364,998 results match your criteria chronic health

Cardiovascular Effects Induced by Fruit Peels from Passiflora edulis in Hypertensive Rats and Fingerprint Analysis by HPLC-ESI-MSn spectrometry.

Planta Med 2021 Aug 3. Epub 2021 Aug 3.

Research Group on Bioactive Natural Products (PNBio), Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.

Hypertension is a chronic disease and a global health problem. Due to its high prevalence, it constitutes the most important risk factor for cardiovascular disease. Fruit peels from fo. Read More

View Article and Full-Text PDF

Exercise during Pregnancy: Developmental Programming Effects and Future Directions in Humans.

Int J Sports Med 2021 Aug 3. Epub 2021 Aug 3.

Human Performance Laboratory, Department of Kinesiology, East Carolina University, Greenville, United States.

Epidemiological studies show that low birth weight is associated with mortality from cardiovascular disease in adulthood, indicating that chronic diseases could be influenced by hormonal or metabolic insults encountered . This concept, now known as the Developmental Origins of Health and Disease hypothesis, postulates that the intrauterine environment may alter the structure and function of the organs of the fetus as well as the expression of genes that impart an increased vulnerability to chronic diseases later in life. Lifestyle interventions initiated during the prenatal period are crucial as there is the potential to attenuate progression towards chronic diseases. Read More

View Article and Full-Text PDF

Association of Surgical Necrotizing Enterocolitis and its Timing with Retinopathy of Prematurity.

Am J Perinatol 2021 Aug 3. Epub 2021 Aug 3.

Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objective:  The study aimed to determine the association of surgical necrotizing enterocolitis (NEC) and its timing, with the development and timing of retinopathy of prematurity (ROP).

Study Design:  This was a secondary data analysis of 7,483 preterm infants from the Postnatal Growth and Retinopathy of Prematurity Study. Associations between infants with surgical NEC, early-onset surgical NEC (8-28 days), and late-onset surgical NEC (over 28 days) with ROP were evaluated by using multivariable logistic regression models, controlling for birth weight, gestational age, small for gestational age status, chronic lung disease, intraventricular hemorrhage, hydrocephalus, patent ductus arteriosus, and periventricular leukomalacia. Read More

View Article and Full-Text PDF

[Acute kidney injury - Update 2021].

Dtsch Med Wochenschr 2021 Aug 3;146(15):988-993. Epub 2021 Aug 3.

Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin.

One in five hospitalized patients suffers acute kidney injury (AKI). Depending on its severity, AKI is associated with an up to 15-fold increased risk of mortality and constitutes a major risk factor for subsequent cardiovascular events and for the development of chronic kidney disease. This concise review summarizes recently published studies, focusing on 1. Read More

View Article and Full-Text PDF

The Impact of the COVID-19 Lockdown on the Quality of Life in Chronic Neurological Diseases: The Results of a COVQoL-CND Study.

Eur Neurol 2021 Aug 3:1-10. Epub 2021 Aug 3.

Department of Neurology, Selcuk University, School of Medicine, Konya, Turkey.

Background: Coronavirus disease 2019 (COVID-19) pandemic and lockdown period may induce an impairment in quality of life (QoL), disruption in treatment (DIT), and posttraumatic stress disorder (PTSD) in chronic neurological diseases (CNDs). To reach this information, a multicenter, cross-sectional study (COVQoL-CND) was planned. Parkinson's disease (PD), headache (HA), multiple sclerosis (MS), epilepsy (EP), polyneuropathy (PNP), and cerebrovascular disease (CVD) were selected as the CND. Read More

View Article and Full-Text PDF

Neglected Tropical Diseases and the Kidneys.

Contrib Nephrol 2021 Aug 3;199:1-28. Epub 2021 Aug 3.

Medical Sciences Graduate Program, Department of Internal Medicine, Federal University of Ceará, Fortaleza, Brazil.

Clinical Background: Neglected tropical diseases (NTDs), a major public health problem, frequently affect the kidneys. In this chapter, we discuss the NTDs which have been most studied in terms of renal involvement and present a summary of current knowledge regarding kidney disease in all NTDs, through a literature review. Epidemiology: There are more than 1 billion people in the world affected by NTDs. Read More

View Article and Full-Text PDF

The Rights of Patients with Chronic Kidney Disease in the World: Legal Perspectives and Challenges in Brazil, India, Portugal, South Africa, and Nigeria.

