34,322 results match your criteria chitosan

Improved Pb(II) removal in aqueous solution by [email protected] and [email protected] biochar composites: Efficiencies and mechanisms.

Chemosphere 2021 Aug 31;287(Pt 1):132087. Epub 2021 Aug 31.

School of Life Science, School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang, 312000, PR China. Electronic address:

Novel biochars, namely nano iron [email protected] walnut shell biochar ([email protected]), [email protected] and [email protected]NS, were prepared by WNS loaded with nano FeS and starch (or chitosan). Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration. The materials were characterized by SEM, EDS, FTIR and XRD, and the preparation was successful. Read More

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Delivery strategies of amphotericin B for invasive fungal infections.

Acta Pharm Sin B 2021 Aug 29;11(8):2585-2604. Epub 2021 Apr 29.

Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China.

Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage in many medical settings, with substantial associated morbidities and mortalities. Among many current therapeutic options for the treatment of IFIs, amphotericin B (AmB) is the most frequently used drug. AmB is considered as a first-line drug in the clinic that has strong antifungal activity and less resistance. Read More

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Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines.

Acta Pharm Sin B 2021 Aug 21;11(8):2565-2584. Epub 2021 May 21.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory infections, and systemic diseases such as diabetes. Most inhaled medicines could be cleared rapidly from the lungs and their therapeutic effects are transit. The inhaled medicines with extended pulmonary exposure may not only improve the patient compliance by reducing the frequency of drug administration, but also enhance the clinical benefits to the patients with improved therapeutic outcomes. Read More

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Oral delivery of proteins and peptides: Challenges, status quo and future perspectives.

Acta Pharm Sin B 2021 Aug 29;11(8):2416-2448. Epub 2021 Apr 29.

Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeutic PPs are usually administered by parenteral route. Given the big demand for oral administration in clinical use, a variety of researches focused on developing new technologies to overcome GI barriers of PPs, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, as well as intestinal microdevices. Read More

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Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque.

Theranostics 2021 18;11(18):8874-8893. Epub 2021 Aug 18.

Multimodal Imaging and Theranostic Lab., Cardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.

Inflammation plays a pivotal role in the pathogenesis of the acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events. Here, we developed a macrophage mannose receptor (MMR)-targeted theranostic nanodrug (mannose-polyethylene glycol-glycol chitosan-deoxycholic acid-cyanine 7-lobeglitazone; MMR-Lobe-Cy) designed to identify inflammatory activity as well as to deliver peroxisome proliferator-activated gamma (PPARγ) agonist, lobeglitazone, specifically to high-risk plaques based on the high mannose receptor specificity. Read More

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Design and Invitro Characterization of Green Synthesized Magnetic Nanoparticles Conjugated with Multitargeted Poly Lactic Acid Copolymers for Co-delivery of siRNA and Paclitaxel.

Eur J Pharm Sci 2021 Sep 11:106007. Epub 2021 Sep 11.

Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address:

Background: The self-assembling of various amphipathic copolymers is a simple method that allows the preparation of complex nanoparticles with several useful properties. In the present study, the polylactic acid-polyethylene glycol-folate (PLA-PEG-FA) (PPF), PLA-PEG-T7 peptide (PPT) and PLA-Chitosan-Spermine (PCS) copolymers were synthesized separately.

Methods: These copolymers combined with FeO magnetic core and loaded with paclitaxel (PTX)/siRNA-FAM to form magnetic PCS/PPF/PPT/PTX/siRNA micelles (MPCSFT/PTX/siRNA) and were characterized using physicochemical and biological analysis. Read More

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September 2021

Fungal-derived carboxymethyl chitosan blended with polyvinyl alcohol as membranes for wound dressings.

Int J Biol Macromol 2021 Sep 11;190:792-800. Epub 2021 Sep 11.

School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea; Research Institute of Cell Culture, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea. Electronic address:

Multifunctional blend membranes composed of poly (vinyl alcohol) (PVA) and fungal mushroom-derived carboxymethyl chitosan (F-CMCS) were produced using a simple solution casting technique for wound dressing applications. The structural interactions between PVA and F-CMCS were confirmed by Fourier infrared spectroscopy. The crystallinity of the membranes was examined by X-ray diffraction. Read More

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September 2021

The Ideal Donor Site Dressing: A Comparison of a Chitosan Based Gelling Dressing to Traditional Dressings.

