54,459 results match your criteria chronic lesions

MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration.

Biomed Pharmacother 2021 Sep 15;143:112170. Epub 2021 Sep 15.

Second Provincial People's Hospital of Gansu, 1 Hezheng West Street, Lanzhou 730000, PR China; Affiliated Hospital of Northwest Minzu Univsity, Lanzhou 730000, PR China. Electronic address:

Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease, which is considered the main cause of low back pain. It seriously affects the quality of life of patients and consequently brings a heavy economic burden to their families and the society. Although IDD is considered a natural process in degenerative lesions, it is mainly caused by aging, trauma, genetic susceptibility and other factors. Read More

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September 2021

Revisiting tuberculosis screening: An insight to complementary diagnosis and prospective molecular approaches for the recognition of the dormant TB infection in human and cattle hosts.

Angel H Alvarez

Microbiol Res 2021 Aug 26;252:126853. Epub 2021 Aug 26.

Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco A.C. (CIATEJ), Consejo Nacional de Ciencia y Tecnología (CONACYT), Av. Normalistas 800 C.P. 44270, Guadalajara, Jalisco, Mexico. Electronic address:

Tuberculosis (TB) is defined as a chronic infection in both human and cattle hosts and many subclinical cases remain undetected. After the pathogen is inhaled by a host, phagocyted bacilli can persist inside macrophages surviving intracellularly. Hosts develop granulomatous lesions in the lungs or lymph nodes, limiting infection. Read More

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Post-burn scar malignancy: 5-year management review and experience.

Int Wound J 2021 Sep 18. Epub 2021 Sep 18.

Surgical Oncology, Medical School of Bany-Swif University, Bany-Swif, Egypt.

The study spotlights a severe uncommon post-burn complication, Marjolin's ulcer, in upper Egypt plastic and wound care centres. This problem is mainly related to inadequate medical care and awareness. No community or race is immune. Read More

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September 2021

Human Immunodeficiency Virus Infection Promotes Human Papillomavirus-Mediated Anal Squamous Carcinogenesis: An Immunologic and Pathobiologic Review.

Pathobiology 2021 Sep 14:1-12. Epub 2021 Sep 14.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Background: Anal squamous cell carcinoma (SCC) is a rare gastrointestinal malignancy with rising incidence, both in the United States and internationally. The primary risk factor for anal SCC is human papillomavirus (HPV) infection. However, there is a growing burden of disease in patients with human immunodeficiency virus (HIV) and HPV coinfection, with the incidence of anal SCC significantly increasing in this population. Read More

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September 2021

Multiple myeloma and malignant lesions: a potential risk factor for local anesthetic systemic toxicity.

Reg Anesth Pain Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.

Background: Multiple myeloma is a cancer of plasma cells that often leads to complications including osteolytic bone lesions, nephropathy and neuropathy. Multiple myeloma is only one etiology of many cancer pain conditions that may necessitate interventional pain treatment when refractory to multimodal medications. Notably, local anesthetic systemic toxicity is a rare but life-threatening complication of local anesthetic administered for these interventions. Read More

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September 2021

Using pneumovaginoscopy to perform the removal of a vaginal fibroid.

Fertil Steril 2021 Sep 14. Epub 2021 Sep 14.

Department of Obstetrics and Gynecology, Assistance Publique Hôpitaux de Marseille, La Conception Hospital, 13005 Marseille, Aix Marseille University, France; Institut Méditerranéen de Biodiversité et d'Écologie marine et continentale (IMBE), Aix Marseille University, CNRS, IRD, Avignon University, Marseille, France. Electronic address:

Objective: To describe and assess the feasibility of a novel surgical technique (pneumovaginoscopy) for performing vaginal surgery.

Design: Video of a single surgical procedure.

Setting: A university hospital. Read More

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September 2021

Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study.

Virol J 2021 Sep 17;18(1):188. Epub 2021 Sep 17.

Division of Clinical Research, Center for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Cheongju, Republic of Korea.

Background: Persistent human papillomavirus (HPV) infection is a key factor for the development and progression of cervical cancer. We sought to identify the type-specific HPV prevalence by cervical cytology and assess disease progression risk based on high-risk persistent HPV infection in South Korea.

Methods: To investigate the HPV prevalence by Pap results, we searched seven literature databases without any language or date restrictions until July 17, 2019. Read More

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September 2021

Effect of dexamethasone on experimental enteritis produced by Giardia lamblia in a Meriones unguiculatus model.

Exp Parasitol 2021 Sep 14:108158. Epub 2021 Sep 14.

Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

Our aim was to evaluate the impact of immunosuppression on the development of giardiasis. Thirty-six gerbils (4-6 weeks old) were distributed in four groups containing nine animals each: Control (CT); Control-Infected by Giardia lamblia (CTIn), Immunosuppressed (IS), and Immunosuppressed-Infected by G. lamblia (ISIn). Read More

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September 2021

Chronic Recurrent Multifocal Osteomyelitis Involving the Mandible - A Rare Case Report.

J Clin Pediatr Dent 2021 Oct;45(4):273-277

Chronic recurrent multifocal osteomyelitis (CRMO) is an uncommon, aseptic, autoinflammatory condition characterized by multifocal bone lesions with pain, swelling, and frequent exacerbations and remissions. It is noteworthy that these lesions occur without any identifiable etiology or microbiologic finding. The clavicle and metaphyses of the long bones are often involved whereas involvement of the mandible is considered rare. Read More

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October 2021

Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Sep 17;PP. Epub 2021 Sep 17.

Chronic thrombi of the deep veins of the leg are resistant to dissolution or removal by current interventions and can act as thrombogenic sources. Histotripsy, a focused ultrasound therapy, uses the mechanical activity of bubble clouds to liquefy target tissues. In vitro experiments have shown that histotripsy enhances thrombolytic agent recombinant tissue plasminogen activator in a highly retracted clot model resistant to lytic therapy alone. Read More

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September 2021

Safety profile of Dupilumab during pregnancy: a data mining and disproportionality analysis of over 37,000 reports from the WHO individual case safety reporting database (VigiBase™).

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5448-5451

Clalit Health Service, Akko, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Atopic dermatitis, known also as atopic eczema, represents a commonly diagnosed, chronic or recurrent/relapsing inflammatory disorder. From a clinical point of view, it is characterized by acute flare-ups of intense itching, eczematous pruritic lesions involving dry skin. Dupilumab is the only biologic agent approved to treat moderate to severe course of atopic dermatitis, which can be particularly severe during pregnancy causing distress and impacting on maternal and fetal health. Read More

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September 2021

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis.

Cell Stress Chaperones 2021 Sep 16. Epub 2021 Sep 16.

Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.

Atopic dermatitis (AD) is one of the most common chronic inflammatory dermatoses characterized by persistent itching and recurrent eczematous lesions. While the primary events and key drivers of AD are topics of ongoing debate, cutaneous inflammation due to inappropriate IgE (auto)antibody-related immune reactions is frequently considered. Highly conserved and immunogenic heat shock protein 90 (Hsp90), a key intra- and extracellular chaperone, can activate the immune response driving the generation of circulating anti-Hsp90 autoantibodies that are found to be elevated in several autoimmune disorders. Read More

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September 2021

Female chronic posterior urethritis is underestimated in patients with lower urinary tract symptoms.

Transl Androl Urol 2021 Aug;10(8):3456-3464

Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China.

Background: As one of the causes of urethral symptoms, female chronic posterior urethritis is a common and distressing disease; however, it is often neglected and misdiagnosed as overactive bladder (OAB) or interstitial cystitis/bladder pain syndrome (IC/BPS). Currently, little is known about the urothelium and lamina propria of the bladder neck and proximal urethra. Thus, identifying urethral lesions is necessary for the diagnosis and treatment of female chronic posterior urethritis. Read More

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HDAC6: A Key Link Between Mitochondria and Development of Peripheral Neuropathy.

Front Mol Neurosci 2021 31;14:684714. Epub 2021 Aug 31.

UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Peripheral neuropathy, which is the result of nerve damage from lesions or disease, continues to be a major health concern due to the common manifestation of neuropathic pain. Most investigations into the development of peripheral neuropathy focus on key players such as voltage-gated ion channels or glutamate receptors. However, emerging evidence points to mitochondrial dysfunction as a major player in the development of peripheral neuropathy and resulting neuropathic pain. Read More

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Treatment of non-culprit lesions in STEMI: An incomplete journey.

Cardiovasc Revasc Med 2021 Sep 11. Epub 2021 Sep 11.

Faculty of Medicine, University of Southampton, UK.

Approximately 50% of patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) have multivessel coronary artery disease (CAD). A number of randomized studies (Table 1) have all shown that complete revascularization (CR), either at the time of primary percutaneous coronary revascularization (PPCI) or within 45 days of the index admission, is safe and reduces the risk of repeat coronary revascularization and myocardial infarction (MI), particularly in the non-infarct related artery (NIRA). Despite consistently showing clinical benefit for CR, the results from the trials show variations in what drives this effect. Read More

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September 2021

Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study.

