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Neutrophil-lymphocyte ratio as a prognostic factor for minute clear cell renal cell carcinoma diagnosed using multi-slice spiral CT.

Medicine (Baltimore) 2021 Jun;100(23):e26292

Department of Radiology, Urumqi Friendship Hospital, No. 558 Shengli Road, Tianshan District, 830049 Urumqi, P.R. China.

Abstract: Minute clear cell renal cell carcinoma (MccRCC) has a diameter of <1.5 cm and can be diagnosed using multi-slice spiral CT (MSCT). Recently, the role of the neutrophil-lymphocyte ratio (NLR) in the development of MccRCC has attracted attention. Read More

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Associations and interaction effects of maternal smoking and genetic polymorphisms of cytochrome P450 genes with risk of congenital heart disease in offspring: A case-control study.

Medicine (Baltimore) 2021 Jun;100(23):e26268

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University.

Abstract: To assess associations and interactions of maternal smoking and cytochrome P450 (CYP450) genetic variants with the developments of congenital heart disease (CHD) and specific subtypes.A case-control study of 654 cases and 666 controls was conducted from November 2017 to March 2020. The exposures of interest were maternal active and passive smoking before/in the early pregnancy and CYP450 genetic polymorphisms. Read More

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Appraisal of awareness on medical emergencies and its management among dentists in Bhubaneswar, India.

Rocz Panstw Zakl Hig 2021 ;72(2):193-201

Department of Public Health Dentistry, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

Background: Medical emergencies can be distressing for any dental professional, whether in a dental practice, hospital or other sites.

Objectives: To assess the knowledge and awareness of dental practitioners towards medical emergencies and its management in Bhubaneswar.

Material And Methods: In this cross-sectional investigation, a self-administered questionnaire which included demographic details and 19 questions regarding knowledge about medical emergencies, was disseminated to a random sample of 183 dentists working in their private dental clinic set up in Bhubaneswar. Read More

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January 2021

Attitude and acceptance of Covid-19 vaccine amongst medical and dental fraternity - a questionnaire survey.

Rocz Panstw Zakl Hig 2021 ;72(2):185-191

Department of Public Health Dentistry, Rayat and Bahra Dental College and Hospital, Mohali, India.

Background: The second wave of Novel Coronavirus disease (COVID-19, SARS-CoV-2) is proving more disastrous than the first because of the new mutant stains. Under these circumstances, vaccination is the only effective solution that can save millions of lives across the globe.

Objectives: The present study was conducted to assess the attitude and acceptance/willingness of health care professionals (medical and dental) towards COVID-19 vaccine. Read More

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January 2021

Post-operative course of pulmonary artery pressure after complete atrioventricular canal defect repair.

Cardiol Young 2021 Jun 11:1-7. Epub 2021 Jun 11.

Division of Pediatric Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.

Complete atrioventricular canal defect is a CHD associated with intra-cardiac shunting of blood, which can lead to irreversible changes in pulmonary vascular resistance and pulmonary artery hypertension if unrepaired. Patients with Trisomy 21 are at risk for early development of pulmonary artery hypertension if left uncorrected.1,2. Read More

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Survey on general practitioners' and pharmacists' opinions regarding patient-initiated treatment of recurring urinary tract infections.

Int J Clin Pharm 2021 Jun 10. Epub 2021 Jun 10.

Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Background The Dutch general practitioners (GP) guideline for urinary tract infections (UTI) recommends patient-initiated treatment for women with recurring UTI. In countries other than the Netherlands, community pharmacists play a role in dispensing antibiotics for recurring UTI without preceding GP consultation. Objective To study GP and pharmacist opinions regarding the desirability of patient-initiated treatment, including potential pharmacist support for, and consequences of, facilitated access to antibiotics. Read More

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Neoadjuvant radiation above NCCN guidelines for rectal cancer is associated with age under 50 and early clinical stage.

Surg Endosc 2021 Jun 10. Epub 2021 Jun 10.

