

J Control Release 2021 Mar 30;333:269-282. Epub 2021 Mar 30.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.

Periodontitis is a chronic inflammation of the soft tissue surrounding and supporting the teeth, which causes periodontal structural damage, alveolar bone resorption, and even tooth loss. Its prevalence is very high, with nearly 60% of the global population affected. Hence, periodontitis is an important public health concern, and the development of effective healing treatments for oral diseases is a major target of the health sciences. Read More

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Regeneration potential of decellularized periodontal ligament cell sheets combined with 15-deoxy-Δ-prostaglandin J nanoparticles in a rat periodontal defect.

Biomed Mater 2021 Apr 1;16(4):045008. Epub 2021 Apr 1.

Department of Periodontology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China. Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, Hangzhou, People's Republic of China.

Periodontitis is a chronic inflammatory disease characterized by loss of attachment and destruction of the periodontium. Decellularized sheet, as an advanced tissue regeneration engineering biomaterial, has been researched and applied in many fields, but its effects on periodontal regeneration remain unclear. In this study, the biological properties of decellularized human periodontal ligament cell (dHPDLC) sheets were evaluated in vitro. Read More

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Porphyromonas gingivalis enhances pneumococcal adhesion to human alveolar epithelial cells by increasing expression of host platelet-activating factor receptor.

FEBS Lett 2021 Mar 31. Epub 2021 Mar 31.

Department of Microbiology, Nihon University School of Dentistry, Tokyo, Japan.

Streptococcus pneumoniae causes pneumonia by infecting the alveolar epithelium via binding to host receptors, such as the platelet-activating factor receptor (PAFR). Although chronic periodontitis has been identified as a pneumonia risk factor, how periodontopathic bacteria cause pneumonia is not known. We found that S. Read More

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Clinical Characteristics of Chronic Lung Abscess Associated with Diagnosed Using Metagenomic Next-Generation Sequencing.

Infect Drug Resist 2021 23;14:1191-1198. Epub 2021 Mar 23.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.

Purpose: () is a Gram-positive anaerobic bacterium distributed in the oral cavity, with a potential to become pathogenic causing lung abscess. Due to the lack of specificity of symptoms and the difficulty in culture, the diagnosis of lung abscess associated with is delayed. It is essential to elucidate the clinical characteristics of lung abscess associated with . Read More

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Influence of scaler tip design on root surface roughness, tooth substance loss and patients' pain perception: an in vitro and a randomised clinical trial.

BMC Oral Health 2021 Mar 31;21(1):169. Epub 2021 Mar 31.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia.

Background: The influence of scaler tip design on root surface roughness, tooth substance loss and patients' pain perception is investigated.

Methods: This article was divided into the following parts: Part 1 Surface roughness and substance loss: an in vitro study, which involves intact extracted teeth sectioned and treated using a piezoelectric ultrasonic device (PM200 EMS Piezon, Switzerland) with a conventional scaler tip (FS-407) and a Perio Slim (PS) scaler tip (Perio Slim DS-016A). All sectioned samples for tooth surface roughness (n = 20) and tooth substance loss (n = 46) analyses were measured and compared using a 3D surface texture analyser and scanning electron microscope (SEM) respectively, at baseline and following scaling. Read More

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