125 results match your criteria children covid-19-associated


Hospitalization of Adolescents Aged 12-17 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 1, 2020-April 24, 2021.

MMWR Morb Mortal Wkly Rep 2021 Jun 11;70(23):851-857. Epub 2021 Jun 11.

Most COVID-19-associated hospitalizations occur in older adults, but severe disease that requires hospitalization occurs in all age groups, including adolescents aged 12-17 years (1). On May 10, 2021, the Food and Drug Administration expanded the Emergency Use Authorization for Pfizer-BioNTech COVID-19 vaccine to include persons aged 12-15 years, and CDC's Advisory Committee on Immunization Practices recommended it for this age group on May 12, 2021.* Before that time, COVID-19 vaccines had been available only to persons aged ≥16 years. Read More

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Immune mediating molecules and pathogenesis of COVID-19-associated neurological disease.

Microb Pathog 2021 Jun 4;158:105023. Epub 2021 Jun 4.

Department of Biochemistry, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, 282001, India.

Background: Long period of SARS-CoV-2 infection has been associated with psychiatric and cognitive disorders in adolescents and children. SARS-CoV-2 remains dormant in the CNS leading to neurological complications. The wide expression of ACE2 in the brain raises concern for its involvement in SARS-CoV-2 infection. Read More

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A worldwide perspective on COVID-19 and diabetes management in 22,820 children from the SWEET project: diabetic ketoacidosis rates increase and glycemic control is maintained.

Diabetes Technol Ther 2021 Jun 4. Epub 2021 Jun 4.

University Medical Centre Ljubljana, 14Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, Ljubljana, Slovenia;

Aims: To investigate the short-term effects of the first wave of COVID-19 on clinical parameters in children with type 1 diabetes (T1D) from 82 worldwide centres participating in the SWEET registry.

Methods: Aggregated data per person with T1D ≤ 21 years of age were compared between May/June 2020 (first wave), August/September 2020 (after wave) and the same periods in 2019. Hierarchic linear and logistic regression models were applied. Read More

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Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease.

BMC Med Genomics 2021 05 24;14(1):138. Epub 2021 May 24.

Department of Surgery, University of California San Diego, La Jolla, CA, USA.

Background: Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes.

Methods: Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2.

Results: Extremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins. Read More

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COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) presenting as appendicitis with shock.

J Pediatr Surg Case Rep 2021 Aug 19;71:101913. Epub 2021 May 19.

Division of General and Thoracic Pediatric Surgery, USA.

Multisystem inflammatory syndrome in children (MIS-C) is an identified complication of the COVID-19 infection. A common presentation of both COVID-19 and MIS-C is acute abdominal pain, sometimes mimicking appendicitis. We report two cases of patients initially diagnosed with appendicitis who either presented with or developed signs of shock and were found to have MIS-C. Read More

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Successful ECMO therapy in a child with COVID-19-associated ARDS and acute lymphoblastic leukemia.

Pediatr Blood Cancer 2021 May 22:e29100. Epub 2021 May 22.

Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.

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[Influence of coronavirus disease 2019 on the nervous system of children].

Zhongguo Dang Dai Er Ke Za Zhi 2021 May;23(5):530-535

Department of Neonatology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and can occur at any age, including children. Children with COVID-19 can develop the clinical symptoms of multiple systems, among which symptoms of the nervous system have been reported increasingly, and thus it is particularly important to understand COVID-19-associated neurological damage in children. This article reviews the mechanisms and types of COVID-19-associated neurological damage in children. Read More

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[COVID-19 associated Kawasaki-like multisystem inflammatory syndrome in an adult].

Rev Esp Anestesiol Reanim (Engl Ed) 2020 Dec 26. Epub 2020 Dec 26.

Professor of Higher education, Department of Anesthesia and Intensive Care Medicine, Cadi Ayyad University, Faculty of Medicine and Pharmacy of Marrakech, Morocco.

Recently, few reports have described a serious condition linked to SARS-CoV-2 that mimics Kawasaki disease called Multisystem inflammatory syndrome, especially in children (MIS-C) and young adults. In this work, we report on a severe form of MIS in a young female adult previously infected by SARS-CoV2. She was treated by plasmapheresis with albumin and steroids, however outcome was fatal. Read More

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December 2020

First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome.

