4,871,924 results match your criteria chemical composition

Sequence dependence of Pd(II)-mediated base pairing by palladacyclic nucleobase surrogates.

J Inorg Biochem 2021 Jun 2;222:111506. Epub 2021 Jun 2.

Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland. Electronic address:

A C-nucleoside derivative of phenylpyridine or the respective palladacycle was incorporated at either 3'- or 5'-terminus of a short oligodeoxynucleotide. Hybridization properties of these modified oligonucleotides were studied in a fluorescence-based competition assay in addition to conventional UV melting temperature analysis and compared with those of a previously prepared analogue featuring the modified nucleoside in the middle of the sequence. With the unpalladated phenylpyridine oligonucleotides, UV melting temperature qualitatively correlated with the ability to displace a strand from a double helix in the competition assay, decreasing in the order 5' > 3' > middle. Read More

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Novel photosensitive dual-anisotropic conductive Janus film endued with magnetic-luminescent properties and derivative 3D structures.

J Colloid Interface Sci 2021 May 26;601:899-914. Epub 2021 May 26.

Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.

A new photosensitive dual-anisotropic conductive Janus film (PDCJF) is proposed for the first time. It is rationally designed and manufactured by facile electrospinning. PDCJF is firstly constructed using 2,7-dibromo-9-fluorenone (DBF) with photoconductive and luminescent properties. Read More

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Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity.

Curr Opin Chem Biol 2021 Jun 9;62:119-129. Epub 2021 Jun 9.

Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458 USA. Electronic address:

The ENCODE and genome-wide association projects have shown that much of the genome is transcribed into RNA and much less is translated into protein. These and other functional studies suggest that the druggable transcriptome is much larger than the druggable proteome. This review highlights approaches to define druggable RNA targets and structure-activity relationships across genomic RNA. Read More

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Insight into the pigmented anthocyanins and the major potential co-pigmented flavonoids in purple-coloured leaf teas.

Food Chem 2021 Jun 3;363:130278. Epub 2021 Jun 3.

Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. Electronic address:

Tea cultivars possessing purple shoots have attracted global interest. In order to gain a better understanding of the major chemical constituents responsible for the purple colouration, we applied widely targeted metabolomics to investigate the pigmented flavonoids of freeze-dried purple-coloured tea leaves (PTLs) in comparison with green-coloured tea leaves (GTLs). Thirty-three anthocyanins were identified, and delphinidin 3-O-galactoside and cyanidin 3-O-galactoside were found to be the most abundant in PTLs. Read More

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Improved SARS-CoV-2 M inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.

Eur J Med Chem 2021 May 30;222:113584. Epub 2021 May 30.

Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada. Electronic address:

Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M) to cleave viral proteins. Consequently, M is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with efficacy as an anti-coronaviral agent in animals, is an effective inhibitor of M in SARS-CoV-2. Read More

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Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists.

Eur J Med Chem 2021 Jun 1;222:113585. Epub 2021 Jun 1.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai, 201203, China. Electronic address:

Cancer immunotherapy has become a research hotspot in recent years. A variety of targets were developed for small molecule immuno-oncology agents, including retinoic acid-related orphan receptor gamma t (RORγt), chemokine receptor, stimulator of interferon genes (Sting), indoleamine 2,3-dioxygenase (IDO), toll-like receptors (TLR), etc. Among them, the retinoic acid receptor-related orphan receptor γt (RORγt) has gradually attracted more attention in these years. Read More

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Benzofuranyl-2-imidazoles as imidazoline I receptor ligands for Alzheimer's disease.

Eur J Med Chem 2021 May 20;222:113540. Epub 2021 May 20.

Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028, Barcelona, Spain. Electronic address:

Recent findings unveil the pharmacological modulation of imidazoline I receptors (I-IR) as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we report the chemical characterization, three-dimensional quantitative structure-activity relationship (3D-QSAR) and ADMET in silico of a family of benzofuranyl-2-imidazoles that exhibit affinity against human brain I-IR and most of them have been predicted to be brain permeable. Acute treatment in mice with 2-(2-benzofuranyl)-2-imidazole, known as LSL60101 (garsevil), showed non-warning properties in the ADMET studies and an optimal pharmacokinetic profile. Read More

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The Mur Enzymes Chink in the Armour of Mycobacterium tuberculosis cell wall.

