22,199 results match your criteria chronic pancreatitis


Systemic lupus erythematous presenting with hemorrhagic shock caused by gastric penetration of pancreatic pseudocyst: a case report.

J Med Case Rep 2021 Sep 18;15(1):460. Epub 2021 Sep 18.

Department of General Surgery, Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Systemic lupus erythematous that causes various organ damage is rarely associated with pancreatic lesion. To the best of our knowledge, no cases presenting with hemorrhage shock caused by gastric penetration of pancreatic pseudocyst due to lupus pancreatitis have been reported. Herein, we report a case of hemorrhage shock caused by gastric penetration of pancreatic pseudocyst due to lupus pancreatitis. Read More

View Article and Full-Text PDF
September 2021

Hereditary Pancreatitis in a Young Adult: Acute to Chronic.

Clin Biochem 2021 Sep 13. Epub 2021 Sep 13.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, USA. Electronic address:

This case report investigates an unusual case of recurrent pancreatitis. A 22-year-old female was admitted to the emergency room for severe abdominal pain, nausea, and weight loss. She reported having these symptoms since she was a toddler. Read More

View Article and Full-Text PDF
September 2021

[Conservative or surgical treatment of chronic pancreatitis?]

Internist (Berl) 2021 Sep 16. Epub 2021 Sep 16.

Medizinische Klinik und Poliklinik II, Klinikum der Universität München, LMU München, München, Deutschland.

The cardinal symptom of chronic pancreatitis is severe belt-like upper abdominal pain, which requires immediate and adequate treatment. Furthermore, advanced stage chronic pancreatitis is often associated with complications, such as pancreatic pseudocysts, pancreatic duct stones and stenosis as well as biliary stenosis. The various endoscopic and surgical treatment options for chronic pancreatitis patients have been controversially discussed for decades. Read More

View Article and Full-Text PDF
September 2021

Pancreatic stones treated via an EUS-guided pancreaticogastrostomy with a fully-covered self-expandable metal stent.

VideoGIE 2021 Sep 8;6(9):419-421. Epub 2021 Jul 8.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo, Japan.

Video 1Pancreatic stones treated via an EUS-guided pancreaticogastrostomy with a fully covered self-expandable metal stent. A 42-year-old man who had undergone a distal pancreatectomy 2 years earlier for chronic pancreatitis due to alcohol use, with pancreatic stones, presented because of severe abdominal pain. Blood tests revealed elevated inflammatory markers and pancreatic enzymes. Read More

View Article and Full-Text PDF
September 2021

T1 relaxation times and MR elastography-derived stiffness: new potential imaging biomarkers for the assessment of chronic pancreatitis.

Abdom Radiol (NY) 2021 Sep 15. Epub 2021 Sep 15.

Mech-Sense, Department of Radiology, Aalborg University Hospital, Hobrovej 18-22, PO. Box 365, 9000, Aalborg, Denmark.

Purpose: Non-invasive imaging methods to detect morphological changes of the pancreas in patients with mild chronic pancreatitis (CP) are needed. This study aimed to compare magnetic resonance imaging-based parameters, pancreatic volume, T1 mapping, magnetic resonance elastography (MRE), and proton density fat fraction between CP patients and controls, and determine the diagnostic performance for diagnosing different stages of CP.

Methods: Nineteen patients with mild CP (Cambridge grade 2 or less or recurring acute pancreatitis; n = 19), 30 with moderate/severe CP (Cambridge grade 3 and 4), and 35 healthy controls underwent pancreatic magnetic resonance imaging to assess the above mentioned magnetic resonance imaging-based parameters. Read More

View Article and Full-Text PDF
September 2021

[Pathogenesis of chronic pancreatitis].

Internist (Berl) 2021 Sep 15. Epub 2021 Sep 15.

Pädiatrische Ernährungsmedizin, Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Technische Universität München (TUM), Gregor-Mendel-Straße 2, 85354, Freising, Deutschland.

