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Switch from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in People Living with HIV: Lipid Changes and Statin Underutilization.

Clin Drug Investig 2021 Sep 21. Epub 2021 Sep 21.

Epividian, Inc., 4819 Emperor Blvd., Suite 400, Durham, NC, 27703, USA.

Background And Objective: Many people living with HIV (PLWH) on stable tenofovir disoproxil fumarate (TDF)-containing regimens have switched to tenofovir alafenamide (TAF), despite the potential lipid-lowering effect of TDF. We aimed to assess the impact of switching from TDF to TAF on lipids in real-world clinical practice.

Methods: PLWH prescribed TDF for ≥ 4 weeks who switched to TAF were identified in the OPERA cohort. Read More

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September 2021

Role of 99mTc sulphur colloid lymphoscintigraphy in a rare case of chylothorax and lymphocele formation post esophageal duplication cyst excision.

Eur J Hybrid Imaging 2021 Sep 21;5(1):17. Epub 2021 Sep 21.

Department of Pediatric Surgery, AII India Institute of Medical Sciences, Jodhpur, Jodhpur, Rajasthan, 342005, India.

We report a rare case of chylothorax with lymphocele formation post esophageal duplication cyst (EDC) excision in a 2 year old male child. Patient developed chylothorax after excision of EDC. Pleural fluid cytology showed increased triglycerides and cholesterol levels. Read More

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September 2021

Association between dietary inflammatory index and cardiometabolic risk factors among Brazilian adolescents: results from a national cross-sectional study.

Br J Nutr 2021 Sep 21:1-24. Epub 2021 Sep 21.

Graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Dietary factors play a role in modulating chronic inflammation and in the development of cardiovascular disease. We aimed to investigate the association between the dietary inflammatory index (DII) and cardiometabolic risk factors among adolescents.A total of 31,684 Brazilian adolescents (12-17 years), from the Study of Cardiovascular Risks in Adolescents (ERICA) were included. Read More

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September 2021

The effect of triglycerides to high-density lipoprotein cholesterol ratio on the reduction of renal function: findings from China health and retirement longitudinal study (CHARLS).

Lipids Health Dis 2021 Sep 20;20(1):110. Epub 2021 Sep 20.

Department of Nephrology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032, Shanghai, China.

Background: Previous studies show that abnormal lipoprotein metabolism can increase the prevalence of chronic kidney disease (CKD). This study prospectively investigated the association of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio and renal dysfunction in the Chinese population.

Methods: This longitudinal cohort research examined 7,316 participants (age range: 22-93) from the China Health and Retirement Longitudinal Study (CHARLS), including 6,560 individuals with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1. Read More

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September 2021

Validation of multiple equations for estimating low-density lipoprotein cholesterol levels in Korean adults.

Lipids Health Dis 2021 Sep 20;20(1):111. Epub 2021 Sep 20.

Department of Laboratory Medicine, Green Cross Laboratories, 107, Ihyeonro 30 beon-gil, Giheng-gu, Yongin-Si, Gyeonggi-do, Republic of Korea.

Background: Limited data are available for validation of low-density lipoprotein cholesterol (LDL) calculation (LDL) in the adult Korean population. The aim of this study was to develop and validate a new equation for LDL and to compare it with previous such equations in a Korean population.

Methods: A new equation for LDL was developed (LDL). Read More

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September 2021

Effects of the Methyl Donors Supplementation on Hippocampal Oxidative Stress, Depression and Anxiety in chronically High Fructose-Treated Rats.

Neuroscience 2021 Sep 17. Epub 2021 Sep 17.

Laboratory of Genetics, Neuro-endocrinology and Biotechnology, Department of Life Sciences, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.

Evidence suggests that oxidative stress plays an important role in the development of anxiety and depression. The aim of the present study was to investigate whether Methyl Donors Supplementation could exert beneficial effects on hippocampal oxidative stress, anxiety and depression in chronically high fructose-treated rats, a new animal model of anxiety and mood disorders. Rats were divided into two groups and treated for 10 weeks as follows: Group 1 represents the control group and Group 2 was treated with 23 % fructose. Read More

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September 2021

The effect of the content of ApoA-I in peripheral blood on the state of immune homeostasis in people living in extreme climatic conditions of the Arctic.

