282,611 results match your criteria childhood


Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood.

Acta Paediatr 2021 Sep 18. Epub 2021 Sep 18.

University of Iceland, Faculty of Medicine, Reykjavík, Iceland.

Aims: The prevalence of allergic diseases is high and increasing in many countries. The aim of this study was to describe the prevalence of allergic diseases and changes in clinical expression in a birth cohort followed for three decades.

Methods: We followed Icelandic citizens born in 1987 for allergic diseases when they were two, four, eight, 15, 21 and 29 years of age. Read More

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September 2021

Macroscopic characteristics of the native liver in children with MPV17-related mitochondrial DNA depletion syndrome: an indication for performing liver transplantation?

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.

Mitochondrial respiratory chain disorders (MRCDs) are rare conditions with various clinical manifestations that depend on the genetic type, with subsequent severity of the liver disease. Clinical presentations include acute liver failure or chronic liver failure with liver cirrhosis, which are cruelly progressive and fatal. We report six cases of LT for acute liver failure diagnosed pathogenic MPV17 variants. Read More

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September 2021

Thyroid dose estimates for the genome-wide association study of thyroid cancer in persons exposed in Belarus to 131I after the Chernobyl accident.

J Radiat Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan.

The Chernobyl accident on 26 April 1986 led to a sharp increase in thyroid cancer (TC) incidence in the individuals exposed to radiation in childhood. The major risk factor for TC was exposure to Iodine-131 (131I). Here, we estimated the thyroid doses due to 131I intake for 2041 participants of the genome-wide association study of TC in Belarusian people exposed to radioactive fallout from the Chernobyl accident. Read More

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September 2021

How much asparaginase is needed for optimal outcome in childhood acute lymphoblastic leukaemia? A systematic review.

Eur J Cancer 2021 Sep 15;157:238-249. Epub 2021 Sep 15.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

This review focuses on asparaginase, a key component of childhood acute lymphoblastic leukaemia (ALL) treatment since the 1970s. This review evaluates how much asparaginase is needed for optimal outcome in childhood ALL. We provide an overview of asparaginase dose intensity, i. Read More

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September 2021

Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Agency with the participation of the Food and Drug Administration.

Eur J Cancer 2021 Sep 15;157:198-213. Epub 2021 Sep 15.

Hospital for Sick Children, Toronto, Canada.

The first (2017) and sixth (2021) multistakeholder Paediatric Strategy Forums focused on anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies. ALK is an important oncogene and target in several paediatric tumours (anaplastic large cell lymphoma [ALCL], inflammatory myofibroblastic tumour [IMT], neuroblastoma and hemispheric gliomas in infants and young children) with unmet therapeutic needs. ALK tyrosine kinase inhibitors have been demonstrated to be active both in ALK fusion-kinase positive ALCL and IMT. Read More

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September 2021

Vastus lateralis muscle volume prediction in early-adolescent boys.

J Biomech 2021 Sep 6;128:110735. Epub 2021 Sep 6.

Department of Training and Movement Sciences, Humboldt-Universität zu Berlin, Berlin, Germany; Berlin School of Movement Science, Berlin, Germany. Electronic address:

The applicability of a simplified approach for muscle volume assessment, based on multiplying muscle length, maximum anatomical cross-sectional area (ACSA) and a muscle-specific shape factor, was investigated in the present study for the vastus lateralis muscle of early-adolescent boys. Muscle length, ACSA and volume were calculated from magnetic resonance image muscle reconstructions of early-adolescent athletes (n = 14) and untrained peers (n = 10). A cohort-specific shape factor was obtained from the ratio of the measured volume and the product of ACSA and muscle length, which did not differ significantly between trained and untrained adolescents despite significant differences in anthropometry and muscle dimensions. Read More

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September 2021

Anomalous self-experiences (ASE) in relation to clinical high risk for psychosis (CHRP), childhood trauma and general psychopathology among adolescent and young adult help seekers.

Schizophr Res 2021 Sep 15;237:182-189. Epub 2021 Sep 15.

Experimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, Warsaw, Poland. Electronic address:

Background: Anomalous self-experiences (ASE) are suggested as a phenotypic core feature of schizophrenia spectrum disorders and present in at risk samples as well. In our study, we investigated the relation between ASE and clinical high risk state for psychosis (CHRP) against the background of further influencing factors like childhood trauma and general psychopathology.

Methods: 126 help-seeking adolescents were included. Read More

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September 2021

Non-pharmacological Treatment for Children With Functional Constipation: A Systematic Review and Meta-analysis.

J Pediatr 2021 Sep 15. Epub 2021 Sep 15.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Gastroenterology and Nutrition, Amsterdam, The Netherlands.

Objective: To evaluate the effectiveness and safety of non-pharmacological interventions for the treatment of childhood functional constipation functional constipation.

Study Design: Randomized controlled trials (RCTs) evaluating non-pharmacological treatments in children with functional constipation which reported at least one outcome of the core outcome set for children with functional constipation.

Results: 52 RCTs were included with 4668 children, aged between 2 weeks and 18 years, of whom 47% were females. Read More

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September 2021

Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK.

J Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatrics, 2nd Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic.

Background: Inborn errors of immunity (IEI) are genetic disorders characterized by various degrees of immune dysregulation that can manifest as immune deficiency, autoimmunity or autoinflammation. The routine use of next-generation sequencing in the clinic has facilitated the identification of an ever-increasing number of IEI, revealing the roles of immunologically important genes in human pathologies. However, despite this progress, treatment is still extremely challenging. Read More

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September 2021

Noma: a neglected oro-facial childhood disease.

Lancet Child Adolesc Health 2021 Oct;5(10):685-686

School of Oral Health Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

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October 2021

Prednisolone for the first rhinovirus induced wheezing reduces use of respiratory medication.

Pediatr Allergy Immunol 2021 Sep 18. Epub 2021 Sep 18.

University of Turku, Faculty of Medicine, Pediatrics and Adolescent Medicine, Turku, Finland.

Rhinovirus-induced early wheezing has been recognized as a major risk factor for subsequent wheezing and childhood asthma. Synergistic risk factors include aeroallergen sensitization, high type 2 cytokine expression, Moraxella-dominant microbiota, rhinovirus C infection and risk genes (CDHR3 and polymorphism at 17q). Read More

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September 2021

Childhood Cancer Drugs in China: An Overview and Comparison of Regulatory Approvals in China and the United States.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China.

Different from less developed countries, 80% of children with cancers in the US are cured. Traditional chemotherapy drugs are the mainstay of therapies; new targeted medications have become available recently. Using publicly available data, we created a database of cancer drugs with paediatric malignancy indications approved by October 31, 2020 in China and the US. Read More

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September 2021

Change in Behavior Problems from Childhood Through Adolescence for Children with Fragile X Syndrome.

J Autism Dev Disord 2021 Sep 18. Epub 2021 Sep 18.

University of Kansas, Lawrence, KS, USA.

In this study, we examined trajectories of specific domains of behavior problems (i.e., attention problems, depression/anxiety, and aggressive behavior) from age 6 to 18 in a sample of 55 children with fragile X syndrome. Read More

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September 2021

Shared medical appointments for weight loss: a systematic review.

Fam Pract 2021 Sep 18. Epub 2021 Sep 18.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.

Purpose: Shared medical appointments (SMAs) may help mitigate some of the barriers for managing obesity in primary care. The primary aim of this systematic review was to measure the effect of weight loss SMAs.

Methods: Systematic searches using keywords and Medical Subject Headings for overweight, obesity, and SMAs were conducted in the CENTRAL, Medline Complete, PsycINFO, Scopus, CINAHL, EMBASE, and Web of Science databases with no date limits. Read More

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September 2021

Child safety programs for primary school children decrease the injury severity of dog bites.

Eur J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Department of Pediatric and Adolescent Surgery, Medical University of Graz, Auenbruggerplatz 34, 8036, Graz, Austria.

