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Restoring NK cells functionality via cytokine activation enhances cetuximab-mediated NK-cell ADCC: A promising therapeutic tool for HCC patients.

Mol Immunol 2021 Jul 17;137:221-227. Epub 2021 Jul 17.

Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Ein-Helwan, Cairo, 11795, Egypt. Electronic address:

Natural Killer (NK) cells are considered the first line of defense against viral infections and tumors. Several factors affect NK cytotoxic activity rendering it dysfunctional and thereby impeding the ability to scavenge abnormal cells as a part of immune escaping mechanisms induced by different types of cancers. NK cells play a crucial role augmenting the activity of various types of anticancer mAb since dysfunctional NK cells are the main reason for the low response to these therapies. Read More

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Applied mutagenesis could improve economically important traits in bitter gourd ( L.).

J Genet 2021 ;100

Faculty of Horticulture, Department of Vegetable Science, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur 741 252, India.

Mutants with unique characters have played a key role in discovery of gene, mapping, functional genomics and breeding in many vegetable crops, but information on bitter gourd is lacking. Induction of mutation by gamma rays (Co source) at five different doses (50 Gy, 100 Gy, 150 Gy, 200 Gy and 250 Gy) was studied in four widely divergent bitter gourd genotypes BG-1346501, Meghna-2, Special Boulder and Selection-1 in M generation. Reduction in seed germination percentage, vine length and pollen fertility occurred in M1 generation with the increasing doses of mutagens. Read More

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January 2021

Reclassification of [] as gen. nov., comb. nov. including Bisgaard taxon 35.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Professor emeritus, Bisgaard Consulting, 40 Horsevænget, DK-4130 Viby Sjælland, Denmark.

[] and the unpublished Bisgaard taxon 35 are associated with respiratory and urogenital tract infections in dogs. A total of 21 strains including the type strain of [] were included in the investigation. Strains of [] and taxon 35 formed a monophyletic group demonstrating at least 97. Read More

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First Report of Colletotrichum fructicola Causing Anthracnose on Camellia yuhsienensis Hu in China.

Plant Dis 2021 Jul 14. Epub 2021 Jul 14.

Chang Sha, China;

Camellia yuhsienensis Hu is an endemic species from China, where is the predominant oilseed crop due to its anthracnose resistance (Kuang 2015; J. Li et al. 2020; Nie et al. Read More

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First Report of Fruit rot Caused by Phytophthora nicotianae on Passion Fruit in Guangxi Province, China.

Plant Dis 2021 Jul 12. Epub 2021 Jul 12.

Microbiology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China;

Passion fruit (Passiflora edulis) is an economically important fruit crop in many tropical and subtropical regions worldwide. In recent years, passion fruit was widely cultivated in Guangxi Province. In 2020, a rot disease occurred on immature fruit of passion fruit in several commercial orchards of Nanning, Guangxi, caused about 50% incidence. Read More

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Gene Expression Profiles Analyzed Using Integrating RNA Sequencing, and Microarray Reveals Increased Inflammatory Response, Proliferation, and Osteoclastogenesis in Pigmented Villonodular Synovitis.

Front Immunol 2021 24;12:665442. Epub 2021 Jun 24.

Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China.

Background: Pigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after surgical resection. However, poor understanding of the pathogenesis limits its effective therapy.

Method: In this study, gene expression profiles of six patients with PVNS, 11 patients with osteoarthritis (OA), nine patients with rheumatoid arthritis (RA) (E-MTAB-6141), and three healthy subjects (GSE143514) were analyzed using integrating RNA sequencing (RNA-seq) and microarray to investigate the PVNS transcriptome. Read More

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Tuning the electronic band structure of metal surfaces for enhancing high-order harmonic generation.

Hicham Agueny

J Chem Phys 2021 Jun;154(24):244702

Department of Physics and Technology, University of Bergen, Allegt. 55, N-5007 Bergen, Norway.

