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Activation of Nrf2 signaling protects hypoxia-induced HTR-8/SVneo cells against ferroptosis.

J Obstet Gynaecol Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Wuhan City, China.

Aim: This article aims to investigate the possible mechanism by which nuclear factor erythroid 2-related factor 2 (Nrf2) signaling exerts protective effects on the progression of preeclampsia (PE).

Methods: HTR-8/SVneo cells were cultured under hypoxic conditions to establish PE cell model. Cell viability and invasion were respectively examined by CCK-8 assay and transwell assay. Read More

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September 2021

Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan.

Ticks Tick Borne Dis 2021 Sep 4;12(6):101821. Epub 2021 Sep 4.

Department of Child Medical Health and Development, Mie University Graduate School of Medicine, Mie, Japan; Department of Pediatrics, National Hospital Organization Mie National Hospital, 357 Osato-kubota, Tsu, Mie, Japan. Electronic address:

In Okinawa prefecture, Japan, the first case of severe fever with thrombocytopenia syndrome (SFTS) was confirmed in August 2016, and this case remains to be the only reported case of SFTS in Okinawa. The epidemiological investigation indicated that the patient had been infected on the main island of Okinawa, but source and route of infection were unknown. Therefore, to understand the possible source and route of SFTS virus (SFTSV) infection in Okinawa, we performed a seroepidemiological study of SFTSV among animals and dwellers in Okinawa and conducted a questionnaire survey to investigate risk factors for tick bites in Okinawa. Read More

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September 2021

Commentary on "Is simultaneous partial splenectomy during pediatric liver transplantation safe and effective for severe hypersplenism? A prospective cohort study" (Int J Surg 2021, 88:105926).

Int J Surg 2021 Sep 12:106097. Epub 2021 Sep 12.

Department of International Medical Services, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, 730050, Gansu, China. Electronic address:

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September 2021

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.

Cell Rep 2021 Sep;36(11):109705

Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. Electronic address:

Mouse embryonic stem cells (mESCs) can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote self-renewal and pluripotency. Here, we find that genetic deletion of the four genes encoding the TCF/LEF transcription factors confers mESCs with the ability to self-renew in N2B27 medium alone. TCF/LEF quadruple knockout (qKO) mESCs display dysregulation of several genes, including Aire, Dnmt3l, and IcosL, located adjacent to each other within a topologically associated domain (TAD). Read More

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September 2021

Personality in Children With Vocal Fold Nodules: A Multitrait Analysis.

J Speech Lang Hear Res 2021 Sep 15:1-17. Epub 2021 Sep 15.

Pediatric Otolaryngology Clinic, Primary Children's Medical Center, Salt Lake City, UT.

Purpose Vocal fold nodules (VNs) are bilateral, symmetrical, callous-like lesions secondary to phonotrauma and possibly related to specific personality traits. This case-control study examined the relation between personality and VNs in children within the context of the Trait Theory of VNs. Method Parents of children with VNs ( = 39, = 7. Read More

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September 2021

Application of the Challenge Point Framework During Treatment of Speech Sound Disorders.

J Speech Lang Hear Res 2021 Sep 15:1-17. Epub 2021 Sep 15.

School of Communication Sciences and Disorders, McGill University, Montréal, Québec, Canada.

Purpose The purpose of this article is to provide trial-by-trial practice performance data in relation to learning (outcome probe data) as collected from 18 treatment sessions provided to children with severe speech sound disorders. The data illustrate the practice-learning paradox: Specific, perfect practice performance is not required for speech production learning. Method We detailed how nine student speech-language pathologists (SSLPs) implemented and modified the motor learning practice conditions to reach a proposed challenge point during speech practice. Read More

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September 2021

Coughing and diaphragmatic breathing exercise: What is the repercussion on respiratory mechanics of children and adolescents with cystic fibrosis?

Int J Clin Pract 2021 Sep 15:e14879. Epub 2021 Sep 15.

Physical Therapist, PhD in Child and Adolescent Health from the University of Campinas (UNICAMP), Full Professor of the Undergraduate and Graduate Programs of Physical Therapy at UDESC, Florianópolis, SC, Brazil.

