5,495 results match your criteria characterized retrospectively


A comprehensive pan-cancer analysis of gene amplification, tumor mutation burden, microsatellite instability, and PD-L1 expression in Chinese cancer patients.

Ann Transl Med 2021 Apr;9(8):677

Department of Oncology, Wuxi People's Hospital, Wuxi, China.

Background: Immune checkpoint inhibitors blocking programmed cell death 1 (PD-1) or programmed cell death ligand 1 (PD-L1) have emerged as effective treatment options for cancer. However, immunotherapy is only effective in a subset of patients. Identifying effective biomarkers to predict the treatment response to PD-1/PD-L1 inhibitors remains an unmet clinical need. Read More

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Healthcare resource utilization and costs among nonalcoholic fatty liver disease patients in Germany.

Ann Transl Med 2021 Apr;9(8):615

Department of Internal Medicine, Ruhr-University Bochum, Bochum, Germany.

Background: Patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are associated with progression to advanced liver diseases that include compensated cirrhosis, decompensated cirrhosis, liver transplantation, and hepatocellular carcinoma (HCC). This study characterized comorbidities, healthcare resource utilization (HRU), and associated costs among NAFLD patients in Germany.

Methods: German healthcare claims data between 2011 and 2016 were analyzed retrospectively. Read More

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Endometrial endometrioid carcinoma, G1, is more aggressive in the elderly than in the young.

Histopathology 2021 May 13. Epub 2021 May 13.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Aims: The aim of this study was to characterize endometrioid carcinoma, G1, in the elderly, using clinicopathological features and immunohistochemical features of surrogate markers of molecular subtypes.

Methods And Results: We retrospectively analyzed tumour samples from 268 patients with endometrioid carcinoma, G1 (<40 years: n=24, 40-59 years: n=169, ≥60 years: n=75), for whom long-term clinical follow-up data were available. Endometrioid carcinoma, G1, in the elderly (≥60 years) was characterized by frequent deep myometrial invasion, less frequent endometrioid intraepithelial neoplasia (EIN), lack of benign hyperplasia (BH), less frequent squamous differentiation and occasional aberrant p53 expression. Read More

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Molecular Profiling Practices in Pancreatic Adenocarcinoma: Academic vs Community Physicians.

Oncology (Williston Park) 2021 May 12;35(5):244-248. Epub 2021 May 12.

Sarah Cannon Research Institute at HealthONE, Denver, CO.

Background: Pancreatic adenocarcinoma (PDAC) is relatively rare but highly aggressive, with most patients diagnosed once they have metastatic or locally invasive disease. Molecular profiling is being explored as a tool for selecting patients for targeted therapy clinical trials and for assessing whether targeted therapies may be effective in PDAC. Whether molecular profiling is being performed at both academic and community oncology clinics has yet to be examined. Read More

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The Impact of Medical Comorbidities on Patient Satisfaction in Chronic Rhinosinusitis.

Ann Otol Rhinol Laryngol 2021 May 12:34894211015736. Epub 2021 May 12.

Department of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, CA, USA.

Background: Patient satisfaction has a significant bearing on medical therapy compliance and patient outcomes. The purpose of this study was to (1) describe patient satisfaction, as characterized by the Patient Satisfaction Questionnaire-18 (PSQ-18), in the care of patients with chronic rhinosinusitis (CRS) and (2) analyze the impact of comorbidities on satisfaction using the functional comorbidity index (FCI).

Methods: Patient demographics, disease severity measures, and PSQ-18 scores for patients with CRS presenting to a tertiary rhinology clinic between November 2019 and April 2020 were collected and analyzed. Read More

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Associations Between Wildfire-Related PM and Intensive Care Unit Admissions in the United States, 2006-2015.

Geohealth 2021 May 1;5(5):e2021GH000385. Epub 2021 May 1.

Division of Biostatistics and Bioinformatics and Department of Immunology and Genomic Medicine National Jewish Health Denver CO USA.

Wildfire smoke is a growing public health concern in the United States. Numerous studies have documented associations between ambient smoke exposure and severe patient outcomes for single-fire seasons or limited geographic regions. However, there are few national-scale health studies of wildfire smoke in the United States, few studies investigating Intensive Care Unit (ICU) admissions as an outcome, and few specifically framed around hospital operations. Read More

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Electrophysiological Evaluation in Identifying Unique Sleep Features Among Anti-LGI1 Encephalitis Patients During Active and Recovery Phase.

Nat Sci Sleep 2021 3;13:527-536. Epub 2021 May 3.

Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan City, Shandong Province, 250021, People's Republic of China.

Objective: The purpose of this study was to illustrate the electrophysiological features of sleep disturbances in patients with anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis in both active and recovery stages.

