5,092,389 results match your criteria chemical composition

Deep-learning-based removal of autofluorescence and fluorescence quantification in plant-colonizing bacteria in vivo.

New Phytol 2022 Jun 26. Epub 2022 Jun 26.

University of Bremen, Faculty of Biology and Chemistry, CBIB Center for Biomolecular Interactions, Department of Microbe-Plant Interactions, P.O. Box 33 04 40, D-28334, Bremen, Germany.

Fluorescence microscopy is common in bacteria-plant interaction studies. However, strong autofluorescence from plant tissues impedes in vivo studies on endophytes tagged with fluorescent proteins. To solve this problem, we developed a deep-learning-based approach to eliminate plant autofluorescence from fluorescence microscopy images, tested for the model endophyte Azoarcus olearius BH72 colonizing Oryza sativa roots. Read More

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Insulin-incubated palladium clusters promote recovery after brain injury.

J Nanobiotechnology 2022 Jun 25;20(1):299. Epub 2022 Jun 25.

Center for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.

Traumatic brain injury (TBI) is a cause of disability and death worldwide, but there are currently no specific treatments for this condition. Release of excess reactive oxygen species (ROS) in the injured brain leads to a series of pathological changes; thus, eliminating ROS could be a potential therapeutic strategy. Herein, we synthesized insulin-incubated ultrasmall palladium ([email protected]) clusters via green biomimetic chemistry. Read More

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Determination of total phenolic content and antioxidant activity of Commiphora mollis (Oliv.) Engl. resin.

BMC Chem 2022 Jun 25;16(1):48. Epub 2022 Jun 25.

Department of Chemistry, College of Natural Science, Jimma University, P.O. Box 378, Jimma, Ethiopia.

In this study, total phenolic contents (TPC) and antioxidant activity of Commiphora mollis (Oliv.) Engl. (Burseraceae) resin were investigated. Read More

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Chemical composition, anticancer and antibacterial activity of Nepeta mahanensis essential oil.

BMC Complement Med Ther 2022 Jun 25;22(1):173. Epub 2022 Jun 25.

Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Background: Conventional cancer treatments, such as chemotherapy, radiation therapy, and surgery, often affect the patients' quality of life due to their serious side effects, indicating the urgent need to develop less toxic and more effective alternative treatments. Medicinal plants and their derivatives are invaluable sources for such remedies. The present study aimed to determine the chemical composition, anticancer and antibacterial activities of Nepeta mahanesis essential oil (EO). Read More

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Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis.

Respir Res 2022 Jun 25;23(1):169. Epub 2022 Jun 25.

Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.

Background: Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD), including a few with sarcoidosis. To date, little is known about this progressive fibrosing phenotype in sarcoidosis. Read More

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Titanium wear from magnetically controlled growing rods (MCGRs) for the treatment of spinal deformities in children.

Sci Rep 2022 Jun 25;12(1):10811. Epub 2022 Jun 25.

Pediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Göttingen, Göttingen, Germany.

Magnetically controlled growing rods (MCGRs) are an effective treatment method for early-onset scoliosis (EOS). In recent years, increasing titanium wear was observed in tissue adjacent to implants and in blood samples of these patients. This study aims to investigate the potential correlation between amount of metal loss and titanium levels in blood during MCGR treatment as well as influencing factors for metal wear. Read More

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The distinct phenotype of primary adipocytes and adipocytes derived from stem cells of white adipose tissue as assessed by Raman and fluorescence imaging.

Cell Mol Life Sci 2022 Jun 25;79(7):383. Epub 2022 Jun 25.

Jagiellonian Centre of Experimental Therapeutics (JCET), Jagiellonian University, 14 Bobrzynskiego Str., 30-348, Kraków, Poland.