Long-term alcohol consumption and gene mutations are the most important causes of chronic pancreatitis. In addition to mutations in acinar genes, such as digestive enzymes and their inhibitors, defects in genes that primarily or exclusively affect the duct cells have also been described in recent years. Genetic changes are found not only in patients with a positive family history (hereditary pancreatitis) but also in so-called idiopathic and, to a lesser extent, in alcoholic chronic pancreatitis. Read More

View Article and Full-Text PDF
September 2021

Single-Cell Analyses of Human Pancreas: Characteristics of two populations of acinar cells in chronic pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2021 Sep 15. Epub 2021 Sep 15.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, grid.21925.3dUniversity of Pittsburgh, Pittsburgh, PA, United States.

Chronic pancreatitis (CP) is a complex inflammatory disorder with numerous associated genetic and environmental risk factors. The most distressing characteristic of CP is recalcitrant pain, often requiring surgical resection including total pancreatectomy with islet autotransplantation (TPIAT). We studied 5 consented subjects undergoing pancreatic resection and processed isolated cells for single cell RNA sequencing (scRNA-Seq). Read More

View Article and Full-Text PDF
September 2021

Pseudohyponatremia Leading to a Fatal Outcome in a Patient With Familial Hypertriglyceridemia.

Cureus 2021 Aug 10;13(8):e17066. Epub 2021 Aug 10.

Internal Medicine, Hackensack Meridian Ocean Medical Center, Brick, USA.

Serum sodium assay is a commonly performed laboratory test in a clinical setting and the results are taken for granted without being aware of the actual methods involved. In conditions like hyperlipidemia and hyperproteinemia, excessive lipids in serum dilute the water component of the serum. Since sodium is dissolved only in the aqueous phase of serum, the sodium content per unit volume of plasma is reduced. Read More

View Article and Full-Text PDF

EUS in Pediatrics: A Multicenter Experience and Review.

Front Pediatr 2021 25;9:709461. Epub 2021 Aug 25.

Cedars-Sinai Medical Center, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.

Endoscopic ultrasound (EUS) is a well-established tool used in the evaluation and treatment of a wide range of pathologies in adult medicine. EUS in pediatrics has been shown to be safe and technically effective, and its use continues to evolve. This article aims to describe the EUS experience at our tertiary-care centers with regard to safety, technical success, and its impact in clinical management. Read More

View Article and Full-Text PDF

Effect of inflammatory bowel disease treatments on patients with diabetes mellitus.

World J Diabetes 2021 Aug;12(8):1248-1254

Department of Gastroenterology, South Warwickshire Foundation Trust, Warwick CV34 5BW, United Kingdom.

As medical care progresses and the number of patients with chronic conditions increases there is the inevitable challenge of managing patients with multiple co-morbidities. Inflammatory bowel disease (IBD) is an umbrella term for are inflammatory conditions affecting the gastrointestinal tract, the two most common forms being Ulcerative Colitis and Crohn's disease. These diseases, usually diagnosed in young adults, exhibit a relapsing and remitting course and usually require long-term treatment. Read More

View Article and Full-Text PDF

Effect of pancreatic endotherapy on quality of life in chronic pancreatitis patients: A systematic review.

World J Gastrointest Endosc 2021 Aug;13(8):336-355

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.

Background: Pancreatic endotherapy provides treatment options for the management of chronic pancreatitis-related structural complications such as pancreatic duct stones, strictures, and pancreatic fluid collections. Most studies detailing endotherapy, however, have focused on technical success outcomes such as stone clearance or stricture resolution.

Aim: To review the effect of pancreatic endotherapy on patient-centered outcomes. Read More

View Article and Full-Text PDF

[A case of pancreatic actinomycosis diagnosed by EUS-FNA].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(9):884-889

Department of Gastroenterology, Toyama Prefectural Central Hospital.