Methods: Retrospectively filed video electroencephalogram (VEEG) and polysomnography (PSG) data in 24 patients with anti-LGI1 encephalitis were analyzed in comparison with that in 20 individuals without sleep disorders as control group.

Results: Sleep efficiency (SE) and total sleep time involving REM and NREM sleep were significantly decreased in patients with anti-LGI1 encephalitis during the active stage compared to that during the recovery stage and in the control group. Read More

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Clinicopathological features of superficial CD34-positive fibroblastic tumor.

World J Clin Cases 2021 Apr;9(12):2739-2750

Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China.

Background: Superficial CD34-positive fibroblastoma (SCPFT) is a newly discovered mesenchymal tumor characterized by high polymorphism, low mitotic rate, and diffuse CD34-positive reactions.

Aim: To further determine the clinicopathological features of SCPFT.

Methods: We retrospectively analyzed the clinicopathological data, immunohistochemistry results, and differential diagnoses of four patients with SCPFT and performed a literature review. Read More

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Molecular Epidemiology of Salmonellosis in Florida, USA, 2017-2018.

Front Med (Lausanne) 2021 22;8:656827. Epub 2021 Apr 22.

Animal Sciences Department, Emerging Pathogens Institute, Food Systems Institute, University of Florida, Gainesville, FL, United States.

The state of Florida reports a high burden of non-typhoidal with approximately two times higher than the national incidence. We retrospectively analyzed the population structure and molecular epidemiology of 1,709 clinical isolates from 2017 and 2018. We found 115 different serotypes. Read More

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Functional recoveries of patients with branch atheromatous disease after rehabilitation: Comparison with other types of cerebral infarction and importance of stratification by clinical categories.

Restor Neurol Neurosci 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurology, Tane General Hospital, Kujou-minami, Nishi-ku, Osaka, Japan.

Background: Functional recoveries after rehabilitation of patients with branch atheromatous disease (BAD) have not been well investigated, however, clinical category of cerebral infarction including BAD itself could be a potential predictive factor for functional outcome.

Objective: To describe characteristics of functional recoveries of patients with BAD through comparison with other types of cerebral infarction.

Methods: We retrospectively compared outcomes of patients with BAD (N = 222), cardioembolic cerebral infarction (CE: N = 177) and atherothrombotic cerebral infarction (AT: N = 219) by using functional independence measure (FIM) and FIM effectiveness (the proportion of potential for improvement achieved). Read More

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Diagnostic yield and safety of bronchofiberscopy for pulmonary alveolar proteinosis.

Respir Investig 2021 May 6. Epub 2021 May 6.

Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka 591-8555, Japan. Electronic address:

Background: Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease characterized by the abnormal accumulation of surfactant-like material within the alveolar spaces and distal bronchioles. If high-resolution computed tomography (HRCT) indicates the presence of PAP, a definitive diagnosis of PAP is established when consistent pathological findings are obtained. Herein, we retrospectively studied the yield and safety of bronchofiberscopy in the diagnosis of PAP. Read More

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Epidemiology and Outcomes of Patients With Brain Metastases From Colorectal Cancer-Who Are These Patients?

Clin Colorectal Cancer 2021 Apr 15. Epub 2021 Apr 15.

Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil; Instituto D'Or de Ensino e Pesquisa, São Paulo Brazil.

Background: Brain metastases (BMs) from colorectal cancer (CRC) are unusual; however, an increase in incidence has been reported. The evidence available on the subject is scarce, and a better understanding is warranted. We aimed to characterize the epidemiology and the outcomes of patients with BMs from CRC. Read More

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Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a Single Institutional Experience with Clinicopathological and Molecular Characteristics.

Hum Pathol 2021 May 4. Epub 2021 May 4.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905. Electronic address:

Aims: Low-grade oncocytic tumor of the kidney (LOT) is characterized by cytoplasmic eosinophilia and a CK7-positive/CD117-negative immunophenotype. Morphologically, they exhibit overlapping features with oncocytoma and chromophobe renal cell carcinoma (chRCC). Our aim was to obtain long-term clinical follow-up data, clinicopathological and molecular characteristics, and incidence of LOT. Read More

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Malignant pertussis in infants: factors associated with mortality in a multicenter cohort study.

Ann Intensive Care 2021 May 7;11(1):70. Epub 2021 May 7.

Service de Réanimation et Urgences Pédiatriques, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677, Bron cedex, France.

Background: Malignant pertussis (MP) affects young infants and is characterized by respiratory distress, perpetual tachycardia and hyperleukocytosis up to 50 G/l, leading to multiple organ failure and death in 75% of cases. Leukodepletion may improve prognosis. A therapeutic strategy based on leukodepletion and extracorporeal life support (ECLS) according to different thresholds of leucocytes has been proposed by Rowlands and colleagues. Read More

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Epidemiology of Drug- and Herb-Induced Liver Injury Assessed for Causality Using the Updated RUCAM in Two Hospitals from China.

