4,139 results match your criteria choline acetyl


A Pilot Study on the Cutoff Value of Related Brain Metabolite in Chinese Elderly Patients With Mild Cognitive Impairment Using MRS.

Front Aging Neurosci 2021 9;13:617611. Epub 2021 Apr 9.

Department of Rehabilitation, Bao'an Hospital, Southern Medical University, Shenzhen, China.

This cross-sectional study aimed to distinguish patients with mild cognitive impairment (MCI) from patients with normal controls (NCs) by measuring the levels of -acetyl aspartate (NAA), total creatinine (tCr), and choline (Cho) in their hippocampus (HIP) and their posterior cingulate gyrus (PCG) by using proton magnetic resonance spectroscopy (MRS) and to predict the cutoff value on the ratios of metabolites. We further aimed to provide a reference for the diagnosis of MCI in elderly patients in China. About 69 patients who underwent a clinical diagnosis of the MCI group and 67 patients with NCs, the Mini-Mental Status Examination (MMSE) score, the Montreal Cognitive Assessment (MoCA) score, and MRS of the bilateral HIP and bilateral PCG were considered. Read More

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Design and optimizing a new CDP-choline in-vitro multi-enzyme producing process starts from D-ribose.

Biotechnol Appl Biochem 2021 Apr 22. Epub 2021 Apr 22.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, No. 30, Puzhu South Road, Nanjing, 211816, China.

Objective: This work designs an in vitro multi-enzyme system to produce CDP-choline form D-ribose, and develop an optimization procedure for one-pot multi-enzyme catalytic system.

Results: The entire process integrated ten enzymes, and an efficient acetate kinase/acetyl phosphate-based ATP regeneration module was applied. Then some optimizations to this system were made including selecting optimum enzyme building blocks and improving expression parameters. Read More

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Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats.

Drug Chem Toxicol 2021 Apr 20:1-9. Epub 2021 Apr 20.

Department of Physiology, Faculty of Medicine, Ege University, Izmir, Turkey.

Aim: Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an increase in inflammation has recently been suggested. Since in previous animal experiments dexpanthenol has anti-inflammatory and neuroprotective activities, effects and role of dexpanthenol in an intracerebroventricular (ICV)-streptozotocin (STZ) induced sporadic-AD(memory impairment) animal model have been examined. Read More

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Chitin Deacetylation Using Deep Eutectic Solvents: -Supported Process Optimization.

ACS Sustain Chem Eng 2021 Mar 5;9(10):3874-3886. Epub 2021 Mar 5.

Department of Catalysis and Chemical Reaction Engineering, National Institute of Chemistry, Hajdrihova ulica 19, 1000 Ljubljana, Slovenia.

Chitin is the most abundant marine biopolymer, being recovered during the shell biorefining of crustacean shell waste. In its native form, chitin displays a poor reactivity and solubility in most solvents due to its extensive hydrogen bonding. This can be overcome by deacetylation. Read More

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Magnetic Resonance Spectroscopy in Depressed Subjects Treated With Electroconvulsive Therapy-A Systematic Review of Literature.

Front Psychiatry 2021 25;12:608857. Epub 2021 Mar 25.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Electroconvulsive therapy (ECT) is considered to be the most effective acute treatment for otherwise treatment resistant major depressive episodes, and has been used for over 80 years. Still, the underlying mechanism of action is largely unknow. Several studies suggest that ECT affects the cerebral neurotransmitters, such as gamma-aminobutyric acid (GABA) and glutamate. Read More

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The ménage à trois of autophagy, lipid droplets and liver disease.

Autophagy 2021 Apr 2:1-24. Epub 2021 Apr 2.

Department of Cell Biology, University of Groningen, University Medical Center Groningen, AV Groningen, The Netherlands.

