264,404 results match your criteria chronic group


Initial therapy of chronic graft vs. host disease: Analysis of practice variation and failure-free survival.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Fred Hutchinson Cancer Research Center, SEATTLE, Washington, United States.

Prior clinical trials largely considered prednisone 1mg/kg/day with or without calcineurin inhibitor as standard initial therapy for chronic graft vs. host disease (cGVHD) but uncertainty remains regarding the extent of practice variation and whether this affects subsequent outcomes. We assembled a cohort of 745 cGVHD patients treated with initial systemic immune suppressive (IS) therapy from three prior Chronic GVHD Consortium observational studies. Read More

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September 2021

Interleukin-37 is down-regulated in serum of patients with severe coronavirus disease 2019 (COVID-19).

Cytokine 2021 Sep 9;148:155702. Epub 2021 Sep 9.

Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq. Electronic address:

Pro-inflammatory and anti-inflammatory cytokines are indicated to play a prominent role in mediating the immunopathogenesis of coronavirus disease 19 (COVID-19). Interleukin (IL-37) is one of the anti-inflammatory cytokines that has been proposed to be involved in disease progression but the data are not overwhelming. Therefore, a case-control study was performed to analyze IL-37 levels in serum of 100 patients with severe COVID-19 and 100 blood donors (control group). Read More

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September 2021

Theories of self-care and self-management of long-term conditions by community-dwelling older adults: A systematic review and meta-ethnography.

Soc Sci Med 2021 Sep 10;287:114393. Epub 2021 Sep 10.

College of Nursing and Health Sciences, Flinders University, Bedford Park, SA, 5042, Australia; Caring Futures Institute, Flinders University, Bedford Park, SA, 5042, Australia.

Rationale: The proportion of older adults living with long-term conditions (LTCs) is increasing. Self-care and self-management approaches are seen as valuable in helping older people with LTCs to manage their health and care, yet the theoretical overlaps and divergences are not always clear.

Objectives: The objectives of this review were to: (1) systematically identify and appraise studies of self-care or self-management of LTCs by community-dwelling older adults (aged ≥60 years) either informed by, applying, creating, or testing theory; (2) explore similarities or points of convergence between the identified theories; and (3) use a meta-ethnographic approach to synthesise the theories and group related concepts into core constructs. Read More

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September 2021

The HEART Camp Exercise Intervention Improves Exercise Adherence, Physical Function, and Patient-Reported Outcomes in Adults with Preserved Ejection Fraction Heart Failure.

J Card Fail 2021 Sep 14. Epub 2021 Sep 14.

College of Nursing, University of Nebraska Medical Center, Omaha, NE 68198.

Background: Despite exercise being one of few strategies to improve outcomes for individuals with heart failure with preserved ejection fraction (HFpEF), exercise clinical trials in HFpEF are plagued by poor interventional adherence. Over the last 2 decades, our research team has developed, tested, and refined Heart failure Exercise And Resistance Training (HEART) Camp, a multi-component behavioral intervention to promote adherence to exercise in HF. We evaluated the effects of this intervention designed to promote adherence to exercise in HF focusing on subgroups of participants with HFpEF and heart failure with reduced ejection fraction (HFrEF). Read More

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September 2021

Effect of dexamethasone on experimental enteritis produced by Giardia lamblia in a Meriones unguiculatus model.

Exp Parasitol 2021 Sep 14:108158. Epub 2021 Sep 14.

Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

Our aim was to evaluate the impact of immunosuppression on the development of giardiasis. Thirty-six gerbils (4-6 weeks old) were distributed in four groups containing nine animals each: Control (CT); Control-Infected by Giardia lamblia (CTIn), Immunosuppressed (IS), and Immunosuppressed-Infected by G. lamblia (ISIn). Read More

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September 2021

Clinical Outcomes Following Durable Mitral Valve Repair for Ischemic Mitral Regurgitation.