High-harmonic generation (HHG) from the condensed matter phase holds promise to promote future cutting-edge research in the emerging field of attosecond nanoscopy. The key for the progress of the field relies on the capability of the existing schemes to enhance the harmonic yield and to push the photon energy cutoff to the extreme-ultraviolet (XUV, 10-100 eV) regime and beyond toward the spectral "water window" region (282-533 eV). Here, we demonstrate a coherent control scheme of HHG, which we show to give rise to quantum modulations in the XUV region. Read More

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Full depth CNN classifier for handwritten and license plate characters recognition.

PeerJ Comput Sci 2021 18;7:e576. Epub 2021 Jun 18.

Department of Electronics & Communication Eng., Kocaeli University, Izmit, Kocaeli, Turkey.

Character recognition is an important research field of interest for many applications. In recent years, deep learning has made breakthroughs in image classification, especially for character recognition. However, convolutional neural networks (CNN) still deliver state-of-the-art results in this area. Read More

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Conditions Mimicking the Cancer Microenvironment Modulate the Functional Outcome of Human Chorionic Villus Mesenchymal Stem/Stromal Cells .

Front Cell Dev Biol 2021 21;9:650125. Epub 2021 Jun 21.

Stem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Center, King Saud bin Abdulal Aziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Mesenchymal stem/stromal cells isolated from chorionic villi of human term placentae (CV-MSCs) possess unique biological characters. They exhibit self-renewal, directional migration, differentiation, and immunomodulatory effects on other cell lineages, by virtue of which they can be utilized as therapeutic carriers, for drug targeting, and therapy. Tumors display characteristic features of a damaged tissue microenvironment, which is saturated with conditions such as hypoxia, sustained inflammation, and increased oxidative stress. Read More

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Interaction between early in ovo stimulation of the gut microbiota and chicken host - splenic changes in gene expression and methylation.

J Anim Sci Biotechnol 2021 Jul 7;12(1):73. Epub 2021 Jul 7.

Department of Animal Biotechnology and Genetics, UTP University of Science and Technology, 85-084, Bydgoszcz, Poland.

Background: Epigenetic regulation of the gene expression results from interaction between the external environment and transcription of the genetic information encoded in DNA. Methylated CpG regions within the gene promoters lead to silencing of the gene expression in most cases. Factors contributing to epigenetic regulation include intestinal microbiota, which in chicken can be potently modified by in ovo stimulation. Read More

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Resistant starch type 2 from lotus stem: Ultrasonic effect on physical and nutraceutical properties.

Ultrason Sonochem 2021 Aug 29;76:105655. Epub 2021 Jun 29.

Department of Physics, Annamalai University, Annamalinagar, India.

Resistant starch type 2 (RS) was isolated from lotus stem using enzymatic digestion method. The isolated RS was subjected to ultrasonication (US) at different sonication power (100-400 W). The US treated and untreated RS samples were characterized using dynamic light scattering (DLS), scanning electron microscopy (SEM), light microscopy and Fourier transform infrared spectroscopy (FT-IR). Read More

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Sand fly identification and screening for Leishmania spp. in six provinces of Thailand.

Parasit Vectors 2021 Jul 3;14(1):352. Epub 2021 Jul 3.

Vector Biology and Control Section, Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, 10400, Thailand.

Background: Phlebotomine sand flies are vectors of Leishmania spp. At least 27 species of sand flies have been recorded in Thailand. Although human leishmaniasis cases in Thailand are mainly imported, autochthonous leishmaniasis has been increasingly reported in several regions of the country since 1999. Read More

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Naturally Formed Chitinous Skeleton Isolated from the Marine Demosponge as a 3D Scaffold for Tissue Engineering.

Materials (Basel) 2021 Jun 1;14(11). Epub 2021 Jun 1.

Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, 60-965 Poznan, Poland.