Spectroscopy-based analysis of chemical composition of cells is a tool still scarcely used in biological sciences, although it provides unique information about the cell identity accessible in vivo and in situ. Through time-lapse spectroscopic monitoring of adipogenesis in brown and white adipose tissue-derived stem cells we have demonstrated that considerable chemical and functional changes occur along with cells differentiation and maturation, yet yielding mature adipocytes with a similar chemical composition, independent of the cellular origin (white or brown adipose tissue). However, in essence, these stem cell-derived adipocytes have a markedly different chemical composition compared to mature primary adipocytes. Read More

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X-ray diffraction study and molecular dynamic simulation of liquid Al-Cu alloys: a new data and interatomic potentials comparison.

J Mol Model 2022 Jun 25;28(7):203. Epub 2022 Jun 25.

Faculty of Chemistry, Taras Shevchenko National University of Kyiv, 12, Lva Tolstoho str., Kiev, 01033, Ukraine.

The experimental X-ray diffraction study of the Al[Formula: see text]Cu[Formula: see text] (at 1010 and 1310 [Formula: see text]C) and Al[Formula: see text]Cu[Formula: see text] (at 1100 and 1400 [Formula: see text]C) melts was performed. MD simulation of the Al[Formula: see text]Cu[Formula: see text], Al[Formula: see text]Cu[Formula: see text], Al[Formula: see text]Cu[Formula: see text], Al[Formula: see text]Cu[Formula: see text], Al[Formula: see text]Cu[Formula: see text], and Al[Formula: see text]Cu[Formula: see text] melts was carried out using several interatomic interaction potentials. It was found that the best agreement with experimental structural and transport data was achieved using the bond-order potential for the Al-Cu melts with predominant content of aluminum and embedded atom method potential for the Cu-based binary melts. Read More

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Extracellular matrix - an emerging research area in biosciences.

Mol Biol Rep 2022 Jun 25. Epub 2022 Jun 25.

Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Lab. of Biochemistry, Dept. of Chemistry, University of Patras, 26110, Patras, Greece.

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Degradation of chlortetracycline hydrochloride by peroxymonosulfate activation on natural manganese sand through response surface methodology.

Environ Sci Pollut Res Int 2022 Jun 25. Epub 2022 Jun 25.

Key Laboratory for Environmental Pollution Prediction and Control, Gansu Province, College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, 730000, People's Republic of China.

This work studies the degradation of chlortetracycline hydrochloride (CTC) by activated peroxymonosulfate (PMS) with natural manganese sand (NMS). Meanwhile, the NMS was characterized and analyzed by isothermal nitrogen adsorption (BET), energy-dispersive X-ray spectroscopy (EDS) and scanning electron microscope (SEM). It can be induced that NMS material may contain C, O, Al, Si, Fe, Mn, and K, and the proportion of each is 6%, 9%, 13%, 34%, 27%, 5%, and 6%. Read More

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Construction of WO [email protected] for rapid photocatalytic degradation of organics in wastewater under sunlight.

Environ Sci Pollut Res Int 2022 Jun 25. Epub 2022 Jun 25.

Key Lab. Eco-Functional Polymer Materials of MOE, Institute of Polymer, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China.

In nowadays, environmental pollution has been greatly improved, but the development of low-cost and environmentally friendly materials are still challenge in the field of water treatment. Herein, a cheap and eco-friendly natural loess particle (LoP) was used for in situ growth of tungsten trioxide nanocubes (WONCs) on its surface via a simple one-pot hydrothermal method, which afforded a stable loess-based photocatalyst ([email protected]). It was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) analysis, UV-Vis diffuse reflectance spectra (UV-Vis DRS), and X-ray photoelectron spectroscopy (XPS). Read More

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A single-cell survey unveils cellular heterogeneity and sensitive responses in mouse cortices induced by oral exposure to triphenyl phosphate.

Arch Toxicol 2022 Jun 25. Epub 2022 Jun 25.

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Rd. 2, Guangzhou, 510080, China.

Triphenyl phosphate (TPhP) is a non-halogenated organophosphorus flame retardant, and there is a higher exposure risk in children. TPhP has been found to be neurotoxic upon developmental exposure, yet the specific mechanism remains unclear. To characterize the cellular responses underlying TPhP-induced developmental neurotoxicity, we administered TPhP (0. Read More

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Identification and characterization of a new ensemble of cometary organic molecules.