Ann Thorac Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: This study aimed to clarify the incidence and determinants of postoperative adverse events in patients with ischemic cardiomyopathy who achieved long-term durable mitral valve repair.

Methods: Between 1999 and 2015, 166 patients with chronic ischemic mitral regurgitation (MR) and left ventricular (LV) ejection fraction ≤40% underwent restrictive mitral annuloplasty. During follow-up (65±34 months), echocardiographic assessments were performed 809 times (mean, 4. Read More

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September 2021

Acalabrutinib, venetoclax, and obinutuzumab as frontline treatment for chronic lymphocytic leukaemia: a single-arm, open-label, phase 2 study.

Lancet Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Background: Both continuous therapy with acalabrutinib and fixed-duration therapy with venetoclax-obinutuzumab are effective for previously untreated chronic lymphocytic leukaemia. We hypothesised that frontline time-limited, minimal residual disease (MRD)-guided triplet therapy with acalabrutinib, venetoclax, and obinutuzumab would induce deep (ie, more patients with undetectable MRD) and durable remissions.

Methods: In this open-label, single-arm, investigator-sponsored, phase 2 study, patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma were recruited from two academic hospitals in Boston, MA, USA. Read More

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September 2021

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial.

Lancet Infect Dis 2021 Sep 14. Epub 2021 Sep 14.

Université de Paris, IAME, INSERM, Paris, France; Département d'Épidémiologie, Biostatistique et Recherche Clinique, Hôpital Bichat, AP-HP, Paris, France.

Background: The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital with COVID-19, with indication of oxygen or ventilator support.

Methods: DisCoVeRy was a phase 3, open-label, adaptive, multicentre, randomised, controlled trial conducted in 48 sites in Europe (France, Belgium, Austria, Portugal, Luxembourg). Read More

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September 2021

Efficacy of a family-based cardiovascular risk reduction intervention in individuals with a family history of premature coronary heart disease in India (PROLIFIC): an open-label, single-centre, cluster randomised controlled trial.

Lancet Glob Health 2021 Oct;9(10):e1442-e1450

Public Health Foundation of India, New Delhi, India; Centre for Chronic Disease Control, New Delhi, India; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Background: Coronary heart disease, a leading cause of death globally, is amenable to lifestyle interventions. The family environment can affect the ability or willingness of individuals to make lifestyle changes. We aimed to investigate the efficacy of a targeted family-based intervention for reduction of total cardiovascular risk in individuals with a family history of premature coronary heart disease. Read More

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October 2021

Community sharing: Contextualizing Western research notions of contamination within an Indigenous research paradigm.

Am J Community Psychol 2021 Sep 17. Epub 2021 Sep 17.

Health Sciences Center: Center for Participatory Research, University of New Mexico, Albuquerque, New Mexico, USA.

Báa nnilah is a chronic illness self-management program designed by and for the Apsáalooke (Crow) community. Arising from a collaboration between an Indigenous nonprofit organization and a university-based research team, Báa nnilah's development, implementation, and evaluation have been influenced by both Indigenous and Western research paradigms (WRPs). Báa nnilah was evaluated using a randomized wait-list control group design. Read More

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September 2021

Effects of a low-carbohydrate ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain: A pilot randomised clinical trial.

Pain Med 2021 Sep 17. Epub 2021 Sep 17.

The University of Sydney, Faculty of Medicine and Health, NSW Australia.

Background: A low-carbohydrate ketogenic diet has been reported to improve chronic pain by reducing inflammation, oxidative stress, and sensitivity within the nervous system. The main aim of this trial is to evaluate the effects of a ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain.

Methods: Participants with chronic musculoskeletal pain were recruited for a 12-week diet intervention that commenced with a 3-week run-in diet removing ultra-processed foods, followed by randomisation to either a whole-food/well-formulated ketogenic diet (WFKD) or to continue with the minimally processed whole-food diet (WFD). Read More

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September 2021

Serum catalytic iron and progression of chronic kidney disease: findings from the ICKD study.