Pediatr Infect Dis J 2021 07;40(7):e274-e276

Health Sciences Graduate Program, Federal University of Sergipe.

Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurologic complications are still poorly understood. Cases of Guillain-Barré Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). Read More

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Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).

Front Immunol 2021 26;12:653786. Epub 2021 Apr 26.

Neurosurgery Service, Complejo Hospitalario Metropolitano, CSS, Panama City, Panama.

Introduction: Although acute transverse myelitis (ATM) is a rare neurological condition (1.34-4.6 cases per million/year) COVID-19-associated ATM cases have occurred during the pandemic. Read More

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Discrepancies in the clinical and radiological profiles of COVID-19: A case-based discussion and review of literature.

World J Radiol 2021 Apr;13(4):75-93

Department of Medicine & Endocrinology, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom.

The current gold standard for the diagnosis of coronavirus disease-19 (COVID-19) is a positive reverse transcriptase polymerase chain reaction (RT-PCR) test, on the background of clinical suspicion. However, RT-PCR has its limitations; this includes issues of low sensitivity, sampling errors and appropriate timing of specimen collection. As pulmonary involvement is the most common manifestation of severe COVID-19, early and appropriate lung imaging is important to aid diagnosis. Read More

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How we approach thrombosis risk in children with COVID-19 infection and MIS-C.

Pediatr Blood Cancer 2021 07 6;68(7):e29049. Epub 2021 May 6.

Division of Clinical Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Thrombosis within the microvasculature and medium to large vessels is a serious and common complication among critically ill individuals with coronavirus disease 2019 (COVID-19). While children are markedly less likely to develop severe disease than adults, they remain at risk for thrombosis during acute infection and with the post-acute inflammatory illness termed multisystem inflammatory syndrome in children. Significant knowledge deficits in understanding COVID-19-associated coagulopathy and thrombotic risk pose clinical challenges for pediatric providers who must incorporate expert opinion and personal experience to manage individual patients. Read More

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Neurological Manifestations of COVID-19 Associated Multi-system Inflammatory Syndrome in Children: A Systematic Review and Meta-analysis.

J Nepal Health Res Counc 2021 Apr 23;19(1):10-18. Epub 2021 Apr 23.

Department of Neurology, University Medicine Associates/ University Health System/ University of Texas Health, San Antonio, Texas, USA.

Background: Children comprise only 1-5% of COVID-19 cases. Recent studies have shown that COVID-19 associated multisystem inflammatory syndrome in children (MIS-C) can present with neurological signs and symptoms. In this systematic review and meta-analysis, we have reviewed neurological involvement in these patients. Read More

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Impact of New Clinical Policies during the COVID-19 Pandemic on Clinical Incidents and Complaints at a UK Teaching Hospital.

Int J Environ Res Public Health 2021 04 9;18(8). Epub 2021 Apr 9.

Division of Family Health, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK.

Background: To investigate any associations between new clinical policies implemented because of the COVID-19 pandemic and harm to patients.

Methods: Retrospective data collection of incidents and complaints reported through Datix, and the Patient Advice and Liaison Service (PALS), respectively. The setting was the Family Health division in a University teaching hospital in the UK. Read More

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MR Imaging Findings in a Neonate With COVID -19-Associated Encephalitis.

Pediatr Neurol 2021 06 9;119:48-49. Epub 2021 Mar 9.

Pediatric Neuroradiologist, Department of Radiology, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana. Electronic address:

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A Peer-to-Peer Live-Streaming Intervention for Children During COVID-19 Homeschooling to Promote Physical Activity and Reduce Anxiety and Eye Strain: Cluster Randomized Controlled Trial.

J Med Internet Res 2021 04 30;23(4):e24316. Epub 2021 Apr 30.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Background: The COVID-19 pandemic has led to worldwide school closures, with millions of children confined to online learning at home. As a result, children may be susceptible to anxiety and digital eye strain, highlighting a need for population interventions.

Objective: The objective of our study was to investigate whether a digital behavior change intervention aimed at promoting physical activity could reduce children's anxiety and digital eye strain while undergoing prolonged homeschooling during the COVID-19 pandemic. Read More

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Rationales and uncertainties for aspirin use in COVID-19: a narrative review.

Fam Med Community Health 2021 04;9(2)

Department of Family Medicine, Suez Canal University Faculty of Medicine, Ismailia, Egypt.

