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Stress Fracture of the Femoral Shaft in Paget's Disease of Bone: A Case Report.

J Bone Metab 2021 May 31;28(2):171-178. Epub 2021 May 31.

Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Paget's disease of bone (PDB) is a progressive bone disorder characterized by increased osteoclast-mediated bone resorption and abnormal bone formation. Incomplete atypical femoral fracture, appearing radiographically as a stress fracture at the lateral aspect of the femur, is an uncommon low-trauma fracture frequently seen in association with long-term bisphosphonate therapy. We describe the case of a 61-year-old female patient with PDB who developed a stress fracture at the lateral femoral cortex after 5 doses of intravenous bisphosphonate. Read More

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Isoflavones alter male and female fertility in different development windows.

Biomed Pharmacother 2021 Jun 12;140:111448. Epub 2021 Jun 12.

Department of Pharmacy, State University of Centro-Oeste, Parana, Brazil; Program in Biotechnology in Human and Animal Health - (PPGBiotec), State University of Ceará, Ceará, Brazil. Electronic address:

Isoflavones are a group of secondary metabolites found in plants belonging to the class of phytoestrogens. These, because they have a chemical structure similar to the endogenous hormone 17β-estradiol, act as endocrine disruptors over the different development window periods. This study aimed to evaluate male and female reproductive systems' responses when exposed to isoflavones during the development window. Read More

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Glioblastoma-specific anticancer activity of newly synthetized 3,5-disubstituted isoxazole and 1,4-disubstituted triazole-linked tyrosol conjugates.

Bioorg Chem 2021 Jun 8;114:105071. Epub 2021 Jun 8.

University of Monastir, Faculty of Science of Monastir, Laboratory of Heterocyclic, Chemistry, Natural Products and Reactivity, TeamMedicinal Chemistry and Natural, Products (LR11ES39), Department of Chemistry, Avenue of Environment, 5019 Monastir, Tunisia. Electronic address:

Two series of 3,5-disubstituted isoxazoles (6a-e) and 1,4-disubstituted triazoles (8a-e) derivatives have been synthesized from tyrosol (1), a natural phenolic compound, detected in several natural sources such as olive oil, and well-known by its wide spectrum of biological activities. Copper-catalyzed microwave-assisted 1,3-dipolar cycloaddition reactions between tyrosol-alkyne derivative 2 and two series of aryl nitrile oxides (5a-e) and azides (7a-e) regiospecifically afforded 3,5-disubstituted isoxazoles (6a-e) and 1,4-triazole derivatives (8a-e), respectively in quantitative yields. Synthesized compounds were purified and characterized by spectroscopic means including 1D and 2D NMR techniques and HRMS analysis. Read More

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Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors.

Neurochem Int 2021 Jun 12:105098. Epub 2021 Jun 12.

Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, 430065, China; New Medicine Innovation and Development Institute, Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China. Electronic address:

Obesity is characterized by a condition of low-grade chronic inflammation that facilitates development of numerous comorbidities and dysregulation of brain homeostasis. It is reported that obesity can lead to behavioral alterations such as cognitive decline and depression-like behaviors both in humans and rodents. Saponins from panax japonicus (SPJ) have been reported to exhibit anti-inflammatory action in mouse model of diet-induced obesity. Read More

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Discovery and Optimization of a Novel 2-Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor.

J Med Chem 2021 Jun 15. Epub 2021 Jun 15.

The State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, College of Pharmacy, Nankai University, Tianjin 300071, P. R. China.

Fibroblast growth factor receptors (FGFRs) have become promising therapeutic targets in various types of cancers. In fact, several selective irreversible inhibitors capable of covalently reacting with the conserved cysteine of FGFRs are currently being evaluated in clinical trials. In this article, we optimized and discovered a novel lead compound with remarkable inhibitory effects against FGFR (1-3), which is a derivative of 2-pyrazolo[3,4-d]pyrimidine. Read More

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Lymphedema complicated by protein-losing enteropathy with a 22q13.3 deletion and the potential role of CELSR1: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26307

Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University.

