26,658 results match your criteria choroidal


Distinguishing swept-source optical coherence tomography findings in active toxoplasmic retinochoroiditis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Objective: To define the swept-source optical coherence tomography (SS-OCT) features which distinguish ocular toxoplasmosis (OT) from other forms of retinochoroiditis.

Methods: This is a prospective diagnostic study enrolling 43 eyes of 43 patients with active toxoplasmic (TOXO) retinochoroiditis matched to 54 eyes (54 lesions) with non-TOXO retinochoroiditis evaluated by structural SS-OCT.

Results: The finding of retinal hyper-reflective round deposits, sub-lesional choroidal thickening, and sub-lesional retinal pigment epithelium elevation were more likely to be found in TOXO lesions with a positive likelihood ratio of 45. Read More

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Expression of purinergic receptors on microglia in the animal model of choroidal neovascularisation.

Sci Rep 2021 Jun 11;11(1):12389. Epub 2021 Jun 11.

Department of Ophthalmology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province, 430060, People's Republic of China.

To investigate the effect of P2 receptor on microglia and its inhibitor PPADS on choroidal neovascularization. Forty CX3CR1 mice were randomly divided into 8 groups. In addition to the normal group, the rest of groups were receiving laser treatment. Read More

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Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy.

Am J Ophthalmol 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; 2010 Retina & Macula Centre, Hong Kong.

Purpose: To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV.

Design: Prospective cross-sectional study.

Methods: Consecutive CSC patients were recruited from retina clinic. Read More

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Hypotony-associated Complications after Deep Sclerectomy: Incidence, Risk Factors, and Long-Term Outcomes.

J Glaucoma 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy Department of Ophthalmology, Calderdale and Huddersfield NHS Trust, Huddersfield, UK.

Precis: Chronic hypotony is not uncommon following deep sclerectomy, but only a minor proportion of patients develop hypotony-associated complications. Numerical hypotony does not affect the visual outcomes. This study identifies factors associated with hypotony. Read More

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Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration.

Medicine (Baltimore) 2021 Jun;100(23):e26239

Department of Ophthalmology, the First Affiliated Hospital of Soochow University.

Rationale: Laser induced maculopathy includes retinal photoreceptor disruption, macular hole, macular hemorrhage, and rarely choroidal neovascularization (CNV). Here we report a case of laser induced CNV that was treated by intravitreal anti-vascular endothelial growth factor (VEGF) injection and resulted in visual improvement and CNV resolution during 1-year follow up. In addition, the case of laser induced CNV treated with intravitreal anti-VEGF injections are reviewed for the first time in literature. Read More

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Pachychoroid Spectrum Disease: Underlying Pathology, Classification, and Phenotypes.

Curr Eye Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Purpose: Pachychoroid spectrum disease encompasses a set of macular disorders secondary to an abnormally thick choroid. However, the pathological process underlying pachychoroid spectrum disease and its overlap with age-related macular degeneration (AMD) remain unclear. This review aimed to understand the underlying pathology, classification, and phenotypes of pachychoroid spectrum disease. Read More

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[Optometric eye screening in schools : First epidemiological data for children and adolescents in grades 5-7].

Ophthalmologe 2021 Jun 10. Epub 2021 Jun 10.

Internationale Innovative Ophthalmochirurgie, Breyer Kaymak Klabe Augenchirurgie, Düsseldorf, Deutschland.

Background: Annually recurring optometric screening helps to identify children with increased axial growth and also to create awareness for wearing properly corrected glasses and for spending enough time outdoors, both of which are crucial for healthy eyes. The obtained biometric data help to expand the epidemiological information on myopia in schoolchildren, which is fundamental for the selection of the correct treatment.

Material And Methods: Contact-free biometry of the eye was used to assess central corneal thickness, anterior chamber depth, lens thickness and axial length. Read More

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Reduced photoreceptor outer segment layer thickness and association with vision in amblyopic children and adolescents with unilateral high myopia.

Curr Eye Res 2021 Jun 10. Epub 2021 Jun 10.

Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China,515041.