Objectives: To review the pathophysiology of COVID-19 disease, potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with COVID-19.

Design: Narrative review.

Setting: The online databases PubMed, OVID Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January 2021. Read More

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Management of COVID-19-associated multisystem inflammatory syndrome in children: A comprehensive literature review.

Prog Pediatr Cardiol 2021 Apr 9:101381. Epub 2021 Apr 9.

Department of Pediatrics, McMaster Children's Hospital, Hamilton, ON, Canada.

Introduction: The prevalence and severity of COVID-19 is greatly reduced in children, yet some pediatric patients develop a syndrome resembling Kawasaki Disease (KD), termed Multisystem Inflammatory Syndrome in Children (MIS-C). With an estimated incidence of 2/100,000 children, MIS-C is relatively rare, but can be fatal. Clinical features can include fever, hyperinflammatory state, gastrointestinal symptoms, myocardial dysfunction, and shock. Read More

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COVID-19-associated inflammatory syndrome in an adult woman with unexplained multiple organ failure: staying vigilant for COVID-19 complications as the pandemic surges.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

Since the emergence of SARS-CoV-2, clinicians have been challenged with a wide spectrum of disease severity. One of the serious complications associated with the virus is multisystem inflammatory syndrome in children (MIS-C). It is characterised by inflammation leading to organ damage, in the setting of positive SARS-CoV-2 infection. Read More

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Characterisation of cardiac pathology in 23 autopsies of lethal COVID-19.

J Pathol Clin Res 2021 07 9;7(4):326-337. Epub 2021 Apr 9.

Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

While coronavirus disease 2019 (COVID-19) primarily affects the respiratory tract, pathophysiological changes of the cardiovascular system remain to be elucidated. We performed a retrospective cardiopathological analysis of the heart and vasculature from 23 autopsies of COVID-19 patients, comparing the findings with control tissue. Myocardium from autopsies of COVID-19 patients was categorised into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive (n = 14) or negative (n = 9) based on the presence of viral RNA as determined by reverse transcriptase polymerase chain reaction (RT-PCR). Read More

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Utility of CDC Screening Guidelines and Autopsy Findings in Identifying Decedents Who Die of SARS-CoV-2 Infection.

Am J Forensic Med Pathol 2021 Jun;42(2):118-120

From the Department of Pathology, University of Michigan, Ann Arbor, MI.

Abstract: We assess the utility of a Centers for Disease Control and Prevention (CDC) guidelines-based coronavirus disease 2019 (COVID-19) screening checklist for postmortem severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surveillance, detailing the relationship between the histologic findings at autopsy and attribution of death to COVID-19.SARS-CoV-2 nasopharyngeal swabs were collected at the time of autopsy in all "checklist-positive" decedents. Additional "checklist-negative" decedents were randomly tested daily. Read More

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[New coronavirus infection (COVID-19) associated with kidney infarction in a seventeen-year-old child].

Urologiia 2021 Mar(1):84-88

Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, St. Petersburg, Russia.

In December 2019, a new SARS-CoV-2 virus, called COVID-19, was identified in the Wuhan province of China, the spread of which determined the development of a pandemic. The lack of publications with evidence-based clinical studies dictate the necessity to cover various, including rare, pathological effects of the virus on the human body and the subsequent effect on it. Nowadays, there is already evidence that the SARS-CoV-2 virus causes specific damage to the vessels (endothelium), myocardium, and kidneys. Read More

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COVID-19-Associated Pulmonary Embolism in Pediatric Patients.

Hosp Pediatr 2021 06 30;11(6):e90-e94. Epub 2021 Mar 30.

Pediatric Critical Care, Department of Pediatrics, College of Medicine, Penn State Health Children's Hospital, Hershey, Pennsylvania

Background And Objectives: Coronavirus disease 2019 (COVID-19) is associated with pulmonary embolism in adults, but the clinical circumstances surrounding its presence are unknown in children. The objectives of this study are to determine the prevalence of pulmonary embolism in pediatric subjects with COVID-19, evaluate patient characteristics, and describe treatments applied.

Methods: We performed a retrospective cohort study using TriNetX electronic health record data of subjects aged <18 years who were diagnosed with COVID-19 infection (, code U07. Read More

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Presumptive Neonatal Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019.

Am J Perinatol 2021 05 23;38(6):632-636. Epub 2021 Mar 23.

