299,143 results match your criteria cholesterol

Genome-wide transcriptional analysis unveils the molecular basis of organ-specific expression of isosteroidal alkaloids biosynthesis in critically endangered Fritillaria roylei Hook.

Phytochemistry 2021 Apr 16;187:112772. Epub 2021 Apr 16.

Biotechnology Department, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh, 176061, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Ghaziabad, Uttar Pradesh, 201 002, India. Electronic address:

Fritillaria roylei Hook. is a critically endangered high altitude Himalayan medicinal plant species with rich source of pharmaceutically active structurally diverse steroidal alkaloids. Nevertheless, except few marker compounds, the chemistry of the plant remains unexplored. Read More

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Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.

Biochem Biophys Res Commun 2021 Apr 16;557:187-191. Epub 2021 Apr 16.

State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300350, China. Electronic address:

Human ATP-binding cassette transporter 8 of subfamily B (hABCB8) is an ABC transporter that located in the inner membrane of mitochondria. The ABCB8 is involved in the maturation of Fe-S and protects the heart from oxidative stress. Here, we present the cryo-EM structure of human ABCB8 binding with AMPPNP in inward-facing conformation with resolution of 4. Read More

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Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways.

Fundam Clin Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, China.

Hyperlipidemia is worth-mentioning risk factor in quickly expanding atherosclerosis, myocardial infarction and stroke. This study attempted to determine effectiveness of selected pyrimidine derivatives: 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9) and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) against hyperlipidemia. In-silico results revealed that SR-5, SR-8, SR-9 and SR-10 exhibited high affinity with 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) possessing binding energy values of -8. Read More

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Cancer Stem Cell-Targeted Gene Delivery Mediated by Aptamer-Decorated pH-Sensitive Nanoliposomes.

ACS Biomater Sci Eng 2021 Apr 19. Epub 2021 Apr 19.

Technical Research Centre, Indian Association for the Cultivation of Science, Kolkata 700032, India.

A new pH-responsive cationic co-liposomal formulation was prepared in this study using the twin version of the amphiphile palmitoyl homocysteine, TPHC; natural zwitterionic lipid, DOPE; and cholesterol-based twin cationic lipid, C5C, at specified molar ratios. This co-liposome was further decorated with a newly designed fluorescently tagged, cholesterol-tethered EpCAM-targeting RNA aptamer for targeted gene delivery. This aptamer-guided nanoliposomal formulation, C5C/DOPE/TPHC at 8:24:1 molar ratio, could efficiently transport the genes in response to low pH of cellular endosomes selectively to the EpCAM overexpressing cancer stem cells. Read More

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Growth performance, tissue precipitation, metallothionein and cytokine transcript expression and economics in response to different dietary zinc sources in growing rabbits.

J Anim Physiol Anim Nutr (Berl) 2021 Apr 19. Epub 2021 Apr 19.

Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

The impact of different dietary zinc sources on the growth, serum metabolites, tissue zinc content, economics and relative expression of cytokine and metallothionein genes was evaluated in this study. A total of 120 35-day-old male New Zealand White (NZW) rabbits were randomly distributed into four dietary experimental groups with 10 replicates per group and 3 animals per replicate. The control group was fed basal diet with a Zn-free vitamin-mineral premix; the other three groups received control basal diet supplemented with 50 mg/kg level with zinc oxide (ZnO; as inorganic source), Zn-methionine (Zn-Met; as organic source) and zinc oxide nanoparticles (nano-ZnO). Read More

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Circulating TNFrII levels predict incidence of ischemic heart disease and total mortality, independently of intima media thickness and pulse wave velocity in male with type 2 diabetes.

Heart Vessels 2021 Apr 19. Epub 2021 Apr 19.

Department of Health, Medicine and Caring Sciences, Linköping University, SE 581 85, Linköping, Sweden.