Introduction: The aim of this study was to investigate the immediate effect of coughing episodes and diaphragmatic breathing exercise (DBE) on respiratory mechanics of children/adolescents with cystic fibrosis (CF).

Methods: It is a cross-sectional analytical study that occurred in a reference center for children with CF. Forty-five children/adolescents with CF [60% male; mean age 10,22±2,84 years old; mean forced expiratory volume in 1 second (FEV ) 73,74±21,38 % predicted] were divided in 3 groups according to the R5 parameter response to the DBE: G1 (increased R5), G2 (no change R5) and G3 (decreased R5). Read More

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September 2021

How to manage irritable bowel syndrome in children.

Acta Paediatr 2021 Sep 15. Epub 2021 Sep 15.

KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Aim: This paper discusses the risk factors and management of paediatric irritable bowel syndrome (IBS), with a focus on the role of the gastro-intestinal microbiome.

Methods: English articles of interest published in PubMed and Google Scholar were searched using subject heading and key words of interest.

Results: Only few randomized controlled trials on the management of IBS in children have been published. Read More

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September 2021

Non-IFNγ Whole Blood Cytokine Responses to Mycobacterium tuberculosis Antigens in HIV-exposed Infants.

Pediatr Infect Dis J 2021 Oct;40(10):922-929

Department of Medicine, University of Washington, Seattle, Washington.

Background: HIV-exposed uninfected (HEU) infants have increased risk of tuberculosis (TB). Testing for Mycobacterium tuberculosis (Mtb) infection is limited by reduced Quantiferon (QFT) sensitivity in infants and tuberculin skin test (TST) cross-reactivity with Bacillus Calmette-Guérin vaccine. Our objective is to assess if non-IFNγ cytokine responses to Mtb-specific antigens have improved sensitivity in detecting Mtb infection in HEU infants compared with QFT. Read More

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October 2021

The broad phenotypic spectrum of 17α-hydroxylase/ 17,20-lyase (CYP17A1) deficiency: a case series.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

J Idkowiak, Institute of Metabolism and Systems Research , University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Context: 17α-hydroxylase/17,20-lyase deficiency (17OHD) caused by mutations in the CYP17A1 gene is a rare form of congenital adrenal hyperplasia typically characterized by cortisol deficiency, mineralocorticoid excess and sex steroid deficiency.

Objective: To examine the phenotypic spectrum of 17OHD by clinical and biochemical assessment and corresponding in silico and in vitro functional analysis.

Design: Case series Patients and Results: We assessed eight patients with 17OHD, including four with extreme 17OHD phenotypes: two siblings presented with failure to thrive in early infancy and two with isolated sex steroid deficiency and normal cortisol reserve. Read More

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September 2021

Ethical Considerations in Dementia Diagnosis and Care: AAN Position Statement.

Neurology 2021 Jul;97(2):80-89

From the Department of Neurology (W.C.), University of California San Francisco; Evidence-Based Practice Center (A.Y.T.), ECRI, Plymouth Meeting, PA; Division of Neurology (A.Y.T.), Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia; Department of Neurology (Z.S.), The Pennsylvania State University, Hershey; School of Law (R.J.B.), University of Virginia, Charlottesville; and Department of Neurology (J.A.R.), Lahey Medical Center, Burlington, MA.

Alzheimer disease and other dementias present unique practical challenges for patients, their families, clinicians, and health systems. These challenges reflect not only the growing public health effect of dementia in an aging global population, but also more specific ethical complexities including early loss of patients' capacity to make decisions regarding their own care, the stigma often associated with a dementia diagnosis, the difficulty of balancing concern for patients' welfare with respect for patients' remaining independence, and the effect on the physical, emotional, and financial well-being of family caregivers. Caring for patients with dementia requires respecting patient autonomy while acknowledging progressively diminishing decisional capacity and continuing to provide care in accordance with other core ethical principles (beneficence, justice, and nonmaleficence). Read More

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Child Mental Health in Brazilian Guidelines: A Normative Analysis.