BMC Cancer 2021 Sep 16;21(1):1034. Epub 2021 Sep 16.

Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed to describe the risk factors associated with ESCC and its precursor lesions.

Methods: We performed an endoscopic examination of 44,857 individuals aged 40-69 years from five high incidence regions of China in 2017-2018. Read More

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September 2021

Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection.

Cytokine 2021 Sep 13;148:155699. Epub 2021 Sep 13.

Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University, Magdeburg, Germany; Institute of Biochemistry, Kiel University, Kiel, Germany; Department of Pathology, Otto-von-Guericke-University, Medical Faculty, Magdeburg, Germany. Electronic address:

Interleukin-11 (IL-11) is an important member of the IL-6 family of cytokines. IL-11 activates its target cells via binding to a non-signaling α-receptor (IL-11R), which results in recruitment and activation of a gp130 homodimer. The cytokine was initially described as an anti-inflammatory protein, but has recently gained attention as a potent driver in certain types of cancer and different fibrotic conditions. Read More

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September 2021

Matrix metalloproteinase-2 on activated platelets triggers endothelial PAR-1 initiating atherosclerosis.

Eur Heart J 2021 Sep 16. Epub 2021 Sep 16.

Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Strada Vicinale Via delle Corse, Perugia 06132, Italy.

Aims : Platelets participate in atherogenesis with mechanisms not yet fully clarified. Vascular wall MMP-2 is involved in the arterial remodelling accompanying atherosclerosis. Platelets contain and release MMP-2 but no informations are available on its role in atherosclerotic lesion formation. Read More

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September 2021

Peripheral ossifying fibroma: A case report.

Stomatologija 2021 ;23(2):56-60

Specialized Medical and Dental Clinic, Wspólna 12, 44-240 Żory, Poland.

Peripheral ossifying fibroma (POF) is a reactive lesion that originates in the gingiva. Morphological similarity to other epulides and similar nomenclature to neoplastic tumors give rise to obvious problems both at the stage of diagnosis and treatment of POF. Although POF is one of the less common gingival lesions, it accounts for up to 2% of all oral lesions, which means that most general dentists will encounter POF in their practice. Read More

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January 2021

Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cells homeostasis.

J Cell Sci 2021 Sep 16. Epub 2021 Sep 16.

Chronic Diseases Research Centre (CEDOC), NOVA Medical School, NOVA University Lisbon, 1169-056 Lisboa, Portugal.

In atherosclerotic lesions, vascular smooth muscle cells (VSMCs) represent half of the foam cell population, characterized by an aberrant accumulation of undigested lipids within lysosomes. Loss of lysosome function impacts VSMCs homeostasis and disease progression. Understanding the molecular mechanisms underlying lysosome dysfunction in these cells is, therefore, crucial. Read More

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September 2021

Reactive arthritis: a clinical review.

J R Coll Physicians Edinb 2021 Sep;51(3):288-297

Department of Rheumatology, University Hospitals of Leicester NHS Trust, Leicester; College of Life Sciences, University of Leicester, Leicester.

Reactive arthritis (ReA) is a form of inflammatory arthritis triggered by a remote antecedent infection, usually in the genitourinary or gastrointestinal tract. It is part of the spondyloarthropathy (SpA) spectrum, an umbrella term for a group of distinct conditions with shared clinical features. Typically, it presents with an asymmetric oligoarthritis of the lower limb joints, and patients may also have sacroiliitis, enthesitis and dactylitis. Read More

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September 2021

[Hybrid operations in treatment of patients with multi-level lesions of lower limb arteries].

Angiol Sosud Khir 2021 ;27(3):173-179

Municipal Clinical Hospital named after S.P. Botkin of the Moscow Healthcare Department, Moscow, Russia.

The article is a review of literature dedicated to simultaneous open and endovascular (hybrid) operations in treatment of patients with chronic ischaemia of lower limbs. Despite good results of endovascular interventions, in many situations involvement of arteries below the inguinal fold and multilevel lesions are arguments in favour of performing an open operation. On the other hand, open multilevel interventions are accompanied by an increased risk of complications and mortality. Read More

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September 2021

[Use of endovascular drug-coated devices in lesions of femoropopliteoltibial arteries].

Angiol Sosud Khir 2021 ;27(3):165-172

Department of Vascular Surgery, Centre of Cardiovascular and Endovascular Surgery, Federal Clinical Centre of High Medical Technologies of the Federal Medical and Biological Agency of the RF Ministry of Public Health, Khimki, Russia.