Purpose: To quantitatively compare reflectivity and other morphological changes of the photoreceptors of normal eyes with amblyopic eyes using the longitudinal reflectance profile (LRP) on swept-source optical coherence tomography (SS-OCT) images in children and adolescents with unilateral high myopia. The relationships between OCT parameters and visual acuity were investigated.

Method: Twenty-six amblyopes with unilateral high myopia and 34 age-, axial length- and spherical equivalent-matched normal controls were recruited. Read More

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Clinical and morphologic features of posterior staphyloma edges by ultra-widefield imaging in pathologic myopia.

Retina 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Faculty of Medicine, Imperial College London, London, United Kingdom Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: To investigate morphologic features along posterior staphyloma edges in eyes with pathologic myopia using ultra-widefield optical coherence tomography (UWF-OCT) imaging.

Methods: Highly myopic patients (refractive error < 8.0 diopters or axial length ≥ 26. Read More

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A Baseline Score to Predict Response to Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration.

Transl Vis Sci Technol 2021 May;10(6):11

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Clinical Pharmacology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Purpose: What are the patient characteristics predictive of response to ranibizumab treatment?

Methods: Model-based characterization of best-corrected visual acuity (BCVA) time profiles of patients with neovascular age-related macular degeneration under ranibizumab or sham treatment based on 24-month observations of BCVA in 2419 patients from randomized multicenter phase 3 trials of ranibizumab: ANCHOR, MARINA, PIER, and HARBOR. Goodness-of-fit plots and precision of parameter estimates were used for measure of accuracy.

Results: The model incorporates a long-term effect on disease progression and an additive and more potent short-term effect of ranibizumab. Read More

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Subthreshold laser therapy with a standardized macular treatment pattern in chronic central serous chorioretinopathy.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, Ludwig-Maximilians-University Munich, Mathildenstrasse 8, 80336, Munich, Germany.

Purpose: There is an ongoing controversial debate about the effectiveness of laser treatments in chronic central serous chorioretinopathy (cCSC). We performed a prospective non-randomized interventional study to learn about the effects of a subthreshold laser treatment (Topcon Endpoint Management™, Topcon Healthcare Inc., Tokyo, Japan) in patients with cCSC. Read More

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Sensitivity and specificity of optical coherence tomography angiography in the diagnosis of active choroidal neovascularization: a systematic review and meta-analysis.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Macular Disease Research Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Purpose: This meta-analysis was performed to evaluate the diagnostic value of optical coherence tomography angiography (OCTA) for active choroidal neovascularization (CNV) of all types and etiologies.

Methods: We searched the Web of Science, PubMed, Cochrane Library, Medline, and Embase databases for all interrelated published studies from inception to August 2020. Meta-disc and STATA were used for the data analyses. Read More

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Retinal Microvascular and Choroidal Changes in Parkinson Disease-Reply.

JAMA Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.

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Retinal Microvascular and Choroidal Changes in Parkinson Disease.

JAMA Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurology, Seoul Metropolitan Government-Seoul National University Hospital Boramae Medical Center and Seoul National University College of Medicine, Seoul, South Korea.

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Elevated YKL-40 serum levels may contribute to wet age-related macular degeneration via the ERK1/2 pathway.

FEBS Open Bio 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, 400016, China.

Choroidal neovascularization (CNV) is a key characteristic of wet age-related macular degeneration (AMD) that can lead to severe vision loss in the elderly. Anti-VEGF therapy is currently the premier strategy for wet AMD, but it has limited efficacy. Previous studies have shown that chitinase-3-like-1 (YKL-40) can promote microangiogenesis and inflammation, but its effect on CNV formation has not yet been studied. Read More

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Successful Treatment of Full-Thickness Macular Hole in Polypoidal Choroidal Vasculopathy with Anti-VEGF Therapy.

J Vitreoretin Dis 2020 Oct 9;4(5):433-436. Epub 2020 Mar 9.

Emory University School of Medicine, Atlanta, GA.

Purpose: To report a case of an 86-year-old man with a full thickness macular hole (FTMH) secondary to polypoidal choroidal vasculopathy (PCV) treated with bevacizumab.

Methods: A retrospective case report is presented.