Nat Commun 2022 Jun 25;13(1):3639. Epub 2022 Jun 25.

Center for Space and Habitability, University of Bern, Gesellschaftsstrasse 6, 3012, Bern, Switzerland.

In-situ study of comet 1P/Halley during its 1986 apparition revealed a surprising abundance of organic coma species. It remained unclear, whether or not these species originated from polymeric matter. Now, high-resolution mass-spectrometric data collected at comet 67P/Churyumov-Gerasimenko by ESA's Rosetta mission unveil the chemical structure of complex cometary organics. Read More

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Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes.

Nat Commun 2022 Jun 25;13(1):3631. Epub 2022 Jun 25.

Program in Biomolecular Science and Engineering, University of California, Santa Barbara, CA, 93106, USA.

Systems of catalytic RNAs presumably gave rise to important evolutionary innovations, such as the genetic code. Such systems may exhibit particular tolerance to errors (error minimization) as well as coding specificity. While often assumed to result from natural selection, error minimization may instead be an emergent by-product. Read More

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Ru(II) photocages enable precise control over enzyme activity with red light.

Nat Commun 2022 Jun 25;13(1):3636. Epub 2022 Jun 25.

Department of Chemistry, University of Kentucky, Lexington, KY, 40506, USA.

The cytochrome P450 family of enzymes (CYPs) are important targets for medicinal chemistry. Recently, CYP1B1 has emerged as a key player in chemotherapy resistance in the treatment of cancer. This enzyme is overexpressed in a variety of tumors, and is correlated with poor treatment outcomes; thus, it is desirable to develop CYP1B1 inhibitors to restore chemotherapy efficacy. Read More

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Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing.

Nat Commun 2022 Jun 25;13(1):3646. Epub 2022 Jun 25.

Department of Research Laboratories and Director of Center for Stem Cell and Cell Therapy, Instituto G. Gaslini Children Hospital Scientific Institute, 16147, Genova, Italy.

The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome (WAS), remain poorly defined. We generated three isogenic WAS models using patient induced pluripotent stem cells and genome editing. These models recapitulated WAS phenotypes and revealed that WASP deficiency causes an upregulation of numerous RNA splicing factors and widespread altered splicing. Read More

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Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.

Nat Commun 2022 Jun 25;13(1):3634. Epub 2022 Jun 25.

Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-deficient susceptible populations and the emergence of antifungal drug resistance, there is an urgent need for novel strategies to combat these life-threatening infections. Read More

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Corrigendum to "Sinoporphyrin sodium triggered sono-photodynamic effects on breast cancer both in vitro and in vivo" [Ultrason. Sonochem. 31 (2016) 437-448].

Ultrason Sonochem 2022 Jun 22:106077. Epub 2022 Jun 22.

Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, China. Electronic address:

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Sonic Hedgehog Signaling in Primary Culture of Human Corpora Cavernosal Tissue From Prostatectomy, Diabetic, and Peyronie's Patients.

J Sex Med 2022 Jun 22. Epub 2022 Jun 22.

Departments of Urology, Physiology, Bioengineering, and Biochemistry, University of Illinois at Chicago, Chicago, IL. Electronic address:

Background: Cavernous nerve (CN) injury causes penile remodeling, including smooth muscle apoptosis and increased collagen, which results in erectile dysfunction (ED), and prevention of this remodeling is critical for novel ED therapy development.

Aim: We developed 2 peptide amphiphile (PA) hydrogel delivery vehicles for Sonic hedgehog (SHH) protein to the penis and CN, which effectively suppress penile distrophic remodeling (apoptosis and fibrosis), in vivo in a rat CN injury model, and the aim of this study is to determine if SHH PA can be used to regenerate human corpora cavernosal smooth muscle deriving from multiple ED origins.