Nephrol Dial Transplant 2021 Sep 17. Epub 2021 Sep 17.

George Institute for Global Health India, New Delhi.

Background: The non-transferrin bound catalytic iron moiety catalyses production of toxic reactive oxygen species and is associated with adverse outcomes. We hypothesized that serum catalytic iron (SCI) is associated with progression of chronic kidney disease (CKD).

Methods: Baseline samples of the Indian Chronic Kidney Disease participants with at least one follow up visit were tested for total iron, iron binding capacity, transferrin saturation, SCI, ferritin and hepcidin. Read More

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September 2021

Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture.

J Neuropathol Exp Neurol 2021 Sep 17. Epub 2021 Sep 17.

Neurosurgery Research Group, Biomedicum, Helsinki, Finland.

Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Read More

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September 2021

Liver and/or Kidney Transplantation After SARS-CoV-2 Infection: Prevalence, Short-Term Outcome and Kinetics of Serum IgG Antibodies.

Transplantation 2021 Sep 16. Epub 2021 Sep 16.

Department of Gastroenterology & Hepatology, University Hospitals Leuven; Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium Clinical Department of Laboratory Medicine and National Reference Center for Respiratory Pathogens, University Hospitals Leuven; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium Department of Abdominal Transplant Surgery, University Hospitals Leuven; Transplantation Research Group, Lab of Abdominal Transplantation, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium Department of Respiratory Diseases, University Hospitals Leuven; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium. Department of Cardiology, University Hospitals Leuven; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium Department of Nephrology & Renal Transplantation, University Hospitals Leuven; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

Background: There is paucity of data on the prevalence, adequate timing and outcome of solid organ transplantation after SARS-CoV-2 infection and the kinetics of IgG antibodies in these patients.

Methods: SARS-CoV-2 anti-nucleocapsid (N) IgG and PCR via nasopharyngeal swab were analyzed in all patients within 24h before liver and/or kidney transplantation. Kinetics of IgG antibodies were analysed and compared with an immune-competent cohort. Read More

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September 2021

An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial.

Pain 2021 Oct;162(10):2486-2498

Division of Pain Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA, United States.

Abstract: Chronic low back pain can be caused by impaired control and degeneration of the multifidus muscles and consequent functional instability of the lumbar spine. Available treatment options have limited effectiveness and prognosis is unfavorable. We conducted an international randomized, double-blind, sham-controlled trial at 26 multidisciplinary centers to determine safety and efficacy of an implantable, restorative neurostimulator designed to restore multifidus neuromuscular control and facilitate relief of symptoms (clinicaltrials. Read More

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October 2021

Health Disparities Among Lesbian, Gay, Bisexual, Transgender, and Nonbinary Adults 50 Years Old and Older in the United States.

Authors:
Jennifer R Pharr

LGBT Health 2021 Sep 17. Epub 2021 Sep 17.

Department of Environmental and Occupational Health, School of Public Health, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.

The purpose of this study was to examine health disparities among LGBT and nonbinary adult subgroups of those 50 years old and older. This was a cross-sectional analysis of data from the 2019 Behavioral Risk Factor Surveillance System survey. Access to health care, disabilities, health risk and healthy behaviors, and general health and chronic diseases and conditions were compared between gay men, bisexual men, lesbian/gay women, bisexual women, transgender women, transgender men, and nonbinary adults 50 years old and older. Read More

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September 2021

Noninvasive ventilation at home reduces mortality in COPD with CRF.

Am J Manag Care 2021 Sep 1;27(9):e308-e315. Epub 2021 Sep 1.

PRECISIONheor, 11100 Santa Monica Blvd, Ste 500, Los Angeles, CA 90034. Email:

Objectives: Patients with chronic respiratory failure resulting from chronic obstructive pulmonary disease (COPD-CRF) have limited treatment options and poor health outcomes. We examined the effect of noninvasive ventilation at home (NIVH) treatment on all-cause mortality, hospitalizations, and emergency department (ED) visits.

