21,769 results match your criteria chemical constituents

LC-MS-based identification and antioxidant evaluation of small molecules from the cinnamon oil extraction waste.

Food Chem 2021 Jul 12;366:130576. Epub 2021 Jul 12.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, China; Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:

Cinnamon oil is obtained by steam distillation from cinnamon leaves and is usually considered highly cost-effective compared to bark oil, however, which results in tons of waste cinnamon leaves (WCL) discarded annually. By using MS/MS molecular networking (MN) assisted profiling, six main chemical diversities including flavonols and flavones, phenolic acids, lactones, terpenoids, phenylpropanoids and flavanols were rapid revealed from WCL aqueous extract. 101 compounds were tentatively identified by assigning their MS/MS fragments within typical pathways under ESI-MS/MS dissociation. Read More

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The macro-debris pollution in the shorelines of Lake Tana: First report on abundance, assessment, constituents, and potential sources.

Sci Total Environ 2021 Jul 22;797:149235. Epub 2021 Jul 22.

Faculty of Chemical and Food Engineering, Bahir Dar Institute of Technology-Bahir Dar University, Bahir Dar, Ethiopia. Electronic address:

Macro-debris monitoring in the shores of freshwater systems is critical to estimate the macro-and micro-plastic pollution levels for the subsequent investigation of ecological pollution. The study aims to report the composition of macro debris and their distribution on the shore of Lake Tana, Ethiopia, as a first baseline document. The distribution of litter surveys was conducted at seven different town/village shorelines of Lake Tana. Read More

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Temperature-Responsive Hydrogel Carrier for Reducing Adsorption Loss of Petroleum Sulfonates.

Langmuir 2021 Aug 3. Epub 2021 Aug 3.

Beijing Key Laboratory for Greenhouse Gas Storage and CO2-EOR, Unconventional Petroleum Research Institute, China University of Petroleum-Beijing, Beijing 102249, China.

As an effective anionic surfactant for chemical flooding, petroleum sulfonate (PS) is often used in conjunction with alkalis to reduce the adsorption loss of PS onto rock and clay surfaces. However, alkali injection can lead to scaling, aggravate the water-sensitive effect of clays, and accelerate polymer hydrolysis. Here, a temperature-responsive biohydrogel-based carrier (XLK) was designed to protect PS from adsorption onto geological features. Read More

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A new acylated iridoid and other chemical constituents from and their biological activities.

Nat Prod Res 2021 Aug 3:1-8. Epub 2021 Aug 3.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.

A new acylated iridoid, valejatadoid H (), along with fourteen known compounds, were obtained from the -BuOH extract of the roots and rhizomes of , and their structures were elucidated by various spectroscopic methods. Among them, compounds , and exhibited potent inhibition on NO production, with IC values of 4.21, 6. Read More

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A chemical window into the impact of RNAi silencing of the StNAC103 gene in potato tuber periderms: Soluble metabolites, suberized cell walls, and antibacterial defense.

Phytochemistry 2021 Jul 31;190:112885. Epub 2021 Jul 31.

Department of Chemistry and Biochemistry, The City College of New York, City University of New York (CUNY) and CUNY Institute for Macromolecular Assemblies, New York, NY, 10031, USA; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA. Electronic address:

The growth and survival of terrestrial plants require control of their interactions with the environment, e.g., to defend against desiccation and microbial invasion. Read More

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Investigating the medicinal potential, material basis and mechanism of Polygoni Orientalis Fructus based on multi-technology integrated network pharmacology.

Phytomedicine 2021 Jul 25;91:153685. Epub 2021 Jul 25.

Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, College of Health Sciences, School of Life Science, Jiangsu Normal University, Xuzhou, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. Electronic address:

Background: Polygoni Orientalis Fructus (POF) refers to the dried ripe fruit of Polygonum orientale L. which has a long historical application in clinic for treatment of various conditions in China. However, its chemical constituents, pharmacological effects and their coupled correlation have not been intensively investigated. Read More

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A review on traditional uses, phytochemistry, pharmacology, toxicology and the analytical methods of the genus Nardostachys.

J Ethnopharmacol 2021 Jul 30:114446. Epub 2021 Jul 30.

State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, PR China. Electronic address:

Ethnopharmacological Relevance: The plants of the genus Nardostachys (Caprifoliaceae) have been used for a long history in different cultural systems of medicine, including Chinese, Ayurvedic, Korean folk medicine and Islamic, for treatments of disorders in nervous, digestive, cardiovascular and integumentary systems.

Aim Of The Review: This review aims to provide comprehensive information on Nardostachys plants including botany update, traditional uses, data mining of uses in traditional Chinese medicine (TCM) and current Chinese medicinal patents, chemical constituents, pharmacological effects, toxicity and analytical method studies.