Introduction: 22q13.3 deletion syndrome is a well-known syndrome characterized by typical clinical findings including neonatal hypotonia, absent or severely delayed speech, intellectual disability, and other various features, and detection of a heterozygous deletion of chromosome 22q13.3 with the involvement of at least part of SHANK3. Read More

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Clinicopathological analysis and genomic profiling of a rare histiocyte-rich rhabdomyoblastic tumor: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26105

Department of General Surgery, Shenzhen University General Hospital & Carson International Cancer Research Centre, Shenzhen, P.R. China.

Rationale: Skeletal muscle tumors are traditionally classified as rhabdomyomas or rhabdomyosarcomas. However, some soft tissue tumors cannot easily be identified as benign or malignant. We report a case of a histiocyte-rich rhabdomyoblastic tumor, with pathologic characteristics distinct from either rhabdomyoma or rhabdomyosarcoma. Read More

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Factors influencing the EULAR Sjögren's Syndrome Patient Reported Index in primary Sjögren's syndrome.

Clin Exp Rheumatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Objectives: The ESSPRI is a validated tool for measuring pain, fatigue and dryness in primary Sjögren's syndrome (pSS). We evaluated its association with disease and non-disease related variables, and its variation though the follow-up.

Methods: We included 130 pSS patients who were interviewed to register demographics, schooling, smoking, menopause, body mass index (BMI), disease duration, use of hormonal replacement, associated sicca drugs, prednisone, immunosuppressors/antimalarials, comorbidities such as diabetes mellitus, hypothyroidism, depression, fibromyalgia and scored the Charlson comorbidity index. Read More

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Predicting Antimicrobial Resistance Using Partial Genome Alignments.

mSystems 2021 Jun 15:e0018521. Epub 2021 Jun 15.

Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.

Antimicrobial resistance (AMR) is an important global health threat that impacts millions of people worldwide each year. Developing methods that can detect and predict AMR phenotypes can help to mitigate the spread of AMR by informing clinical decision making and appropriate mitigation strategies. Many bioinformatic methods have been developed for predicting AMR phenotypes from whole-genome sequences and AMR genes, but recent studies have indicated that predictions can be made from incomplete genome sequence data. Read More

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Time-Dependent Self-Assembly of Copper(II) Coordination Polymers and Tetranuclear Rings: Catalysts for Oxidative Functionalization of Saturated Hydrocarbons.

Inorg Chem 2021 Jun 15. Epub 2021 Jun 15.

Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001, Lisbon, Portugal.

This study describes a time-dependent self-assembly generation of new copper(II) coordination compounds from an aqueous-medium reaction mixture composed of copper(II) nitrate, Hbes biobuffer (,-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid), ammonium hydroxide, and benzenecarboxylic acid, namely, 4-methoxybenzoic (Hfmba) or 4-chlorobenzoic (Hfcba) acid. Two products were isolated from each reaction, namely, 1D coordination polymers [Cu(μ-OH)(μ-fmba)(fmba)(HO)] () or [Cu(μ-OH)(μ-fcba)] () and discrete tetracopper(II) rings [Cu(μ-Hbes)(μ-Hbes)(μ-fmba)]·2HO () or [Cu(μ-Hbes)(μ-Hbes)(μ-fcba)]·4HO (), respectively. These four compounds were obtained as microcrystalline air-stable solids and characterized by standard methods, including the single-crystal X-ray diffraction. Read More

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Silver-N-heterocyclic carbene complexes-catalyzed multicomponent reactions: Synthesis, spectroscopic characterization, density functional theory calculations, and antibacterial study.

Arch Pharm (Weinheim) 2021 Jun 15:e2100111. Epub 2021 Jun 15.

Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Tunis, Tunisia.

Nowadays, silver-N-heterocyclic carbene (silver-NHCs) complexes are widely used in medicinal chemistry due to their low toxic nature toward humans. Due to the success of silver-NHCs in medicinal applications, interest in these compounds is rapidly increasing. Therefore, the interaction of N,N-disubstituted benzimidazolium salts with Ag O in dichloromethane to prepare novel Ag(I)-NHCs complexes was carried out at room temperature for 120 h in the absence of light. Read More

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Evaluation of cadmium and arsenic effects on wild and cultivated cardoon genotypes selected for metal phytoremediation and bioenergy purposes.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

National Research Council, Institute for Agricultural and Forest Systems in the Mediterranean, Via Empedocle, 58, 95128, Catania, Italy.

