16,251 results match your criteria cholesterol transport


Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice.

Biomolecules 2021 Oct 6;11(10). Epub 2021 Oct 6.

Department of Pharmacology, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.

Hyperlipidemia is a potent risk factor for the development of cardiovascular diseases. The reverse cholesterol transport (RCT) process has been shown to alleviate hyperlipidemia and protect against cardiovascular diseases. Recently, rosmarinic acid was reported to exhibit lipid-lowering effects. Read More

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October 2021

High-density lipoproteins: A promising tool against cancer.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Oct 13;1867(1):159068. Epub 2021 Oct 13.

Centro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy. Electronic address:

High-density lipoproteins (HDL) are well known for their protective role against the development and progression of atherosclerosis. Atheroprotection is mainly due to the key role of HDL within the reverse cholesterol transport, and to their ability to exert a series of antioxidant and anti-inflammatory activities. Through the same mechanisms HDL could also affect cancer cell proliferation and tumor progression. Read More

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October 2021

Sexual dimorphism in intestinal absorption and lymphatic transport of dietary lipids.

J Physiol 2021 Oct 14. Epub 2021 Oct 14.

Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45237, USA.

Key Points: Significant differences in intestinal lipid absorption and lymphatic transport were found between female and male animals. Estrogen treatment significantly reduced [ H]-triacylglycerol (TAG) lymphatic output through suppressing TAG transport in ovariectomized (OVX) rats, and this effect is associated with enhanced vegfa gene expression in the intestine. Progesterone treatment significantly decreased the output of [ C]-cholesterol (Chol) in lymph by inhibiting Chol absorption in the OVX rats. Read More

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October 2021

Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases.

Mol Biol Rep 2021 Oct 13. Epub 2021 Oct 13.

Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, Uttarakhand, India.

Nuclear receptors are the regulatory molecules that mediate cellular signals as they interact with specific DNA sequences. NR5A2 is a member of NR5A subfamily having four members (Nr5a1-Nr5a4). NR5A2 shows involvement in diverse biological processes like reverse cholesterol transport, embryonic stem cell pluripotency, steroidogenesis, development and differentiation of embryo, and adult homeostasis. Read More

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October 2021

Vitamin C Differentially Impacts the Serum Proteome Profile in Female and Male Mice.

J Proteome Res 2021 Oct 13. Epub 2021 Oct 13.

Centre de recherche du CHU de Québec, Faculty of Medicine, Université Laval, Québec City, Québec G1 V 4G2, Canada.

A suboptimal blood vitamin C (ascorbate) level increases the risk of several chronic diseases. However, the detection of hypovitaminosis C is not a simple task, as ascorbate is unstable in blood samples. In this study, we examined the serum proteome of mice lacking the gulonolactone oxidase (Gulo) required for the ascorbate biosynthesis. Read More

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October 2021

Transcriptome analysis reveals disruption of circadian rhythms in late gestation dairy cows may increase risk for fatty liver and reduced mammary remodeling.

Physiol Genomics 2021 Oct 13. Epub 2021 Oct 13.

Department of Animal Sciences, Purdue University, West Lafayette, IN, United States.

Circadian disruption increased insulin resistance and decreased mammary development in late gestation, non-lactating (dry) cows. The objective was to measure the effect of circadian disruption on transcriptomes of the liver and mammary gland. At 35 d before expected calving (BEC) multiparous dry cows were assigned to either control (CON) or phase-shifted treatments (PS). Read More

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October 2021

Regulation of ER Composition and Extent, and Putative Action in Protein Networks by ER/NE Protein TMEM147.

Int J Mol Sci 2021 Sep 23;22(19). Epub 2021 Sep 23.

Department of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, Cyprus.

Nuclear envelope (NE) and endoplasmic reticulum (ER) collaborate to control a multitude of nuclear and cytoplasmic actions. In this context, the transmembrane protein TMEM147 localizes to both NE and ER, and through direct and indirect interactions regulates processes as varied as production and transport of multipass membrane proteins, neuronal signaling, nuclear-shape, lamina and chromatin dynamics and cholesterol synthesis. Aiming to delineate the emerging multifunctionality of TMEM147 more comprehensively, we set as objectives, first, to assess potentially more fundamental effects of TMEM147 on the ER and, second, to identify significantly TMEM147-associated cell-wide protein networks and pathways. Read More

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September 2021

Health risk assessment of exposure to organochlorine pesticides in the general population in Seoul, Korea over 12 years: A cross-sectional epidemiological study.

J Hazard Mater 2021 Sep 30;424(Pt B):127381. Epub 2021 Sep 30.