Issues Ment Health Nurs 2021 Sep 15:1-7. Epub 2021 Sep 15.

Department of Nursing, Universidade Regional do Cariri, Crato, Brazil.

This article examines the evolution of the understanding of child mental health based on documents that guide nursing practise in Brazil. Eleven relevant documents were submitted to normative analysis, which revealed four themes: Developmental approach of the child mental health; Brazilian policies and social history of children; Spaces for prevention, promotion, and care in children's mental health; and The (in)visibility of nurses' work in the context of mental health. These are linked through ideological and social constructions that have although transformed through the years yet remained the same in their core. Read More

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September 2021

Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway.

Am J Physiol Regul Integr Comp Physiol 2021 Sep 15. Epub 2021 Sep 15.

Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, United States.

Maternal e-cigarette (e-cig) exposure is a pressing perinatal health concern. Emerging evidence reveals its potential adverse impacts on brain development in offspring, yet the underlying mechanisms are poorly understood. The present study tested the hypothesis that fetal e-cig exposure induces an aberrant DNA methylation profiles in the developing brain, leading to alteration of autophagic flux signaling and programming of a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE). Read More

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September 2021

Pseudoaneurysm following a neonatal coarctation repair; a dreadful complication.

Asian Cardiovasc Thorac Ann 2021 Sep 15:2184923211042414. Epub 2021 Sep 15.

Department of Paediatric Cardiac Intensive Care, Sri Sathya Sai Sanjeevani International Centre for Child Heart Care and Research, India.

Aneurysms of descending thoracic aorta following surgical repair of coarctation have been reported in literature. Almost always, they are seen in repairs involving prosthetic patch aortoplasty. We report a neonate who underwent resection and an extended end to end anastomosis repair of coarctation and subsequently developed a huge pseudoaneurysm at a 3-month follow-up. Read More

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September 2021

Durability of Dolutegravir-Based Regimens: A 5-Year Prospective Observational Study.

AIDS Patient Care STDS 2021 Sep;35(9):342-353

Unit of Infectious and Tropical Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

This study evaluates the frequency and causes of dolutegravir (DTG) discontinuation along 5 years of follow-up, in both antiretroviral treatment (ART)-naive and experienced people living with HIV (PLWH). This is a prospective multi-center cohort study enrolling PLWH on DTG from July 2014 until November 2020. DTG-durability was investigated using the Kaplan-Meier survival curve. Read More

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September 2021

Hip Range of Motion and Strength Predict 12-Month Physical Function Outcomes in Older Adults With Chronic Low Back Pain: The Delaware Spine Studies.

ACR Open Rheumatol 2021 Sep 15. Epub 2021 Sep 15.

University of Delaware, Newark.

Objective: The objective of this study was to investigate whether poor hip range of motion (ROM) and strength predict 12-month physical function decline among older adults with chronic low back pain (LBP) and whether hip osteoarthritis modifies those relationships.

Methods: At baseline, passive ROM and strength measurements were taken for hip flexion, extension, abduction, adduction, internal rotation, and external rotation; ultrasound images and self-reported symptoms were used to evaluate hip osteoarthritis presence (eg, osteophytes and hip pain). At baseline and 12 months, performance-based (repeated chair rise, self-selected gait speed, 6-minute walk test [6MWT]) and self-reported (Quebec LBP Disability Questionnaire, Late-Life Function & Disability Instrument [LLFDI] basic and advanced lower extremity scales) physical function outcomes were assessed. Read More

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September 2021

Dosing Regimen Prediction and Confirmation with Rivaroxaban for Thromboprophylaxis in Children after the Fontan Procedure: Insights from the Phase III UNIVERSE Study.

J Clin Pharmacol 2021 Sep 15. Epub 2021 Sep 15.

Janssen Research & Development, LLC, Raritan, NJ, USA.

