3,219 results match your criteria choroidal lesions

North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):16

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Purpose: North Carolina macular dystrophy (NCMD) is an autosomal dominant, congenital disorder affecting the central retina. Here, we report clinical and genetic findings in three families segregating NCMD and use epigenomic datasets from human tissues to gain insights into the effect of NCMD-implicated variants.

Methods: Clinical assessment and genetic testing were performed. Read More

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Distinguishing swept-source optical coherence tomography findings in active toxoplasmic retinochoroiditis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Objective: To define the swept-source optical coherence tomography (SS-OCT) features which distinguish ocular toxoplasmosis (OT) from other forms of retinochoroiditis.

Methods: This is a prospective diagnostic study enrolling 43 eyes of 43 patients with active toxoplasmic (TOXO) retinochoroiditis matched to 54 eyes (54 lesions) with non-TOXO retinochoroiditis evaluated by structural SS-OCT.

Results: The finding of retinal hyper-reflective round deposits, sub-lesional choroidal thickening, and sub-lesional retinal pigment epithelium elevation were more likely to be found in TOXO lesions with a positive likelihood ratio of 45. Read More

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Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy.

Am J Ophthalmol 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; 2010 Retina & Macula Centre, Hong Kong.

Purpose: To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV.

Design: Prospective cross-sectional study.

Methods: Consecutive CSC patients were recruited from retina clinic. Read More

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Pachychoroid Spectrum Disease: Underlying Pathology, Classification, and Phenotypes.

Curr Eye Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Purpose: Pachychoroid spectrum disease encompasses a set of macular disorders secondary to an abnormally thick choroid. However, the pathological process underlying pachychoroid spectrum disease and its overlap with age-related macular degeneration (AMD) remain unclear. This review aimed to understand the underlying pathology, classification, and phenotypes of pachychoroid spectrum disease. Read More

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[Choroidal metastasis from gastric cancer 8 years after surgery].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):541-548

Department of Surgery, Sumitomo Hospital.

A man in his 50s underwent total gastrectomy with D2 lymphadenectomy for gastric cancer 8 years ago. The pathological stage was pT3N3bM0, pStage IIIC. He took tegafur, gimeracil, and oteracil potassium (S-1) as adjuvant chemotherapy for the next 3 years at his own request. Read More

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Automated Quantification of Choriocapillaris Lesion Area in Patients with Posterior Uveitis.

Am J Ophthalmol 2021 Jun 6. Epub 2021 Jun 6.

Department of Ophthalmology, University of Washington, Seattle, WA. Electronic address:

Purpose: To validate a custom algorithm for automated identification and quantification of clinically relevant inflammatory choriocapillaris (CC) lesions from en face swept source optical coherence tomography (SS-OCTA) images.

Design: observational case series METHODS: : Twenty eyes of 14 patients with posterior uveitis were imaged using the PLEX® Elite 9000. The machine-generated en face OCTA CC slabs were exported to MATLAB where a custom algorithm performed unsupervised lesion boundary delineation and area quantification. Read More

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Microsurgical Clip Trapping of Dorsal Internal Carotid Artery Blister Ruptured Aneurysm: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun 7. Epub 2021 Jun 7.

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Dorsal internal carotid artery (ICA) blister aneurysms are an uncommon aneurysm variant constituting 0.3% to 1% of intracranial aneurysms and can be due to ulceration, atherosclerosis, or dissection.1-3 Despite its rarity, it carries a high risk of rupture with an estimation of 0. Read More

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Erdheim-Chester Disease: a comprehensive review from the ophthalmologic perspective.

Surv Ophthalmol 2021 May 31. Epub 2021 May 31.

National and Kapodistrian University of Athens, 1st University Eye Clinic, G.Genimatas General Hospital, Athens, Greece. Electronic address:

Erdheim-Chester disease (ECD) is a rare clonal histiocytic neoplasm with less than 1200 documented cases to date. The disease is life-threatening and difficult to recognize, although increasing awareness as well as the integration of clinical, imaging, pathology information and genetic studies have led to a recent exponential increase in new reported cases.. Read More

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Classification of Non-Infectious and/or Immune Mediated Choroiditis: A Brief Overview of the Essentials.