J Burn Care Res 2021 Sep 14. Epub 2021 Sep 14.

Department of Surgery, Texas Tech University Health Science Center, Lubbock, Texas, USA.

Introduction: Donor site wound management is critical in split-thickness skin graft surgeries. These sites typically recover in 7-14 days due to the dermal-imbedded keratinocytes that promote skin regeneration. An ideal donor site dressing can help to mitigate pain, reduce infection risk, promote hemostasis, and accelerate healing times. Read More

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September 2021

Polyplexes of retinoic acid: an in vitro study of complex nanostructures against colorectal cancer cell line (HCT-15).

J Mater Sci Mater Med 2021 Sep 14;32(9):122. Epub 2021 Sep 14.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India.

Despite recent advances in the treatment of human colon cancer, the chemotherapeutic efficacy against colon cancer is still unsatisfactory. The complexity in colorectal cancer treatment leads to new research in combination therapy to overcome multidrug resistance in cancer and increase apoptosis. The objective of the present research work was to develop polyplexes for co-delivery of plasmid DNA with retinoic acid against colorectal cancer cell line (HCT-15). Read More

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September 2021

Desalination of duck egg white by biocoagulation to obtain peptide-ferrous chelate as iron delivery system: Preparation, characterization, and Fe2+ release evaluation in vitro.

J Food Sci 2021 Sep 14. Epub 2021 Sep 14.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, People's Republic of China.

The annual output of salted duck egg white (SDEW) is estimated to be over 1.5 million tons in China, most of which is discarded due to high salt content. This has led to serious waste and environmental impact. Read More

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September 2021

Study of Chitosan Ingestion Remitting the Bone Damage on Fluorosis Mice with Micro-CT.

Biol Trace Elem Res 2021 Sep 13. Epub 2021 Sep 13.

Shaxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, Shanxi, People's Republic of China.

Chronic excessive fluoride exposure may lead to fluorosis, which causes health problems like a decrease in bone mechanical strength. It was speculated that chitosan may combine with fluorine to form in vivo organic fluorine, and may reduce the damage caused by fluorine. Hence, it is necessary to conduct a study to investigate the influence of chitosan on fluorosis mice. Read More

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September 2021

Polymeric Materials as Potential Inhibitors Against SARS-CoV-2.

J Polym Environ 2021 Sep 9:1-20. Epub 2021 Sep 9.

Department of Chemical and Process Engineering Technology, Jubail Industrial College, Jubail Industrial City, 31961 Saudi Arabia.

Recently discovered SARS-CoV-2 caused a pandemic that triggered researchers worldwide to focus their research on all aspects of this new peril to humanity. However, in the absence of specific therapeutic intervention, some preventive strategies and supportive treatment minimize the viral transmission as studied by some factors such as basic reproduction number, case fatality rate, and incubation period in the epidemiology of viral diseases. This review briefly discusses coronaviruses' life cycle of SARS-CoV-2 in a human host cell and preventive strategies at some selected source of infection. Read More

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September 2021

Green synthesis of carbamates and amides via [email protected] catalyzed C-O and C-N oxidative coupling accelerated by microwave irradiation.

Sci Rep 2021 Sep 13;11(1):18105. Epub 2021 Sep 13.

Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Islamic Republic of Iran.

A new nano-scale [email protected] ([email protected]) was synthesized through a green, eco-friendly and cost-effective technique. The prepared catalyst was characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDXS), and inductively coupled plasma (ICP) analysis. The synthesized [email protected] catalyst indicated its performance in the C-O and C-N oxidative coupling using the reaction of 1,3-dicarbonyl derivatives/2- substituted phenols with amides for the preparation of carbamates, as well as in the reaction of aldehydes and various amines in the synthesis of amides. Read More

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September 2021

Chitosan and dicationic ionic liquid intercalated clay-coated solid-phase microextraction fiber for determination of sixteen polycyclic aromatic hydrocarbons in coffee and tea samples.