New and clinically useful markers of cardiovascular risk are of great importance in patients with type 2 diabetes since cardiovascular disease is a major cause of death in these patients. We analyzed inflammatory markers and other risk factors for heart disease in 761 patients who participated in the CARDIPP-study, Cardiovascular Risk factors in Patients with Diabetes-a Prospective study in Primary care. All participants had type 2 diabetes and were 55-66 years old at recruitment during the years 2005-2008. Read More

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Diet quality, gut microbiota, and microRNAs associated with mild cognitive impairment in middle-aged and elderly Chinese population.

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

School of Public Health, Capital Medical University, Beijing, China.

Background: Diet, the gut microbiota, and microRNAs (miRNAs) have been recognized as factors possibly influencing the pathogenesis of Alzheimer's disease. However, the combined role of diet, the gut microbiota, and miRNAs in mild cognitive impairment (MCI) has not been extensively investigated.

Objectives: To examine the associations among diet quality, the gut microbiota, miRNAs, and risks of MCI in middle-aged and elderly Chinese population. Read More

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A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial.

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

C2VN, Aix Marseille Univ, INRAE, INSERM, Marseille, France.

Background: Blood lipid concentrations display high interindividual variability in response to dietary interventions, partly due to genetic factors. Existing studies have focused on single nucleotide polymorphisms (SNPs) analyzed individually, which only explain a limited fraction of the variability of these complex phenotypes.

Objective: We aimed to identify combinations of SNPs associated with the variability in LDL cholesterol and triglyceride (TG) concentration changes following 5 dietary interventions. Read More

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Analysis of Liver Microenvironment during Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish.

J Vis Exp 2021 Apr 1(170). Epub 2021 Apr 1.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine; Department of Medicine (Hepatology), Albert Einstein College of Medicine; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine; Marion Bessin Liver Research Center, Albert Einstein College of Medicine;

Liver cancer is currently the third leading cause of cancer related death worldwide, and Hepatocellular Carcinoma (HCC) accounts for 75-90% of all liver cancer cases. With the introduction of effective treatments to prevent and treat hepatitis B/C, non-alcoholic fatty liver disease (NAFLD), and the more aggressive form know as non-alcoholic steatohepatitis (NASH), are quickly becoming the number one risk factors to develop HCC in modern societies. To better understand the role NASH has on the development of HCC we designed a NASH-associated HCC zebrafish. Read More

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Differentiation of clinical patterns and survival outcomes of hepatocellular carcinoma on hepatitis B and nonalcoholic fatty liver disease.

J Chin Med Assoc 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan, ROC Department of Pathology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan, ROC Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan, ROC University of Taipei, Taipei, Taiwan, ROC.

Background: The main etiologies of hepatocellular carcinoma (HCC) were often hepatitis B virus (HBV) or C and alcohol, rarely autoimmune and biliary diseases. Nonalcoholic fatty liver disease (NAFLD) has been an emerging role that could lead to chronic liver disease, nonalcoholic steatohepatitis, cirrhosis, and eventually HCC in recent years. The aim of our study is to investigate and compare the clinical features of HCC in NAFLD and HBV patients, including age, gender, cirrhosis, liver function tests, largest tumor size and cancer stage at the time of diagnosis. Read More

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Adherence to Healthy Lifestyle Improved Clinical Outcomes in Coronary Artery Disease Patients After Coronary Intervention.

J Chin Med Assoc 2021 Apr 13. Epub 2021 Apr 13.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital Taoyuan Branch, Taiwan, ROC Health Care and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Division of Cardiology, Heart Center, Cheng-Hsin General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC Department of Medical Imaging and Radiological Sciences, I-Shou University and Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan, ROC Cardiology Division of Cardiovascular Medical Center and Department of Nuclear Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan, ROC Mackay Memorial Hospital, Mackay Medical College, New Taipei City, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, China Medical University Hospital, and Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, ROC Department of Cardiology, Buddhist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan, ROC Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Department of Primary Care Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei, Taiwan, ROC Institute of Clinical Medicine and Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

Background: Lifestyle modification is suggested for patients with coronary artery disease (CAD), but the impact of adherence to a healthy lifestyle remains undetermined. The aim of this study is to investigate the association of adherence to a healthy lifestyle with future outcomes and biochemical markers in CAD patients.