Tissue engineering (TE) is a field of regenerative medicine that has been experiencing a special boom in recent years. Among various materials used as components of 3D scaffolds, naturally formed chitinous materials seem to be especially attractive because of their abundance, non-toxic and eco-friendly character. In this study, chitinous skeleton isolated from the marine sponge (phylum: Porifera) was used for the first time as a support for the cultivation of murine fibroblasts (Balb/3T3), human dermal fibroblasts (NHDF), human keratinocyte (HaCaT), and human neuronal (SH-SY5Y) cells. Read More

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Phytochemical and In-Vivo Anti-Arthritic Significance of Baker in Combined Therapy with Methotrexate in Adjuvant-Induced Arthritis in Rats.

Molecules 2021 Jun 15;26(12). Epub 2021 Jun 15.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Unlike other widely known species used for treatment of rheumatoid arthritis, this species suffers from a lack of sufficient studies on its biological and chemical characters. This is what drove us to perform this work to evaluate the in vivo anti-arthritic potential of its leaf ethanolic extract. The in vivo anti-arthritic activity of the leaf ethanolic extract at 100 and 200 mg/kg/day b. Read More

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Discovery of Novel (Backusellaceae, Mucorales) Isolated from Invertebrates and Toads in Cheongyang, Korea.

J Fungi (Basel) 2021 Jun 27;7(7). Epub 2021 Jun 27.

Environmental Microbiology Laboratory, Department of Agricultural Biological Chemistry, College of Agriculture & Life Sciences, Chonnam National University, Gwangju 61186, Korea.

Three novel fungal species, sp. nov., . Read More

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Integrative taxonomy and molecular phylogeny of three poorly known tintinnine ciliates, with the establishment of a new genus (Protista; Ciliophora; Oligotrichea).

BMC Ecol Evol 2021 Jun 9;21(1):115. Epub 2021 Jun 9.

College of Fisheries, & Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, 266003, China.

Background: The taxonomic classification of the suborder Tintinnina Kofoid & Campbell, 1929, a species-rich group of planktonic ciliated protistans with a characteristic lorica, has long been ambiguous largely due to the lack of cytological and molecular data for most species. Tintinnopsis is the largest, most widespread, and most taxonomically complex genus within this group with about 170 species occurring in nearshore waters. Previous molecular phylogenetic studies have revealed that Tintinnopsis is polyphyletic. Read More

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Development of stable transgenic maize plants tolerant for drought by manipulating ABA signaling through Agrobacterium-mediated transformation.

J Genet Eng Biotechnol 2021 Jun 24;19(1):96. Epub 2021 Jun 24.

Department of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, 500085, India.

Background: In crop plants, to cope up with the demand of food for rising population, revolutionary crop improvement programmes are being implemented for higher and higher yields. Abiotic stress, especially at flowering stage, causes drastic effect on yield in plants. Deforestation and urbanization made the water table very low and changed the climate which led to untimely and unforeseen rains which affect the yield of a crop through stress, both by lack of water as well as water logging (abiotic stress). Read More

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Backbonding contributions to small molecule chemisorption in a metal-organic framework with open copper(i) centers.

Chem Sci 2020 Dec 18;12(6):2156-2164. Epub 2020 Dec 18.

Chemical Sciences Division, Lawrence Berkeley National Laboratory Berkeley CA 94720 USA

Metal-organic frameworks are promising materials for applications such as gas capture, separation, and storage, due to their ability to selectively adsorb small molecules. The metal-organic framework Cu-MFU-4, which contains coordinatively unsaturated copper(i) centers, can engage in backbonding interactions with various small molecule guests, motivating the design of frameworks that engage in backbonding and other electronic interactions for highly efficient and selective adsorption. Here, we examine several gases expected to bind to the open copper(i) sites in Cu-MFU-4 different electronic interactions, including σ-donation, π-backbonding, and formal electron transfer. Read More

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December 2020

A cyclopenta-fused dibenzo[,]thiophene--phenanthrene macrocyclic tetraradicaloid.