Diagnostics (Basel) 2021 May 24;11(6). Epub 2021 May 24.

Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi Teaching Centre, 1003 Lausanne, Switzerland.

The choroid was poorly accessible to imaging investigation until the last decade of the last century. With the availability of more precise imaging methods such as indocyanine green angiography (ICGA) and, later, optical coherence tomography (OCT), enhanced depth OCT (EDI-OCT), and OCT angiography (OCTA), appraisal of choroidal inflammation has substantially gained in accuracy. This allowed to precisely determine which structures were touched in the different non-infectious choroiditis entities and made it possible to classify this group of diseases, ICGA signs, mainly hypofluorescent lesions, were identified and described. Read More

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The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.

J Cell Mol Med 2021 May 31. Epub 2021 May 31.

Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, China.

Neovascular age-related macular degeneration (AMD), which is characterized by choroidal neovascularization (CNV), leads to vision loss. M2 macrophages produce vascular endothelial growth factor (VEGF), which aggravates CNV formation. The histone acetyltransferase p300 enhances the stability of spliced X-box binding protein 1 (XBP1s) and promotes the transcriptional activity of the XBP1s target gene homocysteine inducible endoplasmic reticulum protein with ubiquitin-like domain 1 (Herpud1). Read More

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Clinical and Multimodal Imaging Features of Subretinal Drusenoid Deposits.

J Ophthalmic Vis Res 2021 Apr-Jun;16(2):187-194. Epub 2021 Apr 29.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To describe the multimodal imaging (MMI) features of subretinal drusenoid deposits (SDD) in Indian population.

Methods: Patients diagnosed to have SDD from January 2016 to December 2018 at our tertiary care center were recruited. The diagnosis of SDD was made on the basis of MMI consisting of a combination of color fundus photography (CFP), optical coherence tomography (OCT), red-free (RF) imaging, blue autofluorescence (BAF), and near-infra red reflectance (NIR) imaging. Read More

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Polypoidal Choroidal Vasculopathy after Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: A Case Report with Long-Term Follow-Up.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):299-305. Epub 2021 Apr 30.

Medical Retina Department, Vista Klinik Binningen, Binningen, Switzerland.

Several adjunct therapies to the gold standard anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections have been discussed for the treatment of neovascular age-related macular degeneration (nAMD). Low-dose stereotactic radiotherapy (SRT) showed the potential to lower the treatment burden by reducing the anti-VEGF treatment frequency at least over 2-3 years but was associated with retinal microvascular abnormalities in a few cases. We report a 6-year follow-up of a case with bilateral nAMD under anti-VEGF treatment which developed multiple polypoid choroidal vasculopathy (PCV) lesions in the eye adjunct treated with low-dose SRT. Read More

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Association Between the Degree of Inclusion of Components Identified on Fluorescein or Indocyanine Green Angiography in Target Spots and Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration After Photodynamic Therapy.

Clin Ophthalmol 2021 18;15:2063-2075. Epub 2021 May 18.

Sakura Medical Center, Toho University, Chiba, Japan.

Purpose: To investigate the association between the inclusion of components identified on images in target spots of photodynamic therapy (PDT) and exudate relapse in eyes with age-related macular degeneration (AMD).

Methods: Forty-one eyes (39 patients) with polypoidal choroidal vasculopathy (PCV) and 32 eyes (31 patients) with typical AMD (tAMD) who underwent PDT were retrospectively investigated. Each component identified on fluorescein (FA) or indocyanine angiography (IA), optical coherence tomography (OCT), or color photography was graded as not depicted, covered with a margin ≥500 µm or <500 µm, and protruding. Read More

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Subfoveal retinal pigment epithelium inflammatory lesion presenting as a sign of reactivation of tubercular multifocal choroiditis.

