20,181 results match your criteria choroidal optic

Intravitreal anti-VEGF use in France: a cross-sectional and longitudinal Nationwide observational study.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

EPI-PHARE (French National Agency for Medicines and Health Products Safety (ANSM) and French National Health Insurance (CNAM)), Saint-Denis, France.

Purpose: To describe the sociodemographic, medical and management characteristics of patients using intravitreal (IVT) anti-vascular endothelial growth factors (VEGF) in France.

Methods: An observational study was conducted in patients treated with IVT ranibizumab or aflibercept, aged 18 years or older using the French National Health Insurance Databases covering 99% of the French population. Patients currently treated in 2018 were included in a cross-sectional approach to describe treatment history over the previous 6 years. Read More

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Predominantly Persistent Subretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Ophthalmol Retina 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Objective: To describe predominantly persistent subretinal fluid (SRF) in eyes receiving ranibizumab or bevacizumab for neovascular age-related macular degeneration and compare visual acuity (VA) to eyes with non-persistent SRF.

Design: Cohort within randomized clinical trial PARTICIPANTS: Comparison of Age-related Macular Degeneration Treatments Trials patients assigned to pro re nata (PRN) treatment.

Methods: Reading center graders evaluated optical coherence tomography scans at baseline and monthly follow-up visits for SRF. Read More

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North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):16

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Purpose: North Carolina macular dystrophy (NCMD) is an autosomal dominant, congenital disorder affecting the central retina. Here, we report clinical and genetic findings in three families segregating NCMD and use epigenomic datasets from human tissues to gain insights into the effect of NCMD-implicated variants.

Methods: Clinical assessment and genetic testing were performed. Read More

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Multifocal Evanescent White Dot Syndrome-like Phenotypes Associated with Inflammatory and Myopic Choroidal Neovascularization.

Ocul Immunol Inflamm 2021 Jun 14:1-8. Epub 2021 Jun 14.

Uveitis Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

: To present the observation of multifocal evanescent white dot syndrome (MEWDS)-like phenotypes developing in association with the onset of choroidal neovascularization (CNV) in a series of patients.: Patients presenting to tertiary-care centers with MEWDS-like phenotypes and CNV were identified.: Five patients presented for the management of CNV in the context of previous diagnoses of punctate inner choroidopathy (PIC) and/or myopia. Read More

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The use of Ologen Collagen Matrix implants to treat ocular hypotony developing after trabeculectomy: A case series.

Eur J Ophthalmol 2021 Jun 12:11206721211023314. Epub 2021 Jun 12.

HCLOE Oftalmologia Especializada, São Paulo, São Paulo, Brazil.

Purpose: Late hypotony is an undesirable and challenging complication of glaucoma surgery. We describe our use of the Ologen Collagen Matrix to treat late hypotony developing after trabeculectomy.

Study Design: A retrospective study performed at three eye surgery centers in Brazil. Read More

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A Review of Aflibercept Treatment for Macular Disease.

Ophthalmol Ther 2021 Jun 13. Epub 2021 Jun 13.

National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.

Aflibercept is a fully human recombinant fusion protein that includes the second domain of human VEGF receptor 1 and the third domain of human VEGF receptor 2. Despite the important role played by VEGF in maintaining the physiological condition of the retina under normal conditions, dysregulation of VEGF can result in pathological alterations including hyperpermeability of the retinal capillaries and migration and proliferation of retinal endothelial cells. Over the years, a number of studies have evaluated the use of intravitreal aflibercept in different retinal diseases. Read More

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The Role of Oral Steroids in the Treatment of Photodynamic Therapy-Associated Exudative Maculopathy, a Case Report and Review of the Literature.

Photodiagnosis Photodyn Ther 2021 Jun 10:102390. Epub 2021 Jun 10.

Loma Linda University Eye Institute, Loma Linda, CA. Electronic address:

Background: Photodynamic therapy (PDT) is an effective treatment of pachychoroid spectrum disease. PDT can cause a rare complication known as PDT-associated exudative maculopathy (PAEM). Treatments including intravitreal anti-vascular endothelial growth factor (anti-VEGF) medications, local or systemic steroids, and observation have been attempted with variable success to address this complication. Read More

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Distinguishing swept-source optical coherence tomography findings in active toxoplasmic retinochoroiditis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Objective: To define the swept-source optical coherence tomography (SS-OCT) features which distinguish ocular toxoplasmosis (OT) from other forms of retinochoroiditis.