Chem Sci 2021 Jan 26;12(11):3952-3957. Epub 2021 Jan 26.

Department of Materials Science, Fudan University Shanghai 200438 China

A cyclopenta-fused macrocyclic tetraradicaloid, , containing alternating phenanthrene (Phen) and dibenzo[,]thiophene (DBTh) units was synthesized and isolated in single-crystal form. Compared with its all-carbon isoelectronic structure, , the incorporation of two sulfur atoms leads to a smaller radical character and a larger singlet-triplet energy gap. X-ray crystallographic analysis reveals that the spin-spin coupling through the DBTh unit is stronger than that through the Phen moiety. Read More

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January 2021

First Report of Passion Fruit Anthracnose Caused by Colletotrichum constrictum.

Plant Dis 2021 Jun 22. Epub 2021 Jun 22.

Chinese Academy of Agricultural Sciences, Research Institute of Pomology, XINGHAINANJIE 98#, XINGCHENG, XINGCHENG, LIAONING, China, 125100.

Passion fruit (Passiflora edulis) is widely cultivated in tropic and subtropic regions. Because of its unique and intense flavour and high acidity, passion fruit juice concentrate is used in making delectable sauces, desserts, candy, ice cream, sherbet, or blending with other fruit juices. Anthracnose of passion fruit is favored by frequent rainfall and average temperatures above 27°C. Read More

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A new Silurian fish close to the common ancestor of modern gnathostomes.

Curr Biol 2021 Jun 12. Epub 2021 Jun 12.

Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; CAS Center for Excellence in Life and Paleoenvironment, Beijing 100044, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

The Silurian Period occupies a pivotal stage in the unfolding of key evolutionary events, including the rise of jawed vertebrates. However, the understanding of this early diversification is often hampered by the patchy nature of the Silurian fossil record, with the articulated specimens of jawed vertebrates only known in isolated localities, most notably Qujing, Yunnan, China. Here, we report a new Silurian maxillate placoderm, Bianchengichthys micros, from the Ludlow of Chongqing, with a near-complete dermatoskeleton preserved in articulation. Read More

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Access to and Reactivity of Fe , Fe , Fe , and Fe PC P Pincer Complexes.

Angew Chem Int Ed Engl 2021 Jun 18. Epub 2021 Jun 18.

Department of Chemistry, National University of Singapore, Singapore.

Despite their promising metal-ligand cooperative reactivity, PC P pincer ligands are rarely reported for first-row transition-metal centres. Using a dehydration methodology, we report access to an Fe PC P pincer complex (1) that proceeds via an isolated α-hydroxylalkyl hydrido complex (3). Reversible carbonyl migration to the carbene position in 1 is found to allow coordination chemistry and E-H bond addition (E=H, B, Cl) across the iron-carbene linkage, representing a unique mechanism for metal-ligand cooperativity. Read More

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Inhibitory effect of thiourea derivatives on the growth of blue-green algae.

J Environ Manage 2021 Sep 10;294:113008. Epub 2021 Jun 10.

Faculty of Science and Marine Environment (FSSM), Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.

High nutrient loading in aquatic environment has become the main causative of harmful algae blooms (HABs) in water resources particularly pond, lake and river. HABs are mostly dominated by microalgae derived from the group of blue-green algae which are capable of releasing harmful toxins. Therefore, this study aims to investigate the inhibitory effects of thiourea derivatives on the growth of such blue-green algae. Read More

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September 2021

Interspecific hybridization between Ganoderma lingzhi and G. applanatum through protoplast fusion.

World J Microbiol Biotechnol 2021 Jun 11;37(7):114. Epub 2021 Jun 11.

Mushroom Research Division, National Institute of Horticultural & Herbal Science, RDA, Chungbuk, Eumseong, 27709, South Korea.

