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Diagnostic accuracy of stroke volume variation for predicting fluid responsiveness in children undergoing cardiac surgery: a systematic review and meta-analysis.

Paediatr Anaesth 2021 Apr 21. Epub 2021 Apr 21.

Department of Intensive Care Unit, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Dong Lake District, Nanchang, 330000, Jiangxi Province, China.

Background: Stroke volume variation (SVV) appears to be reliable for predicting fluid responsiveness (FR) in adults and its predictive value in paediatric patients has been recently reported. However, its predictive value in children undergoing cardiac surgery is unclear.

Methods: A review and meta-analysis were performed on the diagnostic utility of SVV for predicting FR in children undergoing cardiac surgery. Read More

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Asthma Medication Regimens in Pregnancy: Longitudinal Changes in Asthma Status.

Am J Perinatol 2021 Apr 21. Epub 2021 Apr 21.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Objective:  This study aimed to assess the impact of common asthma medication regimens on asthma symptoms, exacerbations, lung function, and inflammation during pregnancy.

Study Design:  A total of 311 women with asthma were enrolled in a prospective pregnancy cohort. Asthma medication regimen was categorized into short-acting β agonist (SABA) alone, SABA + inhaled corticosteroid (ICS), SABA + ICS + long-acting β agonist (LABA), and no asthma medications (reference). Read More

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Data Quality of Chemotherapy-Induced Nausea and Vomiting Documentation.

Appl Clin Inform 2021 Mar 21;12(2):320-328. Epub 2021 Apr 21.

School of Nursing, Columbia University, New York, New York, United States.

Objective:  The objective of the study was to characterize the completeness and concordance of the electronic health record (EHR) documentation of cancer symptoms among multidisciplinary health care professionals.

Methods:  We examined the EHRs of children, adolescents, and young adults who received highly emetogenic chemotherapy and characterized the completeness and concordance of chemotherapy-induced nausea and vomiting (CINV) documentation by clinician type and by the International Classification of Diseases 10th Revision (ICD-10) coding choice.

Results:  The EHRs of 127 patients, comprising 870 patient notes, were abstracted and reviewed. Read More

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[Preventive Check-ups and Routine Vaccinations in Pre-school Children - An Analysis of Mutual Participation Behaviour, Taking into Account Living Conditions].

Authors:
Heribert Stich

Gesundheitswesen 2021 Apr 21. Epub 2021 Apr 21.

Landratsamt Landshut, Abteilung 7 Gesundheitsamt.

Aim Of The Study: Preventive screenings and vaccinations are essential health protecting measures in childhood, but no quantitative data on mutual distribution patterns of acceptance are available. The aim of the study was the quantification of distribution patterns and the identification of associations between preventive check-ups and defined routine vaccinations for children starting school, taking into account the social environment.

Methods: The 2015 school entrance health checks included documented preventive screenings and routine vaccinations on a city-wide basis. Read More

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[The Impact of Parenthood, Support, and Short-Term Contracts on Work-Family Conflict of Female and Male Residents' Career].

Gesundheitswesen 2021 Apr 21. Epub 2021 Apr 21.

Institut für Biochemie und Molekulare Zellbiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

Background: Work factors and work-family interference play an important role in physicians leaving clinical practice.

Objectives: The purpose of this study was to examine residents' work-family conflict and family-work conflict in association with parental status, perceived support, and short-term contracts.

Material And Methods: Data acquisition was carried out within the multi-centric and prospective "KarMed" study in Germany at the end of the postgraduate training in 2016 (N=433). Read More

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Atopic Dermatitis and Infertility: A Nationwide Retrospective Cohort Study.

Dermatology 2021 Apr 21:1-7. Epub 2021 Apr 21.

Siaal Research Center for Family Medicine and Primary Care, Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Given that common pathophysiological factors play a role in atopic dermatitis (AD) and infertility, we assumed that the 2 conditions might demonstrate an epidemiological association. Large-scale epidemiological data on this topic are lacking.