Results: An 86-year-old male presented with a five-month history of metamorphopsia and decreased vision in his right eye and was found to have active exudation secondary to PCV with a concurrent FTMH. Read More

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October 2020

[Choroidal metastasis from gastric cancer 8 years after surgery].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):541-548

Department of Surgery, Sumitomo Hospital.

A man in his 50s underwent total gastrectomy with D2 lymphadenectomy for gastric cancer 8 years ago. The pathological stage was pT3N3bM0, pStage IIIC. He took tegafur, gimeracil, and oteracil potassium (S-1) as adjuvant chemotherapy for the next 3 years at his own request. Read More

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Retinal imaging in Alzheimer's disease.

J Neurol Neurosurg Psychiatry 2021 Jun 9. Epub 2021 Jun 9.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Identifying biomarkers of Alzheimer's disease (AD) will accelerate the understanding of its pathophysiology, facilitate screening and risk stratification, and aid in developing new therapies. Developments in non-invasive retinal imaging technologies, including optical coherence tomography (OCT), OCT angiography and digital retinal photography, have provided a means to study neuronal and vascular structures in the retina in people with AD. Both qualitative and quantitative measurements from these retinal imaging technologies (eg, thinning of peripapillary retinal nerve fibre layer, inner retinal layer, and choroidal layer, reduced capillary density, abnormal vasodilatory response) have been shown to be associated with cognitive function impairment and risk of AD. Read More

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Therapy of uveal melanoma A Review.

Cesk Slov Oftalmol 2020 ;1(Ahead of print):1-13

The aim of intraocular melanoma therapy is to achieve local tumor control, reduce the risk of metastasis development, preserve the eyeball and possibly the visual function of the eye. The choice of therapeutic approach requires a comprehensive view and individual approach to each patient with uveal melanoma. Factors considered include local finding (location, tumor size and shape, tumor activity, central visual acuity, intraocular complications), age and the patients overall physical and psychological condition, as well as the patients wishes. Read More

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Vitreoretinal Complications in Boston Keratoprosthesis Type 1.

Am J Ophthalmol 2021 Jun 6. Epub 2021 Jun 6.

Department of Ophthalmology, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Purpose: To evaluate the incidence of vitreoretinal complications, treatment modalities, and the visual outcomes in a large cohort of eyes that underwent Boston Keratoprosthesis (KPro) implantation.

Design: Retrospective, interventional case series.

Methods: 132 eyes of 114 patients who underwent KPro implantation at the Centre Hospitalier de l'Université de Montréal from 2008 to 2017 were included with at least 1 year follow-up. Read More

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Automated Quantification of Choriocapillaris Lesion Area in Patients with Posterior Uveitis.

Am J Ophthalmol 2021 Jun 6. Epub 2021 Jun 6.

Department of Ophthalmology, University of Washington, Seattle, WA. Electronic address:

Purpose: To validate a custom algorithm for automated identification and quantification of clinically relevant inflammatory choriocapillaris (CC) lesions from en face swept source optical coherence tomography (SS-OCTA) images.

Design: observational case series METHODS: : Twenty eyes of 14 patients with posterior uveitis were imaged using the PLEX® Elite 9000. The machine-generated en face OCTA CC slabs were exported to MATLAB where a custom algorithm performed unsupervised lesion boundary delineation and area quantification. Read More

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Long-term outcome of intravitreal anti-vascular endothelial growth factor treatment for pachychoroid neovasculopathy.

Sci Rep 2021 Jun 8;11(1):12052. Epub 2021 Jun 8.

Kim's Eye Hospital, Konyang University College of Medicine, 156, 4ga, Yeoungdeungpo-dong, Yeoungdeungpo-gu, Seoul, South Korea.

To compare the long-term effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) treatment for pachychoroid neovasculopathy (PNV), polypoidal choroidal vasculopathy/aneurysmal type 1 neovascularization (PCV/AT1), and typical neovascular age-related macular degeneration (nAMD). Forty-one eyes with PNV, 68 eyes with PCV/AT1, and 56 eyes with typical nAMD were retrospectively included for analysis. All patients were treatment-naïve and received a three-monthly loading injection of anti-VEGF, followed by further injections, as required. Read More

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Clinical and Morphologic Characteristics of ERK Inhibitor-Associated Retinopathy.