BMJ Case Rep 2021 May 24;14(5). Epub 2021 May 24.

Smt Kannuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India

Multifocal choroiditis (MFC) can be associated with ocular tuberculosis (TB). Inflammatory peripapillary choroidal neovascular membrane (PPCNVM) is uncommon in TB MFC. Subretinal pigment epithelial inflammatory lesions are suggestive of acute inflammation or reactivation of inflammation in the setting of MFC. Read More

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Nivolumab-Induced Harada-like Uveitis with Bacillary Detachment Mimicking Choroidal Metastasis.

Retin Cases Brief Rep 2021 May 14. Epub 2021 May 14.

West Coast Retina Medical Group, San Francisco, California, USA The Department of Ophthalmology, California Pacific Medical Center, San Francisco, California, USA.

Purpose: To describe a patient with metastatic clear cell renal cell carcinoma in remission on maintenance nivolumab therapy who developed late-onset ocular toxicity manifesting as creamy chorioretinal lesions with exudative retinal detachment concerning for choroidal metastasis.

Method: Case report. Main outcome measures include ophthalmoscopic examination, fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography, and B-scan ultrasonography. Read More

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Optical Coherence Tomography Angiography-Based Quantitative Assessment of Morphologic Changes in Active Myopic Choroidal Neovascularization During Anti-vascular Endothelial Growth Factor Therapy.

Front Med (Lausanne) 2021 7;8:657772. Epub 2021 May 7.

Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

To establish quantitative profile of the morphologic changes among patients with active myopic choroidal neovascularization (mCNV) before and after anti-vascular endothelial growth factor (VEGF) therapy using optical coherence tomography angiography (OCTA) to assess the therapeutic response. Patients with active mCNV who received anti-VEGF injections between February 2017 to October 2020 and fit the study criteria were retrospectively reviewed. Quantitative analysis of their OCTA images were carried out to evaluate the morphologic features and vascular changes of mCNV lesions in response to anti-VEGF therapy. Read More

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Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using Optical Coherence Tomography B-scan.

Ophthalmol Retina 2021 May 19. Epub 2021 May 19.

University of Hawaii John A. Burns School of Medicine, 651 Ilalo St., Honolulu, HI 96813; Hawaii Macula and Retina Institute, 98-1079 Moanalua Road, Suite 470, Aiea, HI 96701; Retina Consultants of Hawaii, 98-1079 Moanalua Road, Suite 470, Aiea, HI 96701; The Retina Center at Pali Momi, 98-1079 Moanalua Road, Suite 470, Aiea, HI 96701.

Purpose: Although polypoidal choroidal vasculopathy (PCV) is best diagnosed with indocyanine green angiography (ICGA), ICGA is often unavailable or not ordered. Optical coherence tomography (OCT) is widely available, and OCT B-scan can visualize polypoidal lesions diagnostic of PCV as inverted U-shaped elevations of the retinal pigment epithelium (RPE) with heterogeneous reflectivity and sometimes ring-shaped lesions within the polypoidal lesion. This study aims to differentiate findings between eyes diagnosed with PCV or typical exudative age-related macular degeneration (AMD) using ICGA, then comparing findings noted on the OCT B-scan line scan in each group. Read More

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Bilateral idiopathic choroidal hyperpigmentation.

Eur J Ophthalmol 2021 May 20:11206721211019573. Epub 2021 May 20.

Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA.

Purpose: To report a series of cases showing bilateral circumpapillary hyperpigmentation on routine fundus examination.

Methods: In this observational case series, three patients showing bilateral circumpapillary hyperpigmentation on routine fundus examination were included. Multimodal retinal imaging was done for these cases. Read More

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Torpedo-like lesions in the ocular fundi of Gardner syndrome: hiding in plain view.

Ophthalmic Genet 2021 May 20:1-7. Epub 2021 May 20.

Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA.