Objectives: The aim of this work was to evaluate the potential association between AD and infertility in a broad community-based population. Read More

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Probiotic Potential of Lactobacillus Species in Allergic Rhinitis.

Int Arch Allergy Immunol 2021 Apr 21:1-12. Epub 2021 Apr 21.

Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.

Since conventional allergy medication for asthma or allergic rhinitis (AR) can cause side effects which limit the patients' quality of life, it is of interest to find other forms of therapy. In particular, probiotic bacteria, such as Lactobacillus species, have shown anti-allergic effects in various mouse and human studies. For instance, administration of some Lactobacillus species resulted in nasal and ocular symptom relief and improvement of quality of life in children and adults suffering from rhinitis. Read More

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Development of detailed pediatric eye models for lens dose calculations.

J Radiol Prot 2021 Apr 21. Epub 2021 Apr 21.

Department of Nuclear Engineering, Hanyang University, Seoul, Korea (the Republic of).

The International Commission on Radiological Protection (ICRP) recently reduced the dose limit for the eye lens for occupational exposure from 150 mSv per year to 20 mSv per year, as averaged over defined periods of 5 years, with no annual dose in a single year exceeding 50 mSv, emphasizing the importance of the accurate estimation of lens dose. In the present study, for more accurate lens dosimetry, detailed eye models were developed for children and adolescents (newborns and 1-, 5-, 10-, and 15-year-olds), which were then incorporated into the pediatric mesh-type reference computational phantoms (MRCPs) and used to calculate lens dose coefficients (DCs) for photon and electron exposures. Finally, the calculated values were compared with those calculated with the adult MRCPs in order to determine the age dependence of the lens DCs. Read More

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Influence of the COVID-19 epidemic on prevention and vaccination behaviors among Chinese children and adolescents: results from an online survey.

JMIR Public Health Surveill 2021 Apr 19. Epub 2021 Apr 19.

School of Public Health, Fudan University, Mailbox 250, 138# Yixueyuan Road, Xuhui District, Shanghai, CN.

Background: The COVID-19 epidemic and the related containment strategies may affect parental and pediatric health behaviors.

Objective: To assess the change in children and adolescents' prevention and vaccination behaviors amid China's COVID-19 epidemic.

Methods: We conducted a cross-sectional online survey in mid-March 2020 using proportional quota sampling in Wuhan (the epicenter) and Shanghai (a non-epicenter). Read More

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Examining the associations between oral health and social isolation: A cross-national comparative study between Japan and England.

Soc Sci Med 2021 Apr 18;277:113895. Epub 2021 Apr 18.

Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo Ward, Tokyo, 113-8510, Japan; Division for Regional Community Development, Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba Ward, Sendai City, Miyagi, 980-8574, Japan. Electronic address:

In Western countries, the most important part of the face in communication is the mouth, whereas it is the eyes in Asian countries; thus oral health could be more important in social interactions in Western countries. Our aim was to examine differences in the association between oral health status and social isolation among older people by comparing Japan and England. We used cross-sectional information obtained from adults aged 65+ in two ongoing prospective cohort studies: The Japan Gerontological Evaluation Study (JAGES, N = 120,195) and the English Longitudinal Study of Ageing (ELSA, N = 3,958). Read More

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'A sleeping volcano that could erupt sooner or later'. Lived experiences of women with multiple sclerosis during childbearing age and motherhood: A phenomenological qualitative study.

Mult Scler Relat Disord 2021 Apr 18;51:102938. Epub 2021 Apr 18.

National Centre for Diseases Prevention and Health Promotion, National Institute of Health, Rome, Italy.

Introduction: Multiple Sclerosis (MS) mainly involves women, impacting many aspects related to childbearing age and maternity. Women with MS can have healthy pregnancies and infants. Needs, challenges and concerns of women with MS should be considered in order to improve care pathway, ensuring a patient-centred approach. Read More

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3D analysis of facial morphology in Dutch children with cancer.