This study focuses on the impact of a prevention program regarding dog bites in children. As a consequence of our previous investigation in 2005, we have initiated a child safety program for primary school children starting January 2008 until present to teach children how to avoid dog attacks and how to behave in case of an attack. In our retrospective study, we analyzed all patients younger than 15 years presenting with dog-related injuries between 2014 and 2018. Read More

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September 2021

Maternal antibiotics exposure during pregnancy and the risk of acute lymphoblastic leukemia in childhood: a systematic review and meta-analysis.

Eur J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Department of Infectious Diseases, Zibo Central Hospital, Shandong, China.

Many epidemiological studies have assessed the association between maternal antibiotic exposure during pregnancy and childhood acute lymphoblastic leukemia (ALL), while reaching inconsistent conclusions. In order to clarify the association, the publications in English that provided information about maternal antibiotic exposure during pregnancy and ALL risk in offspring in the PubMed, Embase, and Web of Science databases were systematically reviewed and we performed a meta-analysis using the random-effect models. Results of pooled analysis showed that maternal antibiotic intake during pregnancy is not associated with childhood ALL risk (pooled odds ratio 1. Read More

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September 2021

Early childhood body mass index trajectory and overweight/obesity risk differed by maternal weight status.

Eur J Clin Nutr 2021 Sep 17. Epub 2021 Sep 17.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Objectives: To evaluate the associations of maternal prepregnancy body mass index (pp-BMI) and gestational weight gain (GWG) with the childhood BMI z-score (BMI-z) trajectories from birth to 2 years old and the risk of overweight/obesity (OWO) at 2 years of age.

Subjects/methods: Mother-child dyads (23,617) were involved in the analysis. They were followed up from early pregnancy to 2 years postpartum with their healthcare data recorded in the Wuhan Maternal and Child Health Management Information System (WMCHMIS). Read More

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September 2021

IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission.

Mol Psychiatry 2021 Sep 17. Epub 2021 Sep 17.

Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.

Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and childhood epilepsy; autism; and severe intellectual disability (ID). We used induced pluripotent stem cell (iPSC) technology to obtain hippocampal neurons to investigate the neuropathology of IQSEC2-mediated disease. The neurons were characterized at three-time points during differentiation to assess developmental progression. Read More

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September 2021

DNA-TG and risk of sinusoidal obstruction syndrome in childhood acute lymphoblastic leukemia.

Leukemia 2021 Sep 17. Epub 2021 Sep 17.

Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.

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September 2021

Transition of Care from Pediatric to Adult Care in Eosinophilic Esophagitis: Insights from a Patient Perspective Survey.

J Pediatr Gastroenterol Nutr 2021 Sep 17. Epub 2021 Sep 17.

Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Digestive Health Institute, Children's Hospital of Colorado Aurora, CO Trinity Partners, LLC, Waltham, MA Shire Human Genetic Therapies, Inc., a Takeda company, Cambridge, MA Takeda Pharmaceuticals USA, Inc., Lexington, MA The Department of Internal Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Abstract: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease. Patients with a childhood diagnosis require ongoing disease management in adulthood. However, knowledge of the patient experience during pediatric to adult healthcare transition is lacking. Read More

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September 2021

Longitudinal prospective study examining the effects of the timing of prenatal stress on infant and child regulatory functioning: the Michigan Prenatal Stress Study protocol.

BMJ Open 2021 Sep 17;11(9):e054964. Epub 2021 Sep 17.

Human Development and Family Studies, Michigan State University, East Lansing, Michigan, USA.

Introduction: A considerable literature implicates prenatal stress as a critical determinant of poor psychological functioning in childhood and beyond. However, knowledge about whether the timing of prenatal stress differentially influences the development of child outcomes, including psychopathology, is virtually unknown. The primary aim of our study is to examine how the timing of prenatal stress differentially affects early childhood regulatory functioning as a marker of psychopathology. Read More

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September 2021

Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma.

Cancer Res 2021 Sep 17. Epub 2021 Sep 17.

Endocrinology, Hospital for Sick Children

Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease. Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains highly favorable. Molecular characterization of PPTC has been lacking. Read More

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September 2021

Overview of Medical Evaluation of Unilateral and Bilateral Hearing Loss in Children.