Methods: The Biosignature CAD study examined 716 CAD patients who underwent a percutaneous coronary intervention (PCI). Read More

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Arrb2 Causes Hepatic Lipid Metabolism Disorder via AMPK Pathway Based on Metabolomics in Alcoholic Fatty Liver.

Clin Sci (Lond) 2021 Apr 19. Epub 2021 Apr 19.

Anhui Medical University, Hefei, China.

Background & Aims: Alcoholic fatty liver (AFL) is an early form of alcoholic liver disease (ALD) that usually manifests as lipid synthesis abnormalities in hepatocytes. Arrb2 is involved in multiple biological processes. This study aimed to explore the role of Arrb2 in the regulation of lipid metabolism in AFL and the underlying mechanism and identify potential targets for the treatment of AFL. Read More

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Update on apolipoprotein B.

Curr Opin Lipidol 2021 Apr 16. Epub 2021 Apr 16.

Mike and Valeria Rosenbloom Centre for Cardiovascular Prevention, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada Department of Laboratory Medicine, AZ St.-Jan Hospital, Bruges, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Purpose Of Review: The 2019 European Society of Cardiology/European Atherosclerosis Society Guidelines concluded that apolipoprotein B (apoB) was a more accurate measure of cardiovascular risk and a better guide to the adequacy of lipid lowering than low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (HDL-C). Also, they stated that apoB can be measured more accurately than LDL-C or non-HDL-C. This strong endorsement of the central role of apoB contrasts with the limited endorsement of apoB by the 2018 American College of Cardiology/American Heart Association Multisociety Guidelines. Read More

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Lipid effects of sodium-glucose cotransporter 2 inhibitors.

Curr Opin Lipidol 2021 Apr 16. Epub 2021 Apr 16.

Department of Medicine Department of Biochemistry Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Purpose Of Review: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used antihyperglycemic drugs that show remarkable cardiorenal protective effects in patients with or without type 2 diabetes. Furthermore, they are effective among patients across a wide range of baseline renal and cardiac function. Numerous mechanisms have been evaluated to understand these remarkable clinical benefits. Read More

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High-Density Lipoprotein Cholesterol and Apolipoprotein A1 in Synovial Fluid: Potential Predictors of Disease Severity of Primary Knee Osteoarthritis.

Cartilage 2021 Apr 17:19476035211007919. Epub 2021 Apr 17.

Department of Orthopaedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.

Objectives: The aim of this study was to detect levels of common lipid species in serum and synovial fluid (SF) of primary knee osteoarthritis (OA) patients and investigate their correlations with disease severity.

Materials And Methods: The study enrolled 184 OA patients receiving arthroscopic debridement or total knee arthroplasty and 180 healthy controls between April 2012 and March 2018. Total triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) levels were analyzed in serum and SF of OA patients, and in serum of healthy individuals. Read More

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Impaired High-Density Lipoprotein Function in Patients With Heart Failure.

J Am Heart Assoc 2021 Apr 17:e019123. Epub 2021 Apr 17.

Department of Pediatrics University of Groningen Groningen The Netherlands.

Background We recently showed that, in patients with heart failure, lower high-density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow-up study, we suggested that this association could be partly explained by HDL proteome composition. However, whether the emerging concept of HDL function contributes to the prognosis of patients with heart failure has not been addressed. Read More

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Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats.

Physiol Genomics 2021 Apr 19. Epub 2021 Apr 19.

Physiology, Medical College of Wisconsin, United States.

Diabetic kidney disease (DKD) is a common complication of diabetes, which frequently leads to end-stage renal failure and increases cardiovascular disease risk. Hyperglycemia promotes renal pathologies such as glomerulosclerosis, tubular hypertrophy, microalbuminuria, and a decline in glomerular filtration rate. Importantly, recent clinical data have demonstrated distinct sexual dimorphism in the pathogenesis of DKD in people with diabetes, which impacts both severity- and age-related risk factors. Read More

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Long-term intake of ginger protease-degraded collagen hydrolysate reduces blood lipid levels and adipocyte size in mice.