Comput Methods Programs Biomed 2021 Apr 9;205:106093. Epub 2021 Apr 9.

Department of Human Genetics, KU Leuven, Leuven, Belgium; Big Data Institute and Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.

Background and Objective; Genetic risk factors for childhood cancer may also influence facial morphology. 3D photography can be used in the recognition of differences in face shape among individuals. In previous research, 3D facial photography was used to identify increased facial asymmetry and greater deviation from normal facial morphology in a group of individuals with distinct morphological features who had childhood cancer compared to healthy controls. Read More

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Biomarker support for ADHD diagnosis based on Event Related Potentials and scores from an attention test.

Psychiatry Res 2021 Mar 19;300:113879. Epub 2021 Mar 19.

Neuropsychiatric Team, Åsebråten Clinic, Østfold Hospital Trust, Fredrikstad, Norway; Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; Institute of Psychology, Norwegian Institute of Science and Technology (NTNU), Trondheim, Norway. Electronic address:

ADHD is a heterogeneous neurodevelopmental disorder associated with dysfunctions in several brain systems. Objective markers of brain dysfunction for clinical assessment are lacking. Many studies applying electroencephalography (EEG) and neuropsychological tests find significant differences between ADHD and controls, but the effect sizes (ES) are often too small for diagnostic purposes. Read More

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Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project.

J Hazard Mater 2021 Jan 20;416:125185. Epub 2021 Jan 20.

Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain. Electronic address:

Background: Perfluoroalkyl substances (PFASs) have been related to neurodevelopmental toxicity in animals. However, human studies are inconclusive.

Objectives: To evaluate the association between prenatal PFAS exposure and neuropsychological development during childhood. Read More

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January 2021

The Broad Autism Phenotype Questionnaire (BAPQ): Strengths, weaknesses and future improvements in Chinese version.

Asian J Psychiatr 2021 Apr 6;60:102655. Epub 2021 Apr 6.

National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital, Central South University, Hunan Medical Center for Mental Health, Changsha, Hunan, China. Electronic address:

Broad Autism Phenotype (BAP) refers to a set of symptoms or personality traits which similar but not meet the diagnostic criteria for autism in relatives of individuals with Autism Spetrum Disorders (ASD).The Broad Autism Phenotype Questionnaire (BAPQ) is one of the new and widely used assessment tools to measure BAP.It has been translated into 8 different languages and some versions were investigated the psychometric properties but not including Chinese version (BAPQ-C). Read More

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Home education for children with autism spectrum disorder during the COVID-19 pandemic: Indonesian mothers experience.

Res Dev Disabil 2021 Apr 5;114:103954. Epub 2021 Apr 5.

Department of Counseling, Faculty of Tarbiyah and Teaching, Universitas Islam Negeri Sumatera Utara, Indonesia. Electronic address:

This study aimed to explore the experiences of mothers and efforts in implementing home education for children with autism, during the COVID-19 pandemic in Indonesia. Five mothers were recruited as participants and interviewed online, as the data obtained were examined through the use of thematic analysis. Also, three main themes were shown, (1) Mothers' experience in implementing home education, as regards adaptability and burden of caregiving, (2) The constraints in home education implementation, as regards maladaptive behaviours of ASD and emerging negative emotions, (3) The efforts to alleviate barriers, as regards problem-focused and religious copings. Read More

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Rapid pH-responsive self-disintegrating nanoassemblies balance tumor accumulation and penetration for enhanced anti-breast cancer therapy.

Acta Biomater 2021 Apr 18. Epub 2021 Apr 18.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

The dilemma of tumor accumulation and deep penetration has always been a barrier in antitumor therapy. Stimuli-responsive size changeable drug delivery systems provide possible solutions. Nevertheless, the low size-shrinkage efficiency limited the antitumor effects. Read More

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Association between breastfeeding during infancy and white matter microstructure in early childhood.