Department of Surgery, UH-RISES: University Hospitals Research in Surgical Outcomes and Effectiveness, 11100 Euclid Avenue, Cleveland, OH, USA.

Introduction: Recent data suggest patients with early-onset rectal cancer (EORC) receive neoadjuvant radiation above recommended doses without oncologic benefit. The use of excessive radiation may lead to worse outcomes and patient harm. We sought to evaluate predictors of aggressive neoadjuvant radiation (A-XRT) use in EORC patients and compare this to late-onset rectal cancer (LORC) patients. Read More

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Prolyl-4-Hydroxylase α Subunit 2 as a Novel Potential Biomarker for Predicting the Prognosis of Epithelial Ovarian Carcinoma.

Cancer Manag Res 2021 3;13:4455-4462. Epub 2021 Jun 3.

Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, People's Republic of China.

Objective: Epithelial ovarian cancer (EOC) is one of the leading causes of death worldwide. The aim of this study was to explore the prognostic significance of prolyl-4-hydroxylase α subunit 2 (P4HA2) in patients with EOC.

Patients And Methods: A total of 217 clinical samples (EOC tissues, 167 cases; normal ovarian, 50 cases) were collected and pathologically confirmed using hematoxylin and eosin (H&E) staining. Read More

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The Value of Relative Size in the Ultrasound Diagnosis of Follicular Thyroid Neoplasm.

Int J Gen Med 2021 3;14:2321-2328. Epub 2021 Jun 3.

Department of Ultrasound, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People's Republic of China.

Purpose: Ultrasonography as the first choice for thyroid nodules is still difficult to distinguish between solid follicular thyroid neoplasm (FTN) and solid nodular goiter (NG). We tried to investigate the value of relative size (M/S, M: the maximum diameter of target nodule, S: the maximum diameter of the largest of the remaining nodules) that may help to differentiate FTN from NG.

Methods: test and chi-square test were used to retrospectively analyze the differences of the clinical and ultrasonographic characteristics between FTN and NG in 422 cases in our hospital. Read More

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ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.

Onco Targets Ther 2021 3;14:3583-3596. Epub 2021 Jun 3.

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Integrin alpha 2 (ITGA2) is highly expressed in various cancers. ITGA2 up regulation promotes tumor proliferation, invasion, migration, and angiogenesis and ITGA2 is a poor prognostic factor in many tumors. However, the mechanism underlying its role in esophageal squamous cell carcinoma (ESCC) is unknown. Read More

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HLA-B27 is associated with reduced disease activity in axial spondyloarthritis.

Sci Rep 2021 Jun 10;11(1):12331. Epub 2021 Jun 10.

OHSU-PSU School of Public Health and Departments of Medicine and Ophthalmology, Oregon Health & Science University, Portland, OR, USA.

HLA-B27 is associated with increased susceptibility and disease activity of ankylosing spondylitis, but the effect of HLA-B27 on the activity of the broader category now called axial spondyloarthritis (AxSpA) is apparently the opposite. A modified Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to assess disease activity among 3435 patients with spondyloarthritis (SpA) who participated in a survey designed to assess the effect of their disease and its treatment on the susceptibility and severity of Covid-19. Chi square testing was used to compare BASDAI scores between HLA-B27 positive and negative subjects. Read More

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Shift Length and Shift Length Preference Among Acute Care Surgeons.

Am Surg 2021 Jun 10:31348211025752. Epub 2021 Jun 10.

419963HonorHealth, Scottsdale Osborn Medical Center, Scottsdale, AZ, USA.

Background: Work hour restrictions have been imposed by the Accreditation Council for Graduate Medical Education since 2003 for medical trainees. Many acute care surgeons currently work longer shifts but their preferred shift length is not known.

Methods: The purpose of this study was to characterize the distribution of the current shift length among trauma and acute care surgeons and to identify the surgeons' preference for shift length. Read More

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Whole-body magnetic resonance imaging (WB-MRI) with diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in prostate cancer: Prevalence and clinical significance of incidental findings.