Cynara cardunculus L. is a multipurpose crop, characterized by high production of biomass suitable for energy purposes and green chemistry. Taking advantage of its already demonstrated ability to grow in polluted environments that characterize many world marginal lands, the aim of this work was to investigate the response of different cardoon genotypes to exposure to cadmium (Cd) and arsenic (As) pollution, in order to use this crop for rehabilitation of contaminated sites and its biomass for energy production. Read More

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Changes in electromyographic activity, mechanical power, and relaxation rates following inspiratory ribcage muscle fatigue.

Sci Rep 2021 Jun 14;11(1):12475. Epub 2021 Jun 14.

Dipartimento Di Elettronica, Informazione E Bioingegneria, Politecnico Di Milano, Milan, Italy.

Muscle fatigue is a complex phenomenon enclosing various mechanisms. Despite technological advances, these mechanisms are still not fully understood in vivo. Here, simultaneous measurements of pressure, volume, and ribcage inspiratory muscle activity were performed non-invasively during fatigue (inspiratory threshold valve set at 70% of maximal inspiratory pressure) and recovery to verify if inspiratory ribcage muscle fatigue (1) leads to slowing of contraction and relaxation properties of ribcage muscles and (2) alters median frequency and high-to-low frequency ratio (H/L). Read More

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Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells.

NPJ Genom Med 2021 Jun 14;6(1):48. Epub 2021 Jun 14.

Translational Medicine Collaborative Innovation Center, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.

Lung adenocarcinoma is heterogeneous and hierarchically organized, with a subpopulation of stem-like cells (CSCs) that reside at the apex of the hierarchy, in which exosomes act as important mediators by transporting specific molecules among different cell populations. Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. Here we present a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells (LSLCs). Read More

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Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.

Nat Commun 2021 06 14;12(1):3601. Epub 2021 Jun 14.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. Read More

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Impact of Preceding Workload on Team Performance in Collegiate Men's Ice Hockey.

J Strength Cond Res 2021 Jun 11. Epub 2021 Jun 11.

Health Sciences, Rocky Mountain University of Health Professions, Provo, Utah; San Francisco 49ers, Santa Clara, California; Athletics, University of Minnesota, Minneapolis, Minnesota; and Kinesiology, Point Loma Nazarene University, San Diego, California.

Abstract: Neeld, KL, Peterson, BJ, Dietz, CC, Cappaert, TA, and Alvar, BA. Impact of preceding workload on team performance in collegiate men's ice hockey. J Strength Cond Res XX(X): 000-000, 2021-Although the workload-injury relationship has received ample research attention, the relationship between prior workload and performance in team sport remains poorly understood. Read More

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High-throughput screening of TRPV1 ligands in the light of the Bioluminescence Resonance Energy Transfer technique.

Mol Pharmacol 2021 Jun 14. Epub 2021 Jun 14.

IMS laboratory / CNRS UMR 5218, Bordeaux University, France

Ion channels are attractive drug targets for many therapeutic applications. However, high-throughput screening (HTS) of drug candidates is difficult and remains very expensive. We thus assessed the suitability of the Bioluminescence Resonance Energy Transfer (BRET) technique as a new HTS method for ion-channel studies by taking advantage of our recently characterized intra- and intermolecular BRET probes targeting the TRPV1 ion channel. Read More

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Economic Burden of Dementia Related Psychosis Among Medicare Beneficiaries: A State-Transition Markov Analysis of Total Annual Direct Costs.

CNS Spectr 2021 Apr;26(2):161

An-L-It-Iks, Inc., Framingham, MA, USA.