Methods: Corpora cavernosal tissue was obtained from prostatectomy, diabetic, hypertension, cardiovascular disease and Peyronie's (control) patients (n = 21). Read More

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Global PBDE contamination in cetaceans. A critical review.

Environ Pollut 2022 Jun 22:119670. Epub 2022 Jun 22.

Department of Instrumental Analysis and Environmental Chemistry, Institute of Organic Chemistry (IQOG-CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.

This review summarizes the most relevant information on PBDEs' occurrence and their impacts in cetaceans at global scale, with special attention on the species with the highest reported levels and therefore the most potentially impacted by the current and continuous release of these substances. This review also emphasizes the anthropogenic and environmental factors that could increase concentrations and associated risks for these species in the next future. High PBDE concentrations above the toxicity threshold and stationary trends have been related to continuous import of PBDE-containing products in cetaceans of Brazil and Australia, where PBDEs have never been produced. Read More

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A Comprehensive Overview of Nanotechnology in Sustainable Agriculture.

J Biotechnol 2022 Jun 22. Epub 2022 Jun 22.

Department of Chemical Engineering, University of Petroleum and Energy Studies, Dehradun, Uttarakhand 248007, India. Electronic address:

Plant nutrition is crucial in crop productivity and providing food security to the ever-expanding population. Application of chemical/biological fertilizers and pesticides are the mainstays for any agricultural economy. However, there are unintended consequences of using chemical fertilizers and pesticides. Read More

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The ROS-generating enzyme NADPH oxidase 1 modulates the colonic microbiota but offers minor protection against dextran sulfate sodium-induced low-grade colon inflammation in mice.

Free Radic Biol Med 2022 Jun 22. Epub 2022 Jun 22.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P. O. Box 5003, N-1432, Ås, Norway. Electronic address:

The enzyme NADPH oxidase 1 (NOX1) is a major producer of superoxide which together with other reactive oxygen and nitrogen species (ROS/RNS) are implicated in maintaining a healthy epithelial barrier in the gut. While previous studies have indicated NOX1's involvement in microbial modulation in the small intestine, less is known about the effects of NOX1-dependent ROS/RNS formation in the colon. We investigated the role of NOX1 in the colon in NOX1-deficient and wild type (WT) mice, under mild and subclinical low-grade inflammation induced by 1% dextran sulfate sodium (DSS). Read More

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Identification of the riboflavin-cofactor binding site in the Vibrio cholerae ion-pumping NQR complex: A novel structural motif in redox enzymes.

J Biol Chem 2022 Jun 22:102182. Epub 2022 Jun 22.

Department of Biological Sciences, Illinois Institute of Technology, Chicago IL. Electronic address:

The ion-pumping NQR complex is an essential respiratory enzyme in the physiology of many pathogenic bacteria. This enzyme transfers electrons from NADH to ubiquinone through several cofactors, including riboflavin (vitamin B2). NQR is the only enzyme reported that is able to use riboflavin as a cofactor. Read More

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Furostanol saponins from Asparagus racemosus as potential hypoglycemic agents.

Phytochemistry 2022 Jun 22:113286. Epub 2022 Jun 22.

Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, India; Sophisticated Analytical Instrument Facility & Research, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, U.P., India. Electronic address:

Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside and β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT4myc myotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats and db/db mice. Furoasparoside E produced a notable decrease in the postprandial blood glucose profile, in leptin receptor-deficient db/db mice, type 2 diabetes model. Read More

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Chitosan mediated layer-by-layer assembly based graphene oxide decorated surface plasmon resonance biosensor for highly sensitive detection of β-amyloid.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Dist: Dhule, MS, India. Electronic address:

Alzheimer's disease (AD), and its consequent effect primarily clinical dementia, Parkinson's disease dementia, etc. currently bring potential avenues for diagnosis centered on identification of beta-amyloid (Aβ). Unfortunately, techniques engaged in AD core biomarker (Aβ) detection are majorly suffering from poor sensitivity and selectivity. Read More

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Different Kraft lignin sources for electrospun nanostructures production: Influence of chemical structure and composition.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Forest Research Center, INIA-CSIC, Ctra. de la Coruña, km 7.5., 28040 Madrid, Spain.