Br J Radiol 2021 Jun 11:20210459. Epub 2021 Jun 11.

Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Objective: Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) is now recommended as a first-line staging modality in prostate cancer patients, and the widespread use of DWIBS may lead to an increased frequency of incidental findings. The aim of this study was to evaluate the prevalence and clinical significance of incidental findings on whole-body magnetic resonance imaging (WB-MRI) with DWIBS.

Methods: Data from 124 patients with prostate cancer (age, 76. Read More

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Disparate Use of Chemoradiation in Elderly Patients With Localized Anal Cancer.

J Natl Compr Canc Netw 2021 Jun 10:1-9. Epub 2021 Jun 10.

1Department of Radiation Oncology.

Background: The incidence of squamous cell carcinoma of the anus (SCCA) is increasing, particularly among the elderly (age ≥65 years). We sought to compare patterns of care for the treatment of SCCA in elderly versus nonelderly patients.

Methods: Data for patients with stages I-III SCCA diagnosed from 2004 through 2015 were obtained from the National Cancer Database. Read More

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Assessment of hand or foot eczema and contact dermatitis among car mechanics.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3737-3744

Department of Dermatology, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia.

Objective: Exposure to mineral oil and petroleum derivatives is common among motor vehicle repair workers, leading to occupation-related dermatological conditions.

Objective: We aimed to determine the prevalence of contact dermatitis among workers of car garages in the unorganized sector and to explore their personal safety measures.

Subjects And Methods: This prospective community-based study was conducted among 200 workers aged 18 years and above employed at 70 car garages in Majmaah City, Saudi Arabia. Read More

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[The relationships between different surgical approaches for maxillary sinus augmentation and implant failure and complications: a retrospective cohort study].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):214-218

Department of Oral and Maxillofacial Surgery, Hefei Stomatology Hospital. Hefei 230001, Anhui Province, China.

Purpose: To investigate the 5-year survival and complication rates of implants placed in grafted sinuses with different surgical approaches and analyze the causes for failure.

Methods: This study retrospectively observed the prognosis of patients who underwent maxillary sinus augmentation by means of lateral window technique(LWT) or transalveolar osteotomy technique (TOT) and simultaneously installed implants performed, in Hefei Stomatological Hospital. The primary predictor variables were surgical approaches, including LWT and TOT. Read More

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[Analysis of 137740 dental emergency cases from 2017 to 2018].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):151-155

Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology. Shanghai 200011, China.

Purpose: To analyze the clinical data of oral emergency cases and the characteristics of oral emergency diseases, and provide clinical basis for improving the quality of oral emergency treatment and making reasonable arrangement.

Methods: A total of 137 740 patients in oral emergency department from January 1st, 2017 to December 31st, 2018 were collected and analyzed retrospectively according to gender, age, time of visit and diagnosis. The results were analyzed with Chi-square test by Excel 7. Read More

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[A five-year experience for treating patients with chronic apical periodontitis with root canal treatment: a retrospective cohort study].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):124-128

Hefei Stomatology Hospital. Hefei 230001, Anhui Province, China.

Purpose: To investigate the clinical outcomes, including survival and periapical healing rates and failure causes, of root canal treatment for patients with periapical lesion.

Methods: A retrospective cohort study was conducted which enrolled patients admitted for the evaluation and management of periapical lesion with root canal treatment. The primary predictor variables were difficulty assessment of root canal therapy (DARCT),which was divided into lower(DARCT =3-4), medium (DARCT =5-7) and higher (DARCT =8-9) difficulty root canal, in terms of canal length, curvature and calcification. Read More

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[Experimental study on the structure and immune cell phenotypes of the lymphoid tissues in oral lichenoid lesions].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):113-119

College of Stomatology, Weifang Medical University. Weifang 261021, Shandong Province, China.

