521,665 results match your criteria child clinical


Snow White and the Seven Dwarfs: a fairytale for endocrinologists.

Endocr Connect 2021 Apr 1. Epub 2021 Apr 1.

S Livadas, Endocrine Unit, Athens Medical Centre, Athens, 10563, Greece.

'Snow White and the Seven Dwarfs', a fairytale that is widely known across the Western world, was originally written by the Brothers Grimm, and published in 1812. Though each dwarf was first given an individual name in the 1912 Broadway play by the same title, in Walt Disney's 1937 film 'Snow White and the Seven Dwarfs', they were renamed, and their names have become household words. As it is well known, myths, fables, and fairytales, though appearing to be merely children's tales about made-up and magical beings and places, have, more often than not, originated from real facts. Read More

View Article and Full-Text PDF

Intrauterine administration of peripheral blood mononuclear cells activated by human chorionic gonadotropin in patients with repeated implantation failure: A meta-analysis.

J Reprod Immunol 2021 Apr 15;145:103323. Epub 2021 Apr 15.

Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu Jinjiang Hospital for Maternal and Child Health Care, Chengdu, China. Electronic address:

The purpose of this study was to assess whether intrauterine administration of peripheral blood mononuclear cells (PBMCs) activated by human chorionic gonadotropin (hCG) could improve the pregnancy and live birth rates in women with repeated implantation failure (RIF), and whether the parameters of co-culture of hCG and PBMCs would affect the clinical outcomes. Six databases (PubMed, Ovid, Medline, NCBI, Cqvip and Wanfang) were searched up to October 2020 by two independent reviewers. Seven studies were included according to specific inclusion and exclusion criteria. Read More

View Article and Full-Text PDF

The intergenerational interplay of adversity on salivary inflammation in young children and caregivers.

Psychoneuroendocrinology 2021 Apr 17;128:105222. Epub 2021 Apr 17.

Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, USA. Electronic address:

Systemic inflammation links exposure to early childhood adversity to later disease. The associations among adversity and disease risk might in part operate through poor oral hygiene and subsequent periodontal inflammation, which can be measured in saliva. Few studies, however, have examined the association between adversity and salivary inflammation in young children. Read More

View Article and Full-Text PDF

An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.

Eur J Med Chem 2021 Apr 7;219:113433. Epub 2021 Apr 7.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, West Donggang Road 199, Lanzhou, 730000, China. Electronic address:

Due to the threat of escalating multi-drug resistant gram-negative bacteria to human health and life, novel antimicrobial agents against gram-negative pathogens are urgently needed. As antimicrobial peptides are not prone to induce bacteria resistance, they are believed to be one kind of promising class of potential antimicrobial agent candidates to combat multi-drug resistant bacteria for long-term use. Jelleine-1, first isolated from the royal jelly of honeybees, is a typical amphiphilic antimicrobial peptide and shows broad antimicrobial spectrum and negligible toxicity. Read More

View Article and Full-Text PDF

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.

Mol Cell 2021 Apr 10. Epub 2021 Apr 10.

Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

Even though SYK and ZAP70 kinases share high sequence homology and serve analogous functions, their expression in B and T cells is strictly segregated throughout evolution. Here, we identified aberrant ZAP70 expression as a common feature in a broad range of B cell malignancies. We validated SYK as the kinase that sets the thresholds for negative selection of autoreactive and premalignant clones. Read More

View Article and Full-Text PDF

Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: a murine study.

J Perinat Med 2021 Apr 20. Epub 2021 Apr 20.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U. S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, USA.

Objectives: Preterm birth remains the leading cause of perinatal morbidity and mortality worldwide. Preterm birth is preceded by spontaneous preterm labor, which is commonly associated with sterile intra-amniotic inflammation; yet, no approved treatment exists for this clinical condition. Corticosteroids are the standard of care to improve neonatal outcomes in women at risk of preterm birth. Read More

View Article and Full-Text PDF

Toll-interacting protein polymorphisms in viral bronchiolitis outcomes.

Pediatr Int 2021 Apr 20. Epub 2021 Apr 20.

Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.

Background: Toll-interacting protein is a key factor in regulating innate immunity responses via gate-keeping Toll-like receptors. Genetic variance in innate immunity has been linked with susceptibility to infections. Children with viral bronchiolitis in infancy are at increased risk of later asthma. Read More

View Article and Full-Text PDF

Analysis of the expression changes of IL-17+ γδ T cells and Treg cells in bone marrow mesenchymal stem cells targeted therapy for allergic rhinitis.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):2858-2865

Department of Otorhinolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China; National Clinical Research Center for Child Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Objective: Bone marrow mesenchymal stem cells (BMSCs) have immunomodulatory and therapeutic effects on immune system diseases. This study intends to assess the regulatory effect of BMSC targeted therapy on the IL-17+ γδ T cells and Treg cells in allergic rhinitis (AR).