Talanta 2021 Dec 31;235:122764. Epub 2021 Jul 31.

Chemistry Department, Dokuz Eylul University, Tınaztepe Campus, 35390, Izmir, Turkey. Electronic address:

In the present study, solid-phase microextraction (SPME) fiber was prepared by coating clay (MMT)-chitosan (CH) and dicationic ionic liquid (DIL) onto the stainless-steel wire step by step. The characterization of fibers was performed by Fourier transform infrared spectroscopy, thermal analysis, x-ray diffraction analysis, and scanning electron microscopy. The prepared fibers were evaluated for separation and determination of 16 polycyclic aromatic hydrocarbons (PAHs) in coffee and tea samples in headspace- and direct immersion-SPME by coupling with gas chromatography/mass spectrometry. Read More

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December 2021

Determination of sorbitol dehydrogenase in microsamples of human serum.

Talanta 2021 Dec 22;235:122730. Epub 2021 Jul 22.

Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA. Electronic address:

The enzyme sorbitol dehydrogenase (SDH) is an emerging biomarker of drug-induced liver injury (DILI). This paper introduces determination of SDH in microliter samples of human serum at commercial glucose test strips. The determination relies on the oxidation of NADH cofactor, which is used by SDH reacting with its substrates. Read More

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December 2021

Natural, low-cost adsorbents for toxic Pb(II) ion sequestration: A state-of-the-art review.

Chemosphere 2021 Sep 2;287(Pt 2):132130. Epub 2021 Sep 2.

Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St, Miami, FL, 33199, USA; Analytical/Environmental Chemistry Unit, Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, P.M.B, 4000, Ogbomoso, Nigeria. Electronic address:

Pb(II) ions is an inorganic pollutant that is present in the environment. Its presence affects both human health and ecosystem. Economically, amongst many wastewater treatment approaches, adsorption is both cheap and environmentally friendly for removing Pb(II) ion from contaminated water. Read More

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September 2021

Glutaraldehyde-cross-linked chitosan-alginate composite for organic dyes removal from aqueous solutions.

Int J Biol Macromol 2021 Sep 10. Epub 2021 Sep 10.

Department of Chemistry, R. T. M. Nagpur University, Nagpur 440010, Maharashtra, India. Electronic address:

We present an approach for synthesis of a micro-porous composite of two well-known biopolymers, namely chitosan and alginate, using glutaraldehyde as the cross-linking agent. Alginate and chitosan were pre-treated before being mixed, and the two biopolymers' proportions were also monitored. Chitosan was modified using aniline with the help of formaldehyde crosslinker and then the twizer was further crosslinked with alginate using glutaraldehyde. Read More

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September 2021

Ultra pH-sensitive nanocarrier based on FeO/chitosan/montmorillonite for quercetin delivery.

Int J Biol Macromol 2021 Sep 10. Epub 2021 Sep 10.

School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.

Harmful side effects of the chemotherapeutic agent have been investigated in many recent studies. Since FeO nanoparticles have proper porosity, they are capable for loading noticeable amount of drugs and controlled release. We developed FeO/chitosan/montmorillonite nanocomposite. Read More

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September 2021

Development of a Bifunctional Edible Coating for Formaldehyde Scavenging and Preservation of Aquatic Products.

J Sci Food Agric 2021 Sep 13. Epub 2021 Sep 13.

College of Food Science & Technology, Shanghai Ocean University, Shanghai, 201306, PR China.

Background: Although the exogenous and endogenous formaldehyde in squid led to severe health threaten, in-depth study on natural edible scavengers for formaldehyde in squid was still lacking.

Results: Response surface methodology (RSM) combined with experimental verification approaches was applied to obtain an optimal "recipe" to achieve formaldehyde removal rate >85%: 6 mg/mL of tea polyphenols, 20 mg/mL of chitosan, 3:2 (V:V) of tea polyphenols and chitosan, 3 of pH and 60 min of treating time. Apart from the capability of removing formaldehyde, the scavenger derived from natural food exhibited significant preservation effect (extension of preservation time up to 40%) on squid during chilled storage process and was safe and environmentally friendly. Read More

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September 2021

essential oil-loaded chitosan-tripolyphosphate nanoparticles: Fabrication, characterization and in-vitro antioxidant and antibacterial activities.