Purpose: To evaluate the existence of tertiary lymphoid structures(TLS) in oral lichenoid lesions and its compositional characteristics of immune cells.

Methods: Tissue samples of normal oral mucosa, oral lichen planus (OLP) and oral lichenoid tissue reaction(OLTR) were collected, thirty cases in each group. Hematoxylin-eosin(H-E) staining was performed to identify the TLS-like structures, and immunohistochemistry (IHC) staining was applied to assess the structure and amount of infiltrating CD3+ T cells, CD19+, CD20+ B cells, CD21+ follicular dendritic cells (FDC), Bcl-6+ germinal centers, CD34+ PNAd+ venules and CD34+ Gp36+ micro lymphatic vessels in TLS of OLL. Read More

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Dynamic Changes in Coagulation Function in Patients With Pneumonia Under Admission and Non-admission Treatment.

Front Med (Lausanne) 2021 24;8:626384. Epub 2021 May 24.

Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

We aimed to explore the dynamic changes in coagulation function and the effect of age on coagulation function in patients with pneumonia under admission and non-admission treatment. We included 178 confirmed adult inpatients with COVID-19 from Wuhan Union Hospital Affiliated to Huazhong University of Science and Technology (Wuhan, China). Patients were classified into common types, and all were cured and discharged after hospitalization. Read More

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Knowledge of adverse events following immunization, its prevalence and actions of mothers of children aged 0-23 months in a tertiary health institution in Jos, North Central Nigeria.

J Med Trop 2020 Jan-Jun;22(1):57-64. Epub 2020 May 20.

Department of Community Medicine, Jos University Teaching Hospital, Jos Plateau State, Nigeria.

Background: Adverse Event Following Immunization (AEFI) is any unfavorable event occurring following vaccination related to the vaccine administration and or its handling. AEFI can lead to death or a life-threatening condition requiring hospitalization with or without permanent sequel. Hence, this study was conducted to determine the knowledge of AEFI among mothers of children aged 0-23 months, its prevalence and actions of mothers of following AEFIs. Read More

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Palmar Musculature: Does It Affect the Development of Carpal Tunnel Syndrome? A Pilot Study.

J Wrist Surg 2021 Jun 3;10(3):196-200. Epub 2021 Jan 3.

Departments of Orthopaedic Surgery and Radiology, School of Medicine, New York University, New York.

 The etiology of carpal tunnel syndrome (CTS) is multifactorial. Static mechanical characteristics of CTS have been described, but dynamic (muscular) parameters remain obscure. We believe that musculature overlying the transverse carpal ligament may have an effect on carpal tunnel pressure and may explain the prevalence of CTS in manual workers. Read More

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Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition.

Front Physiol 2021 24;12:673570. Epub 2021 May 24.

Laboratory of Functional Reserves of Human Organism, Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.

Coordination of cardiovascular and respiratory systems enables a wide range of human adaptation and depends upon the functional state of an individual organism. Hypoxia is known to elicit changes in oxygen and carbon dioxide sensitivity, while training alters cardiorespiratory coordination (CRC). The delayed effect of high altitude (HA) acclimatization on CRC in mountaineers remains unknown. Read More

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Using Cox regression to develop linear rank tests with zero-inflated clustered data.

J R Stat Soc Ser C Appl Stat 2020 Apr 3;69(2):393-411. Epub 2020 Feb 3.

Brigham and Women's Hospital, Boston, MA, U.S.A.

Zero-inflated data arise in many fields of study. When comparing zero-inflated data between two groups with independent subjects, a two degree-of-freedom test has been developed, which is the sum of a 1 degree-of-freedom Pearson chi-square test for the 2×2 table of group vs dichotomized outcome (0,> 0) and a 1 degree-of-freedom Wilcoxon rank-sum test for the values of the outcome > 0. Here, we extend this 2 degree-of-freedom test to clustered data settings. Read More

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Binge eating symptoms are associated with the severity of premenstrual symptoms among university students, cross sectional study from Palestine.