Methods: This is a prospective diagnostic study enrolling 43 eyes of 43 patients with active toxoplasmic (TOXO) retinochoroiditis matched to 54 eyes (54 lesions) with non-TOXO retinochoroiditis evaluated by structural SS-OCT.

Results: The finding of retinal hyper-reflective round deposits, sub-lesional choroidal thickening, and sub-lesional retinal pigment epithelium elevation were more likely to be found in TOXO lesions with a positive likelihood ratio of 45. Read More

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Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy.

Am J Ophthalmol 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; 2010 Retina & Macula Centre, Hong Kong.

Purpose: To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV.

Design: Prospective cross-sectional study.

Methods: Consecutive CSC patients were recruited from retina clinic. Read More

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Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration.

Medicine (Baltimore) 2021 Jun;100(23):e26239

Department of Ophthalmology, the First Affiliated Hospital of Soochow University.

Rationale: Laser induced maculopathy includes retinal photoreceptor disruption, macular hole, macular hemorrhage, and rarely choroidal neovascularization (CNV). Here we report a case of laser induced CNV that was treated by intravitreal anti-vascular endothelial growth factor (VEGF) injection and resulted in visual improvement and CNV resolution during 1-year follow up. In addition, the case of laser induced CNV treated with intravitreal anti-VEGF injections are reviewed for the first time in literature. Read More

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Pachychoroid Spectrum Disease: Underlying Pathology, Classification, and Phenotypes.

Curr Eye Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Purpose: Pachychoroid spectrum disease encompasses a set of macular disorders secondary to an abnormally thick choroid. However, the pathological process underlying pachychoroid spectrum disease and its overlap with age-related macular degeneration (AMD) remain unclear. This review aimed to understand the underlying pathology, classification, and phenotypes of pachychoroid spectrum disease. Read More

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[Optometric eye screening in schools : First epidemiological data for children and adolescents in grades 5-7].

Ophthalmologe 2021 Jun 10. Epub 2021 Jun 10.

Internationale Innovative Ophthalmochirurgie, Breyer Kaymak Klabe Augenchirurgie, Düsseldorf, Deutschland.

Background: Annually recurring optometric screening helps to identify children with increased axial growth and also to create awareness for wearing properly corrected glasses and for spending enough time outdoors, both of which are crucial for healthy eyes. The obtained biometric data help to expand the epidemiological information on myopia in schoolchildren, which is fundamental for the selection of the correct treatment.

Material And Methods: Contact-free biometry of the eye was used to assess central corneal thickness, anterior chamber depth, lens thickness and axial length. Read More

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Reduced photoreceptor outer segment layer thickness and association with vision in amblyopic children and adolescents with unilateral high myopia.

Curr Eye Res 2021 Jun 10. Epub 2021 Jun 10.

Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China,515041.

Purpose: To quantitatively compare reflectivity and other morphological changes of the photoreceptors of normal eyes with amblyopic eyes using the longitudinal reflectance profile (LRP) on swept-source optical coherence tomography (SS-OCT) images in children and adolescents with unilateral high myopia. The relationships between OCT parameters and visual acuity were investigated.

Method: Twenty-six amblyopes with unilateral high myopia and 34 age-, axial length- and spherical equivalent-matched normal controls were recruited. Read More

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Clinical and morphologic features of posterior staphyloma edges by ultra-widefield imaging in pathologic myopia.

Retina 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Faculty of Medicine, Imperial College London, London, United Kingdom Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: To investigate morphologic features along posterior staphyloma edges in eyes with pathologic myopia using ultra-widefield optical coherence tomography (UWF-OCT) imaging.

Methods: Highly myopic patients (refractive error < 8.0 diopters or axial length ≥ 26. Read More

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Elevated YKL-40 serum levels may contribute to wet age-related macular degeneration via the ERK1/2 pathway.

FEBS Open Bio 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, 400016, China.