Biomed Res Int 2021 24;2021:8894498. Epub 2021 Feb 24.

Department of Pharmacy, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Drug- and herb-induced liver injury (DILI and HILI) is an increasingly common and serious condition. Here, data for DILI and HILI patients from two large tertiary hospitals were retrospectively analyzed. Patient characteristics, causes and severity of DILI and HILI, the correlation between expression of p62 and the severity of DILI and HILI, treatment of DILI and HILI, and the prognostic factors of DILI and HILI were studied. Read More

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February 2021

Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy.

Can J Gastroenterol Hepatol 2021 14;2021:8875564. Epub 2021 Apr 14.

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

Introduction: Ischemic enteritis (IE) is a relatively rare small bowel disease that is diagnosed via double-balloon endoscopy (DBE), although the lack of established diagnostic criteria can make it difficult to confirm the diagnosis. This study aimed to describe the clinical characteristics, endoscopic imaging features, and treatments for IE at our center. . Read More

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A novel missense variant in cathepsin C gene leads to PLS in a Chinese patient: A case report and literature review.

Mol Genet Genomic Med 2021 May 5:e1686. Epub 2021 May 5.

School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: Papilon-Lefevre syndrome (PLS; OMIM 245000) is a rare autosomal recessive disease characterized by aggressive periodontitis and palmoplantar keratoderma. The prevalence of PLS in the general population is one to four cases per million. Although the etiology and pathogenic mechanisms underlying PLS remain largely unclear, existing evidence shows loss-of-function mutations of the cathepsin C gene (CTSC; OMIM 602365) could cause PLS. Read More

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Rheumatic mitral regurgitation: is repair justified by the long-term results?

Interact Cardiovasc Thorac Surg 2021 May 5. Epub 2021 May 5.

Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.

Objectives: The best treatment for rheumatic mitral regurgitation is still under debate. Our goal was to assess the long-term results of mitral repair for rheumatic mitral regurgitation performed in 2 referral centres for mitral repair.

Methods: Patients who underwent mitral valve repair between 1999 and 2009 were selected. Read More

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Chest computed tomography imaging features in patients with coronavirus disease 2019 (COVID-19).

J Int Med Res 2021 May;49(5):3000605211010631

Undergraduate, Faculty of Medicine, New Giza University, Egypt.

Objective: To analyze computed tomography (CT) features of symptomatic patients with coronavirus disease 2019 (COVID-19).

Methods: Ninety-five symptomatic patients with COVID-19 confirmed by reverse-transcription polymerase chain reaction from 1 May to 14 July 2020 were retrospectively enrolled. Follow-up CT findings and their distributions were analyzed and compared from symptom onset to late-stage disease. Read More

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Erythropoietic protoporphyria: time to prodrome, the warning signal to exit sun exposure without pain-a patient-reported outcome efficacy measure.

Genet Med 2021 May 3. Epub 2021 May 3.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Purpose: Patients with erythropoietic protoporphyria (EPP), a severe painful photodermatosis, experience prodromal sensations when exposed to sunlight, which are the "warning signals" to exit the sun, as prolonged exposure causes an excruciatingly painful phototoxic attack. The unique prodromal cutaneous sensations are reversible and differ from the severe burning pain attack lasting 2-7 days. Previously, afamelanotide treatment was studied using time to pain or time outside as primary outcome measures. Read More

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Outcomes of 601 Colorectal Endoscopic Submucosal Dissections in a Single Western Center: Is Right Colon Location Still a Major Concern?

Surg Laparosc Endosc Percutan Tech 2021 May 3. Epub 2021 May 3.

Center of Bowel Treatment, Brzeziny Departments of General and Colorectal Surgery Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.

Background: Endoscopic submucosal dissection (ESD), as a minimally invasive procedure for removal of early gastrointestinal neoplasms, is a standard approach in Asian countries. Outcomes of ESD in Western European countries significantly differ, which makes it more difficult to apply this procedure to daily-basis clinical routine. The aim of this study is to analyze the safety and efficiency of colorectal ESD based on a large series of cases performed by a single operator after finishing the learning curve period in a western referral center. Read More

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Prednisolone treatment in acute interstitial nephritis (PRAISE) - protocol for the randomized controlled trial.

BMC Nephrol 2021 May 1;22(1):161. Epub 2021 May 1.

University Clinic in Nephrology and Hypertension, Aarhus University and Gødstrup Hospital, Herning, Denmark.