A 60-year-old male patient had alcoholic chronic pancreatitis. Three months prior, he had undergone an exchange of pancreatic duct stents. In December 201X-1, magnetic resonance imaging and computed tomography (CT) scan results showed a caput pancreatic mass and common bile duct dilatation. Read More

View Article and Full-Text PDF
September 2021

USING THE METHOD OF PANCREATOGASTROSTOMY AT THE STAGE OF RECONSTRUCTION IN PANCREATODUODENECTOMY.

Georgian Med News 2021 Jul-Aug(316-317):16-21

1National Institute of Surgery and Transplantology of the NAMS of Ukraine name after А.А. Shalimov, Kyiv; Ukraine.

The goal of this study was to analyze the effectiveness of pancreatogastrostomy at the stage of reconstruction by assessing its technical aspects and analysis of the frequency of postoperative complications. The article represents results of the study held with a total of 35 pancreatoduodenectomies performed, followed by reconstruction pancreatogastrostomy. The average patients age was 53. Read More

View Article and Full-Text PDF
September 2021

Ruptured Splenic Artery Pseudoaneurysm Causing Hemorrhage Into a Pancreatic Pseudocyst.

Am J Forensic Med Pathol 2021 Sep 10. Epub 2021 Sep 10.

From the Volusia County Medical Examiner's Office, Daytona Beach, FL University of South Carolina School of Medicine Departments of Radiology Pathology, Prisma Health, Greenville, SC.

Abstract: This case report describes fatal exsanguination due to splenic artery hemorrhage into a pancreatic pseudocyst with cystogastrostomy in a 46-year-old woman. The decedent had a complicated medical history including necrotizing pancreatitis, giant pseudocyst formation after cystogastrostomy procedure, and coiling of a hemorrhagic splenic artery. While hospitalized, she underwent embolization of a ruptured splenic artery pseudoaneurysm. Read More

View Article and Full-Text PDF
September 2021

Homozygosity of short VNTR lengths in the CEL gene may confer susceptibility to idiopathic chronic pancreatitis.

Pancreatology 2021 Sep 4. Epub 2021 Sep 4.

Department of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address:

Objective: The carboxyl-ester lipase (CEL) gene contains a variable number of tandem repeats (VNTR) region. It remains unclear whether the number of repeats in the CEL VNTR is related to the risk of pancreatic diseases. The aim of this study was to investigate whether CEL VNTR length is associated with idiopathic chronic pancreatitis (ICP), alcoholic chronic pancreatitis (ACP), or pancreatic cancer in a cohort of Chinese patients. Read More

View Article and Full-Text PDF
September 2021

Diagnostic Dilemma in Groove Pancreatitis: A Case Report.

JNMA J Nepal Med Assoc 2020 Nov 22;58(231):934-937. Epub 2020 Nov 22.

Department of Surgery, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal.

Groove pancreatitis is uncommon form of chronic pancreatitis common in patients with history of smoking and alcohol abuse. High index of suspicion is required as it may masquerade pancreatic ductal adenocarcinoma and both of these conditions are difficult to differentiate preoperatively. Pancreaticoduodenectomy has good outcome in patient with Groove pancreatitis. Read More

View Article and Full-Text PDF
November 2020

Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors.

Int J Mol Sci 2021 Aug 26;22(17). Epub 2021 Aug 26.

Department of Immunohaematology and Blood Transfusion, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Hepatitis E virus (HEV) usually causes self-limiting acute hepatitis, but the disease can become chronic in immunocompromised individuals. HEV infection in pregnant women is reported to cause up to 30% mortality, especially in the third trimester. Additionally, extrahepatic manifestations like neuronal and renal diseases and pancreatitis are also reported during the course of HEV infection. Read More

View Article and Full-Text PDF

Diabetes and pancreatic cancer: Exploring the two-way traffic.

World J Gastroenterol 2021 Aug;27(30):4939-4962

Department of Surgical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India.