Curr Res Food Sci 2021 24;4:175-181. Epub 2021 Mar 24.

Nippi Research Institute of Biomatrix, 520-11 Kuwabara, Toride, Ibaraki, 302-0017, Japan.

Collagen hydrolysate has various beneficial effects, such as bone strengthening, joint/skin protection and lipid metabolism regulation. In this study, the anti-obesity activity of ginger protease-degraded collagen hydrolysate (GDCH) was evaluated in BALB/c mice fed diets containing 14% casein (control group) or 10% casein +4% GDCH (GDCH group) for 10 weeks. In the GDCH group, triglyceride (TG) and cholesterol (CHO) levels in blood and adipocyte size in white adipose tissue were significantly decreased compared with those of the control group. Read More

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miR-155-5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway.

Noncoding RNA Res 2021 Jun 8;6(2):59-69. Epub 2021 Mar 8.

Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using TargetScan and miRdB databases was performed to identify the miRNAs targeting three genes involved in foam cell atherosclerosis (CD36, Vav3, and SOCS1). A total number of three hundred and sixty-seven miRNAs were recognized and only miR-155-5p was selected for further evaluation based on Venn analysis. Read More

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Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index.

Biochem Biophys Rep 2021 Jul 30;26:100990. Epub 2021 Mar 30.

Faculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.

Our present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract of , , L. and in high fat-induced mice with their total phenolic and flavonoid profile. Total phenolic and flavonoid content were determined by Folin-Ciocalteu's and Aluminium chloride UV method respectively. Read More

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Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus.

Mol Ther Oncolytics 2021 Jun 17;21:47-61. Epub 2021 Mar 17.

Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK.

Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity. It has a well-defined safety profile and is being assessed in late-stage clinical trials. However, VV clinical utility is limited by rapid bloodstream neutralization and poor penetration into tumors. Read More

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Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients.

Front Cardiovasc Med 2021 1;8:649181. Epub 2021 Apr 1.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

This study aimed to compare the percentage attainment of fasting and non-fasting LDL-C and non-HDL-C target levels in coronary heart disease (CHD) patients receiving short-term statin therapy. This study enrolled 397 inpatients with CHD. Of these, 197 patients took statins for <1 month (m) or did not take any statin before admission (CHD1 group), while 204 patients took statins for ≥1 m before admission (CHD2 group). Read More

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Using the Major Components (Cellulose, Hemicellulose, and Lignin) of Bamboo Shoot as Dietary Fiber.

Front Bioeng Biotechnol 2021 31;9:669136. Epub 2021 Mar 31.

China National Bamboo Research Center, Hangzhou, China.

Bamboo shoots are a renewable and abundant biomass containing cellulose, hemicellulose, and lignin. Although many studies have explored the applications of each of these components in the preparation of biochemicals and biopolymers, few studies have evaluated the utility of these components as a dietary fiber supplement. In this study, a powder consisting of the main components of bamboo shoots (cellulose, hemicellulose, and lignin) was prepared from fresh shoots and characterized by scanning electron microscopy, infrared spectroscopy, and X-ray diffraction. Read More

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Phytochemical and toxicological evaluations of (GUILL. and PERR.) extract on albino wistar rats.

Toxicol Res 2021 Apr 6;37(2):183-195. Epub 2020 Jul 6.

Institute of Agro-Products Processing, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu China.

In this study, we investigated the phytochemical and toxicological impacts of the ethanol leaf extract of in albino rats. Preliminary phytochemical analysis was done using established methods. Acute and 28-day sub-chronic toxicity evaluations of the extract were carried out in wistar rats. Read More

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Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure.

Toxicol Rep 2021 9;8:646-656. Epub 2021 Mar 9.

Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA.