Contrib Nephrol 2021 Aug 3;199:1-17. Epub 2021 Aug 3.

Department of Public Law, Faculty of Law, University of Cape Town, Cape Town, South Africa.

Clinical Background: Chronic kidney disease (CKD) is a condition that causes important limitations to patients' lives. The limitations imposed as a result of the disease end up hampering the exercise of citizenship by individuals, including work and daily activities. Epidemiology: The prevalence of CKD in Brazil, India, Nigeria, Portugal, and South Africa is, respectively, 5. Read More

View Article and Full-Text PDF

Stroke and Chronic Kidney Disease.

Contrib Nephrol 2021 Aug 3;199:1-11. Epub 2021 Aug 3.

Ottawa Hospital Research Institute, The Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada.

Chronic kidney disease (CKD) is strongly associated with the full spectrum of cerebrovascular disease including ischaemic and haemorrhagic stroke, small vessel disease, and vascular cognitive impairment. Shared conventional vascular risk factors such as age, hypertension, and diabetes mellitus may account for many of these associations, but novel renal-specific risk factors such as uraemia-related coagulopathy or endothelial dysfunction have also been proposed. In this chapter, we will explore the impact of CKD on stroke risk, mechanisms, and outcomes. Read More

View Article and Full-Text PDF

Sickle Cell Disease and the Kidney: Pathophysiology and Novel Biomarkers.

Contrib Nephrol 2021 Aug 3;199:1-8. Epub 2021 Aug 3.

Public Health and Medical Sciences Graduate Programs, School of Medicine, University of Fortaleza, Fortaleza, Brazil.

Clinical Background: Renal involvement in sickle cell disease (SCD), called sickle cell nephropathy (SCN), includes several renal manifestations, such as renal acidification defect, distal nephron dysfunction, renal papillary necrosis, and proteinuria related to glomerular injury, leading to end-stage renal disease. Epidemiology: Many patients with SCD have a defect in urinary concentration, a problem caused by the destruction of the renal medulla that initiates in childhood. The presence of proteinuria in SCD is age-related and starts as microalbuminuria in adolescence and progresses to macroalbuminuria. Read More

View Article and Full-Text PDF

Reasons for Disparities in Access to Kidney Transplantation.

Contrib Nephrol 2021 Aug 3;199:1-10. Epub 2021 Aug 3.

Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil.

Clinical Background: Kidney transplantation (KT) is the best treatment for most patients with end-stage kidney disease (ESKD), providing better survival and quality of life and lower cost when compared to dialysis. Epidemiology: Despite robust evidence showing the superiority of KT over dialysis, a significant percentage of ESKD patients worldwide do not access this treatment. Challenges: Barriers resulting in inequalities and inequities in access to KT involves chronic kidney disease (CKD) diagnosis and management, including difficulties in accessing dialysis therapy before KT; suboptimal referral and enlistment to KT; and imbalance between supply and demand for organs. Read More

View Article and Full-Text PDF

Herbal Nephropathy.

Contrib Nephrol 2021 Aug 3;199:1-12. Epub 2021 Aug 3.

Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

An estimated one-third of adults in developed countries and more than 80% of the population in many low- and middle-income countries use herbal and traditional medicines to promote health or for the treatment of common diseases. Herbal medicines can cause kidney damage as a result of intrinsic toxicity, adulteration, contamination, replacement, misidentification, mistaken labeling, and unfavorable herb-drug interactions. The kidneys, due to their high blood flow rate, large endothelial surface area, high metabolic activity, active uptake by tubular cells, medullary interstitial concentration, and low urine pH are particularly vulnerable to development of toxic injury in the form of different syndromes like acute kidney injury, nephrolithiasis, chronic interstitial fibrosis, or uroepithelial cancer. Read More

View Article and Full-Text PDF

Nutrition and Obesity Impacts on Kidney Health.

Contrib Nephrol 2021 Aug 3;199:1-19. Epub 2021 Aug 3.

Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Clinical Background and Epidemiology: Nutrition and obesity are both important and common clinical issues in chronic kidney disease (CKD). Protein-energy wasting predicts adverse clinical outcomes in CKD. Obesity is associated with poor health outcomes. Read More

View Article and Full-Text PDF

Physical Activity and Health in Chronic Kidney Disease.

Contrib Nephrol 2021 Aug 3;199:1-13. Epub 2021 Aug 3.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.

Clinical Background and Epidemiology: Low physical activity is a common phenotype in individuals living with chronic kidney disease (CKD). It increases as renal function declines and is associated with adverse clinical outcomes and a poor quality of life (QOL). Both behavioral and disease-related factors contribute to the low physical activity levels in CKD. Read More

View Article and Full-Text PDF

Delirium-related distress in the ICU: A qualitative meta-synthesis of patient and family perspectives and experiences.

Int J Nurs Stud 2021 Jul 3;122:104030. Epub 2021 Jul 3.

School of Nursing Sydney, The University of Notre Dame Australia, Darlinghurst, NSW, Australia; The Cunningham Centre for Palliative Care, St Vincent's Health Network Sydney, Darlinghurst, NSW, Australia; University of Technology Sydney, IMPACCT - Improving Palliative, Aged and Chronic Care through Research and Translation, Faculty of Health, Ultimo, NSW, Australia. Electronic address:

Background: Better understanding of patient and family member experiences of delirium and related distress during critical care is required to inform the development of targeted nonpharmacologic interventions.

Objective: To examine and synthesize qualitative data on patient and family member delirium experiences and relieving factors in the Intensive Care Unit (ICU).

Design: We conducted a systematic review and qualitative meta-synthesis. Read More

View Article and Full-Text PDF

Burden of Disease for Psoriasis in Argentina, Brazil, Colombia, and Mexico.

Value Health Reg Issues 2021 Jul 31;26:126-134. Epub 2021 Jul 31.

Eli Lilly and Company, Indianapolis, IN, USA; Division of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, OH, USA.

Objectives: Psoriasis (PsO) is a chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations. The disease is also associated with lower quality of life, lower work productivity, and higher healthcare costs. The objective of this study was to conduct a systematic literature review of the disease burden for PsO in Argentina, Brazil, Colombia, and Mexico. Read More

View Article and Full-Text PDF

Trans-limb embolization for treatment of Type 2 endoleak post EVAR: Case report.

Int J Surg Case Rep 2021 Jul 26;85:106238. Epub 2021 Jul 26.

Vascular Surgery Unit - AOUP Policlinico 'P. Giaccone', Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.

Introduction: Type 2 endoleaks (T2EL) occur after 10%-25% of endovascular abdominal aortic aneurysm repairs and increase the risk factor of endograft repair failure and rupture. Herein we report a case of endovascular treatment of T2EL where we performed a trans-limb embolization.

Presentation Of Case: A 63-years-old male previously treated for AAA with endovascular aortic aneurysms repair (EVAR), showed an angio-CT scan followup with a type 2 endoleak fed from inferior mesenteric artery (AMI) with growth of AAA greater of 1 cm than preoperative CT-scan and increase of chronic lumbar pain. Read More

View Article and Full-Text PDF

Aberrant modulation of brain activity underlies impaired working memory following traumatic brain injury.

Neuroimage Clin 2021 Jul 28;31:102777. Epub 2021 Jul 28.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria 3800, Australia; Monash Epworth Rehabilitation Research Centre, Epworth Healthcare, Melbourne, Australia.

Impaired working memory is a common and disabling consequence of traumatic brain injury (TBI) that is caused by aberrant brain processing. However, little is known about the extent to which deficits are perpetuated by specific working memory subprocesses. Using a combined functional magnetic resonance imaging (fMRI) and working memory paradigm, we tested the hypothesis that the pattern of brain activation subserving working memory following TBI would interact with both task demands and specific working memory subcomponents: encoding, maintenance, and retrieval. Read More

View Article and Full-Text PDF

Adults at risk of pneumococcal disease in France.

Infect Dis Now 2021 Jul 31. Epub 2021 Jul 31.

HEVA, Lyon, France.