Pancreatic cancer (PC) is often associated with a poor prognosis. Long-standing diabetes mellitus is considered as an important risk factor for its development. This risk can be modified by the use of certain antidiabetic medications. Read More

View Article and Full-Text PDF

Screening attendance, prevalence and severity of diabetic retinopathy (DR) in a cohort of patients with diabetes mellitus secondary to chronic pancreatitis (DMsCP) in Northern Ireland.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

The Belfast Pancreatic Diabetes Clinic, Belfast City Hospital Health and Social Services Trust, Belfast, UK

Introduction: This study investigated Northern Ireland Diabetic Eye Screening Programme (NIDESP) attendance and diabetic retinopathy (DR) prevalence/severity in patients with diabetes mellitus secondary to chronic pancreatitis (PwDMsCP).

Research Design And Methods: Medical/NIDESP records for all PwDMsCP attending the pancreatic diabetes clinic were analyzed in 2017 (n=78) and 2019 (n=94).

Results: Between 2017 and 2019, those without DR decreased (76% to 63%); mild non-proliferative DR (NPDR), severe NPDR and PDR were found in 30%, 2% and 5%, respectively (previously 18%, 4%, 2%); diabetic maculopathy (DMac) was present in 12% (previously 10%). Read More

View Article and Full-Text PDF
September 2021

Opioid-related emergency department visits and hospitalizations among patients with chronic gastrointestinal symptoms and disorders dually enrolled in the Department of Veterans Affairs and Medicare Part D.

Am J Health Syst Pharm 2021 Sep 7. Epub 2021 Sep 7.

Center for Communication and Health, Northwestern University School of Communication, Chicago, IL, USA.

Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

View Article and Full-Text PDF
September 2021

Colloid carcinoma derived from intraductal papillary mucinous neoplasm of the pancreatic head with calcification: A case report and literature review.

Surg Case Rep 2021 Sep 6;7(1):202. Epub 2021 Sep 6.

Department of Gastroenterological Surgery, Saitama Cancer Center, 780 Komuro, Ina-machi, Kita-Adachi-gun, Saitama, 362-0806, Japan.

Background: Colloid carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreatic head with prominent calcification is exceedingly rare. Only a few studies about this entity have been reported in the literature. Therefore, its biological behavior, appropriate treatment modalities, and overall patient prognosis remain largely unclear. Read More

View Article and Full-Text PDF
September 2021

A rare case of congenital aneurysm of the portal system at level of spleno-porto-mesenteric confluence complicated by massive thrombosis.

Radiol Case Rep 2021 Nov 30;16(11):3369-3373. Epub 2021 Aug 30.

IBB CNR Naples, Via De Amicis, 95, 80145 Naples, Italy.

Portal venous aneurysm is a rare and potential dangerous vascular pathology, which can result in thrombosis or rupture. It may be congenital or acquired. Acquired form can be related mainly to portal hypertension, chronic hepatic disease, and trauma. Read More

View Article and Full-Text PDF
November 2021

Low and high pancreatic amylase is associated with pancreatic cancer and chronic pancreatitis.

Eur J Epidemiol 2021 Sep 5. Epub 2021 Sep 5.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark.

Incidences of pancreatic cancer and acute and chronic pancreatitis are rising globally, and often no curative treatment is available at the time of diagnosis. We tested the hypothesis that low and high plasma concentrations of pancreatic amylase are associated with increased risk of pancreatic cancer, acute pancreatitis, and chronic pancreatitis in the general population. We included 101,765 individuals (55% women) aged 20-100 years from the Copenhagen General Population Study with baseline measurements of plasma pancreatic amylase. Read More

View Article and Full-Text PDF
September 2021

Common calcium-sensing receptor (CASR) gene variants do not modify risk for chronic pancreatitis in a Hungarian cohort.

Pancreatology 2021 Aug 26. Epub 2021 Aug 26.

Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary. Electronic address:

The calcium-sensing receptor (CASR) is expressed in the pancreas where it might regulate calcium concentrations in pancreatic secretions. Two independent studies reported conflicting results claiming that commonly occurring missense variants of the CASR gene are risk factors for chronic pancreatitis (CP). Here, we attempted to replicate the association between CASR variants and CP. Read More

View Article and Full-Text PDF

A Spy took a bite to get the diagnosis right: the benefit of SpyGlass technology in the diagnosis of autoimmune pancreatitis evading traditional diagnostic methods.

BMJ Open Gastroenterol 2021 Sep;8(1)

Digestive Diseases, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis that is often overlooked and is usually characterised clinically by frequent presentations with obstructive jaundice. Serum IgG4 testing as a means to 'rule out' IgG4-related disease may not be as helpful as initially thought and may lead to a missed diagnosis if suspicion is low. We present a patient with a years long history of recurrent pancreatitis ultimately found to have AIP after undergoing evaluation with a relatively new technology, SpyGlass, which allows for direct cholangioscopy and enabled us to make the correct diagnosis. Read More

View Article and Full-Text PDF
September 2021

Incidence, predictors and patterns of care of patients with very severe hypertriglyceridemia in Ontario, Canada: a population-based cohort study.

Lipids Health Dis 2021 Sep 3;20(1):98. Epub 2021 Sep 3.

St. Joseph's Health Care London, 268 Grosvenor St, London, ON, N6A 4V2, Canada.

Background: The incidence of severe (S-HTG) and very severe hypertriglyceridemia (VS-HTG) among Canadians is unknown. This study aimed to determine the incidence, characteristics, predictors and care patterns for individuals with VS-HTG.

Methods: Using linked administrative healthcare databases, a population-based cohort study of Ontario adults was conducted to determine incidence of new onset S-HTG (serum triglycerides (TG) > 10-20 mmol/L) and VS-HTG (TG > 20 mmol/L) between 2010 and 2015. Read More

View Article and Full-Text PDF
September 2021

Embolization for gastrointestinal bleeding in patients with pancreatitis: Report of two cases and literature review.

Ulus Travma Acil Cerrahi Derg 2021 Sep;27(5):590-594

Department of Surgery, School of Medicine, Nis University Faculty of Medicine, Nis-Serbia.

Gastrointestinal (GI) bleeding is rare but potentially fatal complication of pancreatitis. Early diagnosis and timely radiologic intervention are crucial for survival as when untreated the mortality of these patients is high. We present two patients, one with chronic pancreatitis and one with acute pancreatitis, both complicated with severe upper GI tract bleeding. Read More

View Article and Full-Text PDF
September 2021

Pancreatitis After Pancreaticojejunostomy Procedure? A Tale Involving the Tail of the Pancreas.

ACG Case Rep J 2021 Aug 25;8(8):e00644. Epub 2021 Aug 25.

Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

Recurrent acute pancreatitis (RAP) involving the tail of the pancreas after pancreaticojejunosotomy (PJP) is rare, has very challenging management, and there is minimal literature. We describe a case of idiopathic RAP, complicated with chronic pancreatitis that failed medical and endoscopic management and required PJP. Unfortunately, RAP recurred after PJP, and we describe his clinical course and management. Read More

View Article and Full-Text PDF

Loss of miR-29a/b1 promotes inflammation and fibrosis in acute pancreatitis.

JCI Insight 2021 Aug 31. Epub 2021 Aug 31.

Indiana University School of Medicine, Indianapolis, United States of America.

MicroRNA-29 (miR-29) is a critical regulator of fibro-inflammatory processes in human diseases. In this study, we find a decrease in miR-29a in experimental and human chronic pancreatitis leading us to investigate the regulatory role of miR-29a/b1 cluster in acute pancreatitis (AP) utilizing a novel conditional miR-29a/b1 knockout (KO) mouse model. miR-29a/b1 sufficient (WT) and deficient (KO) mice were administered with supramaximal caerulein to induce AP and characterized at different timepoints, utilizing an array of immunohistochemical and biochemical analyses for AP parameters. Read More

View Article and Full-Text PDF