Neuroimage 2021 Apr 18:118084. Epub 2021 Apr 18.

Alberta Children's Hospital Research Institute; Hotchkiss Brain Institute, Departments of; Radiology. Electronic address:

Introduction: Associations between breastfeeding and brain development, in the context of child, perinatal, and sociodemographic variables, remain unclear. This study investigated whether exclusive breastfeeding for the first 6 months and total duration of breastfeeding were associated with brain white matter microstructure in young children.

Methods: This study included 85 typically developing children (42 males) born to 83 mothers that were predominantly white, highly educated, and in high incomes households. Read More

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Exploring caregiver burden and financial toxicity in caregivers of tracheostomy-dependent children.

Int J Pediatr Otorhinolaryngol 2021 Apr 18;145:110713. Epub 2021 Apr 18.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objective: Measure the prevalence of and factors associated with financial toxicity (FT) and caregiver burden in families of tracheostomy-dependent children. FT is defined as the objective and subjective patient-level impact of the costs of medical care and has been associated with lower quality of life, decreased compliance with treatment, and increased mortality.

Methods: A medical record review was performed on all children with a tracheostomy tube placed from 2009 to 2018 at a tertiary children's hospital to identify and include children younger than 18 years old, not deceased, and not decannulated at the time of review. Read More

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Better late than never? Maternal biopsychosocial predictors of late follow-up from new Jersey's early hearing detection and intervention program.

Int J Pediatr Otorhinolaryngol 2021 Apr 18;145:110708. Epub 2021 Apr 18.

Montclair State University, USA.

Objectives: Early hearing detection and intervention programs are designed to mitigate consequences of hearing loss in infants. Most research examining compliance with program protocols has examined factors related to being lost to follow-up. Another group that warrants study are babies who return for follow-up outside the timelines recommended by public health organizations. Read More

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Airway basal stem cells generate distinct subpopulations of PNECs.

Cell Rep 2021 Apr;35(3):109011

Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

Pulmonary neuroendocrine cells (PNECs) have crucial roles in airway physiology and immunity by producing bioactive amines and neuropeptides (NPs). A variety of human diseases exhibit PNEC hyperplasia. Given accumulated evidence that PNECs represent a heterogenous population of cells, we investigate how PNECs differ, whether the heterogeneity is similarly present in mouse and human cells, and whether specific disease involves discrete PNECs. Read More

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Continuous reference intervals for 19 endocrine, fertility, and immunochemical markers in the CALIPER cohort of healthy children and adolescents.

Clin Biochem 2021 Apr 18. Epub 2021 Apr 18.

CALIPER Program, Pediatric Laboratory Medicine & Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

Background: Reference intervals are traditionally partitioned into discrete ranges by major covariates such as age and sex. However, discrete reference intervals often oversimplify the complex relationship between analyte concentration and age. Continuous reference intervals have been suggested to more accurately represent this complex relationship, particularly in pediatrics. Read More

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Modeling temporal dynamics of face processing in youth and adults.

Soc Neurosci 2021 Apr 21. Epub 2021 Apr 21.

Department of Psychiatry and Behavioral Sciences, University of Washington, CHDD Box # 357920, Seattle, WA 98195.

A hierarchical model of temporal dynamics was examined in adults (=34) and youth (=46) across the stages of face processing during perception of static and dynamic faces. Three ERP components (P100, N170, N250) and spectral power in the mu range were extracted, corresponding with cognitive stages of face processing: low-level vision processing, structural encoding, higher-order processing, and action understanding. Youth and adults exhibited similar yet distinct patterns of hierarchical temporal dynamics such that earlier cognitive stages predicted later stages, directly and indirectly. Read More

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Imaging diagnosis and legal implications of brain injury in survivors following single intrauterine fetal demise from monochorionic twins - a review of the literature.