Thrombosis remains an important complication for children with single ventricle physiology post-Fontan procedure and effective thromboprophylaxis is an important unmet medical need. To obviate conventional dose-finding studies and expedite clinical development, a rivaroxaban dose regimen for this indication was determined utilizing a model-informed drug development approach. A physiologically based pharmacokinetic (PBPK) rivaroxaban model was used to predict a pediatric dosing regimen that would produce drug exposures similar to that of 10 mg once daily in adults. Read More

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September 2021

What are the effects of individualized diet fortification for growth and development in infants born preterm receiving human milk? A Cochrane Review summary with commentary.

Authors:
Sina Arman

Dev Med Child Neurol 2021 Sep 15. Epub 2021 Sep 15.

Department of Physical Medicine and Rehabilitation, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

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September 2021

The Assessment of Functional Movement in Children and Adolescents: A Systematic Review and Meta-Analysis.

Sports Med 2021 Sep 15. Epub 2021 Sep 15.

School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.

Background: The Functional Movement Screen™ (FMS™) is an assessment of human movement that may signal potential deficits that could predispose an otherwise healthy person to injury risk. FMS™ scores are well reported in both athletic and adult samples. However, to date, there has been no comprehensive systematic review and meta-analysis of FMS™ data among school-aged children and adolescents. Read More

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September 2021

Patient and Caregiver Health State Utilities in Tuberous Sclerosis Complex.

Pharmacoecon Open 2021 Sep 15. Epub 2021 Sep 15.

Acaster Lloyd Consulting Ltd, 16 Upper Woburn Place, Bloomsbury, London, WC1H 0BS, UK.

Background: Tuberous sclerosis complex (TSC) is a rare multisystem disorder often associated with treatment-resistant epilepsy. Cost-effectiveness analysis for new antiseizure medications typically requires health state utilities (HSUs) that reflect the burden of a given condition.

Objective: This study aimed to estimate HSUs, with a focus on valuing the impact of seizure type and seizure frequency on health-related quality of life (HRQL) for patients with TSC and their caregivers. Read More

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September 2021

Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected.

J Neurovirol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

We investigated the association of metabolic syndrome (MetS) and its components [abdominal obesity, elevated triglycerides (TG), low HDL cholesterol, elevated blood pressure (BP), and impaired fasting glycemia (IFG)] with neurocognitive impairment in youth with perinatally acquired HIV (YPHIV) or who are perinatally HIV-exposed uninfected (YPHEU). This was an observational study with a comparison group of 350 YPHIV and 68 YPHEU ages 10-19 years. Youth with MetS components measured between 1 year before and 3 months after a baseline neurocognitive assessment (Wechsler Intelligence Scale) were selected from the Pediatric HIV/AIDS Cohort Study (PHACS). Read More

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September 2021

Family Experiences of Decreased Sound Tolerance in ASD.

J Autism Dev Disord 2021 Sep 15. Epub 2021 Sep 15.

Faculty of Education, Simon Fraser University, Burnaby, BC, Canada.

Decreased sound tolerance (DST) is the most common sensory difficulty experienced by autistic individuals. Parents of 88 autistic children and young adults between the ages of 3 and 30 described coping strategies and physical and emotional responses used to deal with distressing sounds, and their impact on daily activities. Loud, sudden, and high-pitched sounds were most commonly endorsed as distressing, most often causing autistic children and young adults to cover their ears or yell, while producing stress, irritation, fear, and anxiety. Read More

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September 2021

Relationships Between Mother-Child Conversations About Emotion and Socioemotional Development of Children with Autism Spectrum Disorder.

J Autism Dev Disord 2021 Sep 15. Epub 2021 Sep 15.

Université Catholique de Louvain, Place de l'Université 1, Ottignies-Louvain-la-Neuve, 1348, Belgium.

Mother-child emotion-related conversations, as a practice of parental socialization of emotion, can help children with autism spectrum disorder (ASD) develop socio-emotional skills. This study intends to explore relationships between mother-child conversations about emotions and socio-emotional skills of children with ASD by accounting for the moderating role of children personality traits and mothers' emotional openness. Mothers of children with ASD (n = 49) responded to five questionnaires describing their conversations about emotions, emotional openness as well as their child's socio-emotional skills and personality. Read More

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September 2021

Use of Medication to Treat Attention-Deficit/Hyperactivity Disorder in Young Children: The Role of Maternal History of Psychotropic Medication Use.