Interspecific hybridization between Ganoderma lingzhi and G. applanatum was attempted through polyethylene glycol (PEG) induced fusion technique. The protoplast isolation procedure was simplified, and we obtained a significant number of protoplasts from both Ganoderma species. Read More

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A re-assessment of the oldest therapsid Raranimus confirms its status as a basal member of the clade and fills Olson's gap.

Naturwissenschaften 2021 Jun 11;108(4):26. Epub 2021 Jun 11.

Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.

The non-mammalian therapsids comprise a paraphyletic assemblage of Permian-Jurassic synapsids closely related to mammals that includes six major clades of largely unresolved phylogenetic affinity. Understanding the early evolutionary radiation of therapsids is complicated by a gap in the fossil record during the Roadian (middle Permian) known as Olson's gap. Because of its early stratigraphic occurrence and its primitive features, Raranimus dashankouensis, from the Dashankou fauna (Rodian), Qingtoushan Formation (China), is currently considered the best candidate to fill this gap. Read More

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Characterization of a Novel Bacteriophage swi2 Harboring Two Lysins Can Naturally Lyse .

Front Microbiol 2021 25;12:670799. Epub 2021 May 25.

College of Veterinary Medicine, Qingdao Agricultural University, Shandong, China.

The novel virulent bacteriophage swi2 was isolated from a pig farm, and its biological characteristics, genome architecture, and infection-related properties were characterized. Phage swi2 has a high titer of 1.01 × 10 PFU/mL with good tolerance to UV rays and remains stable in the pH range of 6-10 and at temperatures less than 50°C. Read More

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Impact of interstitial impurities on the trapping of dislocation loops in tungsten.

Sci Rep 2021 Jun 10;11(1):12333. Epub 2021 Jun 10.

Institute of Physics, Nanotechnology and Telecommunications, Peter the Great St. Petersburg Polytechnic University, 29 Polytekhnicheskaya str, St. Petersburg, Russia, 195251.

Ab initio simulations are employed to assess the interaction of typical interstitial impurities with self-interstitial atoms, dislocation loops and edge dislocation lines in tungsten. These impurities are present in commercial tungsten grades and are also created as a result of neutron transmutation or the plasma in-take process. The relevance of the study is determined by the application of tungsten as first wall material in fusion reactors. Read More

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First report of pearl millet bacterial leaf blight caused by Pantoea stewartii subspecies indologenes in India.

Plant Dis 2021 Jun 9. Epub 2021 Jun 9.

University of Mysore, 29243, Applied Botany and Biotechnology, Mysore, Karnataka, India;

Pearl millet (Cenchrus americanus L.) field-grown plants of cv. 7042S shown unusual water-soaked lesions on leaf tips spreading towards the leaf base from Manasagangothri region (12. Read More

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Fluviispira sanaruensis sp., nov., Isolated from a Brackish Lake in Hamamatsu, Japan.

Curr Microbiol 2021 Aug 4;78(8):3268-3276. Epub 2021 Jun 4.

Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu, Shizuoka, 432-8561, Japan.

Strain RF1110005, which was isolated from brackish lake water sampled at Lake Sanaru in Japan as a "filterable" bacterial strain, was characterized as a novel species in the genus Fluviispira, family Silvanigrellaceae, order Silvanigrellales, the class Oligoflexia and the phylum Bdellovibrionota. Cells of RF1110005 were aerobic, Gram stain negative, and show a pleomorphic morphology of spiral, filamentous and rod shapes. Catalase reaction was positive. Read More

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Pro-resolving lipid mediator lipoxin A attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome.

Cell Rep 2021 Jun;35(9):109201

MS Center Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081 Amsterdam, the Netherlands; Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role of SPMs in MS remains largely unknown. Here, we provide in vivo evidence that treatment with the SPM lipoxin A (LXA) ameliorates clinical symptoms of experimental autoimmune encephalomyelitis (EAE) and inhibits CD4 and CD8 T cell infiltration into the central nervous system (CNS). Read More

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