Eur J Med Chem 2021 Jun 2;222:113568. Epub 2021 Jun 2.

Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, District Dhule, 425405, Maharashtra, India. Electronic address:

TUBERCULOSIS: (TB) transmitted by Mycobacterium tuberculosis (Mtb) is one of the top 10 causes of death globally. Currently, the widespread occurrence of resistance toward Mtb strains is becoming a significant concern to public health. This scenario exaggerated the need for the discovery of novel targets and their inhibitors. Read More

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Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease.

Eur J Med Chem 2021 Jun 2;222:113565. Epub 2021 Jun 2.

Krembil Research Institute, University Health Network, Toronto, Canada; Faculty of Pharmacy, University of Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Ontario, Canada; Department of Chemistry, University of Toronto, Ontario, Canada. Electronic address:

β-Amyloid (Aβ) triggered proteopathic and immunopathic processes are a postulated cause of Alzheimer's disease (AD). Monomeric Aβ is derived from amyloid precursor protein, whereupon it aggregates into various assemblies, including oligomers and fibrils, which disrupt neuronal membrane integrity and induce cellular damage. Aβ is directly neurotoxic/synaptotoxic, but may also induce neuroinflammation through the concomitant activation of microglia. Read More

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Nanoplastics adsorption and removal efficiency by granular activated carbon used in drinking water treatment process.

Sci Total Environ 2021 Jun 1;791:148175. Epub 2021 Jun 1.

Group of Environmental Physical Chemistry, Department F.-A. Forel for Environmental and Aquatic Sciences, University of Geneva, Uni Carl Vogt, 66, boulevard Carl-Vogt, CH-1211 Geneva 4, Switzerland. Electronic address:

In this study Granular Activated Carbon (GAC) used in drinking water treatment processes is evaluated for its capacity to adsorb and remove polystyrene (PS) nanoplastics. Batch experiments are conducted in ultrapure and surface water from Lake Geneva, currently used as drinking water resources. Equilibrium and kinetic studies are conducted to understand adsorption mechanisms and limiting factors. Read More

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Phthalic acid esters degradation by a novel marine bacterial strain Mycolicibacterium phocaicum RL-HY01: Characterization, metabolic pathway and bioaugmentation.

Sci Total Environ 2021 Jun 5;791:148303. Epub 2021 Jun 5.

Shenzhen Research Institute of Guangdong Ocean University, Shenzhen 518108, China; College of Coastal Agricultural Sciences, School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address:

Phthalic acid esters (PAEs) are one of the most widely used plasticizers and the well-studied environmental pollutants with endocrine disrupting properties. Investigation about PAEs in terrestrial ecosystem has been extensively conducted while the fate of PAEs in marine environment remains underexplored. In this study, a novel di-(2-ethylhexyl) phthalate (DEHP) degrading marine bacterial strain, Mycolicibacterium phocaicum RL-HY01, was isolated and characterized from intertidal sediments. Read More

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Pesticides are the dominant stressors for vulnerable insects in lowland streams.

Water Res 2021 May 17;201:117262. Epub 2021 May 17.

Department of River Ecology, Helmholtz Centre for Environmental Research, UFZ, 04318 Leipzig, Germany.

Despite elaborate regulation of agricultural pesticides, their occurrence in non-target areas has been linked to adverse ecological effects on insects in several field investigations. Their quantitative role in contributing to the biodiversity crisis is, however, still not known. In a large-scale study across 101 sites of small lowland streams in Central Europe, Germany we revealed that 83% of agricultural streams did not meet the pesticide-related ecological targets. Read More

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Performance evaluation of nanotubular halloysites from weathered pegmatites in removing heavy metals from water through novel artificial intelligence-based models and human-based optimization algorithm.

Chemosphere 2021 Jun 3;282:131012. Epub 2021 Jun 3.

Department of Exploration Geology, Faculty of Geosciences and Geoengineering, Hanoi University of Mining and Geology, 18 Vien st., Duc Thang ward, Bac Tu Liem dist., Hanoi, Viet Nam.