Background: Acute interstitial nephritis (AIN) is an important and common cause of acute renal failure. There are no generally accepted guidelines for the treatment of AIN, due to the lack of prospective randomized trials. Since AIN is characterized by an enhanced immune response, immunosuppressive treatment could potentially improve prognosis by attenuating inflammation and subsequent fibrosis. Read More

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Factors associated with adjacent-level tumor progression in patients receiving surgery followed by radiosurgery for metastatic epidural spinal cord compression.

Neurosurg Focus 2021 May;50(5):E15

Departments of1Neurosurgery.

Objective: Separation surgery followed by spine stereotactic radiosurgery (SSRS) has been shown to achieve favorable rates of local tumor control and patient-reported outcomes in patients with metastatic epidural spinal cord compression (MESCC). However, rates and factors associated with adjacent-level tumor progression (ALTP) in this population have not yet been characterized. The present study aimed to identify factors associated with ALTP and examine its association with overall survival (OS) in patients receiving surgery followed by radiosurgery for MESCC. Read More

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Significance of cerebral amyloid angiopathy and other co-morbidities in Lewy body diseases.

Authors:
Kurt A Jellinger

J Neural Transm (Vienna) 2021 May 29;128(5):687-699. Epub 2021 Apr 29.

Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150, Vienna, Austria.

Lewy body dementia (LBD) and Parkinson's disease-dementia (PDD) are two major neurocognitive disorders with Lewy bodies (LB) of unknown etiology. There is considerable clinical and pathological overlap between these two conditions that are clinically distinguished based on the duration of Parkinsonism prior to development of dementia. Their morphology is characterized by a variable combination of LB and Alzheimer's disease (AD) pathologies. Read More

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Goods syndrome combined with bronchiectasis: A case report and literature review.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):328-332

Department of Respiratory Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China.

A patient with thymoma associated immunodeficiency syndrome (Good's syndrome) and bronchiectasis was retrospectively analyzed. Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. It is important to bear in mind that Good's syndrome should be included in the differential diagnosis When patients repeatedly visited for bronchiectasis or infection, we should alert to their immune state and history of thymoma. Read More

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Variation of enterohepatic circulation through the image with SeHCAT in the first 3 hours. Scintigraphic patterns and análisis of its association with the diagnosis of bile acid malabsorption.

Rev Esp Med Nucl Imagen Mol 2021 Apr 26. Epub 2021 Apr 26.

Servicio de Medicina Nuclear, Clinica Universitaria de Navarra, Pamplona, Navarra, España.

Objetive: To evaluate the enterohepatic circulation of 75-Selenium turoselecolic acid (Se-SeHCAT) during the first 3 hours and its correlation with the abdominal retention at the 7 day (AR), as contribution to the clinical study of biliar acid malabsorption (BAM).

Materials And Methods: 38 patients with chronic diarrhea were retrospectively studied. Acquisition protocol included static abdominal images at 1, 2 and 3 hour and the 7 day after oral administration of the radiopharmaceutical. Read More

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Risk factors for secondary hemophagocytic lymphohistiocytosis in severe coronavirus disease 2019 adult patients.

BMC Infect Dis 2021 Apr 29;21(1):398. Epub 2021 Apr 29.

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197, Rui Jin 2nd road, Shanghai, 200025, China.

Background: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory event and a fatal complication of viral infections. Whether sHLH may also be observed in patients with a cytokine storm induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still uncertain. We aimed to determine the incidence of sHLH in severe COVID-19 patients and evaluate the underlying risk factors. Read More

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Loss-of-Function Mutations of Are an Independent Marker of Adverse Outcomes in Intensively Treated Patients with Acute Myeloid Leukemia.

Cancers (Basel) 2021 Apr 26;13(9). Epub 2021 Apr 26.

Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital, 60177 Brno, Czech Republic.

Acute myeloid leukemia (AML) is characterized by recurrent genetic events. The corepressor and its homolog, the , have been reported to be rare but recurrent mutations in AML. Previously, smaller studies have reported conflicting results regarding impacts on outcomes. Read More

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Public Health Workforce Burnout in the COVID-19 Response in the U.S.

Int J Environ Res Public Health 2021 04 20;18(8). Epub 2021 Apr 20.

Epidemiology Program, University of Delaware, Newark, DE 19713, USA.

While the health impacts of the COVID-19 pandemic on frontline health care workers have been well described, the effects of the COVID-19 response on the U.S. public health workforce, which has been impacted by the prolonged public health response to the pandemic, has not been adequately characterized. Read More

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A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis.

J Clin Med 2021 Apr 17;10(8). Epub 2021 Apr 17.

Cell Therapy Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France.

(1) Background: The emergence of injectable "biologic" medication creates a new approach to treat osteoarthritis (OA). Among them, the use of intra-articular injection of PRP became widespread despite the absence of consensus regarding its optimal composition. The aim of this study was to retrospectively correlate an extensive biological characterization of injected PRP to the clinical responses of patients presenting knee OA. Read More

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