Otolaryngol Clin North Am 2021 Sep 14. Epub 2021 Sep 14.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, 660 South Euclid Avenue, Campus Box 8115, St. Louis, MO 63110, USA. Electronic address:

Early identification, treatment, and medical evaluation of childhood hearing loss are essential to promoting language and social development, regardless of their age of presentation. Evaluation of hearing loss in children should prioritize reversible and treatable causes. Multiple algorithms have been established to address the changing prevalence of genetic or infectious contributions to hearing loss and include recommendations on laboratory testing, imaging, and genetic testing. Read More

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September 2021

Quality of life and related demographic factors in long-term survivors of childhood non-Hodgkin's lymphoma.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):882-888

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China (Zhu J, Email: cn).

Objectives: To evaluate the quality of life and related demographic factors in long-term survivors of childhood non-Hodgkin's lymphoma (NHL).

Methods: A retrospective analysis was performed on the medical and demographic data of the NHL patients who received treatment in the Sun Yat-sen University Cancer Center and achieved long-term survival at follow-up, with an age of <18 years at initial diagnosis and a present age of ≥18 years. A questionnaire survey was performed using 36-Item Short-Form Health Survey (SF-36) and the symptom subscale of the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30). Read More

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September 2021

Shaanxi Provincial Diagnosis and Treatment Center of Kawasaki Disease.

Authors:

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):867-876

Kawasaki disease is an acute, self-limited vascuitis that mainly occurs in children under 5 years of age. Intravenous immunoglobulin (IVIG) has become an effective treatment regimen, which can effectively reduce the incidence of cardiovascular complications. However, there has been no consensus or clinical guidelines for the application of IVIG in children with Kawasaki disease till now. Read More

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September 2021

Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016-2018: a multicenter, retrospective study.

BMC Pediatr 2021 Sep 17;21(1):409. Epub 2021 Sep 17.

Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.

Background: The prevalence of allergic diseases (ADs), such as asthma and allergic rhinitis (AR), is increasing worldwide in both adults and children. Although ADs are common and frequently coexist in outpatient care, city-level data regarding the characteristics of childhood AD remain limited in China. This study aimed to assess the profile and characteristics of ADs in the city of Shanghai. Read More

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September 2021

Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

University of Yamanashi, School of Medicine, Yamanashi, Japan.

Asparaginase therapy is a key component of chemotherapy for T-cell acute lymphoblastic leukemia (T-ALL) patients. Asparaginase depletes serum asparagine by deamination into aspartic acid. Normal hematopoietic cells can survive due to asparagine synthetase (ASNS) activity, while leukemia cells are supposed to undergo apoptosis due to silencing of the ASNS gene. Read More

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September 2021

Psychological and social risk factors associated with development of psychopathology, controlling for biological influence.

Curr Opin Psychiatry 2021 Sep 16. Epub 2021 Sep 16.

Department of neuroscience, Child and adolescent psychiatry, Uppsala University, Uppsala, Sweden Drs Johan Isaksson and Vendela Zetterqvist contributed equally to this study.

Purpose Of The Review: To evaluate and summarize recent research investigating psychological, social and environmental risk factors for development of psychopathology in childhood, while controlling for biological (genetic) influences by using a matched sibling, twin or adoptee design.

Recent Findings: Nineteen studies were included, of which eleven were longitudinal and eight were cohort studies. Included studies used adequate designs and statistical methods, controlled for unmeasured confounders and, in many cases, for other measured risk factors. Read More

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September 2021

Developmental Changes in Gaze Behavior and the Effects of Auditory Emotion Word Priming in Emotional Face Categorization.

Multisens Res 2021 Sep 16:1-21. Epub 2021 Sep 16.

Department of Developmental Psychology, Justus-Liebig-Universität Gießen, 35394 Giessen, Germany.

Social interactions often require the simultaneous processing of emotions from facial expressions and speech. However, the development of the gaze behavior used for emotion recognition, and the effects of speech perception on the visual encoding of facial expressions is less understood. We therefore conducted a word-primed face categorization experiment, where participants from multiple age groups (six-year-olds, 12-year-olds, and adults) categorized target facial expressions as positive or negative after priming with valence-congruent or -incongruent auditory emotion words, or no words at all. Read More

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September 2021