J Eat Disord 2021 Jun 9;9(1):68. Epub 2021 Jun 9.

Program of Therapeutic Nutrition, College of Medicine and Health Sciences, Palestine Polytechnic University, Hebron, Palestine.

Background: Premenstrual syndrome (PMS) is considered one of the most prevailing disorders among childbearing age women that could considerably interfere with daily living activities life. PMS is underrecognized in Palestine. It is reported that binge eating symptoms are significantly related to premenstrual syndrome. Read More

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Rheumatologist perspective of the Brazilian consensus for detection of auto antibodies in HEp-2 CELLS.

Adv Rheumatol 2021 Jun 9;61(1):32. Epub 2021 Jun 9.

Pontifícia Universidade Católica de Goiás (PUC Goiás), Escola de Ciências Médicas, Farmacêuticas e Biomédicas, Avenida Universitária 1.440, Setor Universitário, Goiânia, GO, Brazil.

Objective: To evaluate the perception of rheumatologists regarding the recommendations of the Brazilian Consensus for detection of Autoantibodies (BCA) on HEp-2 Cells by Indirect Immunofluorescence assay (IFA) and how BCA recommendations help in clinical practice.

Methodology: A structured questionnaire regarding the BCA recommendations for detection and interpretations of autoantibodies in HEp-2 cells was applied to randomly selected rheumatologists. The results were tabulated using the Microsoft® Excel program, expressed as a simple percentage and the dichotomous data were analyzed using the Chi-square test and the Epi Info® program. Read More

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The societal cost and economic impact of surgical care on patients' households in rural Uganda; a mixed method study.

BMC Health Serv Res 2021 Jun 9;21(1):568. Epub 2021 Jun 9.

Program for the Advancement of Surgical Equity, Department of Surgery, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Background: The epidemiology and cost of surgical care delivery in low-and middle-income countries (LMICs) is poorly understood. This study characterizes the cost of surgical care, rate of catastrophic medical expenditure and medical impoverishment, and impact of surgical hospitalization on patients' households at Soroti Regional Referral Hospital (SRRH), Uganda.

Methods: We prospectively collected demographic, clinical, and cost data from all surgical inpatients and caregivers at SRRH between February 2018 and January 2019. Read More

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The survival rates and risk factors of implants in the early stage: a retrospective study.

BMC Oral Health 2021 Jun 9;21(1):293. Epub 2021 Jun 9.

Department of Periodontology and Oral Implantology, Stomatological Hospital, Southern Medical University, Guangzhou, 510280, China.

Background: Few large-sample studies in China have focused on the early survival of dental implants. The present study aimed to report the early survival rates of implants and determine the related influencing factors.

Methods: All patients receiving dental implants at our institution between 2006 and 2017 were included. Read More

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Early combined rehabilitation intervention to improve the short-term prognosis of premature infants.

BMC Pediatr 2021 Jun 9;21(1):269. Epub 2021 Jun 9.

Department of Neonatology, Sichuan Provincial Maternity and Child Health Care Hospital, No. 290 West Second Street, Shayan Road, Chengdu, 610031, Sichuan, China.

Background: To explore the clinical effect of early combined rehabilitation intervention on premature infants in the neonatal intensive care unit (NICU).

Methods: Premature infants with gestational ages less than 32 weeks or birth weights less than 1500 g were included in the present study.The participants were divided into the intervention group and control group. Read More

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Brazilian version of the Neck Bournemouth Questionnaire does not have a well-defined internal structure in patients with chronic neck pain.

Clin Rehabil 2021 Jun 10:2692155211024034. Epub 2021 Jun 10.

Postgraduate Program on Physical Education, Universidade Federal do Maranhão, São Luís, MA, Brazil.

Objective: To investigate the structural validity of the Brazilian version of the Neck Bournemouth Questionnaire in patients with chronic neck pain.

Design: Cross-sectional study.

Setting: Community participants collected via online platform. Read More

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