Ophthalmol Retina 2021 Jun 5. Epub 2021 Jun 5.

Ophthalmic Oncology Service; Department of Medicine.

Purpose: Investigate clinical and morphologic characteristics of serous retinal disturbances in patients taking extracellular signal-regulated kinase (ERK) inhibitors.

Participants: Of 61 patients receiving ERK inhibitors for treatment of metastatic cancer, this study included 40 eyes of 20 patients with evidence of retinopathy confirmed by optical coherence tomography (OCT).

Design: Single center, retrospective study of prospectively collected data METHODS: Clinical exam, fundus photography and OCT were used to evaluate ERK inhibitor retinopathy. Read More

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Auricular acupressure for myopia prevention and control in children and its effect on choroid and retina: a randomized controlled trial protocol.

Trials 2021 Jun 7;22(1):387. Epub 2021 Jun 7.

Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Background: Nowadays, because of the increasing incidence, the prevention and control of myopia has become an urgent issue. In China, auricular acupressure has been commonly used in the clinical treatment of myopia in children, but the exact effectiveness remains unproven. The purpose of this trial is to observe the efficacy of auricular acupressure in myopia prevention and control, as well as its effect on the choroidal and retinal thickness. Read More

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[Research advances of morphological changes of the choroid in high myopia].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):459-464

Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing 100191, China.

Choroidal thinning is an important feature of high myopia and has a negative correlation with the degree of myopia. However, due to the limitations of choroidal imaging, specific changes in choroidal thickness and vasculature are unclear. In recent years, the development of optical coherence tomography technology and optical coherence tomography angiography technology has made it possible to solve the problem. Read More

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[Minimally invasive vitrectomy for the treatment of severe proliferative diabetic retinopathy].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):440-446

Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Tianjin 300384, China.

To report the efficacy and safety of minimally invasive vitrectomy for the treatment of severe proliferative diabetic retinopathy (PDR) and the effect of preoperative retinal photocoagulation on prognosis. Case-series study and cohort study. This study included 48 severe PDR patients (53 eyes). Read More

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[Macular choroidal volume in patients with highly myopic foveoschisis and its clinical value].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):419-425

Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China.

To study the macular choroidal volume (MCV) of patients with highly myopic foveoschisis and its clinical value. In this cross-sectional study, 39 outpatients (39 eyes) with highly myopic foveoschisis were included from January 2016 to December 2020 in Peking University People's Hospital, including 18 males and 21 females. Their age was (59. Read More

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[Paying attention to the fundus complications and improving the prevention and treatment of pathological myopia].

Authors:
W B Wei L Dong

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):401-405

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Laboratory, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Pathological myopia, an important blinding eye disease worldwide, has caused a heavy social burden. The patients have become younger in recent years. In general, people have limited knowledge of pathological myopia. Read More

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Treatment of a Giant Thrombotic M1 Segment Middle Cerebral Artery Aneurysm With Radial Artery Bypass and Distal Occlusion to Create a "Blind Sac" Following Endovascular Failure: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun 7. Epub 2021 Jun 7.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA.

The case is of a 36-yr-old male with a previously coiled aneurysm arising from the proximal M1 segment of the middle cerebral artery (MCA) just beyond the internal carotid artery (ICA) bifurcation who presented to our institution with subjective left hemiparesis, headache, and vomiting. Physical exam revealed a left facial droop, but neurological exam was otherwise normal, including full motor strength. Neuroimaging showed a large partially thrombosed aneurysm recurrence, measuring 5. Read More

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Microsurgical Clip Trapping of Dorsal Internal Carotid Artery Blister Ruptured Aneurysm: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun 7. Epub 2021 Jun 7.

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Dorsal internal carotid artery (ICA) blister aneurysms are an uncommon aneurysm variant constituting 0.3% to 1% of intracranial aneurysms and can be due to ulceration, atherosclerosis, or dissection.1-3 Despite its rarity, it carries a high risk of rupture with an estimation of 0. Read More

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