The coexistence of fundus torpedoes and Gardner syndrome was initially reported in 1989 and 1992 by Gass and Roseman. Gardner syndrome is a dominantly inherited disease characterized by a multitude of potentially lethal gastrointestinal polyps. Over the ensuing quarter century, several publications demonstrated uncommon, but easily recognized, fundus lesions called Torpedo Maculopathy in apparently normal individuals. Read More

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Clinical characterization and the improved molecular diagnosis of autosomal dominant cone-rod dystrophy in patients with SCA7.

Mol Vis 2021 7;27:221-232. Epub 2021 May 7.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Purpose: To evaluate the retinal phenotype and genetic features of Chinese patients with spinocerebellar ataxia type 7 (SCA7).

Methods: Detailed ophthalmic examinations, including electroretinograms, fundus photography, fundus autofluorescence and optical coherence tomography, were performed to analyse the retinal lesions of patients with SCA7. A molecular genetic analysis was completed to confirm the number of CAG repeats in gene on the patients and their family members. Read More

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Comparison of Polypoidal Choroidal Vasculopathy Lesion Sizes Measured on Multicolor Imaging and Indocyanine Green Angiography.

Transl Vis Sci Technol 2021 Feb;10(2):35

National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.

Purpose: To evaluate the areas of lesion components of polypoidal choroidal vasculopathy (PCV) measured using multicolor imaging compared to indocyanine green angiography (ICGA).

Methods: In a prospective study of 50 consecutive treatment-naïve PCV patients, multicolor imaging and ICGA were performed. The images were independently graded by reading center-certified retinal specialists to confirm the diagnosis of PCV and identify lesion components. Read More

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February 2021

Massive advancing non-exudative type 1 choroidal neovascularization in CTRP5 Late Onset Retinal Degeneration: longitudinal findings on multimodal imaging and implications for age-related macular degeneration.

Retina 2021 May 3. Epub 2021 May 3.

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA Center for Ocular Regenerative Therapy, UC Davis Eye Center, University of California Davis, Sacramento, CA, USA.

Purpose: To describe longitudinal multimodal imaging findings of non-exudative choroidal neovascularization (CNV) in CTRP5 late-onset retinal degeneration (CTRP5-LORD).

Methods: Four patients with CTRP5-positive LORD underwent repeated ophthalmoscopic examination and multimodal imaging. All four patients (two siblings and their cousins, from a pedigree described previously) had the heterozygous S163R mutation. Read More

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Cesk Slov Oftalmol 2021 ;77(2):94-100

Uveal melanoma is the most common intraocular tumour in adults, it is a form of cancer that affects mostly older adults, as the average age at detection of this tumour is 60 years, but it can occur in any age group with no significant gender difference. However, uveal melanoma is very rare in children compared to the adult population, accounting for 1 % of all cases. In pediatric patients, malignant uveal melanoma is more frequently manifested during puberty, leading to speculation of an association between uveal melanoma and growth hormone levels. Read More

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Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation.

Invest Ophthalmol Vis Sci 2021 May;62(6):14

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To investigate the characteristics of treatment-naïve nonexudative macular neovascularization (MNV) in age-related macular degeneration before the onset of exudation using swept-source optical coherence tomography angiography.

Methods: MNV area, choriocapillaris (CC) flow deficits (FDs), vessel area density (VAD), vessel skeleton density (VSD), retinal pigment epithelial detachment (PED) volume, mean choroidal thickness (MCT), and choroid vascularity index (CVI) measurements were assessed at two visits prior to exudation. We compared measurements made at the second visit and the rate of change between visits in eyes with and without exudation. Read More

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Intravitreal injection of anti-miRs against miR-142-3p reduces angiogenesis and microglia activation in a mouse model of laser-induced choroidal neovascularization.