Klin Lab Diagn 2021 Sep;66(9):539-545

Federal State Budgetary Institution of Science N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences.

The paper presents data on the impacts of the content of ApoA-I in peripheral blood on the state of immune homeostasis in people living in extreme climatic conditions of the Arctic. From the village of Revda, Murmansk region, 191 people were examined, 160 women and 31 men, aged from 21 to 55 years. The analysis of the results was carried out depending on the level of ApoA-I content: 111 examined people had a low content of ApoA-I (< 115 mg/dl) and 80 people had a concentration of ApoA-I - within the physiological norm (115-220 mg/dl). Read More

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September 2021

Effects of aerobic exercise and resistance exercise on physical indexes and cardiovascular risk factors in obese and overweight school-age children: A systematic review and meta-analysis.

PLoS One 2021 20;16(9):e0257150. Epub 2021 Sep 20.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

Background: Obesity is a serious social and public health problem in the world, especially in children and adolescents. For school-age children with obesity, this stage is in the transition from childhood to adolescence, and both physical, psychological, and external environments will be full of challenges. Studies have showed that school-age children are the largest proportion of people who continue to be obese in adulthood. Read More

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September 2021

A Cross-Sectional Study of the Effects of Physical Activity and Nutrient Intakes on Blood Glucose Control Rates in Middle-Aged and Elderly Diabetes Patients: Korean National Health and Nutrition Examination Survey 2015-2017.

Inquiry 2021 Jan-Dec;58:469580211035727

A&P Lab, Inc., Research Institute of Consilience, Seoul, Republic of Korea.

This study aimed to investigate factors affecting blood glucose control among middle-aged and older diabetic patients taking medications or receiving insulin therapy. In 2015-2017 data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES), 1257 patients with diabetes were divided into a controlled group and an uncontrolled group based on blood glucose levels (cutoff ≥126 mg/dL). After adjusting for confounding factors, the BMI, total cholesterol level, and triglycerides level of the uncontrolled group were significantly higher than the controlled group. Read More

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September 2021

Lipid Metabolism Was Associated With Oocyte Maturation in Women With Polycystic Ovarian Syndrome Undergoing Unstimulated Natural Cycle.

Front Cell Dev Biol 2021 3;9:719173. Epub 2021 Sep 3.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Objective: Hyperlipidemia are common polycystic ovarian syndrome (PCOS)-related metabolic dysfunctions and can adversely affect assisted reproductive technology (ART) outcomes in controlled ovarian hyperstimulation (COH) cycles. The objective of this study is to analyze the relationship between lipid metabolism and ART outcomes in unstimulated natural cycles without the utilization of ovarian induction drugs, which is still uncertain.

Methods: This retrospective study included infertile women with PCOS between 21 and 40 years old undergoing unstimulated natural cycles from January 01, 2006 to December 31, 2019. Read More

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September 2021

Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis.

Int J Ophthalmol 2021 18;14(9):1430-1440. Epub 2021 Sep 18.

Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.

Aim: To explore the correlation between cystatin C (Cys-C) and diabetic retinopathy (DR) in those patients with type 2 diabetes mellitus (DM) in China.

Methods: Articles were collected from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, EMBASE, Cochrane Library, Clinical Trials.gov, and Google Scholar. Read More

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September 2021

Adipokines and C-reactive protein as indicators of MetS presence in obese Greek children: The Healthy Growth Study.

Toxicol Rep 2021 30;8:1645-1650. Epub 2021 Aug 30.

Department of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Victoria, 3086, Australia.

Background: Metabolic syndrome (MetS) occurs in a proportion of overweight and obese children and increases their future risk of serious health complications, even in adolescence and young adulthood. We aimed to explore the role of certain adipokines and inflammatory markers in identifying children with MetS.

Methods: This study is a secondary analysis of data coming from the Healthy Growth Study, a cross-sectional study conducted with schoolchildren in Greece. Read More

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Bariatric Metabolic Surgery Reduced Liver Enzyme Levels in Patients with Non-Alcohol Fatty Liver Disease.