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential building blocks that are indispensable for liver functions. Energy deficiencies are compensated by breaking down lipid droplets (LDs), intracellular organelles that store neutral lipids, in part by a selective type of autophagy, referred to as lipophagy. The process of lipophagy does not appear to be properly regulated in fatty liver diseases (FLDs), an important risk factor for the development of hepatocellular carcinomas (HCC). Read More

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Clinical value of N-acetyl mucinous compounds and lipid peaks in differentiating benign and malignant ovarian mucinous tumors by MR spectroscopy.

Clin Imaging 2021 Mar 22;78:127-135. Epub 2021 Mar 22.

Department of Radiology, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima zip: 7708503, Japan. Electronic address:

Purpose: To retrospectively evaluate the clinical significance of the peaks of N-acetyl mucinous compounds (NAMC) at 2 ppm and lipid at 1.3 ppm in in-vivo proton magnetic resonance (MR) spectroscopy for distinguishing benign and malignant mucinous tumors in patients with ovarian masses.

Methods: MR spectroscopy was performed in patients with pathologically diagnosed mucinous ovarian tumors at 3 T MRI system. Read More

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Interaction of Serum Copper and Neurometabolites on Executive Dysfunction in Unmedicated Patients With Major Depressive Disorder.

Front Psychiatry 2021 3;12:564375. Epub 2021 Mar 3.

Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China.

The mechanism of executive function (EF) impairment in major depressive disorder (MDD) remains unclear. Previous studies have demonstrated that altered serum copper levels and neurometabolic alterations may be associated with the psychopathology and cognitive impairment of MDD. While, their inter-relationships in MDD remain uncertain. Read More

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Management of thymomatous myasthenia gravis - Case report of a rare Covid19 infection sequelae.

Int J Surg Case Rep 2021 Apr 13;81:105771. Epub 2021 Mar 13.

Grant Medical College and Sir JJ Group of Hospitals, Byculla, Mumbai, 400008, India.

Introduction: SARS CoV19 infection can predispose to many autoimmune and neurological conditions, thymomatous myasthenia gravis being one of them. The rarity of these case poses therapeutic dilemmas about their further management.

Presentation Of Case: A 61 year old gentleman who had covid19 infection 2 months back, presented with new onset myasthenia gravis and an anterior mediastinal mass. Read More

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Carvedilol improves heart rate variability indices, biomarkers but not cardiac nerve density in streptozotocin-induced T2DM model of diabetic cardiac autonomic neuropathy.

J Basic Clin Physiol Pharmacol 2021 Mar 18. Epub 2021 Mar 18.

Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.

Objectives: There has been increasing recognition of the significant relationship between the autonomic nervous system and cardiovascular sequel in diabetes mellitus (DM) patients. Diabetic cardiac autonomic neuropathy (DCAN) still poses a treatment challenge in the clinical settings despite several research interventions. This study was designed to investigate the effect of carvedilol on experimentally induced DCAN in type 2 DM rat model. Read More

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Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary.

Front Endocrinol (Lausanne) 2021 25;12:636600. Epub 2021 Feb 25.

Centre for Neurobiochemical Studies in Neuroendocrine Diseases, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Independencia, Chile.

The functioning of the ovary is influenced by the autonomic system (sympathetic and cholinergic intraovarian system) which contributes to the regulation of steroid secretion, follicular development, and ovulation. There is no information on the primary signal that activates both systems. The nerve growth factor (NGF) was the first neurotrophic factor found to regulate ovarian noradrenergic neurons and the cholinergic neurons in the central nervous system. Read More

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February 2021

Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise.

J Diabetes Res 2021 23;2021:5123241. Epub 2021 Feb 23.

MIMS Research Foundation, Mankavu P.O., Calicut, Kerala 673007, India.

Insulin resistance is a state of impaired responsiveness to insulin action. This condition not only results in deficient glucose uptake but increases the risk for cardiovascular diseases (CVD), stroke, and obesity. The present work investigates the molecular mechanisms of high carbohydrate and fat diet in inducing prediabetic hyperinsulinemia and effect of exercise on InsR signaling events, muscular AChE, and lactate dehydrogenase activity. Read More

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February 2021

[Role of 1, 25-dihydroxyvitamin D3 in liver lipid metabolism induced by methionine-choline-deficient diet in rats].