Study Objective: Dementia related psychosis (DRP), characterized by debilitating symptoms such as hallucinations and delusions, is estimated to affect 2.4M people with dementia in the US. Patients with DRP may have twice the rate of dementia progression compared to patients with no DRP. Read More

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Enhanced solubility of Albendazole in Cyclodextrin Inclusion Complex: A Molecular Modeling Approach and Physicochemical Evaluation.

Curr Drug Deliv 2021 Jun 13. Epub 2021 Jun 13.

Laboratório de Tecnologia dos Medicamentos, Universidade Federal de Pernambuco, Recife/PE, Brazil.

Background: Albendazole (ABZ) is the drug of choice for the treatment of a variety of human and veterinary parasites. However, it has low aqueous solubility and low bioavailability. Cyclodextrins (CD) are pharmaceutical excipients with the ability to modulate the solubilization property of hydrophobic molecules. Read More

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Gastroretentive Metformin loaded Nanoparticles for the effective management of Type-2 Diabetes Mellitus.

Curr Drug Deliv 2021 Jun 13. Epub 2021 Jun 13.

SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (C.G.) 495 009, India.

Introduction: Metformin, an anti-diabetic drug, has low bioavailability and a short biological half-life. Thus, bioavailability enhancement and prolonged release of the drug are highly desirable. In this regard, we aimed to developed gastroretentive nanoparticles made of jackfruit seed starch (JFSS) loaded with metformin. Read More

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Vulnerability of personality disorder during the Covid-19 crises - a multicenter survey of treatment experiences among patients referred to treatment.

Nord J Psychiatry 2021 Jun 14:1-12. Epub 2021 Jun 14.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: The societal shutdown due to the Covid-19 pandemic involved mental health services for personality disorder (PD) and was introduced from 12 March 2020 in Norway. Rapid implementation of treatment modifications was required for patients typically characterized by insecure attachment and vulnerability to separation.

Aim: To investigate immediate reactions to the shutdown of services; alternative treatment received; and differences related to age in a clinical sample of patients with PD. Read More

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Synthesis, characterization and C-H amination reactivity of nickel iminyl complexes.

Chem Sci 2019 Dec 11;11(5):1260-1268. Epub 2019 Dec 11.

Department of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge Massachusetts 02138 USA

Metalation of the deprotonated dipyrrin (L)Li with NiCl(py) afforded the divalent Ni product (L)NiCl(py) () (L: 1,9-di(1-adamantyl)-5-perfluorophenyldipyrrin; py: pyridine). To generate a reactive synthon on which to explore oxidative group transfer, we used potassium graphite to reduce , affording the monovalent Ni synthon (L)Ni(py) () and concomitant production of a stoichiometric equivalent of KCl and pyridine. Slow addition of mesityl- or 1-adamantylazide in benzene to afforded the oxidized Ni complexes (L)Ni(NMes) () and (L)Ni(NAd) (), respectively. Read More

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December 2019

Harpagide, a natural product, promotes synaptic vesicle release as measured by nanoelectrode amperometry.

Chem Sci 2019 Nov 28;11(3):778-785. Epub 2019 Nov 28.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University Wuhan 430072 China

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DAergic) neurons and low level of dopamine (DA) in the midbrain. Recent studies suggested that some natural products can protect neurons against injury, but their role on neurotransmitter release and the underlying mechanisms remained unknown. In this work, nanoelectrode electrochemistry was used for the first time to quantify DA release inside single DAergic synapses. Read More

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November 2019

Molecular cloning and characterization of the novel adropin from tilapia (Oreochromis niloticus): Involvement in the control of food intake.

Neuropeptides 2021 Jun 8;88:102165. Epub 2021 Jun 8.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China. Electronic address:

Adropin has been shown to be involved in the regulation of food intake in mice. However, the mechanism of adropin in feeding regulation is still largely unknown. Using the tilapia, Oreochromis niloticus, we identified and characterized a novel form of adropin (designated adropin-b) encoding a 68-amino acid precursor. Read More

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Both pH and salinity shape the microbial communities of the lakes in Badain Jaran Desert, NW China.

Sci Total Environ 2021 Jun 6;791:148108. Epub 2021 Jun 6.