Materials And Methods: BALB/c mice were sensitized by ovalbumin (OVA), while BMSCs were injected intravenously before sensitization and followed by an analysis of nasal symptoms, inflammation, cytokines, and immunoglobulins. Read More

View Article and Full-Text PDF

Clinical application of flash spiral mode of high-pitch dual source CT in carotid, cardiac and cerebral vessels combined one-stop angiography.

Eur Rev Med Pharmacol Sci 2021 04;25(7):2852-2857

Department of Radiology, Rizhao People’s Hospital, Rizhao, Shandong, China.

Objective: This study aims to evaluate the clinical application value of flash spiral mode of high-pitch dual source CT in carotid, cardiac and cerebral vessels combined one-stop imaging.

Patients And Methods: A total of 100 consecutive patients were given carotid, cardiac and cerebral vessels combined one-stop imaging at flash spiral mode of high-pitch dual source CT. 27 patients received DSA examination of carotid and cerebral vessels, and 38 patients received digital subtraction angiography (DSA) examination of the coronary artery at the same time. Read More

View Article and Full-Text PDF

An Exploratory Study of Epigenetic Age in Preeclamptic and Normotensive Pregnancy Reveals Differences by Self-Reported Race but Not Pregnancy Outcome.

Reprod Sci 2021 Apr 20. Epub 2021 Apr 20.

Department of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.

Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. Chronological age and race are associated with preeclampsia, but the role of these factors is not entirely understood. We hypothesized that DNA methylation age, a measure of biological age, would be higher in individuals with preeclampsia than in individuals with normotensive pregnancy and that DNA methylation age would differ by race across pregnancy. Read More

View Article and Full-Text PDF

Retrospective Analysis of Clinical Characteristics and Neonatal Outcomes of Pregnant Women with SARS-COV-2 Infection.

Curr Med Sci 2021 Apr 20;41(2):306-311. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.

This retrospective study aimed to investigate the clinical characteristics and neonatal outcomes of pregnant women with SARS-COV-2 in Wuhan Children's Hospital and further suggested a possible management strategy for infected pregnant women under epidemic situation. In this study, 8 pregnant women with SARS-COV-2 who were admitted into Wuhan Children's Hospital, China from February 1, 2020 to March 30, 2020 and the clinical features, laboratory data, maternal and neonatal outcomes were analyzed. The mean age of the women at the time of admission was 30. Read More

View Article and Full-Text PDF

Optimal administration of bronchodilators with valved holding chambers in preschool children: a review of literature.

Eur J Pediatr 2021 Apr 20. Epub 2021 Apr 20.

Allergy Centre, Tampere University Hospital, Tampere, Finland.

Our aim was to synthesize the published literature on factors that potentially affect the delivery of bronchodilators using valved holding chambers (VHC) in preschool children. We also aimed to identify those attributes that are not yet incorporated or clearly stated in the guidelines and those topics that are still lacking sufficient data. There is strong evidence supporting several recommendations in current guidelines. Read More

View Article and Full-Text PDF

Folic Acid and Infant Allergy: Avoiding Rash Judgments.

J Nutr 2021 Apr 20. Epub 2021 Apr 20.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute for Child Health and Human Development, Bethesda, MD, USA.

View Article and Full-Text PDF

Moderate acute malnutrition prevention with a ready-to-use supplementary food in pre-school children from rural communities.

Gac Med Mex 2020 ;156(6):499-508

Global R&D Life Sciences, Nutrition Sciences, PepsiCo Inc.

Introduction: Child malnutrition in Mexico reaches a prevalence as high as 27.5 % in rural areas.

Objective: To assess the effectiveness of a ready-to-use supplementary food (RUSF) to correct mild acute malnutrition and prevent moderate acute malnutrition in preschool children from rural communities. Read More

View Article and Full-Text PDF
January 2020

Endometriosis in adolescent and young women.

Minerva Obstet Gynecol 2021 Apr 20. Epub 2021 Apr 20.

Shanghai Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China.