Child Psychiatry Hum Dev 2021 Sep 15. Epub 2021 Sep 15.

Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

We examine whether, among children diagnosed with ADHD, are those whose mothers have a history of psychotropic medication use more likely to treat their ADHD with medication? Children born in Manitoba, Canada from 2000 to 2010 diagnosed with ADHD between their 4th and 8th birthday. Maternal psychotropic medication use was assessed from one year before the child's birth to the child's fourth birthday. Logistic regression models examine the relationship between maternal history of psychotropic medication use and the use of medication to treat ADHD in children. Read More

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September 2021

Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci.

Child Psychiatry Hum Dev 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Genetics, Mental Health Research Center, Moscow, Russia.

The study explored whether schizophrenia risk alleles of the DRD2 rs2514218 and ZNF804A rs1344706 polymorphisms also influenced the risk and severity of childhood-onset schizophrenia (COS) and differentiated it from autism spectrum disorders (ASD). We compared 75 children with COS to 75 children with ASD, 150 patients with adult-onset schizophrenia and 150 healthy individuals. Frequency of the DRD2 T-allele, assumed to be protective against schizophrenia overall, was higher in COS compared to adult-onset schizophrenia and healthy controls. Read More

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September 2021

Post-traumatic stress disorder in refugee minors in an outpatient care center: prevalence and associated factors.

Eur Child Adolesc Psychiatry 2021 Sep 15. Epub 2021 Sep 15.

Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.

Due to their likelihood for experiencing a number of traumatic events, refugee minors have an increased risk of developing post-traumatic stress disorder (PTSD). However, the prevalence of PTSD in refugee children varies widely between studies, and it remains somewhat unclear what factors increase children's risk of PTSD. This study aimed to assess the prevalence of PTSD in a clinical outpatient sample of refugee minors, and to evaluate the association of different risk factors with a PTSD diagnosis. Read More

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September 2021

Uterine kisspeptin receptor critically regulates epithelial estrogen receptor Α transcriptional activity at the time of embryo implantation in a mouse model.

Mol Hum Reprod 2021 Sep 15. Epub 2021 Sep 15.

Laboratory of Human Growth and Reproductive Development, Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

Embryo implantation failure is a major cause of infertility in women of reproductive age and a better understanding of uterine factors that regulate implantation is required for developing effective treatments for female infertility. This study investigated the role of the uterine kisspeptin receptor (KISS1R) in the molecular regulation of implantation in a mouse model. To conduct this study, a conditional uterine knockout (KO) of Kiss1r was created using the Pgr-Cre (progesterone receptor-CRE recombinase) driver. Read More

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September 2021

Evaluation of Epidural Analgesia Use During Labor and Infection in Full-term Neonates Delivered Vaginally.

JAMA Netw Open 2021 Sep 1;4(9):e2123757. Epub 2021 Sep 1.

Department of Anesthesia, the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Importance: Quantification of potential consequences associated with the use of epidural analgesia during labor could help to improve the safety and quality of labor and delivery care for parturient women.

Objective: To evaluate the association between epidural analgesia use during labor and neonatal infection in a large cohort of parturient women.

Design, Setting, And Participants: This propensity score-matched cohort study was conducted at a university-affiliated hospital in Shanghai, China. Read More

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September 2021

Association of Timing and Duration of Prenatal Analgesic Opioid Exposure With Attention-Deficit/Hyperactivity Disorder in Children.

JAMA Netw Open 2021 Sep 1;4(9):e2124324. Epub 2021 Sep 1.

PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Importance: Prior studies have reported that the use of illicit opioids during pregnancy is associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring; however, evidence regarding the association of analgesic opioids is limited.

Objective: To examine the association of timing and duration of prenatal analgesic opioid exposure with ADHD in children.

Design, Setting, And Participants: This cohort study uses data from the Norwegian Mother, Father and Child Cohort study (1999-2008), a nationwide birth cohort study linked to national health registries, with a mean (SD) follow-up of 10. Read More

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September 2021