Background: Immunocompromised patients and those with certain underlying medical conditions are at risk of pneumococcal disease, but in France their vaccine coverage is largely unknown. We aimed to assess the number of adult patients eligible for pneumococcal vaccination in France.

Methods: We conducted an annual cross-sectional study based on retrospective data from the French National Health Data System. Read More

View Article and Full-Text PDF

Biomechanical changes in the lumbar spine following spaceflight 1 and factors associated with post2 spaceflight disc herniation.

Spine J 2021 Jul 31. Epub 2021 Jul 31.

Department of Orthopaedic Surgery, University of California, San Francisco, USA.

Background Context: For chronic low back pain, the causal mechanisms between pathological features from imaging and patient symptoms are unclear. For instance, disc herniations can often be present without symptoms. There remains a need for improved knowledge of the pathophysiological mechanisms that explore spinal tissue damage and clinical manifestations of pain and disability. Read More

View Article and Full-Text PDF

Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice.

Brain Behav Immun 2021 Jul 31. Epub 2021 Jul 31.

Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada; Molecular Medicine Department, Université Laval, Québec City, QC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; The Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada. Electronic address:

Chronic psychological stress is one of the most important triggers and environmental risk factors for neuropsychiatric disorders. Chronic stress can influence all organs via the secretion of stress hormones, including glucocorticoids by the adrenal glands, which coordinate the stress response across the body. In the brain, glucocorticoid receptors (GR) are expressed by various cell types including microglia, which are its resident immune cells regulating stress-induced inflammatory processes. Read More

View Article and Full-Text PDF

Antibody-mediated rejection of the liver allograft: an update and a clinico-pathological perspective.

J Hepatol 2021 Jul 31. Epub 2021 Jul 31.

Division of Liver Diseases, Department of Medicine, Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, New York.. Electronic address:

Antibody-mediated rejection after liver transplantation is an under-recognized cause of allograft injury. While definitions of acute and chronic antibody-mediated rejection have increased clinical awareness, timely identification and management of antibody-mediated rejection remain difficult due to complexities in diagnosis and histopathology, lack of treatment protocols, and unclear long-term outcomes. While recent cohort studies assessing the importance of donor-specific antibodies have aided in its diagnosis, treatment experiences of antibody-mediated rejection in liver transplantation remain limited to case reports and small series. Read More

View Article and Full-Text PDF

<> A potentially challenging diagnosis but an important one for patients.

J Am Acad Dermatol 2021 Jul 31. Epub 2021 Jul 31.

Department of Clinical Chemistry Pathology, St Richard's Hospital, Chichester, UK.

View Article and Full-Text PDF


Diabetes Res Clin Pract 2021 Jul 31:108972. Epub 2021 Jul 31.

Boden Institute, University of Sydney, Australia.

Executive Summary This document updates the 1999 World Health Organization (WHO) classification of diabetes. It prioritizes clinical care and guides health professionals in choosing appropriate treatments at the time of diabetes diagnosis, and provides practical guidance to clinicians in assigning a type of diabetes to individuals at the time of diagnosis. It is a compromise between clinical and aetiological classification because there remain gaps in knowledge of the aetiology and pathophysiology of diabetes. Read More

View Article and Full-Text PDF

Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.

J Biol Chem 2021 Jul 31:101023. Epub 2021 Jul 31.

Departments of Inflammation & Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis, heart failure and chronic obstructive pulmonary disease, initiates a hyperammonemic stress response (HASR) in tissues including skeletal muscle and in myotubes. Perturbations in levels of specific regulatory molecules have been reported, but the global responses to hyperammonemia are unclear. Read More

View Article and Full-Text PDF

Cytokine responses in non-lesional psoriatic skin as clinical predictor to anti-TNF agents.

J Allergy Clin Immunol 2021 Jul 31. Epub 2021 Jul 31.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

Background: A major issue with the current management of psoriasis is our inability to predict treatment response.

Objective: Our aim was to evaluate the ability to use baseline molecular expression profiling to assess treatment outcome for psoriatic patients.

Methods: We conducted a longitudinal study of 46 patients with chronic plaque psoriasis treated with anti-TNF agent etanercept, and molecular profiles were assessed in over 200 RNA-seq samples. Read More

View Article and Full-Text PDF

Prevalence and impact of neuropathic and non-neuropathic pain in chronic spinal cord injury.