Kans J Med 2021 1;14:209-214. Epub 2021 Sep 1.

University of Kansas School of Medicine-Wichita, Wichita, KS.

Introduction: Approximately 93.3 million Americans are obese (BMI > 30 kg/m) and 51% have non-alcoholic fatty liver disease (NAFLD). Progression of NAFLD can lead to non-alcoholic steatohepatitis (NASH), which is the leading cause of liver transplant in the United States. Read More

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September 2021

The Association Between Risk Factors for Metabolic Syndrome and Meibomian Gland Disease in a Dry Eye Cohort.

Clin Ophthalmol 2021 11;15:3821-3832. Epub 2021 Sep 11.

Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Purpose: Risk factors for metabolic syndrome include abdominal obesity, insulin resistance, hypertension, high triglycerides and/or low high-density lipoprotein cholesterol, and hyperglycemia. Risk factors for metabolic syndrome have been associated with dry eye disease; however, their association with meibomian gland disease (MGD), a subtype of dry eye, is unclear. In the present study, we investigated risk factors for metabolic syndrome in a dry eye cohort with and without MGD. Read More

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September 2021

Effect of Microalgae Arthrospira on Biomarkers of Glycemic Control and Glucose Metabolism: A Systematic Review and Meta-analysis.

Curr Probl Cardiol 2021 Jul 24:100942. Epub 2021 Jul 24.

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Diabetes mellitus and insulin resistance are associated with an increased risk of cardiovascular disease (CVD) incidence and a higher rate of CVD-related death. In this study, the effects of Arthrospira (Spirulina) a blue-green algae supplementation on biomarkers of glycemic control and glucose metabolism has been evaluated. PubMed, Scopus, and ISI Web of Science were searched systematically of English human subjects and PubMed for pre-clinical animal studies (rats and mice) from January 2008 until November 2020. Read More

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[Assessment of relationship of lipid and carbon profile indicators with vitamin D supply in children depending on body mass index].

Vopr Pitan 2021 22;90(4):112-121. Epub 2021 Jul 22.

Ryazan State Medical University named after academician I.P. Pavlov of the Ministry of Healthcare of the Russian Federation, 390026, Ryazan, Russian Federation.

Overweight children represent a particularly vulnerable group for hypovitaminosis D. Clinical studies on the relationship between vitamin D (VD) deficiency and metabolic risk factors for cardiovascular disorders are controversial, and for children of primary school age who have overweight and obesity are insufficient. of the research was to study the relationship between lipid and carbohydrate metabolism indicators and VD status in children, depending on the body mass index. Read More

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Contact activated kallikrein generation is reduced six months after gastric bypass.

Thromb Res 2021 Sep 14;207:50-54. Epub 2021 Sep 14.

Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark.

Background: Prothrombotic and inflammatory variables decrease after obesity surgery. The contact activation system may be a common denominator of these changes.

Objective: To characterize the contact system before and 6 months after Roux-en-Y gastric bypass (RYGB) and to evaluate associations with changes (post-surgery minus pre-surgery) in metabolic variables. Read More

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September 2021

Myrianthus arboreus P. Beauv improves insulin sensitivity in high fat diet-induced obese mice by reducing inflammatory pathways activation.

J Ethnopharmacol 2021 Sep 16:114651. Epub 2021 Sep 16.

CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012, Granada, Spain.

Ethnopharmacological Relevance: Metabolic syndrome is currently recognized as the major cause of morbidity, with dramatic complications on life expectancy and health status. Myrianthus arboreus is a medicinal plant traditionally used in local communities as a safe remedy in treating diabetes and other metabolic diseases.

Aim Of The Study: This study aimed to investigate the impact of a methanol extract of Myrianthus arboreus leaf (MAL) in a mice model of metabolic syndrome induced by a high-fat diet (HFD) intake. Read More

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September 2021

Comparison of metabolic risk factors, physical performances, and prevalence of low back pain among categories determined by visceral adipose tissue and trunk skeletal muscle mass in middle-aged men.