Zhonghua Gan Zang Bing Za Zhi 2021 Feb;29(2):163-168

Department of Gastroenterology, Affiliated Hospital of Hebei University of Technology, Handan 056004, China.

To investigate the role of 1, 25-dihydroxyvitamin D3 [1.25(OH) (2)D(3)] in liver lipid metabolism so as to provide the clues for elucidating the mechanism of non-alcoholic fatty liver. 26 SD rats were randomly divided into control group (methionine-choline-sufficient diet, MCS), model group (methionine-choline-deficiency diet, MCD) and intervention group [MCD+1. Read More

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February 2021

Accuracy of magnetic resonance spectroscopy in discrimination of neoplastic and non-neoplastic brain lesions.

Curr Med Imaging 2021 Feb 23. Epub 2021 Feb 23.

Diagnostic Radiology Department, College of Medical Applied Sciences, King Khalid University, Abha. Saudi Arabia.

Background: Differentiation of brain lesions by conventional MRI alone is not enough. The introduction of sophisticated imaging methods, such as MR spectroscopy (MRS), will have considered contribution and accuracy to the differentiation.

Objective: To determine the diagnostic accuracy of MRS in differentiating neoplasm and non-neoplastic brain lesion. Read More

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February 2021

Myasthenia gravis masquerading as acute stroke: a case report.

Pan Afr Med J 2020 2;37:305. Epub 2020 Dec 2.

Department of Neurology, Sree Narayana Institute of Medical Sciences (SNIMS), Kunnukara, India.

Among non-iatrogenic neuromuscular disorders, myasthenia gravis remains the most prevalent. Diagnosing this disorder may become challenging in certain cases such as in patients with coexisting comorbid illnesses and non-specific clinical symptoms. This is a case of atypical myasthenia gravis in a middle-aged hypertensive male, who initially presented symptoms suggestive of an acute ischemic stroke. Read More

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Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.

Lab Invest 2021 Mar 1. Epub 2021 Mar 1.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, PR China.

The key pathophysiological process leading to heart failure is cardiac remodeling, a term referring to cardiac hypertrophy, fibrosis, and apoptosis. We explored circadian rhythm disruption and calcium dyshomeostasis in cardiac remodeling and investigated the cardioprotective effect of choline. The experiments were conducted using a model of cardiac remodeling by abdominal aorta coarctation (AAC) in Sprague-Dawley rats. Read More

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Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase 3 and is a Therapeutic Target.

Gastroenterology 2021 Feb 27. Epub 2021 Feb 27.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. Electronic address:

Backgrounds & Aims: Squalene epoxidase (SQLE) is the rate-limiting enzyme for cholesterol biosynthesis. We elucidated the functional significance, molecular mechanisms, and clinical impact of SQLE in nonalcoholic steatohepatitis (NASH).

Methods: We performed studies with hepatocyte-specific Sqle overexpression transgenic (Sqle tg) mice and mice given high-fat high-cholesterol (HFHC) or methionine- and choline-deficient (MCD) diet to induce NASH. Read More

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February 2021

Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro-in vivo extrapolation.

Arch Toxicol 2021 04 19;95(4):1433-1442. Epub 2021 Feb 19.

Institute of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin Institute of Health, Berlin, Germany.

Amiodarone is an antiarrhythmic agent inducing adverse effects on the nervous system, among others. We applied physiologically based pharmacokinetic (PBPK) modeling combined with benchmark dose modeling to predict, based on published in vitro data, the in vivo dose of amiodarone which may lead to adverse neurological effects in patients. We performed in vitro-in vivo extrapolation (IVIVE) from concentrations measured in the cell lysate of a rat brain 3D cell model using a validated human PBPK model. Read More

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Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection.

Anal Chem 2021 03 12;93(8):3976-3986. Epub 2021 Feb 12.

Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth WA6150, Australia.