The efforts of this study aimed to evaluate the feasibility of the nanotubular halloysites in weathered pegmatites (NaHWP) for removing heavy metals (i.e., Cd, Pb) from water. Read More

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Recovery trend to co-exposure of iron oxide nanoparticles (γ-FeO) and glyphosate in liver tissue of the fish Poecilia reticulata.

Chemosphere 2021 Jun 1;282:130993. Epub 2021 Jun 1.

Laboratory of Cellular Behavior, Department of Morphology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address:

Citrate-coated iron oxide nanoparticles (IONPs) have potential use in environmental remediation, with possibilities in decontaminating aquatic environments exposed to toxic substances. This study analyzed IONPs associated to Roundup Original, a glyphosate-based herbicide (GBH), and pure glyphosate (GLY), through ultrastructural and histopathological biomarkers in liver tissue, from females of Poecilia reticulata exposed to: iron ions (0.3 mg/L) (IFe) and IONPs (0. Read More

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Advanced multichannel submersible probe for autonomous high-resolution in situ monitoring of the cycling of the potentially bioavailable fraction of a range of trace metals.

Chemosphere 2021 May 29;282:131014. Epub 2021 May 29.

University of Bordeaux, UMR CNRS 5805 EPOC, 33615 Pessac, France.

We report here on the development and application of a submersible, compact, low power consumption, integrated multichannel trace metal sensing probe (TracMetal). This probe is unique in that it allows high-resolution, simultaneous in-situ measurements of the potentially bioavailable (so-called dynamic) fraction of Hg(II), As(III), Cd(II), Pb(II), Cu(II), Zn(II). The TracMetal incorporates nanostructured Au-plated and Hg-plated gel-integrated microelectrode arrays. Read More

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Impact of time and phosphorus application rate on phosphorus bioavailability and efficiency of secondary fertilizers recovered from municipal wastewater.

Chemosphere 2021 May 28;282:131017. Epub 2021 May 28.

Ghent University, Faculty of Bioscience Engineering, Laboratory of Analytical Chemistry and Applied Ecochemistry (Ecochem), Coupure Links 653, B Block, 6th Floor, 9000, Ghent, Belgium. Electronic address:

Demand for phosphorus (P) resources other than non-renewable P rock has driven the development of several P recovery technologies from municipal wastewater treatment and directed recovery of P into valuable fertilizers (struvite, ash, iron phosphate, etc.). Although the bioavailability of novel secondary P fertilizers has been examined in previous studies, insufficient attention has been paid to defining optimal plant growth duration and monitoring conditions to assess the dynamic changes in P. Read More

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Regeneration of porous FeO nanosheets from deep eutectic solvent for high-performance electrocatalytic nitrogen reduction.

J Colloid Interface Sci 2021 Jun 3;602:64-72. Epub 2021 Jun 3.

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, China.

The production of ammonia through electrocatalytic nitrogen reduction reaction (NRR) is environmentally friendly and energy-saving, but it still suffers from the low NH yield rate and poor selectivity. Herein, enlightened by the unique solubility of FeO in deep eutectic solvent (DES), we, for the first time, reported a DES-based regeneration strategy to fabricate porous FeO nanosheets utilizing commercial FeO powder as raw materials. The as-regenerated porous FeO nanosheets exhibited satisfactory electrocatalytic performance toward NRR, affording a NH yield rate of 12. Read More

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Synthesis of a 2D copper(II)-carboxylate framework having ultrafast adsorption of organic dyes.

J Colloid Interface Sci 2021 May 31;602:43-54. Epub 2021 May 31.

Department of Chemistry, GC University Lahore, 54000, Pakistan. Electronic address:

Two-dimensional (2D) coordination polymers are very interesting materials for their attractive applications. A novel 2D metal-organic framework (MOF) was derived from copper(II) and amino benzoic acid under both room temperature and solvothermal reaction conditions using different solvents. From both of the synthesis methods, an identical MOF was crystalized with monoclinic crystal system having P2/c space group. Read More

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Determination of ultra-trace levels of uranium and thorium in electrolytic copper using radiochemical neutron activation analysis.