This work focuses on the structural features and physicochemical properties of different Kraft lignins and how they can influence the electrospinning process to obtain nanostructures. Structural features of Kraft lignins were characterized by Nuclear Magnetic Resonance, Size Exclusion Chromatography, Fourier-transform Infrared Spectroscopy, and thermal analysis, whereas chemical composition was analyzed by standard method. The addition of cellulose acetate (CA) improves the electrospinning process of Kraft lignins (KL). Read More

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A naked-eye colorimetric molecular "light switch" based on ruthenium(II) polypyridyl complex [Ru(phen)ttbd] as binder and stabilizer for RNA duplex and triplex.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

College of Chemistry, Xiangtan University, Xiangtan 411105, People's Republic of China. Electronic address:

Binding of [Ru(phen)ttbd] (phen = 1,10-phenanthroline, ttbd = 4-(6-propenylpyrido-[3,2-a]- phenzain-10-yl-benzene-1,2-diamine) to the RNA triplex poly(U-A*U) (herein "-" and "*" refer to the Watson-Crick and Hoogsteen binding, respectively) and the duplex poly(A-U) have been investigated by spectral technology and viscosity method. Analysis of spectral titrations and viscosity experiments as well as melting measurements suggest that [Ru(phen)ttbd] binds to the studied RNA triplex and duplex through intercalation, while its binding constant toward the triplex is greater than the duplex. Luminescent titrations indicate that [Ru(phen)ttbd] can act as a molecular "light switch" for the two RNAs and the switch effect can be detected by the naked-eye. Read More

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In-situ synthesis silver nanoparticles in chitosan/Bletilla striata polysaccharide composited microneedles for infected and susceptible wound healing.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China. Electronic address:

A novel antibacterial strategy is urgently required to develop for solving bacterial biofilm obstruction and bacterial drug resistance in the infected wound healing process. Herein, the Chitosan/Bletilla striata polysaccharide composited microneedles were prepared by chitosan, tannic acid, AgNO and Bletilla striata polysaccharide through step centrifugation. In our design system, the porous structure of microneedles gradually disappeared, and the mechanical properties were significantly improved after multiple fillings. Read More

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Synchronous catalytic depolymerization of alkaline lignin to monophenols with in situ-converted hierarchical zeolite for bio-polyurethane production.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

School of Chemistry & Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, 100 Daxuedong Road, Nanning 530004, China. Electronic address:

Catalytic depolymerization of lignin to high-value chemicals is crucial to the comprehensive achievement of sustainable and economic concerns. Herein, we propose a green, practical, and economic strategy for the synchronous catalytic depolymerization of lignin based on in situ conversion of geopolymer precursor to hierarchical zeolite, using water as a mild solvent and without external H, additives, co-catalysts or co-solvents. The in situ-converted hierarchical analcime (ANA) zeolite outperformed previously reported representative catalysts, such as PTA/MCM-41 and CuAlMgO in lignin depolymerization with a high monophenol yield (95. Read More

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Carbon-based adsorbents as proficient tools for the removal of heavy metals from aqueous solution: A state of art-review emphasizing recent progress and prospects.

Environ Res 2022 Jun 22:113723. Epub 2022 Jun 22.

Department of Environmental Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address:

Carbon-centric adsorbents (CCA) are diverse forms, from simple biochar (BC) to graphene derivatives, carbon nanotubes (CNTs), and activated carbon (AC), which have been vastly explored for their removal of a plethora of pollutants, including heavy metals (HM). The prominent features of CCA are their operational attributes like extensive surface area, the occurrence of flexible surface functional groups, etc. This work offers a comprehensive examination of contemporary research on CCA for their superior metal removal aptitude and performances in simulated solutions and wastewater flows; via portraying the recent research advances as an outlook on the appliances of CACs for heavy metal adsorption for removal via distinct forms like AC, BC, Graphene oxide (GO), and CNTs. Read More

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