We have applied nuclear magnetic resonance spectroscopy based plasma phenotyping to reveal diagnostic molecular signatures of SARS-CoV-2 infection combined diffusional and relaxation editing (DIRE). We compared plasma from healthy age-matched controls ( = 26) with SARS-CoV-2 negative non-hospitalized respiratory patients and hospitalized respiratory patients ( = 23 and 11 respectively) with SARS-CoV-2 rRT-PCR positive respiratory patients ( = 17, with longitudinal sampling time-points). DIRE data were modelled using principal component analysis and orthogonal projections to latent structures discriminant analysis (O-PLS-DA), with statistical cross-validation indices indicating excellent model generalization for the classification of SARS-CoV-2 positivity for all comparator groups (area under the receiver operator characteristic curve = 1). Read More

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[Effects of Moringa flavone on cognitive function and neuropathological indexes in diabetic encephalopathy rats].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Dec;32(12):1491-1495

Department of Anatomy, Cangzhou Medical College, Cangzhou 061000, Hebei, China. Corresponding author: Sui Yuelin, Email:

Objective: To investigate the effect of Moringa flavone on cognitive impairment and neuropathological indexes in diabetic encephalopathy (DE) rats.

Methods: Sixty male Sprague-Dawley (SD) rats were divided into control group, model group, positive drug group, Moringa low-dose and high-dose groups according to the random number table method, with 10 rats in each group. Diabetic rat model was established by intraperitoneal injection of 25 mg/kg streptozotocin (STZ) after continuous feeding of high fat and high sugar diet for one week. Read More

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December 2020

The Role of Lipids in -Host Interaction.

Int J Mol Sci 2021 Feb 2;22(3). Epub 2021 Feb 2.

Department of Genetics and Microbiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka St. 19, 20-033 Lublin, Poland.

are Gram-stain-negative rods associated with water environments: either natural or man-made systems. The inhalation of aerosols containing bacteria leads to the development of a severe pneumonia termed Legionnaires' disease. To establish an infection, these bacteria adapt to growth in the hostile environment of the host through the unusual structures of macromolecules that build the cell surface. Read More

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February 2021

Naringin Exhibits Mas Receptor-Mediated Neuroprotection Against Amyloid Beta-Induced Cognitive Deficits and Mitochondrial Toxicity in Rat Brain.

Neurotox Res 2021 Feb 3. Epub 2021 Feb 3.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, 281 406, Mathura, India.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with clinical manifestation of loss in cognitive functions in an individual. Though several drug candidates have been developed in the management of AD, an alternative option is still required due to serious adverse effects of the former. Recently, naringin exerts therapeutic benefits through rennin angiotensin system in experimental animals. Read More

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February 2021

Polycythemia Vera and Essential Thrombocythemia Patients Exhibit Unique Serum Metabolic Profiles Compared to Healthy Individuals and Secondary Thrombocytosis Patients.

Cancers (Basel) 2021 Jan 27;13(3). Epub 2021 Jan 27.

Drug Discovery Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.

Most common myeloproliferative neoplasms (MPNs) include polycythemia vera (PV) and essential thrombocythemia (ET). Accurate diagnosis of these disorders remains a clinical challenge due to the lack of specific clinical or molecular features in some patients enabling their discrimination. Metabolomics has been shown to be a powerful tool for the discrimination between different hematological diseases through the analysis of patients' serum metabolic profiles. Read More

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January 2021

Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model.

Front Mol Neurosci 2020 11;13:617229. Epub 2021 Jan 11.

QPS Austria GmbH, Grambach, Austria.

Huntington's disease (HD) is caused by an expansion of CAG triplets in the huntingtin gene, leading to severe neuropathological changes that result in a devasting and lethal phenotype. Neurodegeneration in HD begins in the striatum and spreads to other brain regions such as cortex and hippocampus, causing motor and cognitive dysfunctions. To understand the signaling pathways involved in HD, animal models that mimic the human pathology are used. Read More

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January 2021

Proton MR spectroscopic features of the cisternal segment of the trigeminal nerve in patients with trigeminal neuralgia: A pilot study.