Endometriosis in adolescence represents a specific variant of the disease with its own characteristics and, in some cases, even a possibly different pathogenesis. It has its own clinical presentation, diagnostic and therapeutic modalities. The condition is not rare as once thought and certainly deserves attention in view of increasing evidence of its likely progressive nature. Read More

View Article and Full-Text PDF

Clinical management of hypertensive disorders in postpartum women. A narrative review.

Minerva Obstet Gynecol 2021 Apr 20. Epub 2021 Apr 20.

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

View Article and Full-Text PDF

Half of the children with overweight or obesity and attention-deficit/hyperactivity disorder reach normal weight with stimulants.

Acta Paediatr 2021 Apr 20. Epub 2021 Apr 20.

Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Aim: Treatment of childhood obesity is often insufficient and may be aggravated by high co-occurrence of attention-deficit/hyperactivity disorder (ADHD). We aimed to investigate whether children with overweight or obesity normalised in weight when receiving stimulant treatment for ADHD.

Methods: Growth data of 118 children were obtained from medical records at outpatient paediatric and children's psychiatric services in the Gothenburg area, Sweden. Read More

View Article and Full-Text PDF

Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease.

Proc Natl Acad Sci U S A 2021 Apr;118(15)

Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, 75015 Paris, France;

Human inborn errors of IFN-γ underlie mycobacterial disease, due to insufficient IFN-γ production by lymphoid cells, impaired myeloid cell responses to this cytokine, or both. We report four patients from two unrelated kindreds with intermittent monocytosis and mycobacterial disease, including bacillus Calmette-Guérin-osis and disseminated tuberculosis, and without any known inborn error of IFN-γ. The patients are homozygous for variants (p. Read More

View Article and Full-Text PDF

Long-term neurodevelopmental outcome after prenatal exposure to maternal hematological malignancies with or without cytotoxic treatment.

Child Neuropsychol 2021 Apr 20:1-12. Epub 2021 Apr 20.

Center for Gynecologic Oncology Amsterdam, the Netherlands Cancer Institute, Amsterdam, The Netherlands.

Data on the long-term neurodevelopmental outcomes of children exposed to hematological maternal cancer with or without treatment during pregnancy are lacking. A total of 57 children, of whom 33 males and 24 females, prenatally exposed to hematological malignancies and its treatment, were invited for neuropsychological and physical examinations at 18 months, 36 months, 6, 9, 12, 15 and 18 years of age. Oncological, obstetrical, neonatal and follow-up data of these children were collected. Read More

View Article and Full-Text PDF

Fear avoidance behavior in youth with poor recovery from concussion: measurement properties and correlates of a new scale.

Child Neuropsychol 2021 Apr 20:1-11. Epub 2021 Apr 20.

Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.

The objective of the current study was to develop a measure of fear avoidance behavior after concussion for youth and parent respondents and examine its basic psychometric properties and correlates. Children (N = 51) who were seen in a hospital concussion clinic after sustaining a concussion (M = 7.6 months, SD = 7. Read More

View Article and Full-Text PDF

The diagnostic value of intravoxel incoherent motion imaging in differentiating high-grade from low-grade gliomas: a systematic review and meta-analysis.

Br J Radiol 2021 May;94(1121):20201321

Department of Radiology, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objective: This meta-analysis was carried out for assessing the accuracy of intravoxel incoherent motion (IVIM) parameters true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) in differentiating low-grade gliomas (LGGs) from high-grade gliomas (HGGs).

Methods: Literatures concerning IVIM in the grading of brain gliomas published prior to October 20, 2020, searched in the Embase, PubMed, and Cochrane library. Use the quality assessment of diagnostic accuracy studies 2 (QUADAS 2) to evaluate the quality of studies. Read More

View Article and Full-Text PDF

A pregnant woman with acute abdomen.

Tidsskr Nor Laegeforen 2021 Apr 19;141(6). Epub 2021 Apr 19.

Background: Acute abdomen in pregnancy is challenging. The presentation of symptoms and available diagnostic tools are directed and complicated by the pregnancy. A rare cause of acute abdomen in pregnancy requiring immediate intervention is presented. Read More

View Article and Full-Text PDF

Appraisal of clinical practice guidelines for the evaluation and management of neck masses in children.

J Paediatr Child Health 2021 Apr 20. Epub 2021 Apr 20.

Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Aim: The purpose of this systematic review was to use the Appraisal of Guidelines for Research and Evaluation tool to assess the methodological quality of clinical practice guidelines (CPGs) for the workup and management of paediatric neck masses.