J Perinat Med 2021 Apr 22. Epub 2021 Apr 22.

Obstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Brain injury of the surviving twin from monochorionic pregnancies following intrauterine fetal demise during the second and third trimesters is a rare but severe complication. Monochorionicity and gestational age at the time of stillbirth seem to be decisive factors in terms of long-term neurologic outcome prediction for the survivor. Magnetic resonance imaging (MRI), diffusion weighted imaging (DWI) in particular, seem to bring the earliest and most accurate diagnosis. Read More

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Clinical characteristics and outcome of hospitalized children and adolescent patients with type 1 diabetes during the COVID-19 pandemic: data from a single center surveillance study in Egypt.

J Pediatr Endocrinol Metab 2021 Apr 22. Epub 2021 Apr 22.

Division of Pediatric and Adolescent Diabetes Unit (PADU), Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Objectives: COVID-19 pandemic significantly impacted the diagnosis of type 1 diabetes and its acute complications. Thus, the study aimed to evaluate the characteristics of pediatric patients with type 1 diabetes hospitalized during the first wave of the pandemic and the prevalence of new onset diabetes among patients with evidence of COVID-19 infection.

Methods: A single-center surveillance study included all patients with diabetes admitted to Children's Hospital, Ain Shams University, in Egypt between May to August 2020. Read More

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2D Gadolinium Oxide Nanoplates as T Magnetic Resonance Imaging Contrast Agents.

Adv Healthc Mater 2021 Apr 21:e2001780. Epub 2021 Apr 21.

Departments of Chemistry and Engineering, Brown University, Providence, RI, 02912, USA.

Millions of people a year receive magnetic resonance imaging (MRI) contrast agents for the diagnosis of conditions as diverse as fatty liver disease and cancer. Gadolinium chelates, which provide preferred T contrast, are the current standard but face an uncertain future due to increasing concerns about their nephrogenic toxicity as well as poor performance in high-field MRI scanners. Gadolinium-containing nanocrystals are interesting alternatives as they bypass the kidneys and can offer the possibility of both intracellular accumulation and active targeting. Read More

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Comprehensive investigation of sources of misclassification errors in routine HIV testing in Zimbabwe.

J Int AIDS Soc 2021 Apr;24(4):e25700

Department of Infectious Disease Epidemiology, Imperial College London School of Public Health, London, UK.

Introduction: Misclassification errors have been reported in rapid diagnostic HIV tests (RDTs) in sub-Saharan African countries. These errors can lead to missed opportunities for prevention-of-mother-to-child-transmission (PMTCT), early infant diagnosis and adult HIV-prevention, unnecessary lifelong antiretroviral treatment (ART) and wasted resources. Few national estimates or systematic quantifications of sources of errors have been produced. Read More

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Spanish version of Super Skills for Life in individual modality: Improvement of children's emotional well-being from a transdiagnostic approach.

J Clin Psychol 2021 Apr 21. Epub 2021 Apr 21.

Department of Health Psychology, Miguel Hernández University, Alicante, Spain.

Objective(s): This study analyzed the short-term effects of the Super Skills for Life (SSL) program in its individual format from the parents' perspective.

Methods: Parents of 70 Spanish children aged 8-11 years (M = 9.31; SD = 1. Read More

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Practice patterns of prenatal and perinatal testing in Canadian cytogenetics laboratories.

Prenat Diagn 2021 Apr 21. Epub 2021 Apr 21.

Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.

Objective: To survey patterns of practice in Canadian cytogenetics laboratories and evaluate whether newer technologies have influenced testing algorithms for the detection of common aneuploidies and other genomic imbalances in the prenatal and perinatal settings.

Methods: Cytogenetics laboratories across Canada were invited to participate in two patterns-of-practice surveys: one in 2016 and one in 2019. They were asked to identify the prenatal and perinatal specimen types tested at their facility and which testing methods were used for initial testing and for follow-up. Read More

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