Endovascular intervention is one of the main methods of treatment in atherosclerotic lesions of the infrainguinal segment in patients with chronic lower limb ischaemia. Recent years have witnessed active use of drug-eluting techniques, significantly improving the long-term outcomes of peripheral reconstructions. This article is a review of publications on the results of using modern drug-eluting balloon catheters and stents in the femoropopliteoltibial position. Read More

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September 2021

Alternative femoral endarterectomies: technical aspects and short-term results.

Angiol Sosud Khir 2021 ;27(3):104-113

Centre for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland; Department of Surgery, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Finnish Cardiovascular Research Center, Tampere, Finland.

Background: Femoral endarterectomies are often performed by means of longitudinal arteriotomies with patching. Autologous and synthetic patches can be used. Synthetic patches in the groin may expose patients to infection. Read More

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September 2021

Radiographic and CT appearance of cavitary pulmonary lesions in a lamb.

Aust Vet J 2021 Sep 15. Epub 2021 Sep 15.

Golden Plains Animal Hospital, Bannockburn, Victoria, Australia.

Background: Pulmonary abscesses may be cavitary lesions on thoracic radiographs and computed tomography (CT).

Case Report: A 26-day-old, cross-breed lamb presented for respiratory distress despite procaine penicillin treatment. Thoracic radiographs revealed several pulmonary ovoid thin-walled gas and soft tissue opacity structures. Read More

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September 2021

Non-melanoma Skin Cancers in Patients on Hydroxyurea for Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Systematic Review.

Cureus 2021 Aug 7;13(8):e16978. Epub 2021 Aug 7.

Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Hydroxyurea (HU) or hydroxycarbamide is a cytotoxic antimetabolite widely used to treat Philadelphia chromosome-negative Myeloproliferative Neoplasms (Ph-MPN) like Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF). Patients with Ph-MPN are at an increased risk of Non-melanoma skin cancers (NMSC). The cause of this finding remains uncertain. Read More

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Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort Study.

Stroke 2021 Sep 16:STROKEAHA121034347. Epub 2021 Sep 16.

Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland. (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.).

Background And Purpose: The aim of this study was to assess the rate of chronic covert brain infarctions (CBIs) in patients with acute ischemic stroke (AIS) and to describe their phenotypes and diagnostic value.

Methods: This is a single-center cohort study including 1546 consecutive patients with first-ever AIS on magnetic resonance imaging imaging from January 2015 to December 2017. The main study outcomes were CBI phenotypes, their relative frequencies, location, and association with vascular risk factors. Read More

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September 2021

Endovascular therapy for severely calcified plaque at the superficial femoral artery using myocardial biopsy forceps.

CVIR Endovasc 2021 Sep 15;4(1):69. Epub 2021 Sep 15.

Department of Cardiovascular Medicine, Toho University Faculty of Medicine Graduate School of Medicine, Tokyo, Ota-ku, Japan.

Background: Currently, the success rate of EVT for treating CTO of the SFA is high; however, EVT is still found to be insufficient in treating CTOs with severely calcified lesions. Even if the guidewire crosses the lesion, the calcifications may still cause difficulties during stent expansion.

Main Text: A 78-year-old male had been reported to have intermittent claudication with chronic total occlusion (CTO) of the right superficial femoral artery (SFA). Read More

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September 2021

A cooperative approach for treatment of Zenker's diverticulum.

Surg Endosc 2021 Sep 15. Epub 2021 Sep 15.

Digestive Disease Institute, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, 2nd Floor, Weston, FL, 33331, USA.

Background: Symptomatic Zenker's diverticulum management has evolved from an open intervention to an endoscopic management. At our center, both an otolaryngologist and a gastroenterologist are present in the operating room when treating these lesions. An intra-procedural consensus is reached to undergo either rigid endoscopy or flexible endoscopic diverticulotomy with ENT guidance. Read More

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September 2021

Pilot study: specific immunotherapy in patients with Papular urticaria by Cimex lectularius.

Eur Ann Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Immunology and Allergy, Hospital General De México (Dr Eduardo Liceaga), Ciudad De Mexico, Mexico.

Summary: Papular urticaria is a chronic allergic reaction induced by insect bites. In México the most common causative arthropods reported are bed bugs, fleas and mosquitoes. Approximately 70% of people who are bitten by experience hypersensitive reactions, papular urticaria, extensive erythema, urticaria, and even anaphylaxis has been reported, Pruritus is the major complaint, impairing quality of life and sleep. Read More

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September 2021