Materials And Methods: Studies of the genus Nardostachys were collected via Google Scholar and Baidu Scholar, ScienceDirect, SciFinder, Wiley Online Library, ACS Publications, NLM/NCBI, Web of Science, CNKI, WANFANG DATA, EMBASE, Huabeing database and Traditional Chinese Medicine Resource Network and libraries. Read More

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Chemical composition determination and evaluation of the antibacterial activity of essential oils from (Mart. Ex Ness) Lindau and L. against oral streptococci.

Nat Prod Res 2021 Aug 2:1-5. Epub 2021 Aug 2.

Laboratório Integrado de Biomoléculas, Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, CE, Brazil.

This study investigated the chemical composition and evaluated the antibacterial and antibiofilm activities of essential oils (EOs) extracted from (EORA) and (EORP) against oral streptococci. The EO constituents were analyzed by gas chromatography/mass spectrometry. The antimicrobial potential of EOs was evaluated using the minimum inhibitory concentration, minimum bactericidal concentration, and time-kill determination. Read More

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Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and Validation.

Front Pharmacol 2021 16;12:709607. Epub 2021 Jul 16.

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens the health of the elderly. At present, no drugs have been proven to cure or delay the progression of the disease. Due to the multifactorial aetiology of this disease, the multi-target-directed ligand (MTDL) approach provides an innovative and promising idea in search for new drugs against AD. Read More

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Metabolites Identification of Chemical Constituents From the Eggplant ( L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities.

Front Pharmacol 2021 15;12:655008. Epub 2021 Jul 15.

Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China.

Eggplant ( L.) Calyx is a medicinal and edible traditional Chinese medicine with anti-inflammatory, anti-oxidant, and anti-cancer properties. However, the pharmacodynamic components and metabolic characteristics remain unclear. Read More

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TCMIP v2.0 Powers the Identification of Chemical Constituents Available in Xinglou Chengqi Decoction and the Exploration of Pharmacological Mechanisms Acting on Stroke Complicated With Tanre Fushi Syndrome.

Front Pharmacol 2021 15;12:598200. Epub 2021 Jul 15.

Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.

Xinglou Chengqi (XLCQ) decoction, composed of three botanical drugs and one inorganic drug, is used in clinics during the treatment of acute stroke complicated with Tanre Fushi (TRFS) syndrome in China. However, its active ingredients and the molecular mechanism have not been clarified. So, we aimed to preliminarily characterize its chemical constituents and investigate its pharmacological mechanisms using an integrative pharmacology strategy, including component analysis, network prediction, and experimental verification. Read More

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Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL: Inhibition potentials, covalent binding sites and inhibitory mechanisms.

Int J Biol Macromol 2021 Jul 29. Epub 2021 Jul 29.

Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Coronavirus 3C-like protease (3CL) is a crucial target for treating coronavirus diseases including COVID-19. Our preliminary screening showed that Ampelopsis grossedentata extract (AGE) displayed potent SARS-CoV-2-3CL inhibitory activity, but the key constituents with SARS-CoV-2-3CL inhibitory effect and their mechanisms were unrevealed. Herein, a practical strategy via integrating bioactivity-guided fractionation and purification, mass spectrometry-based peptide profiling and time-dependent biochemical assay, was applied to identify the crucial constituents in AGE and to uncover their inhibitory mechanisms. Read More

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Isolation, characterization, and antimicrobial activity of communic acid from .

J Complement Integr Med 2021 Jul 29. Epub 2021 Jul 29.

Laboratory of Organic Synthesis, Extraction and Valorisation, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, BP. 20000, Casablanca, Morocco.

Objectives: A mixture of Z and E communic acid is isolated for the first time from the cones of Its biological activity was studied.

Methods: The plant material was extracted in a Soxhlet apparatus with -hexane, the resulting extract was subjected to column chromatography (CC) on silica gel. The structure elucidation of the constituents of the isolated fraction was identified by comparison of its spectroscopic properties H and C NMR data with those reported in the literature. Read More

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A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thumb.

J Ethnopharmacol 2021 Jul 28:114472. Epub 2021 Jul 28.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Essential oils (EOs) are important active ingredients in Chinese herbal medicine. Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L. Read More

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Separation of chemical constituents in Bidens pilosa Linn. var. radiata Sch. Bip. by elution-extrusion counter-current chromatography using two new three-phase solvent systems.

J Sep Sci 2021 Jul 30. Epub 2021 Jul 30.

Shandong Academy of Traditional Chinese Medicine, Jinan, 250014, PR China.