School of Water Resources and Environment, China University of Geosciences, Beijing 100083, China; Department of Geology and Environmental Earth Science, Miami University, Oxford, OH 45056, USA.

Badain Jaran Desert (BJD), characterized by extremely arid climate and tallest sand dunes in the world, is the second largest desert in China. Surprisingly, there are a large number of permanent lakes in this desert. At present, little is known about the composition and distribution of microbial communities in these desert lakes, which are an important bioresource and play a fundamental role in the elemental cycles of the lakes. Read More

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Catalytic reduction of 4-nitrophenol and methylene blue pollutants in water by copper and nickel nanoparticles decorated polymer sponges.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 26;261:120019. Epub 2021 May 26.

Institute of Chemical Science, University of Peshawar, Peshawar, Pakistan.

In the present study, two catalysts based-on copper and nickel nanoparticles anchored on agarose-coated sponge (Cu-AG-sponge and Ni-AG-sponge) were prepared, respectively. Both catalysts were characterized by analytical techniques of thermogravimetric analysis energy dispersive X-ray spectroscopy (EDX) and scanning electron microscopy (SEM). Spherical Cu and Ni nanoparticles on struts of AG-coated sponge were observed by FESEM and the samples' elemental composition was confirmed by EDX technique. Read More

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Preparation of fluorescent bimetallic silver/copper nanoparticles and their utility of dual-mode fluorimetric and colorimetric probe for Hg.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 29;261:120035. Epub 2021 May 29.

Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province, Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, Heilongjiang 150025, China; Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge CB2 1EW, UK. Electronic address:

A dual-mode colorimetric and fluorimetric probe was successfully established based on silver/copper bimetallic nanoparticles (AgCu-BNPs). The AgCu-BNPs were confirmed as individually bimetallic nanoparticles with a mean size of 7.7 ± 0. Read More

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Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase.

Exp Gerontol 2021 Jun 11:111449. Epub 2021 Jun 11.

Multidisciplinary Institute of Health, Anísio Teixeira Campus, Federal University of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 Vitória da Conquista, Bahia, Brazil. Electronic address:

Aging in women is characterized by extreme hormonal changes leading them to develop a chronic low-grade inflammation that is linked to the development of systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM). In this scenario, physical activity emerges as an interesting methodology, since it seems to be connected to a decrease in serum levels of some pro-inflammatory cytokines. Nevertheless, most studies evaluate these cytokines in an isolated manner not considering the influence of comorbidities on the responsiveness of participants to the benefits of physical activity. Read More

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F-type lectin from serum of the Antarctic teleost fish Trematomus bernacchii (Boulenger, 1902): Purification, structural characterization, and bacterial agglutinating activity.

Comp Biochem Physiol B Biochem Mol Biol 2021 Jun 11:110633. Epub 2021 Jun 11.

Marine Immunobiology Laboratory, Department of Earth and Marine Sciences, University of Palermo, Palermo, Italy. Electronic address:

The increasing availability of sequenced genomes has enabled a deeper understanding of the complexity of fish lectin repertoires involved in early development and immune recognition. The teleost fucose-type lectin (FTL) family includes proteins that preferentially bind fucose and display tandemly arrayed carbohydrate-recognition domains (CRDs) or are found in mosaic combinations with other domains. They function as opsonins, promoting phagocytosis and the clearance of microbial pathogens. Read More

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Distribution of glutamatergic and glycinergic inputs onto human auditory coincidence detector neurons.

Neuroscience 2021 Jun 11. Epub 2021 Jun 11.

Henry Ford Macomb Hospital, Department of Otolaryngology - Facial Plastic Surgery, Clinton Township, MI, United States. Electronic address:

Localization of sound sources in the environment requires neurons that extract interaural timing differences (ITD) in low-frequency hearing animals from fast and precisely timed converging inputs from both ears. In mammals, this is accomplished by neurons in the medial superior olive (MSO). MSO neurons receive converging excitatory input from both the ipsilateral and contralateral cochlear nuclei and glycinergic, inhibitory input by way of interneurons in the medial and lateral nuclei of the trapezoid body (MNTB and LNTB, respectively). Read More

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