Choroidal neovascularization (CNV) is a key characteristic of wet age-related macular degeneration (AMD) that can lead to severe vision loss in the elderly. Anti-VEGF therapy is currently the premier strategy for wet AMD, but it has limited efficacy. Previous studies have shown that chitinase-3-like-1 (YKL-40) can promote microangiogenesis and inflammation, but its effect on CNV formation has not yet been studied. Read More

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Successful Treatment of Full-Thickness Macular Hole in Polypoidal Choroidal Vasculopathy with Anti-VEGF Therapy.

J Vitreoretin Dis 2020 Oct 9;4(5):433-436. Epub 2020 Mar 9.

Emory University School of Medicine, Atlanta, GA.

Purpose: To report a case of an 86-year-old man with a full thickness macular hole (FTMH) secondary to polypoidal choroidal vasculopathy (PCV) treated with bevacizumab.

Methods: A retrospective case report is presented.

Results: An 86-year-old male presented with a five-month history of metamorphopsia and decreased vision in his right eye and was found to have active exudation secondary to PCV with a concurrent FTMH. Read More

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October 2020

[Choroidal metastasis from gastric cancer 8 years after surgery].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):541-548

Department of Surgery, Sumitomo Hospital.

A man in his 50s underwent total gastrectomy with D2 lymphadenectomy for gastric cancer 8 years ago. The pathological stage was pT3N3bM0, pStage IIIC. He took tegafur, gimeracil, and oteracil potassium (S-1) as adjuvant chemotherapy for the next 3 years at his own request. Read More

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Retinal imaging in Alzheimer's disease.

J Neurol Neurosurg Psychiatry 2021 Jun 9. Epub 2021 Jun 9.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Identifying biomarkers of Alzheimer's disease (AD) will accelerate the understanding of its pathophysiology, facilitate screening and risk stratification, and aid in developing new therapies. Developments in non-invasive retinal imaging technologies, including optical coherence tomography (OCT), OCT angiography and digital retinal photography, have provided a means to study neuronal and vascular structures in the retina in people with AD. Both qualitative and quantitative measurements from these retinal imaging technologies (eg, thinning of peripapillary retinal nerve fibre layer, inner retinal layer, and choroidal layer, reduced capillary density, abnormal vasodilatory response) have been shown to be associated with cognitive function impairment and risk of AD. Read More

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Therapy of uveal melanoma A Review.

Cesk Slov Oftalmol 2020 ;1(Ahead of print):1-13

The aim of intraocular melanoma therapy is to achieve local tumor control, reduce the risk of metastasis development, preserve the eyeball and possibly the visual function of the eye. The choice of therapeutic approach requires a comprehensive view and individual approach to each patient with uveal melanoma. Factors considered include local finding (location, tumor size and shape, tumor activity, central visual acuity, intraocular complications), age and the patients overall physical and psychological condition, as well as the patients wishes. Read More

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Long-term outcome of intravitreal anti-vascular endothelial growth factor treatment for pachychoroid neovasculopathy.

Sci Rep 2021 Jun 8;11(1):12052. Epub 2021 Jun 8.

Kim's Eye Hospital, Konyang University College of Medicine, 156, 4ga, Yeoungdeungpo-dong, Yeoungdeungpo-gu, Seoul, South Korea.

To compare the long-term effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) treatment for pachychoroid neovasculopathy (PNV), polypoidal choroidal vasculopathy/aneurysmal type 1 neovascularization (PCV/AT1), and typical neovascular age-related macular degeneration (nAMD). Forty-one eyes with PNV, 68 eyes with PCV/AT1, and 56 eyes with typical nAMD were retrospectively included for analysis. All patients were treatment-naïve and received a three-monthly loading injection of anti-VEGF, followed by further injections, as required. Read More

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Clinical and Morphologic Characteristics of ERK Inhibitor-Associated Retinopathy.

Ophthalmol Retina 2021 Jun 5. Epub 2021 Jun 5.

Ophthalmic Oncology Service; Department of Medicine.

Purpose: Investigate clinical and morphologic characteristics of serous retinal disturbances in patients taking extracellular signal-regulated kinase (ERK) inhibitors.

Participants: Of 61 patients receiving ERK inhibitors for treatment of metastatic cancer, this study included 40 eyes of 20 patients with evidence of retinopathy confirmed by optical coherence tomography (OCT).

Design: Single center, retrospective study of prospectively collected data METHODS: Clinical exam, fundus photography and OCT were used to evaluate ERK inhibitor retinopathy. Read More

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Auricular acupressure for myopia prevention and control in children and its effect on choroid and retina: a randomized controlled trial protocol.