Food Sci Technol Int 2021 Sep 13:10820132211040917. Epub 2021 Sep 13.

Food Safety Research Center, 556492Shahid Beheshti University of Medical Sciences, Tehran, Iran.

essential oil (ZEO) was encapsulated in chitosan nanoparticles at different concentrations using the emulsion-ionic gelation technique and its antioxidant and antibacterial effects were investigated. The results indicated that ZEO level had a significant effect on encapsulation efficiency (EE), loading capacity (LC), particle size and zeta potential. The value obtained for EE, LC, mean particle size and zeta potential were 49. Read More

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September 2021

A voltammetric sensor based on a carbon black and chitosan-stabilized gold nanoparticle nanocomposite for ketoconazole determination.

Anal Methods 2021 Sep 13. Epub 2021 Sep 13.

Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, 13560-970, Brazil.

A modified glassy carbon electrode with carbon black (CB) and gold nanoparticles (AuNPs) within a crosslinked chitosan (CTS) film is proposed in this work. The electroanalytical performance of the modified CB-CTS-AuNPs/GCE has been evaluated towards the voltammetric sensing of ketoconazole (KTO), a widespread antifungal drug. The nanocomposite was characterized by scanning electron microscopy, X-ray diffraction spectroscopy, and electrochemistry experiments. Read More

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September 2021

Characterization of Cellulose-Chitosan-Based Materials from Different Lignocellulosic Residues Prepared by the Ethanosolv Process and Bleaching Treatment with Hydrogen Peroxide.

ACS Omega 2021 Sep 23;6(35):22791-22802. Epub 2021 Aug 23.

The Joint Graduate School for Energy and Environment (JGSEE), King Mongkut's University of Technology Thonburi, Prachauthit Road, Bangmod, Bangkok 10140, Thailand.

Cellulose-based composites are promising biomaterials with potent applications in absorbents, cosmetics, and healthcare industries. In this study, the cellulose fractions from various agricultural residues, including bagasse (BG), rice straw (RS), corncob (CC), and palm fiber (PF), were prepared by the organosolv process using 70% v/v ethanol, followed by bleaching and forming with chitosan powder. Organosolv treatment at 180 °C of BG, RS, and PF and at 190 °C of CC for 60 min using HSO as the catalyst was optimal for high cellulose recovery (87. Read More

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September 2021

Structural Polymorphism of Chitin and Chitosan in Fungal Cell Walls From Solid-State NMR and Principal Component Analysis.

Front Mol Biosci 2021 25;8:727053. Epub 2021 Aug 25.

Department of Chemistry, Louisiana State University, Baton Rouge, LA, United States.

Chitin is a major carbohydrate component of the fungal cell wall and a promising target for novel antifungal agents. However, it is technically challenging to characterize the structure of this polymer in native cell walls. Here, we recorded and compared C chemical shifts of chitin using isotopically enriched cells of six , , and strains, with data interpretation assisted by principal component analysis (PCA) and linear discriminant analysis (LDA) methods. Read More

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Enhanced visualization of the root canal morphology using a chitosan-based endo-radiopaque solution.

Restor Dent Endod 2021 Aug 4;46(3):e33. Epub 2021 Jun 4.

Adult Restorative Dentistry - Endodontics, Oman Dental College, University Complutense of Madrid, Oman, Sultanate of Oman.

Objectives: This study aimed to investigate the efficacy of ionic and non-ionic-based contrast media ( study) and the combinatorial effect of chitosan-based endo-radiopaque solution (CERS) ( study) for visualization of the root canal anatomy.

Materials And Methods: o study (120 teeth): The root canal of maxillary premolars and molars ( group 1 and 2 respectively, = 60 each) were analyzed using 4 different contrast media (subgroups: Omnipaque 350, Iopamidol, Xenetix 350, and Urografin 76; = 15 each) in combination with 5.25% sodium hypochlorite (NaOCl). Read More

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----Evaluation of Design and Fabrication of Food-Grade Nanofibers from Chitosan-Gelatin for Nanoencapsulation of Stigmasterol Using the Electrospinning Method.