Division of Environmental Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea. Electronic address:

This study evaluated the 12-year trends in serum levels of 28 organochlorine pesticides (OCPs) in 880 adults living in Seoul, Korea. The OCP levels decreased from 2006 to 2017, and p,p'-dichlorodiphenyldichloroethylene was a predominant compound. OCP levels were higher in females than in males, and showed positive associations with BMI and age. Read More

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September 2021

HDL and reverse cholesterol transport in humans and animals: Lessons from pre-clinical models and clinical studies.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Oct 9;1867(1):159065. Epub 2021 Oct 9.

Division of Translational Medicine & Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA.

The ability to accept cholesterol from cells and to promote reverse cholesterol transport (RCT) represents the best characterized antiatherogenic function of HDL. Studies carried out in animal models have unraveled the multiple mechanisms by which these lipoproteins drive cholesterol efflux from macrophages and cholesterol uptake to the liver. Moreover, the influence of HDL composition and the role of lipid transporters have been clarified by using suitable transgenic models or through experimental design employing pharmacological or nutritional interventions. Read More

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October 2021

Novel Symbiotic Genome-Scale Model Reveals 's Arboviral Pathogen Blocking Mechanism in Aedes aegypti.

mBio 2021 Oct 12:e0156321. Epub 2021 Oct 12.

Centre for Biotechnology and Bioengineering (CeBiB), Department of Chemical Engineering, Biotechnology and Materials, University of Chilegrid.443909.3, Santiago, Chile.

are endosymbiont bacteria known to infect arthropods causing different effects, such as cytoplasmic incompatibility and pathogen blocking in Aedes aegypti. Although several strains have been studied, there is little knowledge regarding the relationship between this bacterium and their hosts, particularly on their obligate endosymbiont nature and its pathogen blocking ability. Motivated by the potential applications on disease control, we developed a genome-scale model of two strains: Mel and the strongest Dengue blocking strain known to date: MelPop. Read More

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October 2021

Proteomic and microbial assessments on the effect of Antrodia cinnamomea in C57BL/6 mice.

Arch Biochem Biophys 2021 Oct 8;713:109058. Epub 2021 Oct 8.

Institute of Bioinformatics and Structural Biology and Department of Medical Sciences, National Tsing Hua University, Hsinchu, 30013, Taiwan. Electronic address:

Antrodia cinnamomea (AC) is a nutraceutical fungus and studies have suggested that AC has the potential to prevent or alleviate diseases. However, little is known about the AC-induced phenotypes on the intestine-liver axis and gut microbial alterations. Here, we performed two-dimensional difference gel electrophoresis (2D-DIGE) and MALDI-Biotyper to elaborate the AC-induced phenotypes on the intestine-liver axis and gut microbial distribution of C57BL/6 mice. Read More

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October 2021

Identification of inhibitors of cholesterol transport proteins through the synthesis of a diverse, sterol-inspired compound collection.

Angew Chem Int Ed Engl 2021 Oct 9. Epub 2021 Oct 9.

Technical University of Denmark: Danmarks Tekniske Universitet, Chemistry, DENMARK.

Cholesterol transport proteins regulate a vast array of cellular processes including lipid metabolism, vesicular and nonvesicular trafficking, organelle contact sites, and autophagy. Despite their undoubted importance, the identification of selective modulators of this class of proteins has been challenging due to the structural similarities in the cholesterol-binding site. Herein we report a general strategy for the identification of selective inhibitors of cholesterol transport proteins via the synthesis of a diverse sterol-inspired compound collection. Read More

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October 2021

Apolipoproteins in vascular biology and atherosclerotic disease.

Nat Rev Cardiol 2021 Oct 8. Epub 2021 Oct 8.

Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Apolipoproteins are important structural components of plasma lipoproteins that influence vascular biology and atherosclerotic disease pathophysiology by regulating lipoprotein metabolism. Clinically important apolipoproteins related to lipid metabolism and atherogenesis include apolipoprotein B-100, apolipoprotein B-48, apolipoprotein A-I, apolipoprotein C-II, apolipoprotein C-III, apolipoprotein E and apolipoprotein(a). Apolipoprotein B-100 is the major structural component of VLDL, IDL, LDL and lipoprotein(a). Read More

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October 2021

High-density lipoproteins (HDL): Novel function and therapeutic applications.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Oct 5:159058. Epub 2021 Oct 5.

National Institute for Health and Medical Research (INSERM), UMRS 1166, ICAN, Faculty of Medicine Pitié-Salpêtrière, Sorbonne University, Paris, France. Electronic address:

The failure of high-density lipoprotein (HDL)-raising agents to reduce cardiovascular disease (CVD) together with recent findings of increased cardiovascular mortality in subjects with extremely high HDL-cholesterol levels provide new opportunities to revisit our view of HDL. The concept of HDL function developed to explain these contradictory findings has recently been expanded by a role played by HDL in the lipolysis of triglyceride-rich lipoproteins (TGRLs) by lipoprotein lipase. According to the reverse remnant-cholesterol transport (RRT) hypothesis, HDL critically contributes to TGRL lipolysis via acquirement of surface lipids, including free cholesterol, released from TGRL. Read More

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October 2021

Molecular markers of brain cholesterol homeostasis are unchanged despite a smaller brain mass in a mouse model of cholesteryl ester storage disease.