Two new three-phase solvent systems combined with elution-extrusion counter-current chromatography mode was used to study the chemical constituents in Bidens pilosa Linn. var. radiata Sch. Read More

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Chemical compositions and experimental and computational modeling activity of sea cucumber Holothuria parva ethanolic extract against herpes simplex virus type 1.

Biomed Pharmacother 2021 Jul 20;141:111936. Epub 2021 Jul 20.

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address:

Sea cucumber has antiviral activities against various viruses including herpes simplex virus type 1 (HSV-1). The purpose of the current study was to determine the chemical profile and inhibitory effects of tegument ethanolic extract of Holothuria parva on HSV-1 infection and to elucidate the mechanism of antiviral action of this marine invertebrate. Cytotoxic activity of the extract on Vero cell line was determined using the methyl thiazolyl tetrazolium (MTT) method. Read More

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Characterization of essential oils and volatiles from the aerial parts of L. (Lamiaceae) using microwave-assisted hydrodistillation (MAHD) and headspace solid phase microextraction (HS-SPME) in combination with GC-MS.

Nat Prod Res 2021 Jul 30:1-5. Epub 2021 Jul 30.

Department of Chemistry, Faculty of Science, Hakim Sabzevari University, Sabzevar, Iran.

Herein, the chemical profiles of the essential oils and volatiles obtained from the aerial parts of L. (Lamiaceae) are reported respectively using microwave-assisted hydrodistillation (MAHD) and headspace solid phase microextraction (HS-SPME) approaches associated to gas chromatography-mass spectrometric (GC-MS) quantification. Using MAHD-GC-MS and HS-SPME-GC-MS techniques, 30 and 28 constituents were screened in the essential oils and volatiles of L. Read More

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Colloidal and vesicular delivery system for herbal bioactive constituents.

Daru 2021 Jul 29. Epub 2021 Jul 29.

Columbia Institute of Pharmacy Raipur, Raipur, Chhattisgarh, India.

Objectives: The main objective of the present review is to explore and examine the effectiveness of currently developed novel techniques to resolve the issues which are associated with the herbal constituents/extract.

Methods: A systematic thorough search and collection of reviewed information from Science direct, PubMed and Google Scholar databases based on various sets of key phrases have been performed. All the findings from these data have been studied and briefed based on their relevant and irrelevant information. Read More

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Comparison of Essential Oils of Thunb. from Different Processing Methods and Harvest Seasons Based on GC-MS and Chemometric Analysis.

Int J Anal Chem 2021 16;2021:8324169. Epub 2021 Jul 16.

College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

Houttuyniae Herba (HH) refers to the dried aerial part of Thunb. (DHC) or the fresh whole grass of Thunb. (FHC), where DHC are harvested in summer and FHC around the year. Read More

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Dodecagonal quasicrystals of oil-swollen ionic surfactant micelles.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455;

A delicate balance of noncovalent interactions directs the hierarchical self-assembly of molecular amphiphiles into spherical micelles that pack into three-dimensional periodic arrays, which mimic intermetallic crystals. Herein, we report the discovery that adding water to a mixture of an ionic surfactant and -decane induces aperiodic ordering of oil-swollen spherical micelles into previously unrecognized, aqueous lyotropic dodecagonal quasicrystals (DDQCs), which exhibit local 12-fold rotational symmetry and no long-range translational order. The emergence of these DDQCs at the nexus of dynamically arrested micellar glasses and a periodic Frank-Kasper (FK) σ phase approximant sensitively depends on the mixing order of molecular constituents in the assembly process and on sample thermal history. Read More

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A review of chemical constituents and health-promoting effects of citrus peels.

Food Chem 2021 Jul 13;365:130585. Epub 2021 Jul 13.

Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300193, China. Electronic address:

Citrus is one of the main fruits processed worldwide, producing a lot of industrial by-products. As the main part of citrus "residue", citrus peels have a wide application prospect. They could not only be directly used to produce various food products, but also be used as promising biofuels to produce ethanol and methane. Read More

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Chemical profiling of Houttuynia cordata Thunb. by UPLC-Q-TOF-MS and analysis of its antioxidant activity in C2C12 cells.

J Pharm Biomed Anal 2021 Jul 16;204:114271. Epub 2021 Jul 16.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Houttuynia cordata Thunb. ("Yu-Xing-Cao"), a traditional Chinese medicinal herb, has long been used to treat various diseases. However, detailed information regarding the chemical constituents of H. Read More

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Lychnophora pinaster's effects on inflammation and pain in acute gout.

J Ethnopharmacol 2021 Jul 26;280:114460. Epub 2021 Jul 26.

Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address:

Ethnopharmacological Relevance: Ethanolic extract of aerial parts from Lychnophora pinaster Mart. are used in traditional Brazilian medicine for treating pain, rheumatism and inflammation.

Aim Of The Study: Drugs for the treatment of gout present severe adverse effects, justifying the need to search for new therapeutic options. Read More

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Bioactive compounds of mango (Mangifera Indica): Extraction technologies and chemical constituents - A review.

J Sci Food Agric 2021 Jul 29. Epub 2021 Jul 29.

Research Group of Complex Fluid Engineering and Food Rheology, University of Cartagena, Cartagena, Colombia.

Background: Mango (Mangifera indica) has been recognized as a rich source of bioactive compounds with potential pharmaceutical and nutraceutical applications, attracted increasing interest from research.

Results: Phytochemistry studies have demonstrated that phenolic compounds are one of the most important biologically active components of Mangifera indica extracts. Ultrasounds and microwave-assisted extractions, and supercritical fluids have been employed for the obtention of bioactive molecules, such as phenolic acids, terpenoids, carotenoids, and fatty acids. Read More

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Chemical Constituents from a Mangrove-Derived Actinobacteria Isoptericola chiayiensis BCRC 16888 and Evaluation of Their Anti-NO Activity.

Chem Biodivers 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.

Cultivation of the actinobacteria strain Isoptericola chiayiensis, a mangrove-derived actinobacteria that was isolated from a mangrove soil collected in Chiayi County, resulted in the isolation of one new 2-furanone derivative, isopterfuranone (1), one new sesquiterpenoid, isopterchiayione (2), one new benzenoid derivative, isopterinoid (3), five new flavonoids, chiayiflavans A-E (4-8), and 4 metabolites isolated for the first time from nature source, methyl 3-(4-methyl-2,5-dioxopyrrolidin-3-yl)propanoate (9), 3-ethyl-4-methylpyrrolidine-2,5-dione (10), chiayiensol (11) and chiayiensic acid (12). Their structures were determined through in-depth spectroscopic and mass-spectrometric analyses. Most of the isolates showed potent inhibitory effects on NO production in LPS-stimulated RAW 264. Read More

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Dairy-Derived and Egg White Proteins in Enhancing Immune System Against COVID-19.

Front Nutr 2021 12;8:629440. Epub 2021 Jul 12.

Université Aix-Marseille, Institut de Neuro-Physiopathologie (INP), UMR 7051, Faculté de Pharmacie, Marseille, France.

Coronavirus disease (COVID-19) is a global health challenge, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) triggers a plethora of respiratory disturbances and even multiple organs failure that can be fatal. Nutritional intervention is one of the key components toward to a proper management of COVID-19 patients, especially in those requiring medication, and should thus be considered the first-line treatment. Immuno-modulation and -stimulation are currently being explored in COVID-19 management and are gaining interest by food and pharmaceutical industries. Read More

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Orthobiologics with phytobioactive cues: A paradigm in bone regeneration.

Biomed Pharmacother 2020 Oct 18;130:110754. Epub 2020 Sep 18.

Department of Biological Science and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India; Centre for Environmental Sciences and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India; Centre for Nanosciences, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India. Electronic address:

Bone injuries occur due to various traumatic and disease conditions. Healing of bone injury occurs via a multi-stage intricate process. Body has the potential to rectify most of the bone injuries but some severe traumatic cases with critical size defects may require interventions. Read More

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October 2020

Medium supplementation and thorough optimization to induce carboxymethyl cellulase production by under solid state fermentation of nettle biomass.

Prep Biochem Biotechnol 2021 Jul 28:1-8. Epub 2021 Jul 28.

Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Tehran, Iran.

In the present study, the production of cellulase by under solid-state fermentation of nettle biomass was promoted through supplementation of the culture media using carbonaceous additives and comprehensive optimization of the cultivation via the Taguchi method. CMCase activities about 5.5-6. Read More

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Influence of the choice of precursors on the synthesis of two-dimensional transition metal dichalcogenides.

Dalton Trans 2021 Jul 27. Epub 2021 Jul 27.

Institute of Inorganic Chemistry, University of Cologne, Greinstraße 6, D-50939 Cologne, Germany.

The interest in transition metal dichalcogenides (TMDCs; MEy/2; M = transition metal; E = chalcogenide, y = valence of the metal) has grown exponentially across various science and engineering disciplines due to their unique structural chemistry manifested in a two-dimensional lattice that results in extraordinary electronic and transport properties desired for applications in sensors, energy storage and optoelectronic devices. Since the properties of TMDCs can be tailored by changing the stacking sequence of 2D monolayers with similar or dis-similar materials, a number of synthetic routes essentially based on the disintegration of bulk (e.g. Read More

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