Clin Imaging 2021 Jun 14;74:93-99. Epub 2021 Jan 14.

University of Health Sciences, Department of Pediatrics, Ankara, Turkey.

Purpose: To investigate normal quantitative proton magnetic resonance spectroscopy (MRS) features of the cisternal segment of the trigeminal nerve and evaluate possible metabolite concentration differences in the affected and unaffected nerves of trigeminal neuralgia patients.

Material And Methods: A total of 33 consecutive patients who underwent a MR study of the internal auditory canal/posterior fossa and dedicated trigeminal nerve multivoxel MRS were enrolled. Measurements of N-acetyl aspartate (NAA), creatine (Cr), choline (Cho), myoinositol (mI), glutamate-glutamine (Glx) concentrations, and ratios of NAA-to-Cr, Cho-to-Cr, and Cho-to-NAA were automatically calculated by the dedicated software. Read More

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Association of gut-related metabolites with outcome in acute heart failure.

Am Heart J 2021 04 14;234:71-80. Epub 2021 Jan 14.

Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Leicester, United Kingdom. Electronic address:

Background: Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes. However, TMAO is the final product of a complex metabolic pathway (ie, choline/carnitine) that has never been entirely investigated in HF. The present study investigates a panel of metabolites involved in the TMAO-choline/carnitine metabolic pathway for their associations with outcome in acute HF patients. Read More

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GABA quantification in human anterior cingulate cortex.

PLoS One 2021 15;16(1):e0240641. Epub 2021 Jan 15.

Philips, Stockholm, Sweden.

γ-Aminobutyric acid (GABA) is a primary inhibitory neurotransmitter in the human brain. It has been shown that altered GABA concentration plays an important role in a variety of psychiatric and neurological disorders. The main purpose of this study was to propose a combination of PRESS and MEGA-PRESS acquisitions for absolute GABA quantification and to compare GABA estimations obtained using total choline (tCho), total creatine (tCr), and total N-acetyl aspartate (tNAA) as the internal concentration references with water referenced quantification. Read More

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Brain Temperature Measured by Magnetic Resonance Spectroscopy to Predict Clinical Outcome in Patients with Infarction.

Sensors (Basel) 2021 Jan 12;21(2). Epub 2021 Jan 12.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, 2-1 Seiryomachi, Sendai, Miyagi 980-8575, Japan.

Acute ischemic stroke is characterized by dynamic changes in metabolism and hemodynamics, which can affect brain temperature. We used proton magnetic resonance (MR) spectroscopy under everyday clinical settings to measure brain temperature in seven patients with internal carotid artery occlusion to explore the relationship between lesion temperature and clinical course. Regions of interest were selected in the infarct area and the corresponding contralateral region. Read More

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January 2021

Integrated Strategy Drives Direct Infusion-Tandem Mass Spectrometry as an Eligible Tool for Shotgun Pseudo-Targeted Metabolomics of Medicinal Plants.

Anal Chem 2021 02 13;93(4):2541-2550. Epub 2021 Jan 13.

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, East Road of North 3rd Ring, Chaoyang District, Beijing 100029, China.

Direct infusion (DI) has an extraordinary high-throughput advantage. Pseudo-targeted metabolomics (PTM) has been demonstrated integrating the merits of both nontargeted and targeted metabolomics. Herein, we attempted to implant DI into the PTM concept to configure a new strategy allowing shotgun PTM. Read More

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February 2021

Differential Protein Expression in Exponential and Stationary Growth Phases of subsp. 104.

Molecules 2021 Jan 8;26(2). Epub 2021 Jan 8.

Department of Bacteriology, Niigata University Graduate School of Medicine, Niigata 951-8510, Japan.

complex (MAC) is the most common non-tuberculous mycobacterium (NTM) and causes different types of pulmonary diseases. While genomic and transcriptomic analysis of 104 ( 104) has been extensive, little is known about the proteomics of 104. We utilized proteomics technology to analyze the changes in the whole proteome of 104 during exponential and stationary growth phases. Read More

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January 2021