Exp Gerontol 2021 Sep 16:111554. Epub 2021 Sep 16.

Research Center of Health, Physical Fitness and Sports, Nagoya University, Furo-cho, Chikusa, Nagoya, Aichi 464-8601, Japan.

The present study compared metabolic risk factors, physical performances, and musculoskeletal impairment among categories determined by visceral adipose tissue (VAT) and trunk skeletal muscle (SM) mass in middle-aged Japanese men. In total, 1026 healthy Japanese males aged between 35 and 59 years were categorized into 4 groups according to the amount of VAT and SM in the trunk measured using low-dose computed tomography (LowVAT-HighSM, LowVAT-LowSM, HighVAT-HighSM, and HighVAT-LowSM). Height, body mass waist circumference, body fat, intramuscular adipose tissue (IntraMAT), subcutaneous adipose tissue, biochemical blood profiles (triglycerides, high-density lipoprotein cholesterol, fasting blood glucose, aspartate transaminase, alanine transaminase and γ-glutamyl trans peptidase), physical performances (trunk flexibility, the chair-stand test, two-step length and hand-grip strength), the prevalence of low back pain, and lifestyle habits for exercise, alcohol intake and smoking, were compared among the groups. Read More

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September 2021

Cardiometabolic outcomes in children and adolescents with West syndrome.

BMC Pediatr 2021 Sep 18;21(1):412. Epub 2021 Sep 18.

Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel.

Background: West syndrome is a convulsive disorder of infancy with unique seizures and a characteristic background electroencephalograph pattern. Adrenocorticotropic hormone (ACTH) is effective in spasm cessation, yet metabolic consequences of this therapeutic agent in childhood have not been published.

Methods: In this observational study we explored the cardiometabolic outcomes of 117 children with West syndrome (78 ACTH-treated and 39 non-ACTH-treated) monitored at a single medical center from 1995 to 2019 (median follow-up 7. Read More

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September 2021

A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.

Crit Care 2021 09 17;25(1):341. Epub 2021 Sep 17.

Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Objective: Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We sought to characterize lipoprotein predictive ability for poor outcomes and contribution to sepsis heterogeneity.

Design: Prospective cohort study with independent replication cohort. Read More

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September 2021

Mendelian randomization rules out the causal relationship between serum lipids and cholecystitis.

BMC Med Genomics 2021 Sep 17;14(1):224. Epub 2021 Sep 17.

Secondary Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130021, China.

Background: The relationship between serum lipids and cholecystitis is still under investigation. To examine the causal effect of serum lipids on cholecystitis using the Mendelian randomization method.

Methods: We conducted univariable Mendelian randomization (MR) analyses using summary statistics from two independent genome-wide association studies (GWAS) on serum lipids (n = 132,908) and cholecystitis (n = 361,194). Read More

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September 2021

Triclosan elicited biochemical and transcriptomic alterations in Labeo rohita larvae.

Environ Toxicol Pharmacol 2021 Sep 14;88:103748. Epub 2021 Sep 14.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.

In the current study, Triclosan (TCS, a commonly used antimicrobial agent) induced alterations in biochemical parameters and gene expression were recorded in the larvae of Labeo rohita after 96 h exposure and 10 days recovery period to find out health status biomarkers. 96 h exposure to 0.06, 0. Read More

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September 2021

Case study of hypertriglyceridemia from COVID-19 Pfizer-BioNTech vaccination in a patient with familial hypercholesteremia.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5525-5528

Saint Bernards Healthcare, Jonesboro, AR, USA.

The Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine is the first novel nucleoside-modified messenger ribonucleic acid (modRNA) vaccine to receive Emergency Use Authorization from the Food and Drug Administration in the United States. It is indicated to be used in patients ≥12 years-of-age as of May 25th, 2021, including populations with high atherosclerotic cardiovascular disease (ASCVD) burden. However, little is known about the potential impact this vaccine may have on serum lipoprotein levels in patients with familial hypercholesteremia (FH), who are predisposed to high ASCVD burden due to elevated low-density lipoprotein cholesterol (LDL-C). Read More

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September 2021

Muscle strength and its association with cardiometabolic variables in adolescents: does the expression of muscle strength values matter?