Arch Phys Med Rehabil 2021 Jul 31. Epub 2021 Jul 31.

Department of Physical Medicine and Rehabilitation, The University of Texas Health Science Center at Houston, Houston, TX.

Objective: Compare prevalence, intensity ratings, and interference ratings of neuropathic pain (NeuP) and nociceptive pain in people with chronic spinal cord injury (SCI) DESIGN: Cross-sectional survey SETTING: Six SCI Model System centers in the US PARTICIPANTS: Convenience sample of 391 individuals with traumatic SCI, aged 18 years or older, 81% male, 57% white INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: Survey based on the International Spinal Cord Injury Pain Basic Data Set (ISCIPBDS) and the Spinal Cord Injury Pain Instrument (SCIPI), including 0-10 numerical ratings of pain intensity and pain interference with daily activities, mood, and sleep RESULTS: 80% of those surveyed reported having at least one pain problem; 58% reported two or more pain problems; 56% had probable NeuP; and 49% had non-NeuP. When comparing ratings for all pains (n=354 for NeuP, n=290 for non-NeuP) across subjects, probable NeuPs were significantly more intense (6.9 vs. Read More

View Article and Full-Text PDF

Mucosal immune responses in the trachea after chronic infection with Mycoplasma gallisepticum in unvaccinated and vaccinated mature chickens.

Cell Microbiol 2021 Aug 3:e13383. Epub 2021 Aug 3.

Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Tracheitis associated with the chronic respiratory disease in chickens caused by Mycoplasma gallisepticum is marked by infiltration of leukocytes into the mucosa. Although cytokines/chemokines are known to play a key role in recruitment, differentiation and proliferation of leukocytes, those that are produced and secreted into the trachea during the chronic stages of infection with M. gallisepticum have not been described previously. Read More

View Article and Full-Text PDF

A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing.

Wound Repair Regen 2021 Aug 3. Epub 2021 Aug 3.

Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Chronic wounds caused by underlying physiological causes such as diabetic wounds, pressure ulcers, venous leg ulcers and infected wounds affect a significant portion of the population. In order to treat chronic wounds, a strong debridement, removal of necrotic tissue, elimination of infection and stimulation of granulation tissue are required. Maggot debridement therapy (MDT), which is an alternative treatment method based on history, has been used quite widely. Read More

View Article and Full-Text PDF

Identifying the most important confounders when assessing the association between low-grade systemic inflammation and musculoskeletal pain: A modified Delphi study.

Pain Med 2021 Aug 3. Epub 2021 Aug 3.

Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 7 1081 BT Amsterdam, The Netherlands.

Objective: The association between low-grade systemic inflammation and musculoskeletal pain may be influenced by multiple factors. However, little is known about the relative importance of these factors, and few studies account for them. This Delphi study aimed to reach consensus on the most important confounders which influence the association between low-grade systemic inflammation and musculoskeletal pain. Read More

View Article and Full-Text PDF

Patients with Clinically Elevated Depressive Symptoms Report Improvements in Mood, Pain, and Functioning following Participation in Interdisciplinary Pain Rehabilitation.

Pain Med 2021 Aug 3. Epub 2021 Aug 3.

Michigan State University College of Human Medicine, 15 Michigan St. NE, Grand Rapids, MI, 49503.

Objective: Chronic pain and depression frequently co-occur and exacerbate one another; therefore, it is important to treat both conditions to improve patient outcomes. The current study evaluates an interdisciplinary pain rehabilitation program (IPRP) with respect to the following questions: 1) How do clinically elevated depressive symptoms impact pain-related treatment outcomes? and 2) To what extent does IPRP participation yield reliable and clinically significant change in depressed mood?

Methods: Participants in this study included 425 adults who engaged in a 10-week IPRP and completed self-report measures of pain, mood, and functioning at intake and discharge. Participants were categorized into 4 groups based on self-reported depressive symptoms (PROMIS Depression): within normal limits (WNL; n = 121), Mild (n = 115), Moderate (n = 153), and Severe (n = 36). Read More

View Article and Full-Text PDF