Appl Radiat Isot 2021 Jun 9;175:109801. Epub 2021 Jun 9.

Faculty of Mathematics, Physics and Informatics, Comenius University, 84248, Bratislava, Slovakia.

Uranium and thorium as natural radioactive elements are present everywhere in the environment. Their trace levels are also present in various materials, such as copper, used as a shielding material in gamma-ray spectrometry, usually located very close to the detector. Ultra-low levels of uranium and thorium in electrolytic copper were determined in this study using radiochemical neutron activation analysis (RNAA) via their induced nuclides U-239/Np-239 and Pa-233, respectively. Read More

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Integrating multiple-chromatographic approaches to evaluate chemical consistency of Chang-Kang-Fang preparations from mixed-herb decoction and combined single-herb decoction.

J Pharm Biomed Anal 2021 Jun 3;203:114186. Epub 2021 Jun 3.

Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, PR China. Electronic address:

Chang-Kang-Fang formula (CKF), a multi-herbs traditional Chinese medicine (TCM) prescription for treating irritable bowel syndrome (IBS), has been clinically applied in the traditional form of mixed-herb decoction (MHD), or in the modern form of combined single-herb decoction (cSHD, so called dispensing granule decoction) in the near decades, but the chemical consistency between the MHD and cSHD is still unknown. Herein, a new strategy by integrating multiple-chromatographic approaches to characterize both polysaccharides and small molecules was developed to compare the chemical consistency between MHD and cSHD. Sixteen small molecules were simultaneously qualified and quantified by UPLC-QTOF-MS/MS, the molecular weight distribution of polysaccharides was characterized by HPGPC-ELSD, while the monosaccharide composition and total saccharides content were determined by HPLC-PDA and UV-VIS, respectively. Read More

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The influence of age and gender on the quality of raw and roasted wild boars (Sus scrofa) meat.

Meat Sci 2021 Jun 6;181:108600. Epub 2021 Jun 6.

Department of Meat Technology and Chemistry, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, Plac Cieszyński 1, 10-719 Olsztyn, Poland.

The aim of this study was to determine the influence of age and gender on the chemical composition, colour, texture and sensory attributes of wild boars meat (Sus scrofa, n = 48). The animals were analysed in 6 groups (n = 8), differed in age (piglets below 1 year, yearlings 1-2 years, and adults over 2 years) and gender (male and female). Protein content in raw meat was affected by age, whereas in roasted meat by animals gender. Read More

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Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1.

Stem Cell Res 2021 Jun 6;54:102415. Epub 2021 Jun 6.

Department of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address:

Superoxide Dismutase 1 (SOD1) is an antioxidant enzyme that protects the cells from radical oxygen species. To study the behavior of endogenous SOD1 under a microscope, we genetically modified H1 human embryonic stem cells (hESCs) to express SOD1 fused with a SNAP-tag, a protein tag that can be covalently labeled with a variety of synthetic probes. The engineered homozygous clone expressing SOD1-SNAP fusion proteins has normal stem cell morphology and karyotype, expresses pluripotency markers, and can be differentiated into all three germ layers in vitro, providing a versatile platform for imaging-based studies of SOD1. Read More

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Corrigendum to "Facile construction of ratiometric electrochemical immunosensor using hierarchical PtCoIr nanowires and porous [email protected] nanoparticles for accurate detection of septicemia biomarker" [Bioelectrochemistry 140 (2021) 107802].

Bioelectrochemistry 2021 Jun 9;141:107866. Epub 2021 Jun 9.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China. Electronic address:

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Antimicrobial activity and toxicological risk assessment of silver nanoparticles synthesized using an eco-friendly method with Gloeophyllum striatum.

J Hazard Mater 2021 Jun 4;418:126316. Epub 2021 Jun 4.

Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. Electronic address:

Recently, nanomaterials synthesized ecologically using microorganisms have attracted much interest. In the present study, the ability of Gloeophyllum striatum to synthesize silver nanoparticles is described for the first time. Nanoparticles were formed in an eco-friendly extracellular manner and characterized by UV-Vis, FT-IR, MADLS and SEM techniques. Read More

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Occurrence and migration of phthalates in adhesive materials to fruits and vegetables.