Study Design: Retrospective cohort study. Read More

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September 2021

An outpatient critical care transition clinic model reduces admissions/readmissions in medically complex patients.

Am J Manag Care 2021 Sep 1;27(9):e301-e307. Epub 2021 Sep 1.

Ascension St. Vincent Hospital - Indianapolis, 2001 W 86th St, Indianapolis, IN 46260. Email:

Objectives: Reducing hospital admissions in patients with multiple complex chronic conditions is both a quality indicator and cost-effective to health care systems. This study assesses and compares utilization rates and cost of encounters between patients referred and seen in an outpatient critical care transition clinic (Healthy Transitions Clinic [HTC]) and those referred and not seen.

Study Design: Retrospective cohorts. Read More

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September 2021

Nutritional status of children with primary immunodeficiency: a single center experience.

Pediatr Int 2021 Sep 17. Epub 2021 Sep 17.

Division of Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Turkey.

Background: Nutritional status in primary immunodeficiencies (PID) is a major factor influencing immune defence. We aimed to evaluate the nutritional status in patients with PID.

Methods: Demographic findings, anthropometric measurements of 104 patients were recorded for this cross-sectional study. Read More

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September 2021

Chronic intravascular coagulation in liver cirrhosis predicts a high hemorrhagic risk.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5518-5524

Hemostasis and Thrombosis Unit, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Objective: In liver cirrhosis, a complex coagulopathy does exist. The aim was to investigate whether a possible chronic consumption coagulopathy is the underlying phenomenon of the disease.

Patients And Methods: We measured endogenous thrombin generation with and without thrombomodulin (ETP ratio) along with D-Dimer in a group of consecutive 282 cirrhotic patients. Read More

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September 2021

Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.

Aging Clin Exp Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Aging Medicine and Aging Research, University Hospital Zurich and University of Zurich, Raemistrasse 101, 8091, Zurich, Switzerland.

Background: The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults.

Aims: To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated with changes from baseline in high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels over 3 years.

Methods: This is a post-hoc observational analysis of DO-HEALTH, a double-blind, randomized controlled trial including 2157 European community-dwelling adults age 70+. Read More

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September 2021

Cortical Synaptic Reorganization Under Chronic Arsenic Exposure.

Neurotox Res 2021 Sep 17. Epub 2021 Sep 17.

Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.

There is solid epidemiological evidence that arsenic exposure leads to cognitive impairment, while experimental work supports the hypothesis that it also contributes to neurodegeneration. Energy deficit, oxidative stress, demyelination, and defective neurotransmission are demonstrated arsenic effects, but it remains unclear whether synaptic structure is also affected. Employing both a triple-transgenic Alzheimer's disease model and Wistar rats, the cortical microstructure and synapses were analyzed under chronic arsenic exposure. Read More

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September 2021

Prolyl Hydroxylase Inhibitors: a New Opportunity in Renal and Myocardial Protection.

Cardiovasc Drugs Ther 2021 Sep 17. Epub 2021 Sep 17.

Atherothrombosis Research Unit, Icahn School of Medicine At Mount Sinai, One Gustave L. Levy Pl, New York, NY, 10029-0310, USA.

Hypoxia, via the activity of hypoxia-inducible factors (HIFs), plays a crucial role in fibrosis, inflammation, and oxidative injury, processes which are associated with progression of cardiovascular and kidney diseases. HIFs are key transcription heterodimers consisting of regulatory α-subunits (HIF-1α, HIF-2α, HIF-3α) and a constitutive β-subunit (HIF-β). The stability of HIFs is regulated by the prolyl hydroxylases (PHDs). Read More

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September 2021

The safety of povidone-iodine solution in tympanoplasty: a randomised, triple-blind, placebo-controlled study.