Methods: MEDLINE, Embase, Cochrane and grey literature were searched to identify CPG incorporating paediatric neck masses. Four authors with previous training of the Appraisal of Guidelines for Research and Evaluation tool evaluated the included studies. Read More

View Article and Full-Text PDF

Comparative genomics of invasive Streptococcus pneumoniae CC320/271 serotype 19F/19A before the introduction of pneumococcal vaccine in India.

Mol Biol Rep 2021 Apr 19. Epub 2021 Apr 19.

Department of Clinical Microbiology, Christian Medical College, Vellore, India.

The emergence of multi drug resistant clone CC320 serotype19F/19A and their capsular (cps) antigenic variants due to selective pressures such as vaccine had been reported worldwide. Hence, it is important to identify the prevalent clones, sequence types and cps variants of serotype 19F/19A in India, where PCV13 has been recently introduced. Multi-locus sequence typing (MLST) was performed for all (n = 21) invasive S. Read More

View Article and Full-Text PDF

Changes in oral health-related quality of life after treatment of hypersensitive molar incisor hypomineralization-affected molars with a sealing.

Clin Oral Investig 2021 Apr 20. Epub 2021 Apr 20.

Department of Paediatric Dentistry, Medical University of Vienna, University Clinic of Dentistry, Sensengasse 2a, 1090, Vienna, Austria.

Objectives: The aim of this study was to investigate the changes in oral health-related quality of life (OHRQoL) before and after treatment of hypersensitive molars affected by molar incisor hypomineralization (MIH) with a sealing.

Methods: Thirty-eight children with two MIH-affected molars showing hypersensitivity and non-occlusal breakdowns were included. Hypersensitivity was assessed with an evaporative (air) stimulus. Read More

View Article and Full-Text PDF

Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

Brain 2021 Apr 20. Epub 2021 Apr 20.

NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Institute of Neurology, London, UK.

While multiple sclerosis can affect any part of the CNS, it does not do so evenly. In white matter it has long been recognized that lesions tend to occur around the ventricles, and grey matter lesions mainly accrue in the outermost (subpial) cortex. In cortical grey matter, neuronal loss is greater in the outermost layers. Read More

View Article and Full-Text PDF

Update on Pediatric Tracheostomy: Indications, Technique, Education, and Decannulation.

Curr Otorhinolaryngol Rep 2021 Apr 15:1-12. Epub 2021 Apr 15.

Department of Otolaryngology, Head and Neck Surgery, University of Arkansas for Medical Sciences, 1 Children's Way, Little Rock, AR 72202 USA.

Purpose Of Review: Tracheostomy in a child demands critical pre-operative evaluation, deliberate family education, competent surgical technique, and multidisciplinary post-operative care. The goals of pediatric tracheostomy are to establish a safe airway, optimize ventilation, and expedite discharge. Herein we provide an update regarding timing, surgical technique, complications, and decannulation, focusing on a longitudinal approach to pediatric tracheostomy care. Read More

View Article and Full-Text PDF

Evolving Roles for Health Care in Supporting Healthy Child Development.

Future Child 2020 ;30(2):143-164

Adam Schickedanz is an assistant professor in residence in the Department of Pediatrics at the David Geffen School of Medicine at the University of California, Los Angeles. Neal Halfon is the founding director of the Center for Healthier Children, Families and Communities; a professor of pediatrics in the David Geffen School of Medicine; a professor of health policy and management in the Fielding School of Public Health; and a professor of public policy in the Luskin School of Public Affairs, all at the University of California, Los Angeles.

Health care reaches more children under age three in the United States than any other family-facing system and represents the most common entry point for developmental assessment of and services for children. In this article, Adam Schickedanz and Neal Halfon examine how well the child health care system promotes healthy child development early in life. They also review children's access to health care through insurance coverage, the health care system's evolution in response to scientific and technical advances, and the shifting epidemiology of health and developmental risk. Read More

View Article and Full-Text PDF
January 2020

One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency.

Genet Med 2021 Apr 19. Epub 2021 Apr 19.

Sanofi, Bridgewater, NJ, USA.

Purpose: To assess olipudase alfa enzyme replacement therapy for non-central nervous system manifestations of acid sphingomyelinase deficiency (ASMD) in children.

Methods: This phase 1/2, international, multicenter, open-label trial (ASCEND-Peds/NCT02292654) administered intravenous olipudase alfa every 2 weeks with intrapatient dose escalation to 3 mg/kg. Primary outcome was safety through week 64. Read More

View Article and Full-Text PDF