Trials 2021 Jun 7;22(1):387. Epub 2021 Jun 7.

Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Background: Nowadays, because of the increasing incidence, the prevention and control of myopia has become an urgent issue. In China, auricular acupressure has been commonly used in the clinical treatment of myopia in children, but the exact effectiveness remains unproven. The purpose of this trial is to observe the efficacy of auricular acupressure in myopia prevention and control, as well as its effect on the choroidal and retinal thickness. Read More

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[Research advances of morphological changes of the choroid in high myopia].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):459-464

Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing 100191, China.

Choroidal thinning is an important feature of high myopia and has a negative correlation with the degree of myopia. However, due to the limitations of choroidal imaging, specific changes in choroidal thickness and vasculature are unclear. In recent years, the development of optical coherence tomography technology and optical coherence tomography angiography technology has made it possible to solve the problem. Read More

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[Minimally invasive vitrectomy for the treatment of severe proliferative diabetic retinopathy].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):440-446

Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin 300384, China.

To report the efficacy and safety of minimally invasive vitrectomy for the treatment of severe proliferative diabetic retinopathy (PDR) and the effect of preoperative retinal photocoagulation on prognosis. Case-series study and cohort study. This study included 48 severe PDR patients (53 eyes). Read More

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[Macular choroidal volume in patients with highly myopic foveoschisis and its clinical value].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):419-425

Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China.

To study the macular choroidal volume (MCV) of patients with highly myopic foveoschisis and its clinical value. In this cross-sectional study, 39 outpatients (39 eyes) with highly myopic foveoschisis were included from January 2016 to December 2020 in Peking University People's Hospital, including 18 males and 21 females. Their age was (59. Read More

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[Paying attention to the fundus complications and improving the prevention and treatment of pathological myopia].

W B Wei L Dong

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):401-405

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Laboratory, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Pathological myopia, an important blinding eye disease worldwide, has caused a heavy social burden. The patients have become younger in recent years. In general, people have limited knowledge of pathological myopia. Read More

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Etiology, Treatment Patterns, and Outcomes for Choroidal Neovascularization in the Pediatric Population: an IRIS Registry Study.

Ophthalmol Retina 2021 Jun 3. Epub 2021 Jun 3.

Retina and Vitreous of Texas, Houston, TX.

Objective: Choroidal neovascularization (CNV) is a rare, but devastating cause of vision loss in children with the majority of current publications limited to small case series. Utilizing a large clinical registry allows us to understand the most common etiologies of this disease and visual outcomes.

Design: Retrospective analysis. Read More

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Ipsilateral orbital metastasis following enucleation of intraocular ciliochoroidal melanoma: a rare occurrence.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Ocular Oncology, LV Prasad Eye Institute, Hyderabad, Telangana, India

This case report demostrates an unusual occurence of orbital metastasis along with liver metastasis 5 years following enucleation for ciliochoroidal melanoma with no extraocular extension. It exemplifies that metastasis of the tumour can occur in the ipsilateral orbit after enucleation. Importance of close clinical follow-up after enucleation for choroidal melanoma, careful socket examination, and regular systemic metastatic workup is demonstrated. Read More

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Reply to Letter to Editor: Choroidal Thickness in Pediatric Population.

J Curr Ophthalmol 2021 Jan-Mar;33(1):98-99. Epub 2021 Mar 26.

Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

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Non-Neovascular Pachychoroid Disease Mimicking Exudative Age-Related Macular Degeneration.

J Curr Ophthalmol 2021 Jan-Mar;33(1):82-87. Epub 2021 Mar 26.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Purpose: To describe a case of pachychoroid disease most compatible with central serous chorioretinopathy (CSC) presented with a large relapsing retinal pigment epithelial detachment (PED) associated with only a small amount of subretinal fluid (SRF) in the background of macular drusen in an elderly patient mimicking neovascular age-related macular degeneration (AMD).

Methods: This was a review of 32 months of the clinical course and findings on multimodal imaging including fundus photography, optical coherence tomography, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and optical coherence tomography angiography (OCTA).

Results: A large relapsing PED sometimes with small amount of SRF at its apex was found in the background of macular drusen in the right eye of a 63-year-old Thai woman. Read More

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