Lipids 2021 Oct 7. Epub 2021 Oct 7.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Lysosomal acid lipase (LAL), encoded by the gene LIPA, facilitates the intracellular processing of lipids by hydrolyzing cholesteryl esters and triacylglycerols present in newly internalized lipoproteins. Loss-of-function mutations in LIPA result in cholesteryl ester storage disease (CESD) or Wolman disease when mutations cause complete loss of LAL activity. Although the phenotype of a mouse CESD model has been extensively characterized, there has not been a focus on the brain at different stages of disease progression. Read More

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October 2021

Pcpe2: A New Partner for SR-B1 in Selective HDL Lipid Uptake.

Arterioscler Thromb Vasc Biol 2021 Oct 7:ATVBAHA121316971. Epub 2021 Oct 7.

Department of Biochemistry and Biomedical Sciences, Thrombosis and Atherosclerosis Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.

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October 2021

Hedgehog lipids: Promotors of alternative morphogen release and signaling?: Conflicting findings on lipidated Hedgehog transport and signaling can be explained by alternative regulated mechanisms to release the morphogen.

Bioessays 2021 Oct 5:e2100133. Epub 2021 Oct 5.

Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, North Rhine-Westphalia, Germany.

Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens-an N-terminal palmitate and a C-terminal cholesterol-are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute to Hh signaling remained obscure. Recently, cryogenic electron microscopy revealed different modes by which one or both lipids may contribute directly to Hh binding and signaling to its receptor Patched1 (Ptc). Read More

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October 2021

Targeting cholesterol homeostasis in hematopoietic malignancies.

Blood 2021 Oct 5. Epub 2021 Oct 5.

Istituto Scientifico San Raffaele, Milan, Italy.

Cholesterol is a vital lipid for cellular functions. It is necessary for membrane biogenesis, cell proliferation and differentiation. In addition to maintaining cell integrity and permeability, increasing evidence indicates a strict link between cholesterol homeostasis, inflammation and haematological tumors. Read More

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October 2021

Treatment trials in Niemann-Pick type C disease.

Metab Brain Dis 2021 Oct 1. Epub 2021 Oct 1.

Department of Genetics, Institute of Psychiatry and Neurology, Al. Sobieskiego 9, 02-957, Warsaw, Poland.

Niemann-Pick type C (NPC) disease is a genetically determined neurodegenerative metabolic disease. It belongs to the lysosomal storage diseases and its main cause is impaired cholesterol transport in late endosomes or lysosomes. It is an autosomal recessive inherited disease that results from mutations in the NPC1 or NPC2 genes. Read More

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October 2021

A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1.

BMC Biol 2021 10 1;19(1):218. Epub 2021 Oct 1.

Division of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, DHHS, 10CRC, Rm. 5-2571, 10 Center Dr, Bethesda, MD, USA.

Background: Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis, a lipid essential for cellular function. Cellular cholesterol levels are tightly regulated, and mutations in either NPC1 or NPC2 lead to deficient transport and accumulation of unesterified cholesterol in the late endosome/lysosome compartment, and progressive neurodegeneration in affected individuals. Previous cell-based studies to understand the NPC cellular pathophysiology and screen for therapeutic agents have mainly used patient fibroblasts. Read More

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October 2021

High-density lipoprotein 3 cholesterol and primary open-angle glaucoma: metabolomics and mendelian randomization analyses.

Ophthalmology 2021 Sep 27. Epub 2021 Sep 27.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore,; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore. Electronic address:

Objective: We hypothesized that the effect of blood lipid-related metabolites on POAG would differ according to specific lipoprotein particles and lipid sub-fractions. We thus investigated the associations of blood levels of lipoprotein particles and lipid sub-fractions with POAG.

Design: Cross-sectional study. Read More

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September 2021

Structural insights into the substrate-binding proteins Mce1A and Mce4A from .

IUCrJ 2021 Sep 28;8(Pt 5):757-774. Epub 2021 Jul 28.

Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

(), which is responsible for more than a million deaths annually, uses lipids as the source of carbon and energy for its survival in the latent phase of infection. cannot synthesize all of the lipid molecules required for its growth and pathogenicity. Therefore, it relies on transporters such as the mammalian cell entry (Mce) complexes to import lipids from the host across the cell wall. Read More

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September 2021

Characteristic attributes limiting the transport rates in NCX orthologs.