Adv Pharm Bull 2021 May 24;11(3):514-521. Epub 2020 Aug 24.

School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In this research, electrospinning method was employed to fabricate food-grade nanofibers (NFs) from chitosan-gelatin combination for stigmasterol encapsulation. The spinnability of mixed chitosan and gelatin solutions was investigated at different polymer ratios, and the physicochemical properties of the NFs were evaluated. The mixture solution of chitosan (1. Read More

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Integrated printed BDNF/collagen/chitosan scaffolds with low temperature extrusion 3D printer accelerated neural regeneration after spinal cord injury.

Regen Biomater 2021 Oct 12;8(6):rbab047. Epub 2021 Aug 12.

Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.

Recent studies have shown that 3D printed scaffolds integrated with growth factors can guide the growth of neurites and promote axon regeneration at the injury site. However, heat, organic solvents or cross-linking agents used in conventional 3D printing reduce the biological activity of growth factors. Low temperature 3D printing can incorporate growth factors into the scaffold and maintain their biological activity. Read More

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October 2021

Comparison between the effect of adding microhydroxyapatite and chitosan on surface roughness and Microhardness of resin modified and conventional glass ionomer cements.

J Clin Exp Dent 2021 Aug 1;13(8):e737-e744. Epub 2021 Aug 1.

Postgraduate Student, Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: This study aimed to compare the effect of chitosan (CH) and hydroxyapatite (HP) on the surface roughness and microhardness of a conventional glass ionomer cement (CGIC) and a resin modified glass ionomer cement (RMGIC).

Material And Methods: 60 disk-shaped specimens (2mm x 6mm) were prepared in 6 groups; group I: CGIC, group II: RMGIC, group III: CGIC + 15% volume CH solution in liquid, group IV: CGIC +10% weight micro-HP in powder, group V: RMGIC + 15% volume CH, group VI: RMGIC + 10% weight micro-HP. After storage in deionized water at room temperature for 24 hours, the surface roughness and microhardness of the specimens were measured using a surface profilometer and Vickers microhardness (VHN) tester, respectively. Read More

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With Chitosan and PLGA as the Delivery Vehicle, Oxidoreductase-Based DNA Vaccines Decrease Parasite Burdens in Mice.

Front Immunol 2021 27;12:726615. Epub 2021 Aug 27.

Ministry of Education (MOE) Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

() is an intracellular parasitic protozoan that can cause serious public health problems. However, there is no effectively preventive or therapeutic strategy available for human and animals. In the present study, we developed a DNA vaccine encoding oxidoreductase from short-chain dehydrogenase/reductase family (TgSDRO-pVAX1) and then entrapped in chitosan and poly lactic-co-glycolic acid (PLGA) to improve the efficacy. Read More

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Design and Optimization of New Enteric Nanoparticles of Ceftriaxone for Oral Delivery: In vitro and in vivo Assessments.

Int J Nanomedicine 2021 28;16:5937-5953. Epub 2021 Aug 28.

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Purpose: Development of new strategies for oral delivery of existing antibiotics administered exclusively through intravenous route is one of the global priorities of pharmaceutical research. The encapsulation of these active pharmaceutical agents within nanosized natural products offers several traits due to their tunable surface properties. Ceftriaxone (CTX) is an injectable, third-generation cephalosporin that suffers poor oral bioavailability. Read More

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Understanding the Effect of Conformational Rigidity on Rheological Behavior and Formation of Polysaccharide-Based Hybrid Hydrogels.

Biomacromolecules 2021 Sep 16;22(9):4016-4026. Epub 2021 Aug 16.

Research Center for High Performance Polymer and Composite Systems (CREPEC), Department of Chemical Engineering, Polytechnique Montréal, Montréal, Québec H3C 3A7, Canada.

The importance of conformational rigidity on macroscopic rheological properties was revealed using two model polysaccharides, namely, xanthan gum and hyaluronic acid. Xanthan gum has a rigid tertiary conformation due to its ordered double-helical structure, and the interactions between the tertiary structures result in the formation of a network/quaternary structure. In comparison, hyaluronic acid possesses a relatively flexible tertiary conformation due to its secondary random coil structure. Read More

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September 2021