Department of Pediatrics, Rocky Mountain Hospital for Children at Presbyterian/St. Luke, HealthONE, Denver, Colorado.

Objective: The study aimed to alert the neonatal community to the possibility of multisystem inflammatory syndrome in children (MIS-C) like disease in critically ill neonates born to mothers with coronavirus disease 2019 (COVID-19).

Study Design: Diagnosis of MIS-C like disease was pursued after echocardiography showed severely depressed ventricular function and pathological coronary artery dilation in the setting of medically refractory multisystem organ failure and maternal COVID-19 infection. The neonate did not respond to standard medical therapy, and there was no alternative disease that could explain the clinical course. Read More

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The impact of contact tracing and household bubbles on deconfinement strategies for COVID-19.

Nat Commun 2021 03 9;12(1):1524. Epub 2021 Mar 9.

Centre for Health Economic Research and Modelling Infectious Diseases, University of Antwerp, Antwerp, Belgium.

The COVID-19 pandemic caused many governments to impose policies restricting social interactions. A controlled and persistent release of lockdown measures covers many potential strategies and is subject to extensive scenario analyses. Here, we use an individual-based model (STRIDE) to simulate interactions between 11 million inhabitants of Belgium at different levels including extended household settings, i. Read More

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COVID-19-associated multisystem inflammatory syndrome in children presenting uniquely with sinus node dysfunction in the setting of shock.

Cardiol Young 2021 Mar 22:1-3. Epub 2021 Mar 22.

Department of Pediatric Critical Care Medicine, INOVA Fairfax Children's Hospital, 3300 Gallows Road, Falls Church, VA22042, USA.

SARS-CoV-2, which causes the disease COVID-19, generally has a mild disease course in children. However, a severe post-infectious inflammatory process known as multisystem inflammatory syndrome in children has been observed in association with COVID-19. This inflammatory process is a result of an abnormal immune response with similar clinical features to Kawasaki disease. Read More

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Racial and Ethnic Disparities in COVID-19 Incidence by Age, Sex, and Period Among Persons Aged <25 Years - 16 U.S. Jurisdictions, January 1-December 31, 2020.

MMWR Morb Mortal Wkly Rep 2021 Mar 19;70(11):382-388. Epub 2021 Mar 19.

The COVID-19 pandemic has disproportionately affected racial and ethnic minority groups in the United States. Whereas racial and ethnic disparities in severe COVID-19-associated outcomes, including mortality, have been documented (1-3), less is known about population-based disparities in infection with SARS-CoV-2, the virus that causes COVID-19. In addition, although persons aged <30 years account for approximately one third of reported infections, there is limited information on racial and ethnic disparities in infection among young persons over time and by sex and age. Read More

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Brain death in a child as a result of COVID-19-associated acute stroke: The first case.

J Paediatr Child Health 2021 Mar 12. Epub 2021 Mar 12.

Pediatric Intensive Care Department, Saglik Bilimleri Üniversitesi Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

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Targeting mesenchymal stem cell therapy for severe pneumonia patients.

World J Stem Cells 2021 Feb;13(2):139-154

Research and Development, Help Therapeutics Co. Ltd., Nanjing 211100, Jiangsu Province, China.

Pneumonia is the inflammation of the lungs and it is the world's leading cause of death for children under 5 years of age. The latest coronavirus disease 2019 (COVID-19) virus is a prominent culprit to severe pneumonia. With the pandemic running rampant for the past year, more than 1590000 deaths has occurred worldwide up to December 2020 and are substantially attributable to severe pneumonia and induced cytokine storm. Read More

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February 2021

A novel multi-omics-based highly accurate prediction of symptoms, comorbid conditions, and possible long-term complications of COVID-19.

Mol Omics 2021 04 8;17(2):317-337. Epub 2021 Mar 8.

Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India.

Comprehensive clinical pictures, comorbid conditions, and long-term complications of COVID-19 are still unknown. Recently, using a multi-omics-based strategy, we predicted potential drugs for COVID-19 with ∼70% accuracy. Herein, using a novel multi-omics-based bioinformatic approach and three ways of analysis, we identified the symptoms, comorbid conditions, and short-, mid-, and possible long-term complications of COVID-19 with >90% precision including 27 parent, 170 child, and 403 specific conditions. Read More

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