J Hazard Mater 2021 Jun 2;418:126277. Epub 2021 Jun 2.

Beijing Advanced Innovation Centre for Food Nutrition and Human Health. Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, PR China. Electronic address:

Labels or tapes are widely used on fresh fruits and vegetables, which may contain phthalates (PAEs). There are few studies on the contamination pathway of PAEs from labels or tapes to food stuff. In this study, the concentrations of eleven PAEs in adhesive labels, tapes, labeled fruits and vegetables on the market were investigated. Read More

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Spectral imaging for characterization and detection of plastic substances in branded teabags.

J Hazard Mater 2021 Jun 5;418:126328. Epub 2021 Jun 5.

School of Biosystems and Food Engineering, University College of Dublin (UCD), Belfield, Dublin 4, Ireland.

The addition of plastic substances in teabags is of increasing concern for conscious consumers due to the harmful effects on the environment and the potential threats to human health. This work introduces an innovative and cost-effective approach to detect and quantify plastic substances in teabags by applying near infrared hyperspectral imaging (951-2496 nm) coupled with multivariate analysis. Teabags from 6 popular brands were investigated and categorized into three classes based on spectral unmixing and target detection results: 1) the plastic teabag primarily made of nylon 6/6; 2) those made of a composite with various polypropylene and cellulose ratios; 3) biodegradable teabags free from any plastic traces. Read More

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Unraveling the influence of substrate on the growth rate, morphology and covalent structure of surface adherent polydopamine films.

Colloids Surf B Biointerfaces 2021 Jun 2;205:111897. Epub 2021 Jun 2.

Department of Chemistry and Physics of Surfaces and Interfaces, Institute of Macromolecular Chemistry, Czech Academy of Sciences, 162 06, Prague 6, Czech Republic. Electronic address:

Polydopamine (PDA), also known as synthetic melanin, is widely used as a biomimetic anchoring layer for the modification of various solid substrates. PDA is utilized for a wide range of biomedical, sensing and tribological applications, even though the polymer's precise covalent structure has not been completely revealed yet. Even more, it is not evident to which extent the chemical nature of the substrate, on which the layer is formed, influences and predetermines the covalent structure of resulting PDA. Read More

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Potency testing of cannabinoids by liquid and supercritical fluid chromatography: Where we are, what we need.

J Chromatogr A 2021 Jun 1;1651:462304. Epub 2021 Jun 1.

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, Ferrara 44121, Italy. Electronic address:

Hemp and cannabis industry is undergoing a renewed interest due to legalization of marijuana (a topic that all countries are discussing, especially in recent years) and the growing importance of therapeutic properties of cannabinoids. Together with an increment in the production of hemp and recreational cannabis, there has been an increasing demand for accurate potency testing of products (i.e. Read More

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In vitro generation of oxidized standards for lipidomics. Application to major membrane lipid components.

J Chromatogr A 2021 May 19;1651:462254. Epub 2021 May 19.

Centre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Madrid. Spain. Electronic address:

Membrane lipids (sphingolipids, glycerophospholipids, cardiolipins, and cholesteryl esters) are critical in cellular functions. Alterations in the levels of oxidized counterparts of some of these lipids have been linked to the onset and development of many pathologies. Unfortunately, the scarce commercial availability of chemically defined oxidized lipids is a limitation for accurate quantitative analysis, characterization of oxidized composition, or testing their biological effects in lipidomic studies. Read More

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AIE-based fluorescent boronate probe and its application in peroxynitrite imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 4;261:120044. Epub 2021 Jun 4.

Institute of Environmental Science, Shanxi University, Taiyuan 030006, PR China. Electronic address:

Fluorescent probes have contributed greatly to our understanding of the biological role of peroxynitrite (ONOO). The ONOO fluorescence probe characterized by the arlyboronate received a moderate opening fluorescence response, and the borate-masked probe significantly increased the sensitivity of ONOO. Thus, two simple fluorescent probes (ADB and ANB) with the recognition receptor of phenyl boronate moiety were constructed for the detection of ONOO. Read More

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