Aging (Albany NY) 2021 05 5;13(9):12359-12377. Epub 2021 May 5.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Age-related macular degeneration (AMD) is a worldwide leading cause of blindness affecting individuals over 50 years old. The most aggressive form, wet AMD, is characterized by choroidal neovascularization (CNV) and inflammation involving microglia recruitment. By using a laser-induced CNV mouse model, we provide evidence for a key role played by miR-142-3p during CNV formation. Read More

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One year outcomes of treat and extend and pro re nata (PRN) treatment regimens with aflibercept for polypoidal choroidal vasculopathy.

Eur J Ophthalmol 2021 May 5:11206721211014717. Epub 2021 May 5.

Department of Ophthalmology, University of Athens Medical School, 'Attikon' General Hospital Athens, Haidari, Athens, Greece.

Purpose: To compare the 1-year outcomes of treat-and-extend and pro re nata (PRN) treatment regimens with aflibercept for polypoidal choroidal vasculopathy (PCV), by the means of visual acuity (VA), frequency of recurrence of polypoidal lesions and developed fibrosis, and the number of intravitreal injections, and thus to determine which one is preferable in the maintenance phase in PCV.

Methods: In our prospective study, only naive and previously untreated PCV patients were included. Initially one session of photodynamic therapy (PDT) and three monthly intravitreal injections of 2. Read More

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Disseminated coccidioidomycosis in a patient with juvenile idiopathic arthritis receiving infliximab.

Pediatr Rheumatol Online J 2021 May 1;19(1):63. Epub 2021 May 1.

Presbyterian Healthcare Services, New Mexico, Albuquerque, USA.

Background: Coccidioides immitis is a dimorphic fungus endemic to the arid climates of the Southwest United States, Mexico and parts of Central and South America. Human infection occurs through inhalation of spores with less than half of exposures progressing to a symptomatic state that primarily consists of pulmonary manifestations. Disseminated coccidioidomycosis is exceedingly rare, occurring in fewer than 1 % of symptomatic infections. Read More

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Anterior ischemic optic neuropathy and cilioretinal artery occlusion secondary to polyarteritis nodosa: A case report.

Photodiagnosis Photodyn Ther 2021 Apr 27;34:102299. Epub 2021 Apr 27.

Erciyes University Faculty of Medicine, Department of Ophthalmology, Kayseri, Turkey.

Introduction: Polyarteritis nodosa is a systemic vasculitis characterized by necrotizing inflammatory lesions affecting the middle and small arteries.

Case Presentation: A 23-year-old male presented to our ophthalmology clinic with a 1-day history of sudden vision loss in his left eye. Posterior segment examination the left eye showed optic disc borders were faint, hyperemic and fluffy with cilioretinal artery occlusion signs present. Read More

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Assessment of a New Nanostructured Microemulsion System for Ocular Delivery of Sorafenib to Posterior Segment of the Eye.

Int J Mol Sci 2021 Apr 22;22(9). Epub 2021 Apr 22.

Research, Preclinical Development and Patents, SIFI S.p.A., Lavinaio-Aci S. Antonio, 95025 Catania, Italy.

Eye drop formulations allowing topical treatment of retinal pathologies have long been sought as alternatives to intravitreal administration. This study aimed to assess whether a novel nanostructured microemulsions system (NaMESys) could be usefully employed to deliver sorafenib to the retina following topical instillation. NaMESys carrying 0. Read More

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Adjuvant Intravitreal Bevacizumab Injection for Choroidal and Orbital Metastases of Refractory Invasive Ductal Carcinoma of the Breast.

Medicina (Kaunas) 2021 Apr 22;57(5). Epub 2021 Apr 22.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.

The efficacy of combined intravitreal bevacizumab injection with systemic chemotherapy, palliative radiotherapy, and hormonal therapy to treat choroidal and orbital metastases is not known. Herein, we report the case of a 48-year-old woman with systemic chemotherapy-resistant choroidal and orbital metastases of the left eye originating from a stage IV invasive ductal carcinoma of the left breast. We describe the addition of a single intravitreal injection of bevacizumab in addition to treatment with systemic chemotherapy, hormonal therapy, and palliative radiotherapy. Read More

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