World J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Research Center in Kinanthropometry and Human Performance, Federal University of Santa Catarina, Trinity University Campus, Florianópolis, SC, CEP 88010-970, Brazil.

Background: We investigate the association between different muscle strength (MS) indices with cardiometabolic variables in adolescents.

Methods: Cross-sectional study comprising 351 adolescents (male 44.4%, age 16. Read More

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September 2021

Evaluation of the Obesity Prevention, Blood Glucose, and Blood Lipid Control of Vietnamese Rice Varieties in High-Fat Diet-Induced Obese Mice.

Int J Food Sci 2021 7;2021:4880603. Epub 2021 Sep 7.

Ho Chi Minh City University of Technology and Education, Ho Chi Minh City, Vietnam.

Five Vietnamese rice varieties, which differ in their basic chemical composition (starch content, amylose content, fiber content) including polished rices and whole grain rices, were chosen for this study. High-fat diet-induced obesity, using these rice, was subjected to in vivo experiments to evaluate the effects of body weight gain, caloric intake, postprandial blood glucose level (PBGL), and glycemic index (GI) in tested mice groups. PBGL peaks appeared at 30 minute after eating, and GI of each experimental group was ranked in order as GN > TL > HR > GM > LĐ and GN > LT > HR > LĐ > GM, respectively, in which, brown rice (LĐ) and germinated brown rice (GM) had low GI. Read More

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September 2021

Exploring the prophylactic role of soy isoflavones against polycystic ovarian syndrome.

Food Sci Nutr 2021 Sep 9;9(9):4738-4744. Epub 2021 Jul 9.

Department of Food Science Faculty of Life Sciences Government College University Faisalabad Pakistan.

Soy isoflavones (SI) have strong estrogenic effect in tissues by binding to estrogen receptors and might be beneficial for women with polycystic ovarian syndrome (PCOS) by reduction in testosterone, cholesterol, insulin, weight gain, inflammatory markers, and oxidative stress. The study was planned to examine the effect of various levels of SI on nutrient intake, digestibility, lipid profile, insulin, and reproductive hormones of estradiol valerate (4 mg/rat/IM) PCOS induced rat models. Thirty-six Wistar 45 days old rats weighing 95 ± 5 g were divided into 4 groups, each having 9 rats: C (control: without SF), SF10 (SF 0. Read More

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September 2021

Non-traditional Lipid Parameters as Potential Predictors of Asymptomatic Intracranial Arterial Stenosis.

Front Neurol 2021 31;12:679415. Epub 2021 Aug 31.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Intracranial arterial stenosis (ICAS) is a common cause of stroke. Identifying effective predictors of ICAS that could be easily obtained in clinical practice is important. The predictive values of serum individual lipid parameters have been well-established. Read More

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Black rice anthocyanins alleviate hyperlipidemia, liver steatosis and insulin resistance by regulating lipid metabolism and gut microbiota in obese mice.

Food Funct 2021 Sep 16. Epub 2021 Sep 16.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.

Hyperlipidemia, liver steatosis and insulin resistance are common metabolic diseases associated with obesity. The present study was designed to investigate the protective value of black rice anthocyanins (BRAN) on hyperlipidemia, liver steatosis and insulin resistance in mice with high-fat-diet (HFD)-induced obesity and elucidate the underlying mechanism. Specific pathogen-free male C57BL/6J mice (four weeks old, weighing 17. Read More

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September 2021

Cardiovascular Risk Factors in Colombian Penitentiary Staff: An Interdisciplinary View of a High-Risk Occupation.

Hisp Health Care Int 2021 Sep 16:15404153211043886. Epub 2021 Sep 16.

27952Universidad de Santander UDES, Bucaramanga, Colombia.

Introduction: Cardiovascular risk factors have been measured under different conditions, there is some missing information related to specific occupations, such as penitentiary staff which due to their characteristics could have an increased cardiovascular risk. To determine cardiovascular risk factors on military staff from penitentiary institutions in Santander-Colombia. Cross-sectional study conducted with 182 workers. Read More

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September 2021