Acta Otorhinolaryngol Ital 2021 Aug;41(4):377-382

Otolaryngology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Nowadays, povidone-iodine is commonly used as a disinfectant in head and neck procedures. The present study investigated the effect of povidone-iodine, which is used as a disinfectant solution in tympanoplasty, on patients' hearing.

Methods: A povidone-iodine solution was used as disinfection in chronic otitis media patients undergoing tympanoplasty. Read More

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[Endoplasmic reticulum stress in hepatic stellate cells induced by tunicamycin promotes apoptosis and cell cycle arrest].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Sep;37(9):794-800

Guizhou Provincial Key Laboratory of Pathogensis & Drug Research for Common Chronic Diseases, Department of Pathophysiology, College of Basic Medicine, Guizhou Medical University, Guiyang 550000, China. *Corresponding author, E-mail:

Objective To investigate the effect of endoplasmic reticulum stress (ERS) induced by tunicamycin on proliferation, activation, and apoptosis of HSC-T6 rat hepatic stellate cells and its possible mechanism. Methods With the expression level of glucose regulated protein 78 (GRP78) as an indicator to explore the optimal concentration and time, a cell model of tunicamycin-induced ERS in HSC-T6 cells was established. HSC-T6 cells were randomized into control group, treatment group with 1 mL/L of dimethyl sulfoxide (DMSO), and treatment group with 1 μg/mL of tunicamycin, and the cells were treated for 12 h. Read More

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September 2021

An anti-hair loss treatment in the management of mild androgenetic alopecia: results from a large, international observational study.

Dermatol Ther 2021 Sep 16:e15134. Epub 2021 Sep 16.

Laboratoires Vichy International, Levallois Perret, France.

Introduction: Androgenic alopecia (AGA) is a common and chronic condition. It may impact self-esteem, self-image and quality of life. Benefit, tolerability, cosmetic acceptance and patient satisfaction are key to ensuring good treatment outcome. Read More

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September 2021

Chronic opioid use is associated with obstructive and spastic disorders in the esophagus.

Neurogastroenterol Motil 2021 Sep 16:e14233. Epub 2021 Sep 16.

Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.

Background And Aims: Chronic opioid effects on the esophagus are poorly understood. We investigated whether opioids were associated with increased prevalence of esophageal motility disorders.

Methods: A retrospective study of all patients undergoing high-resolution manometry (HREM) at the Yale Gastrointestinal Motility Lab between January 2014 and August 2019. Read More

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September 2021

Exposure-Response Analysis of Acalabrutinib and its Active Metabolite, ACP-5862, in Patients With B-Cell Malignancies.

Br J Clin Pharmacol 2021 Sep 17. Epub 2021 Sep 17.

Quantitative Clinical Pharmacology, AstraZeneca, South San Francisco, USA.

Aim: Examine relationships between the systemic exposure of acalabrutinib, a highly selective, next-generation Bruton tyrosine kinase inhibitor, and its active metabolite (ACP-5862) versus efficacy and safety responses in patients with B-cell malignancies who received acalabrutinib as monotherapy or in combination with obinutuzumab.

Methods: For exposure-efficacy analyses, patients with untreated chronic lymphocytic leukemia (CLL) were assessed for best overall response, progression-free survival (PFS), and tumor regression. For exposure-safety analyses, incidences of grade ≥2 adverse events (AEs), grade ≥3 AEs, and grade ≥2 events of clinical interest were assessed in patients with B-cell malignancies. Read More

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September 2021

Cannabinoids for the treatment of dementia.

Cochrane Database Syst Rev 2021 Sep 17;9:CD012820. Epub 2021 Sep 17.

Center for Evidence-Based Medicine and Health Care, Catholic University of Croatia, Zagreb, Croatia.

Background: Dementia is a common chronic condition, mainly affecting older adults, characterised by a progressive decline in cognitive and functional abilities. Medical treatments for dementia are limited. Cannabinoids are being investigated for the treatment of dementia. Read More

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September 2021