Biochim Biophys Acta Biomembr 2021 Sep 25;1864(1):183792. Epub 2021 Sep 25.

Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel. Electronic address:

The NaCa exchangers (NCXs) modulate the Ca2+ signaling and homeostasis in health and disease. The transport cycle turnover rates (kcat) and the kcat/Km values of eukaryotic NCXs are ~10-times higher than those of prokaryotic NCXs. Three ion-coordinating residues (out of twelve) differ between eukaryotic NCXs and NCX_Mj. Read More

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September 2021

The role of lysosomal membrane proteins in glucose and lipid metabolism.

FASEB J 2021 10;35(10):e21848

Department of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, China.

Lysosomes have long been regarded as the "garbage dump" of the cell. More recently, however, researchers have revealed novel roles for lysosomal membranes in autophagy, ion transport, nutrition sensing, and membrane fusion and repair. With active research into lysosomal membrane proteins (LMP), increasing evidence has become available showing that LMPs are inextricably linked to glucose and lipid metabolism, and this relationship represents mutual influence and regulation. Read More

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October 2021

Prostate Cancer-Focus on Cholesterol.

Cancers (Basel) 2021 Sep 19;13(18). Epub 2021 Sep 19.

Group for Research on Epigenetic Biomarkers (Epimark), School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Prostate cancer (PC) is the most common malignancy in men. Common characteristic involved in PC pathogenesis are disturbed lipid metabolism and abnormal cholesterol accumulation. Cholesterol can be further utilized for membrane or hormone synthesis while cholesterol biosynthesis intermediates are important for oncogene membrane anchoring, nucleotide synthesis and mitochondrial electron transport. Read More

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September 2021

Association of a vaccine adjuvant with endogenous HDL increases lymph uptake and dendritic cell activation.

Eur J Pharm Biopharm 2021 Sep 24. Epub 2021 Sep 24.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia. Electronic address:

Vaccines are a powerful health intervention but there is still an unmet need for effective preventative and therapeutic vaccines for many diseases such as cancer and infections. Interstitial (e.g. Read More

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September 2021

Lysis reagents, cell numbers, and calculation method influence high-throughput measurement of HDL-mediated cholesterol efflux capacity.

J Lipid Res 2021 Sep 24:100125. Epub 2021 Sep 24.

Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:

HDL-mediated cholesterol efflux capacity (CEC) may protect against cardiovascular disease. However, CEC assays are not standardized, hampering their application in large cohorts and comparison between studies. To improve standardization, we systematically investigated technical differences between existing protocols that influence assay performance that have not been previously addressed. Read More

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September 2021

Dyslipidemia in Chronic Kidney Disease: Contemporary Concepts and Future Therapeutic Perspectives.

Am J Nephrol 2021 Sep 17:1-9. Epub 2021 Sep 17.

Department of Nephrology, General Hospital of Nikaia-Piraeus, Athens, Greece.

Background: Chronic kidney disease (CKD) is an increasingly prevalent disease state met with great morbidity and mortality primarily resulting from the high incidence of adverse cardiovascular outcomes. Therapeutic strategies in this patient population aim at controlling modifiable cardiovascular risk factors, including dyslipidemia.

Summary: In this review article, we first provide the latest pathophysiologic evidence regarding the altered dyslipidemia pattern in CKD, followed by its contemporary management according to the latest guidelines. Read More

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September 2021

Trimethylamine N-oxide-a marker for atherosclerotic vascular disease.

Rev Cardiovasc Med 2021 Sep;22(3):787-797

Department of Cardiology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, 300120 Tianjin, China.

As a potential causative factor in various cardiovascular diseases, the gut microbe-generated metabolite trimethylamine N-oxide (TMAO) has courted considerable research interest as a potential biomarker. TMAO is a small molecule considered to be beneficial for the health of deep-water animals due to its ability to protect proteins against hydrostatic pressure stress. However, it may cause deleterious effects in humans as mounting evidence suggests that TMAO may enhance atherosclerosis, independent of traditional risk factors. Read More

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September 2021

The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis.

J Inherit Metab Dis 2021 Sep 26. Epub 2021 Sep 26.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Peroxisomes metabolize a specific subset of fatty acids, which include dicarboxylic fatty acids (DCAs) generated by ω-oxidation. Data obtained in vitro suggest that the peroxisomal transporter ABCD3 (also known as PMP70) mediates the transport of DCAs into the peroxisome, but in vivo evidence to support this role is lacking. In this work, we studied an Abcd3 KO mouse model generated by CRISPR-Cas9 technology using targeted and untargeted metabolomics, histology, immunoblotting, and stable isotope tracing technology. Read More

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September 2021