Humans are frequently exposed to Quaternary Ammonium Compounds (QACs). QACs are ubiquitously used in medical settings, restaurants, and homes as cleaners and disinfectants. Despite their prevalence, nothing is known about the health effects associated with chronic low-level exposure. Read More

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Improvement of testosterone deficiency by fermented extracts in aging male rats.

Food Sci Biotechnol 2021 Mar 6;30(3):443-454. Epub 2021 Feb 6.

Department of Biomedical Science, Jungwon University, 85 Munmu-ro, Geosan-eup , Goesan-gun, Chungbuk 28024 South Korea.

This study evaluated the efficacy of (MC; bitter melon) extracts against andropause symptoms. We fermented MC with and verified the ability of the fermented MC extracts (FMEs) to control testosterone deficiency by using aging male rats as an animal model of andropause. FME administration considerably increased total and free testosterone levels, muscle mass, forced swimming time, and total and motile sperm counts in aging male rats. Read More

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Comparing the stability of retinol in liposomes with cholesterol, β-sitosterol, and stigmasterol.

Food Sci Biotechnol 2021 Mar 27;30(3):389-394. Epub 2021 Mar 27.

School of Bioconvergence, Kyungnam University, Kyungnamdaehak-ro 7, Changwon, 51767 Korea.

In this study, cholesterol (CH), β-sitosterol (SI), and stigmasterol (ST) were explored to improve the stability of retinol in the liposome bilayer. Retinol was incorporated into liposomes composed of soybean-derived L-α-phosphatidylcholine (PC) and 10% sterol (w/w), which were prepared as multilamellar vesicles. Under all conditions, the efficiency of retinol incorporation into liposomes was higher than 99%, and the average particle size of liposomes was similar to that of PC alone. Read More

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Chronic Kidney Disease Progression and Transition Probabilities in a Large Preventive Cohort in Colombia.

Int J Nephrol 2021 31;2021:8866446. Epub 2021 Mar 31.

Renal Therapy Services-Latin America, Bogotá, Colombia.

Background: Variability in chronic kidney disease (CKD) progression is a well-known phenomenon that underlines the importance of characterizing the said outcome in specific populations. Our objectives were to evaluate changes in the estimated glomerular filtration rate (eGFR) over time and determine the frequency of dialysis admission and factors associated with this outcome, to estimate the rate of program's loss-to-follow-up and the probability of transition between CKD stages over time.

Methods: The study type was an observational analytic retrospective cohort in patients treated in a CKD prevention program in Bogota, Colombia, between January 1, 2009, and December 31, 2013, with follow-up until December 31, 2018. Read More

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Substrate Inhibition of 5β-Δ-3-Ketosteroid Dehydrogenase in sp. Strain Chol11 Acts as Circuit Breaker During Growth With Toxic Bile Salts.

Front Microbiol 2021 23;12:655312. Epub 2021 Mar 23.

Institut für Molekulare Mikrobiologie und Biotechnologie, Westfälische Wilhelms-Universität Münster, Münster, Germany.

In contrast to many steroid hormones and cholesterol, mammalian bile salts are 5β-steroids, which leads to a bent structure of the steroid core. Bile salts are surface-active steroids excreted into the environment in large amounts, where they are subject to bacterial degradation. Bacterial steroid degradation is initiated by the oxidation of the A-ring leading to canonical Δ-3-keto steroids with a double bond in the A-ring. Read More

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Applications of Transcriptomics and Proteomics for Understanding Dormancy and Resuscitation in .

Front Microbiol 2021 31;12:642487. Epub 2021 Mar 31.

Department of Chemistry, Bose Institute, Kolkata, India.

can survive within its host for extended periods of time without any clinical symptoms of disease and reactivate when the immune system is weakened. A detailed understanding of how enters into and exits out of dormancy, is necessary in order to develop new strategies for tackling tuberculosis. Omics methodologies are unsupervised and unbiased to any hypothesis, making them useful tools for the discovery of new drug targets. Read More

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